Amide compound and thrombopoietin receptor activator

ABSTRACT

The present invention provides compounds useful for prevention, treatment or alleviation of diseases against which activation of the thrombopoietin receptor is effective. 
     A compound represented by the formula (1): 
                         
wherein A, B, R 1 , L 1 , R 2 , L 2 , L 3 , Y, L 4 , R 3  and X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

TECHNICAL FIELD

The present invention relates to preventive, therapeutic and improving agents having affinity for and agonistic action on the thrombopoietin receptor for diseases against which activation of the thrombopoietin receptor is effective. Specifically, it relates to pharmaceutical compositions comprising compounds which increase platelets through stimulation of differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes or compounds for therapeutic angiogenesis or with anti arteriosclerosis action that stimulate differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells.

BACKGROUND ART

Thrombopoietin is a cytokine consisting of 332 amino acids that increases platelet production by stimulating differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes mediated by its receptor and therefore is promising as a drug for hematological disorders. Recent reports that it stimulates differentiation and proliferation or vascular endothelial cells and endothelial progenitor cells have raised expectations of therapeutic angiogenesis, anti-arteriosclerosis and prevention of cardiovascular events (for example, non-patent document 1, non-patent document 2 and non-patent document 3.

Biologically active substances which have been known so far to regulate platelet production through the thrombopoietin receptor include, in addition to thrombopoietin itself, low molecular weight peptides having affinity for the thrombopoietin receptor (for example, patent document 1, patent document 2, patent document 3 and patent document 4).

As a result of search for nonpeptidic low molecular weight compounds that increase platelet production mediated by the thrombopoietin receptor, low molecular weight compounds having affinity for the thrombopoietin receptor have been reported (for example, patent document 5 to patent document 25).

-   1) Applications filed by Hokuriku Seiyaku Co., Ltd. relating to     1,4-benzodiazepine derivatives (patent documents 5 and 6) -   2) International Laid-open Patent Applications filed by Shionogi a     Co., Ltd (patent documents 7-10) -   3) International Laid-open Patent Applications filed by SmithKline     Beecham Corp (patent documents 11-19) -   4) Japanese Laid-open Patent Application filed by Torii     Pharmaceutical Co., Ltd. (patent document 20) -   5) International Laid-open Patent Application filed by Roche     Diagnostics GMBH (patent document 21) -   6) International Laid-open Patent Applications filed by Yamanouchi     Pharmaceutical Co., Ltd. (patent documents 22 and 23) -   7) Japanese Laid-open Patent Application filed by Japan Tabacco Inc.     (patent document 24) -   8) Japanese Laid-open Patent Applications filed by Nissan Chemical     Industries, Ltd. (patent documents 25 and 26) -   Patent document 1 JP-A-10-72492 -   Patent document 2 WO96/40750 -   Patent document 3 WO96/40189 -   Patent document 4 WO98/25965 -   Patent document 5 JP-A-11-1477 -   Patent document 6 JP-A-11-152276 -   Patent document 7 WO01/07423 -   Patent document 8 WO01/53267 -   Patent document 9 WO02/059099 -   Patent document 10 WO02/059100 -   Patent document 11 WO00/35446 -   Patent document 12 WO00/66112 -   Patent document 13 WO01/34585 -   Patent document 14 WO01/17349 -   Patent document 15 WO01/39773 -   Patent document 16 WO01/21180 -   Patent document 17 WO01/89457 -   Patent document 18 WO02/49413 -   Patent document 19 WO02/085343 -   Patent document 20 JP-A-2001-97948 -   Patent document 21 WO99/11262 -   Patent document 22 WO02/062775 -   Patent document 23 WO03/062233 -   Patent document 24 JP-A-2003-238565 -   Patent document 25 WO04/033433 -   Patent document 26 WO04/108683 -   Non-patent document 1 Microvasc. Res., 1999: 58, p. 108-113 -   Non-patent document 2 Circ. Res., 1999: 84, p. 785-796 -   Non-patent document 3 Blood 2001:98, p. 71a-72a

DISCLOSURE OF THE INVENTION

Thrombopoietin and low molecular weight peptides having affinity for the thrombopoietin receptor are likely to be easily degraded in the gastrointestinal tract and are usually difficult to orally administer. As to thrombopoietin itself, the appearance of anti-thrombopoietin antibodies have been reported.

Besides, though it is probably possible to orally administer nonpeptidic low molecular weight compounds, no practical drugs have been put on the market.

Therefore, orally administrable low molecular weight compounds having excellent affinity for and agonistic action on the thrombopoietin receptor as preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective have been demanded. Specifically low molecular weight compounds which can serve as platelet increasing agents or increasing agents for other blood cells by stimulating differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes or low molecular weight compounds which can be used for therapeutic angiogenesis or as preventive and therapeutic agents for arteriosclerosis by stimulating endothelial cells and endothelial progenitor cells have been demanded.

The present inventors conducted extensive research to find low molecular weight compounds having affinity for and agonistic action on the thrombopoietin receptor, and as a result, found that the compounds of the present invention have high affinity and agonistic action which enable them to show potent platelet increasing action by stimulating differentiation and proliferation of megakaryocytic progenitor cells and megakaryocytes. The present invention was accomplished on the basis of this discovery.

Namely the present invention relates to:

1. A compound represented by the formula (1):

wherein A is a nitrogen atom or CR⁴ (wherein R⁴ is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C₂₋₆ alkenyl group or a C₂₋₆ alkynyl group), a thiol group (the thiol group may be substituted with a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C₂₋₆ alkenyl groups or one or two C₂₋₆ alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group and the C₁₋₁₀ alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) SO₂R⁵, SOR⁵ or COR⁵ (wherein R⁵ is a hydroxyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group and the C₁₋₁₀ alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) or NR⁶R⁷ (wherein each of R⁶ and R⁷ is independently a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₄₋₁₄ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), or R⁶ and R⁷ mean, together with each other, —(CH₂)_(m1)-E-(CH₂)_(m2)— (wherein E is an oxygen atom, a sulfur atom, CR²⁶R²⁷ (wherein each of R²⁶ and R²⁷ is independently a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR⁸ (wherein R⁸ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))),

B is an oxygen atom, a sulfur atom or NR⁹ (wherein R⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)) (provided that when A is a nitrogen atom, B is not NH),

R¹ is a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be substituted with one or more substituents selected from the group consisting of: halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonyloxy groups and the C₁₋₁₀ alkoxycarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups (the C₂₋₁₄ aryl groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or two substituents selected from the group consisting of: formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups and C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)))),

L¹ is a bond, CR¹⁰R¹¹ (wherein each of R¹⁰ and R¹¹ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms)), an oxygen atom, a sulfur atom or NR¹² (wherein R¹² is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)),

X is OR¹³, SR¹³ or NR¹⁴R¹⁵ (wherein R¹³ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), and each of R¹⁴ and R¹⁵ is independently a hydrogen atom, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)),

R² is a hydrogen atom, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups),

L² is a bond, CR³⁴R³⁵ (wherein each of R³⁴ and R³⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms)), an oxygen atom, a sulfur atom or NR¹⁶ (wherein R¹⁶ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)),

L³ is a bond, CR¹⁷R¹⁸ (wherein each of R¹⁷ and R¹⁸ is independently a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group; a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), an oxygen atom, a sulfur atom or NR¹⁹ (wherein R¹⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group, the C₁₋₁₀ alkoxy group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), L is a bond, CR²⁰R²¹ (wherein each of R²⁰ and R²¹ is independently a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), an oxygen atom, a sulfur atom or NR²² (wherein R²² is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)),

Y is an oxygen atom, a sulfur atom or NR²³ (wherein R²³ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), and

R³ is a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group is optionally substituted with one or more substituents independently represented by —V¹ (wherein V¹ is a hydrogen atom, a hydroxyl group, a protected hydroxyl group, an amino group, a thiol group, a nitro group, a cyano group, a halogen atom, a carboxyl group, a carbamoyl group, a sulfamoyl group, a sulfo group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkoxy group, a C alkylcarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylaminosulfonyl group, a C₁₋₁₀ alkylaminocarbonyl group, a C₁₋₁₀ alkylsulfonylamino group, a C₁₋₁₀ thioalkyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyl group, the C₁₋₁₀ alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylaminosulfonyl group, the C₁₋₁₀ alkylaminocarbonyl group, the C₁₋₁₀ alkylsulfonylamino group and the C₁₋₁₀ thioalkyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)) and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom, a hydroxyl group, an amino group, a C₂₋₁₄ alkyl group or a C₁₋₆ alkoxy group (the C₁₋₆ alkyl group and the C₁₋₆ alkoxy group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or CR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₂₋₁₄ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), and R³⁰ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group, a C₂₋₉ heterocyclyl group (the amino group, the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) and with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfo groups, sulfamoyl groups and C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or R²⁹ and R³⁰ mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is CR³¹R³² (wherein R³¹ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group (the C₁₋₁₀ alkyl group, the C₂₋₁₄ aryl group, the C₁₋₁₀ alkoxy group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R³² is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or NR³³ (wherein R³³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5), or NR²⁹R³⁰, as a whole, means a nitrogen-containing C₂₋₉ cyclyl group (the nitrogen-containing C₂₋₉ cyclyl group may be optionally substituted with one or more hydrogen atoms and is substituted with two or three substituents independently selected from the group consisting of: hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylsulfonylamino groups, the C₁₋₁₀ thioalkyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or a substituted C₂₋₉ heterocyclyl group (the substituted C₂₋₉ heterocyclyl group may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylsulfonylamino groups, the C₁₋₁₀ thioalkyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))))), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group is optionally substituted with one or more substituents independently represented by —V¹ (wherein V¹ is the same as defined above) and with one or more substituents selected from the group consisting of: C₁₋₆ alkyl groups, C₂₋₆ alkenyl groups and C₂₋₁₆ alkynyl groups (the C₁₋₆ alkyl groups, the C₂₋₆ alkenyl groups and the C₂₋₆ alkynyl groups are optionally substituted with one or more substituents selected from the group consisting of: hydroxyl groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups and C₁₋₆ alkoxy groups (the mono- or di-C₁₋₁₀ alkylamino groups and the C₁₋₆ alkoxy groups may be substituted with one or more halogen atoms), with one or more substituents independently represented by —V² (wherein V² is the same as V¹, and V¹ is the same as defined above) and with —W⁵ (wherein W⁵ is SO₂R⁴², SOR⁴², COR⁴² (wherein R⁴² is a hydrogen atom, a hydroxyl group or NR⁴³R⁴⁴, R⁴³ is the same as R⁶, R⁴⁴ is the same as R⁷ and R⁶ and R⁷ are the same as defined above) or W⁴, and W⁴ is the same as defined above))), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group is optionally substituted with one or more substituents independently represented by —V¹ (wherein V¹ is the same as defined above) and with one or more substituents selected from the group consisting of: C₁₋₆ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylthiocarbonyl groups and C₁₋₁₀ alkylsulfonyl groups (the C₁₋₆ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylthiocarbonyl groups and the C₁₋₁₀ alkylsulfonyl groups are optionally substituted with one or more substituents independently represented by —V² (wherein V² is the same as V¹ and V¹ is the same as defined above) and with one or more substituents selected from C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups are optionally substituted with one or more substituents independently represented by —V³ (wherein V³ is the same as V¹, and V¹ is the same as defined above)))), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group is optionally substituted with one or more substituents independently represented by —V¹ (wherein V¹ is the same as defined above) and with one or more substituents selected from the group consisting of: C₁₋₆ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylthiocarbonyl groups and C₁₋₁₀ alkylsulfonyl groups (the C₁₋₆ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C alkylcarbonyl groups, the C₁₋₁₀ alkylthiocarbonyl groups and the C₁₋₁₀ alkylsulfonyl groups are optionally substituted with one or more substituents independently represented by —V² (wherein V² is the same as V¹, and V¹ is the same as defined above) and with one or more substituents selected from the group consisting of: amino groups (the amino groups are substituted with a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group is optionally substituted with one or more substituents independently represented by —V³ (wherein V³ is the same as V¹, and V¹ is the same as defined above)) and with a C₂₋₉ heterocyclyl group or a C₂₋₁₄ aryl group (the C₂₋₉ heterocyclyl group and the C₂₋₁₄ aryl group are optionally substituted with one or more substituents independently represented by —V⁴ (wherein V⁴ is the same as V¹, and V¹ is the same as defined above))), amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ thioalkyl groups, C₁₋₁₀ alkylsulfonyl groups, sulfonyl groups, sulfinyl groups and thiol groups (the amino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ thioalkyl groups, the C₁₋₁₀ alkylsulfonyl groups, the sulfonyl groups, the sulfinyl groups and the thiol groups are optionally substituted with one or more C₂₋₉ heterocyclyl groups or one or more C₂₋₁₄ aryl groups (the C₂₋₉ heterocyclyl groups and the C₂₋₁₄ aryl groups are optionally substituted with one or more substituents independently represented by —V⁵ (wherein V⁵ is the same as V¹, and V¹ is the same as defined above)))) or a C₂₋₁₄ substituted aryl group (the C₂₋₁₄ substituted aryl group may be optionally substituted with one or more substituents independently represented by —V¹ wherein V¹ is the same as defined above)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

2. The compound according to 1, wherein A is a nitrogen atom, and B is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

3. The compound according to 1, wherein A is a nitrogen atom, and B is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

4. The compound according to 1, wherein A is a nitrogen atom, and B is NR⁹ other than NH (wherein R⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 5. The compound according to 1 wherein A is CR⁴ (wherein R⁴ is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C₂₋₆ alkenyl group or a C₂₋₆ alkynyl group), a thiol group (the thiol group may be substituted with a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C₂₋₆ alkenyl groups or one or two C₂₋₆ alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group and the C₁₋₁₀ alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) SO₂R⁵, SOR⁵ or COR⁵ (wherein 5 is a hydroxyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group and the C₁₋₁₀ alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, n nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) or NR⁶R⁷ (wherein each of R⁶ and R⁷ is independently a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) or R⁶ and R⁷ mean, together with each other, —(CH₂)_(m1)-E-(CH₂)_(m2)— (wherein E is an oxygen atom, a sulfur atom, CR²⁶R²⁷ (wherein each of R²⁶ and R²⁷ is independently a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR⁸ (wherein R⁸ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, C₂₋₆ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 6. The compound according to 1, wherein A is the same as defined in 5, and B is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 7. The compound according to 1, wherein A is the same as defined in 5, and B is NR⁹ (wherein R⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 8. The compound according to any one of 1 to 7, wherein L¹ is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 9. The compound according to any one of 1 to 8, wherein L² is a bond a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 10. The compound according to any one of 1 to 9, wherein L³ is NR¹⁹ (wherein R¹⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group, the C₁₋₁₀ alkoxy group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 11. The compound according to any one of 1 to 10, wherein L³ is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 12. The compound according to 10, wherein L⁴ is NR²² (wherein R²² is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 13. The compound according to 11, wherein L⁴ is the same as defined in 12, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 14. The compound according to 10 or 11, wherein L⁴ is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 15. The compound according to 10 or 11, wherein L⁴ is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 16. The compound according to any one of 12 to 15, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 17. The compound according to any one of 12 to 15, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 18. The compound according to 16, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 19. The compound according to 17, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 20. The compound according to 16 or 18, wherein R³ is a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group is optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ fluoroalkyl groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom, a hydroxyl group, an amino group, a C₁₋₆ alkyl group or a C₁₋₆ alkoxy group (the C₁₋₆ alkyl group and the C₁₋₆ alkoxy group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R²⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), and R³⁰ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group, a C₂₋₉ heterocyclyl group (the amino group, the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups-cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups; C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) and with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfo groups, sulfamoyl groups and C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))))))), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 21. The compound according to 17 or 19, wherein R³ is the same as defined in 20, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 22. The compound according to 16 or 18, wherein R³ is a C₂₋₁₄ aryl group (wherein the C₂₋₁₄ aryl group is optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ fluoroalkyl groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom, a hydroxyl group, an amino group, a C₁₋₆ alkyl group or a C₁₋₆ alkoxy group (the C₁₋₆ alkyl group and the C₁₋₆ alkoxy group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ and R³⁰ mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is CR³¹R³² (wherein R³¹ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group (the C₁₋₁₀ alkyl group, the C₂₋₁₄ aryl group, the C₁₋₁₀ alkoxy group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms; C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R³² is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups; C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups; C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or NR³³ (wherein R³³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))))), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 23. The compound according to 17 or 19, wherein R³ is the same as defined in 22, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 24. The compound according to 16 or 18, wherein R³ is a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group is optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups C₁₋₁₀ fluoroalkyl groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom, a hydroxyl group an amino group, a C₁₋₆ alkyl group or a C₁₋₆ alkoxy group (the C₁₋₆ alkyl group and the C₁₋₆ alkoxy group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein NR²⁹R³⁰, as a whole, means a nitrogen-containing C₂₋₉ cyclyl group (the nitrogen-containing C₂₋₉ cyclyl group may be optionally substituted with one or more hydrogen atoms and is substituted with two or three substituents independently selected from the group consisting of: hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylsulfonylamino groups, the C₁₋₁₀ thioalkyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of; C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or a substituted C₂₋₉ heterocyclyl group (the substituted C₂₋₉ heterocyclyl group may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylsulfonylamino groups, the C₁₋₁₀ thioalkyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))))), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 25. The compound according to 17 or 19, wherein R³ is the same as defined in 24, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 26. The compound according to 16 or 18, wherein R³ is a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group is optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups C₁₋₁₀ fluoroalkyl groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups are optionally substituted with one or more substituents selected from the group consisting of: hydroxyl groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups and C₁₋₆ alkoxy groups (the mono- or di-C₁₋₁₀ alkylamino groups and the C₁₋₆ alkoxy groups may be substituted with one or more halogen atoms), with one or more substituents independently represented by —V¹ (wherein V¹ is the same as defined in 1) and with —W⁵ (wherein We is SO₂R⁴², SOR⁴², COR⁴² (wherein R⁴² is a hydroxyl group or NR⁴³R⁴⁴ and R⁴³ and R⁴⁴ are the same as defined in 1) or W⁴ wherein W⁴ is the same as defined in 1))), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 27. The compound according to 17 or 19 wherein R³ is the same as defined in 26, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 28. The compound according to 16 or 18, wherein R³ is a C₂₋₁₄ substituted aryl group (the C₂₋₁₄ substituted aryl group may be optionally substituted with one or more substituents independently represented by —V¹ (wherein V¹ is the same as defined in 1)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 29. The compound according to 17 or 19, wherein R³ is the same as defined in 28, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 30. The compound according to 16 or 18, wherein R³ is a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group is optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, hydroxy groups C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ fluoroalkyl groups, C₁₋₁₀ alkoxy groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents selected from the group consisting of: C₁₋₆ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylthiocarbonyl groups and C₁₋₁₀ alkylsulfonyl groups (the C₁₋₆ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylthiocarbonyl groups and the C₁₋₁₀ alkylsulfonyl groups are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, C₁₋₁₀ alkyl groups, C₁₋₁₀ alkoxy groups (the C₁₋₁₀ alkyl groups and the C₁₋₁₀ alkoxy groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups and with one or more substituents selected from C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups, C₁₋₁₀ alkoxy groups (the C₁₋₁₀ alkyl groups and the C₁₋₁₀ alkoxy groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 31. The compound according to 17 or 19, wherein R³ is the same as defined in 30, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 32. The compound according to 16 or 18, wherein R³ is a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group is optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ fluoroalkyl groups, C₁₋₁₀ fluoroalkoxy groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more groups selected from the group consisting of: C₁₋₆ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylthiocarbonyl groups and C₁₋₁₀ alkylsulfonyl groups (the C₁₋₆ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylthiocarbonyl groups and the C₁₋₁₀ alkylsulfonyl groups are optionally substituted with one or more substituents selected from the group consisting of: amino groups (the amino groups are substituted with a C₁₋₁₀ alkyl group and with a C₂₋₆ heterocyclyl group or a C₂₋₁₄ aryl group (the C₂₋₉ heterocyclyl group and the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups, C₁₋₁₀ alkoxy groups (the C₁₋₁₀ alkyl groups and the C₁₋₁₀ alkoxy groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ thioalkyl groups, C₁₋₁₀ alkylsulfonyl groups, sulfonyl groups, sulfinyl groups and thiol groups (the amino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ thioalkyl groups, the C₁₋₁₀ alkylsulfonyl groups, the sulfonyl groups, the sulfinyl groups and the thiol groups are optionally substituted one or more C₂₋₉ heterocyclyl groups or one or more C₂₋₁₄ aryl groups (the C₂₋₉ heterocyclyl groups and the C₂₋₁₄ aryl groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups, C₁₋₁₀ alkoxy groups (the C₁₋₁₀ alkyl groups and the C₁₋₁₀ alkoxy groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)))), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 33. The compound according to 17 or 19, wherein R³ is the same as defined in 32, a tautomer prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 34. Medicament containing the compound according to any one of 1 to 33, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, as an active ingredient. 35. A thrombopoietin receptor activator containing the compound according to any one of 1 to 33, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, as an active ingredient. 36. A preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective, which contains the compound according to any one of 1 to 33, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient. 37. A platelet increasing agent containing the compound according to any one of 1 to 33, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows the proliferation of UT7/EPO-mpl cells when stimulated by the compound of the present invention (Synthetic Example 2).

FIG. 2 shows the proliferation of UT7/EPO cells when stimulated by the compound of the present invention (Synthetic Example 2).

BEST MODE FOR CARRYING OUT THE INVENTION

In the present invention, “n” denotes normal, “i” denotes iso, “s” denotes secondary, “t” denotes tertiary “c” denotes cyclo, “o” denotes ortho, “m” denotes meta, “p” denotes para, “Ph” denotes phenyl, “Py” denotes pyridyl, “Naphthyl” denotes naphthyl, “Me” denotes methyl, “Et” denotes ethyl, “Pr” denotes propyl, “Bu” denotes butyl and “Ac” denotes acetyl.

First the terms in the respective substituents R¹ to R⁴⁴ will be explained.

As a halogen atom, a fluorine atom, a chlorine atom, a bromine atom or an iodine atom may be mentioned.

A C₁₋₃ alkyl group may be linear, branched or a C₃ cycloalkyl group, and methyl, ethyl, n-propyl, i-propyl and c-propyl and the like may be mentioned.

A C₁₋₆ alkyl group may be linear, branched or a C₃₋₆ cycloalkyl group, and in addition to those mentioned above, n-butyl, i-butyl, s-butyl, t-butyl, c-butyl, 1-methyl-c-propyl, 2-methyl-c-propyl, n-pentyl, 1-methyl-n-butyl, 2-methyl-n-butyl, 3-methyl-n-butyl, 1,1-dimethyl-n-propyl, 1,2-dimethyl-n-propyl, 2,2-dimethyl-n-propyl, 1-ethyl-n-propyl, c-pentyl, 1-methyl-c-butyl, 2-methyl-c-butyl, 3-methyl-c-butyl, 1,2-dimethyl-c-propyl, 2,3-dimethyl-c-propyl, 1-ethyl-c-propyl, 2-ethyl-c-propyl, n-hexyl, 1-methyl-n-pentyl, 2-methyl-n-pentyl, 3-methyl-n-pentyl, 4-methyl-n-pentyl, 1,1-dimethyl-n-butyl, 1,2-dimethyl-n-butyl, 1,3-dimethyl-n-butyl, 2,2-dimethyl-n-butyl, 2,3-dimethyl-n-butyl, 3,3-dimethyl-n-butyl, 1-ethyl-n-butyl, 2-ethyl-n-butyl, 1,1,2-trimethyl-n-propyl, 1,2,2-trimethyl-n-propyl, 1-ethyl-1-methyl-n-propyl, 1-ethyl-2-methyl-n-propyl, c-hexyl, 1-methyl-c-pentyl, 2-methyl-c-pentyl, 3-methyl-c-pentyl, 1-ethyl-c-butyl, 2-ethyl-c-butyl, 3-ethyl-c-butyl, 1,2-dimethyl-c-butyl, 1,3-dimethyl-c-butyl, 2,2-dimethyl-c-butyl, 2,3-dimethyl-c-butyl, 2,4-dimethyl-c-butyl, 3,3-dimethyl-c-butyl, 1-n-propyl-c-propyl, 2-n-propyl-c-propyl, 1-i-propyl-c-propyl, 2-i-propyl-c-propyl, 1,2,2-trimethyl-c-propyl, 1,2,3-trimethyl-c-propyl, 2,2,3-trimethyl-c-propyl, 1-ethyl-2-methyl-c-propyl, 2-ethyl-1-methyl-c-propyl, 2-ethyl-2-methyl-c-propyl, 2-ethyl-3-methyl-c-propyl and the like may be mentioned.

A C₁₋₁₀ alkyl group may be linear, branched or a C₃₋₁₀ cycloalkyl group, and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentyl, 1-heptyl, 2-heptyl, 1-ethyl-1,2-dimethyl-n-propyl, 1-ethyl-2,2-dimethyl-n-propyl, 1-octyl, 3-octyl, 4-methyl-3-n-heptyl, 6-methyl-2-n-heptyl, 2-propyl-1-n-heptyl, 2,4,4-trimethyl-1-n-pentyl, 1-nonyl, 2-nonyl, 2,6-dimethyl-4-n-heptyl, 3-ethyl-2,2-dimethyl-3-n-pentyl, 3,5,5-trimethyl-1-n-hexyl, 1-decyl, 2-decyl, 4-decyl, 3,7-dimethyl-1-n-octyl, 3,7-dimethyl-3-n-octyl and the like may be mentioned.

As a C₂₋₆ alkynyl group, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-1-pentynyl, 3-methyl-4-pentynyl, 4-methyl-1-pentynyl, 4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 1-n-propyl-2-propynyl, 2-ethyl-3-butynyl, 1-methyl-1-ethyl-2-propynyl, 1-i-propyl-2-propynyl and the like may be mentioned.

A C₂₋₆ alkenyl group may be linear, branched or a C₃₋₆ cycloalkenyl group, and ethenyl, 1-propenyl, 2-propenyl, 1-methyl-1-ethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 2-methyl-1-propenyl, 2-methyl-2-propenyl, 1-ethylethenyl, 1-methyl-1-propenyl-1-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-n-propylethenyl, 1-methyl-1-butenyl, 1-methyl-2-butenyl, 1-methyl-3-butenyl, 2-ethyl-2-propenyl, 2-methyl-1-butenyl, 2-methyl-2-butenyl, 2-methyl-3-butenyl, 3-methyl-1-butenyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1-i-propylethenyl, 1,2-dimethyl-1-propenyl, 1,2-dimethyl-2-propenyl, 1-c-pentenyl, 2-c-pentenyl, 3-c-pentenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-1-pentenyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-4-pentenyl, 1-n-butylethenyl, 2-methyl-1-pentenyl, 2-methyl-2-pentenyl, 2-methyl-3-pentenyl, 2-methyl-4-pentenyl, 2-n-propyl-2-propenyl, 3-methyl-1-pentenyl, 3-methyl-2-pentenyl, 3-methyl-3-pentenyl, 3-methyl-4-pentenyl, 3-ethyl-3-butenyl, 4-methyl-1-pentenyl, 4-methyl-2-pentenyl, 4-methyl-3-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-1-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1-methyl-2-ethyl-2-propenyl, 1-s-butylethenyl, 1,3-dimethyl-1-butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 1-i-butylethenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-1-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 2-i-propyl-2-propenyl, 3,3-dimethyl-1-butenyl, 1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 1-n-propyl-1-propenyl, 1-n-propyl-2-propenyl, 2-ethyl-1-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-t-butylethenyl, 1-methyl-1-ethyl-2-propenyl, 1-ethyl-2-methyl-1-propenyl, 1-ethyl-2-methyl-2-propenyl, 1-i-propyl-1-propenyl, 1-i-propyl-2-propenyl, 1-methyl-2-c-pentenyl, 1-methyl-3-c-pentenyl, 2-methyl-1-c-pentenyl, 2-methyl-2-c-pentenyl, 2-methyl-3-c-pentenyl, 2-methyl-4-c-pentenyl, 2-methyl-5-c-pentenyl, 2-methylene-c-pentyl, 3-methyl-1-c-pentenyl, 3-methyl-2-c-pentenyl, 3-methyl-3-c-pentenyl, 3-methyl-4-c-pentenyl, 3-methyl-5-c-pentenyl, 3-methylene-c-pentyl, 1-c-hexenyl, 2-c-hexenyl, 3-c-hexenyl and the like may be mentioned.

A C₂₋₉ heterocyclyl group may be a heteromonocyclic or fused heterobicyclic group consisting of at least one atom optionally selected from nitrogen atoms, oxygen atoms and sulfur atoms and from 2 to 9 carbon atoms, and specifically mentioned are:

A nitrogen-containing C₂₋₉ heterocyclyl group may be, among those give above, a heteromonocyclic or fused heterobicyclic group which contains least one nitrogen atom, may contain at least one atom optionally selected from oxygen atoms and sulfur atoms and contains from 2 to 9 carbon atoms, and specifically mentioned are:

A substituted C₂₋₉ heterocyclyl group may be, among the C₂₋₉ heterocyclyl groups and the nitrogen-containing C₂₋₉ heterocyclyl groups, a heteromonocyclic or fused heterobicyclic group which has no nitrogen atoms and one or three carbonyl groups or thiocarbonyl groups as ring constituting carbon atoms, and specifically mentioned are:

A C₂₋₁₄ aryl group may be a C₆₋₁₄ aryl group containing no hetero atoms as ring constituting atoms or a C₂₋₉ aromatic heterocyclic group, and a C₂₋₉ aromatic heterocyclic group may be a 5 to 7-membered C₂₋₆ heteromonocyclic group or 8 to 10-membered C₅₋₉ fused heterobicyclic group containing from 1 to 3 oxygen atoms, nitrogen atoms or sulfur atoms singly or in combination.

As a C₆₋₁₄ aryl group containing no hetero atoms, a phenyl group, a 1-indenyl group, a 2-indenyl group, a 3-indenyl group, a 4-indenyl group, a 5-indenyl group, a 6-indenyl group, a 7-indenyl group, an α-naphthyl group, a β-naphthyl group, a 1-tetrahydronaphthyl group, a 2-tetrahydronaphthyl group, a 5-tetrahydronaphthyl group, a 6-tetrahydronaphthyl group, an o-biphenylyl group, a m-biphenylyl group, a p-biphenylyl group, a 1-anthryl group, a 2-anthryl group, a 9-anthryl group, a 1-phenanthryl group, a 2-phenanthryl group, a 3-phenanthryl group, a 4-phenanthryl group, a 9-phenanthryl group or the like may be mentioned.

A 5 to 7-membered C₂₋₆ heteromonocyclic group may be a 2-thienyl group, a 3-thienyl group, a 2-furyl group, a 3-furyl group, a 2-pyranyl group, a 3-pyranyl group, a 4-pyranyl group, a 1-pyrrolyl group, a 2-pyrrolyl group, a 3-pyrrolyl group, a 1-imidazolyl group, a 2-imidazolyl group, a 4-imidazolyl group, a 1-pyrazolyl group, a 3-pyrazolyl group, a 4-pyrazolyl group, a 2-thiazolyl group, a 4-thiazolyl group, a 5-thiazolyl group, a 3-isothiazolyl group, a 4-isothiazolyl group, a 5-isothiazolyl group, a 2-oxazolyl group, a 4-oxazolyl group, a 5-oxazolyl group, a 3-isoxazolyl group, a 4-isoxazolyl group, a 5-isoxazolyl group, a 2-pyridyl group, a 3-pyridyl group, a 4-pyridyl group, a 2-pyrazinyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group, a 5-pyrimidinyl group, a 3-pyridazinyl group, a 4-pyridazinyl group, a 2-1,3,4-oxadiazolyl group, a 2-1,3,4-thiadiazolyl group, a 3-1,2,4-oxadiazolyl group, a 5-1,2,4-oxadiazolyl group, a 3-1,2,4-thiadiazolyl group, a 5-1,2,4-thiadiazolyl group, a 3-1,2,5-oxadiazolyl group, a 3-1,2,5-thiadiazolyl group or the like.

A 8 to 10-membered C₅₋₉ fused heterocyclic group may be a 2-benzofuranyl group, a 3-benzofuranyl group, a 4-benzofuranyl group, a 5-benzofuranyl group, a 6-benzofuranyl group, a 7-benzofuranyl group, a 1-Isobenzofuranyl group, a 4-isobenzofuranyl group, a 5-isobenzofuranyl group, a 2-benzothienyl group, a 3-benzothienyl group, a 4-benzothienyl group, a 5-benzothienyl group, a 6-benzothienyl group, a 7-benzothienyl group, a 1-isobenzothienyl group, a 4-isobenzothienyl group, a 5-isobenzothienyl group, a 2-chromenyl group, a 3-chromenyl group, a 4-chromenyl group, a 5-chromenyl group, a 6-chromenyl group, a 7-chromenyl group, a 8-chromenyl group, a 1-indolizinyl group, a 2-indolizinyl group, a 3-indolizinyl group, a 5-indolizinyl group, a 6-indolizinyl group, a 7-indolizinyl group, a 8-indolizinyl group, a 1-isoindolyl group, a 2-isoindolyl group, a 4-isoindolyl group, a 5-isoindolyl group, a 1-indolyl group, a 2-indolyl group, a 3-indolyl group, a 4-indolyl group, a 5-indolyl group, a 6-indolyl group, a 7-indolyl group, 1-indazolyl group, a 2-indazolyl group, a 3-indazolyl group, a 4-indazolyl group, a 5-indazolyl group, a 6-indazolyl group, a 7-indazolyl group, a 1-purinyl group, a 2-purinyl group, a 3-purinyl group, a 6-purinyl group, a 7-purinyl group, a 8-purinyl group, a 2-quinolyl group, a 3-quinolyl group a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group, a 8-quinolyl group, a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group, a 8-isoquinolyl group, a 1-phthalazinyl group, a 5-phthalazinyl group, a 6-phthalazinyl group, a 1-2,7-naphthyridinyl group, a 3-2,7-naphthyridinyl group, a 4-2,7-naphthyridinyl group, a 1-2,6-naphthyridinyl group, a 3-2,6-naphthyridinyl group, a 4-2,6-naphthyridinyl group, a 2-1,8-naphthyridinyl group, a 3-1,8-naphthyridinyl group, a 4-1,8-naphthyridinyl group, a 2-1,7-naphthyridinyl group, a 3-1,7-naphthyridinyl group, a 4-1,7-naphthyridinyl group, a 5-1,7-naphthyridinyl group, a 6-1,7-naphthyridinyl group, a 8-1,7-naphthyridinyl group, 2-1,6-naphthyridinyl group, a 3-1,6-naphthyridinyl group, a 4-1,6-naphthyridinyl group, a 5-1,6-naphthyridinyl group, a 7-1,6-naphthyridinyl group, a 8-1,6-naphthyridinyl group, a 2-1,5-naphthyridinyl group, a 3-1,5-naphthyridinyl group, a 4-1,5-naphthyridinyl group, a 6-1,5-naphthyridinyl group, a 7-1,5-naphthyridinyl group, a 8-1,5-naphthyridinyl group, a 2-quinoxalinyl group, a 5-quinoxalinyl group, a 6-quinoxalinyl group, a 2-quinazolinyl group, a 4-quinazolinyl group, a 5-quinazolinyl group, a 6-quinazolinyl group, a 7-quinazolinyl group, a 8-quinazolinyl group, a 3-cinnolinyl group, a 4-cinnolinyl group, a 5-cinnolinyl group, a 6-cinnolinyl group, a 7-cinnolinyl group, a 8-cinnolinyl group, a 2-pteridinyl group, a 4-pteridinyl group, a 6-pteridinyl group, a 7-pteridinyl group or the like.

A C₂₋₁₄ substituted aryl group may be a fused bicyclic or tricyclic group resulting from fusion of the above-mentioned C₂₋₁₄ aryl group with a C₂₋₉ heterocyclyl group, a nitrogen-containing C₂₋₉ heterocyclyl group or a substituted C₂₋₉ heterocyclyl group, and specifically mentioned are:

A C₂₋₁₄ aryloxy group may be a C₆₋₁₄ aryloxy group containing no hetero atoms as ring constituting atoms or a C₂₋₉ aromatic heterocyclyloxy group, and a C₂₋₉ aromatic heterocyclyloxy group may be a 5 to 7-membered C₂₋₆ monocyclic heterocyclyloxy group or 8 to 10-membered C₅₋₉ fused bicyclic heterocyclyloxy group containing from 1 to 3 oxygen atoms, nitrogen atoms or sulfur atoms singly or in combination.

As a C₆₋₁₄ aryloxy group containing no hetero atoms, a phenyloxy group, a 1-indenyloxy group, a 2-indenyloxy group, a 3-indenyloxy group, a 4-indenyloxy group, a 5-indenyloxy group, a 6-indenyloxy group, a 7-indenyloxy group, an α-naphthyloxy group, a β-naphthyloxy group, a 1-tetrahydronaphthyloxy group, a 2-tetrahydronaphthyloxy group, a 5-tetrahydronaphthyloxy group, a 6-tetrahydronaphthyloxy group, an o-biphenylyloxy group, a m-biphenylyloxy group, a p-biphenylyloxy group, a 1-anthryloxy group, a 2-anthryloxy group, a 9-anthryloxy group, a 1-phenanthryloxy group, a 2-phenanthryloxy group, a 3-phenanthryloxy group, a 4-phenanthryloxy group, a 9-phenanthryloxy group or the like may be mentioned.

A 5 to 7-membered C₂₋₆ monocyclic heterocyclyloxy group may be a 2-thienyloxy group, a 3-thienyloxy group, a 2-furyloxy group, a 3-furyloxy group, a 2-pyranyloxy group, a 3-pyranyloxy group, a 4-pyranyloxy group, a 1-pyrrolyloxy group, a 2-pyrrolyloxy group, a 3-pyrrolyloxy group, a 1-imidazolyloxy group, a 2-imidazolyloxy group, a 4-imidazolyloxy group, a 1-pyrazolyloxy group, a 3-pyrazolyloxy group, a 4-pyrazolyloxy group, a 2-thiazolyloxy group, a 4-thiazolyloxy group, a 5-thiazolyloxy group, a 3-isothiazolyloxy group, a 4-isothiazolyloxy group, a 5-isothiazolyloxy group, a 2-oxazolyloxy group, a 4-oxazolyloxy group, a 5-oxazolyloxy group, a 3-isoxazolyloxy group, a 4-isoxazolyloxy group, a 5-isoxazolyloxy group, a 2-pyridyloxy group, a 3-pyridyloxy group, a 4-pyridyloxy group, a 2-pyrazinyloxy group, a 2-pyrimidinyloxy group, a 4-pyrimidinyloxy group, a 5-pyrimidinyloxy group, a 3-pyridazinyloxy group, a 4-pyridazinyloxy group, a 2-1,3,4-oxadiazolyloxy group, a 2-1,3,4-thiadiazol-yloxy group, a 3-1,2,4-oxadiazolyloxy group, a 5-1,2,4-oxadiazolyloxy group, a 3-1,2,4-thiadiazolyloxy group, a 5-1,2,4-thiadiazolyloxy group, a 3-1,2,5-oxadiazolyloxy group, a 3-1,2,5-thiadiazolyloxy group or the like.

A 8 to 10-membered C₅₋₉ fused bicyclic heterocyclyloxy group may be a 2-benzofuranyloxy group, a 3-benzofuranyloxy group, a 4-benzofuranyloxy group, a 5-benzofuranyloxy group, a 6-benzofuranyloxy group, a 7-benzofuranyloxy group, a 1-isobenzofuranyloxy group, a 4-isobenzofuranyloxy group, a 5-isobenzofuranyloxy group, a 2-benzothienyloxy group, a 3-benzothienyloxy group, a 4-benzothienyloxy group, a 5-benzothienyloxy group, a 6-benzothienyloxy group, a 7-benzothienyloxy group, a 1-isobenzothienyloxy group, a 4-isobenzothienyloxy group, a 5-isobenzothienyloxy group, a 2-chromenyloxy group, a 3-chromenyloxy group, a 4-chromenyloxy group, a 5-chromenyloxy group, a 6-chromenyloxy group, a 7-chromenyloxy group, a 8-chromenyloxy group, a 1-indolizinyloxy group, a 2-indolizinyloxy group, a 3-indolizinyloxy group, a 5-indolizinyloxy group, a 6-indolizinyloxy group, a 7-indolizinyloxy group, a 8-indolizinyloxy group, a 1-isoindolyloxy group, a 2-isoindolyloxy group, a 4-isoindolyloxy group, a 5-isoindolyloxy group, a 1-indolyloxy group, a 2-indolyloxy group, a 3-indolyloxy group, a 4-indolyloxy group, a 5-indolyloxy group, a 6-indolyloxy group, a 7-indolyloxy group, 1-indazolyloxy group, a 2-indazolyloxy group, a 3-indazolyloxy group, a 4-indazolyloxy group, a 5-indazolyloxy group, a 6-indazolyloxy group, a 7-indazolyloxy group, a 1-purinyloxy group, a 2-purinyloxy group, a 3-purinyloxy group, a 6-purinyloxy group, a 7-purinyloxy group, a 8-purinyloxy group, a 2-quinolyloxy group, a 3-quinolyloxy group, a 4-quinolyloxy group, a 5-quinolyloxy group, a 6-quinolyloxy group, a 7-quinolyloxy group, a 8-quinolyloxy group, a 1-isoquinolyloxy group, a 3-isoquinolyloxy group, a 4-isoquinolyloxy group, a 5-isoquinolyloxy group, a 6-isoquinolyloxy group, a 7-isoquinolyloxy group, a 8-isoquinolyloxy group, a 1-phthalazinyloxy group, a 5-phthalazinyloxy group, a 6-phthalazinyloxy group, a 1-2,7-naphthyridinyloxy group, a 3-2,7-naphthyridinyloxy group, a 4-2,7-naphthyridinyloxy group, a 1-2,6-naphthyridinyloxy group, a 3-2,6-naphthyridinyloxy group, a 4-2,6-naphthyridinyloxy group, a 2-1,8-naphthyridinyloxy group, a 3-1,8-naphthyridinyloxy group, a 4-1,8-naphthyridinyloxy group, a 2-1,7-naphthyridinyloxy group, a 3-1,7-naphthyridinyloxy group, a 4-1,7-naphthyridinyloxy group, a 5-1,7-naphthyridinyloxy group, a 6-1,7-naphthyridinyloxy group, a 8-1,7-naphthyridinyloxy group 2-1,6-naphthyridinyloxy group, a 3-1,6-naphthyridinyloxy group, a 4-1,6-naphthyridinyloxy group, a 5-1,6-naphthyridinyloxy group, a 7-1,6-naphthyridinyloxy group a 8-1,6-naphthyridinyloxy group, a 2-1,5-naphthyridinyloxy group, a 3-1,5-naphthyridinyloxy group, a 4-1,5-naphthyridinyloxy group, a 6-1,5-naphthyridinyloxy group, a 7-1,5-naphthyridinyloxy group a 8-1,5-naphthyridinyloxy group, a 2-quinoxalinyloxy group, a 5-quinoxalinyloxy group, a 6-quinoxalinyloxy group, a 2-quinazolinyloxy group, a 4-quinazolinyloxy group, a 5-quinazolinyloxy group, a 6-quinazolinyloxy group, a 7-quinazolinyloxy group, a 8-quinazolinyloxy group, a 3-cinnolinyloxy group, a 4-cinnolinyloxy group, a 5-cinnolinyloxy group, a 6-cinnolinyloxy group, a 7-cinnolinyloxy group, a 8-cinnolinyloxy group, a 2-pterdinyloxy group, a 4-pterdinyloxy group, a 6-pterdinyloxy group, a 7-pterdinyloxy group or the like.

A C₁₋₆ alkylcarbonyl group may linear, branched or a C₃₋₆ cycloalkylcarbonyl group, and be methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, i-propylcarbonyl, c-propylcarbonyl, n-butylcarbonyl, i-butylcarbonyl, s-butylcarbonyl, t-butylcarbonyl, c-butylcarbonyl, 1-methyl-c-propylcarbonyl, 2-methyl-c-propylcarbonyl, n-pentylcarbonyl, 1-methyl-n-butylcarbonyl, 2-methyl-n-butylcarbonyl, 3-methyl-n-butylcarbonyl, 1,1-dimethyl-n-propylcarbonyl, 1,2-dimethyl-n-propylcarbonyl, 2,2-dimethyl-n-propylcarbonyl, 1-ethyl-n-propylcarbonyl, c-pentylcarbonyl, 1-methyl-c-butylcarbonyl, 2-methyl-c-butylcarbonyl, 3-methyl-c-butylcarbonyl, 1,2-dimethyl-c-propylcarbonyl, 2,3-dimethyl-c-propylcarbonyl, 1-ethyl-c-propylcarbonyl, 2-ethyl-c-propylcarbonyl, n-hexylcarbonyl, 1-methyl-n-pentylcarbonyl, 2-methyl-n-pentylcarbonyl, 3-methyl-n-pentylcarbonyl, 4-methyl-n-pentylcarbonyl, 1,1-dimethyl-n-butylcarbonyl, 1,2-dimethyl-n-butylcarbonyl, 1,3-dimethyl-n-butylcarbonyl, 2,2-dimethyl-n-butylcarbonyl, 2,3-dimethyl-n-butylcarbonyl, 3,3-dimethyl-n-butylcarbonyl, 1-ethyl-n-butylcarbonyl, 2-ethyl-n-butylcarbonyl, 1,1,2-trimethyl-n-propylcarbonyl, 1,2,2-trimethyl-n-propylcarbonyl, 1-ethyl-1-methyl-n-propylcarbonyl, 1-ethyl-2-methyl-n-propylcarbonyl, c-hexylcarbonyl, 1-methyl-c-pentylcarbonyl, 2-methyl-c-pentylcarbonyl, 3-methyl-c-pentylcarbonyl, 1-ethyl-c-butylcarbonyl, 2-ethyl-c-butylcarbonyl, 3-ethyl-c-butylcarbonyl, 1,2-dimethyl-c-butylcarbonyl, 1,3-dimethyl-c-butylcarbonyl, 2,2-dimethyl-c-butyl-carbonyl, 2,3-dimethyl-c-butylcarbonyl, 2,4-dimethyl-c-butylcarbonyl, 3,3-dimethyl-c-butyl carbonyl, 1-n-propyl-c-propylcarbonyl, 2-n-propyl-c-propylcarbonyl, 1-i-propyl-c-propylcarbonyl, 2-i-propyl-c-propylcarbonyl, 1,2,2-trimethyl-c-propylcarbonyl, 1,2,3-trimethyl-c-propylcarbonyl, 2,2,3-trimethyl-c-propylcarbonyl, 1-ethyl-2-methyl-c-propylcarbonyl, 2-ethyl-1-methyl-c-propylcarbonyl, 2-ethyl-2-methyl-c-propylcarbonyl, 2-ethyl-3-methyl-c-propylcarbonyl or the like may be mentioned.

A C₁₋₁₀ alkylcarbonyl may be linear, branched or a C₃₋₁₀ cycloalkylcarbonyl group and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentylcarbonyl, 1-heptylcarbonyl, 2-heptylcarbonyl, 1-ethyl-1,2-dimethyl-n-propylcarbonyl, 1-ethyl-2,2-dimethyl-n-propylcarbonyl, 1-octylcarbonyl, 3-octylcarbonyl, 4-methyl-3-n-heptylcarbonyl, 6-methyl-2-n-heptylcarbonyl, 2-propyl-1-n-heptylcarbonyl, 2,4,4-trimethyl-1-n-pentylcarbonyl, 1-nonylcarbonyl, 2-nonylcarbonyl, 2,6-dimethyl-4-n-heptylcarbonyl, 3-ethyl-2,2-dimethyl-3-n-pentylcarbonyl, 3,5,5-trimethyl-1-n-hexylcarbonyl, 1-decylcarbonyl, 2-decylcarbonyl, 4-decylcarbonyl, 3,7-dimethyl-1-n-octylcarbonyl, 3,7-dimethyl-3-n-octylcarbonyl or the like may be mentioned.

A C₁₋₁₀ alkyl group may linear, branched or a C₃₋₁₀ cyclothioalkyl group, and be methylthio, ethylthio, n-propylthio, i-propylthio, c-propylthio, n-butylthio, i-butylthio, s-butylthio, t-butylthio, c-butylthio, 1-methyl-c-propylthio, 2-methyl-c-propylthio, n-pentylthio, 1-methyl-n-butylthio, 2-methyl-n-butylthio, 3-methyl-n-butylthio, 1,1-dimethyl-n-propylthio, 1,2-dimethyl-n-propylthio, 2,2-dimethyl-n-propylthio, 1-ethyl-n-propylthio, c-pentylthio, 1-methyl-c-butylthio, 2-methyl-c-butylthio, 3-methyl-c-butylthio, 1,2-dimethyl-c-propylthio, 2,3-dimethyl-c-propylthio, 1-ethyl-c-propylthio, 2-ethyl-c-propylthio, n-hexylthio, 1-methyl-n-pentylthio, 2-methyl-n-pentylthio, 3-methyl-n-pentylthio, 4-methyl-n-pentylthio, 1,1-dimethyl-n-butylthio, 1,2-dimethyl-n-butylthio, 1,3-dimethyl-n-butylthio, 2,2-dimethyl-n-butylthio, 23-dimethyl-n-butylthio, 3,3-dimethyl-n-butylthio, 1-ethyl-n-butylthio, 2-ethyl-n-butylthio, 1,1,2-trimethyl-n-propylthio, 1,2,2-trimethyl-n-propylthio, 1-ethyl-1-methyl-n-propylthio, ethyl-2-methyl-n-propylthio, c-hexylthio, 1-methyl-c-pentylthio, 2-methyl-c-pentylthio, 3-methyl-c-pentylthio, 1-ethyl-c-butylthio, 2-ethyl-c-butylthio, 3-ethyl-c-butylthio, 1,2-dimethyl-c-butylthio, 1,3-dimethyl-c-butylthio, 2,2-dimethyl-c-butylthio, 2,3-dimethyl-c-butylthio, 2,4-dimethyl-c-butylthio, 3,3-dimethyl-c-butylthio, 1-n-propyl-c-propylthio, 2-n-propyl-c-propylthio, 1-i-propyl-c-propylthio, 2-i-propyl-c-propylthio, 1,2,2-trimethyl-c-propylthio, 1,2,3-trimethyl-c-propylthio, 2,2,3-trimethyl-c-propylthio, 1-ethyl-2-methyl-c-propylthio, 2-ethyl-1-methyl-c-propylthio, 2-ethyl-2-methyl-c-propylthio, 2-ethyl-3-methyl-c-propylthio, 1-methyl-1-ethyl-n-pentylthio, 1-heptylthio, 2-heptylthio, 1-ethyl-1,2-dimethyl-n-propylthio, 1-ethyl-2,2-dimethyl-n-propylthio, 1-octylthio, 3-octylthio, 4-methyl-3-n-heptylthio, 6-methyl-2-n-heptylthio, 2-propyl-1-n-heptylthio, 2,4,4-trimethyl-1-n-pentylthio, 1-nonylthio, 2-nonylthio, 2,6-dimethyl-4-n-heptylthio, 3-ethyl-2,2-dimethyl-3-n-pentylthio, 3,5,5-trimethyl-1-n-hexylthio, 1-decylthio, 2-decylthio, 4-decylthio, 3,7-dimethyl-1-n-octylthio, 3,7-dimethyl-3-n-octylthio or the like may be mentioned.

A C₁₋₆ alkylsulfonylamino group may be linear, branched or a C₃₋₆ cycloalkylsulfonylamino group, and methylsulfonylamino, ethylsulfonylamino, n-propylsulfonylamino, i-propylsulfonylamino, c-propylsulfonylamino, n-butylsulfonylamino, i-butylsulfonylamino, s-butylsulfonylamino, t-butylsulfonylamino, c-butylsulfonylamino, 1-methyl-c-propylsulfonylamino, 2-methyl-c-propylsulfonylamino, n-pentylsulfonylamino, 1-methyl-n-butylsulfonylamino, 2-methyl-n-butylsulfonylamino, 3-methyl-n-butylsulfonylamino, 1,1-dimethyl-n-propylsulfonylamino, 1,2-dimethyl-n-propylsulfonylamino, 2,2-dimethyl-n-propylsulfonylamino, 1-ethyl-n-propylsulfonylamino, c-pentylsulfonylamino, 1-methyl-c-butylsulfonylamino, 2-methyl-c-butylsulfonylamino, 3-methyl-c-butylsulfonylamino, 1,2-dimethyl-c-propylsulfonylamino, 2,3-dimethyl-c-propylsulfonylamino, 1-ethyl-c-propylsulfonylamino, 2-ethyl-c-propylsulfonylamino, n-hexylsulfonylamino, 1-methyl-n-pentylsulfonylamino, 2-methyl-n-pentylsulfonylamino, 3-methyl-n-pentylsulfonylamino, 4-methyl-n-pentylsulfonylamino, 1,1-dimethyl-n-butylsulfonylamino, 1,2-dimethyl-n-butylsulfonylamino, 1,3-dimethyl-n-butylsulfonylamino, 2,2-dimethyl-n-butylsulfonylamino, 2,3-dimethyl-n-butylsulfonylamino, 3,3-dimethyl-n-butylsulfonylamino, 1-ethyl-n-butylsulfonylamino, 2-ethyl-n-butylsulfonylamino, 1,1,2-trimethyl-n-propylsulfonylamino, 1,2,2-trimethyl-n-propylsulfonylamino, 1-ethyl-1-methyl-n-propylsulfonylamino, 1-ethyl-2-methyl-n-propylsulfonylamino, c-hexylsulfonylamino, 1-methyl-c-pentylsulfonylamino, 2-methyl-c-pentylsulfonylamino, 3-methyl-c-pentylsulfonylamino, 1-ethyl-c-butylsulfonylamino, 2-ethyl-c-butylsulfonylamino, 3-ethyl-c-butylsulfonylamino, 1,2-dimethyl-c-butylsulfonylamino, 1,3-dimethyl-c-butylsulfonylamino, 2,2-dimethyl-c-butylsulfonylamino, 2,3-dimethyl-c-butylsulfonylamino, 2,4-dimethyl-c-butylsulfonylamino, 3,3-dimethyl-c-butylsulfonylamino, 1-n-propyl-c-propylsulfonylamino, 2-n-propyl-c-propylsulfonylamino, 1-i-propyl-c-propylsulfonylamino, 2-i-propyl-c-propylsulfonylamino, 1,2,2-trimethyl-c-propylsulfonylamino, 1,2,3-trimethyl-c-propylsulfonylamino, 2,2,3-trimethyl-c-propylsulfonylamino, 1-ethyl-2-methyl-c-propylsulfonylamino, 2-ethyl-1-methyl-c-propylsulfonylamino, 2-ethyl-2-methyl-c-propylsulfonylamino, 2-ethyl-3-methyl-c-propylsulfonylamino or the like may be mentioned.

A C₁₋₁₀ alkylsulfonylamino group may be linear, branched or a C₃₋₁₀ cycloalkylsulfonylamino group, and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentylsulfonylamino, 1-heptylsulfonylamino, 2-heptylsulfonylamino, 1-ethyl-1,2-dimethyl-n-propylsulfonylamino, 1-ethyl-2,2-dimethyl-n-propylsulfonylamino, 1-octylsulfonylamino, 3-octylsulfonylamino, 4-methyl-3-n-heptylsulfonylamino, 6-methyl-2-n-heptylsulfonylamino, 2-propyl-1-n-n-heptylsulfonylamino, 2,4,4-trimethyl-1-n-pentylsulfonylamino, 1-nonylsulfonylamino, 2-nonylsulfonylamino, 2,6-dimethyl-4-n-heptylsulfonylamino, 3-ethyl-2,2-dimethyl-3-n-pentylsulfonylamino, 3,5,5-trimethyl-1-n-hexylsulfonylamino, 1-decylsulfonylamino, 2-decylsulfonylamino, 4-decylsulfonylamino, 3,7-dimethyl-1-n-octylsulfonylamino, 3,7-dimethyl-3-n-octylsulfonylamino, c-heptylsulfonylamino, c-octylsulfonylamino, 1-methyl-c-hexylsulfonylamino, 2-methyl-c-hexylsulfonylamino, 3-methyl-c-hexylsulfonylamino, 1,2-dimethyl-c-hexylsulfonylamino, 1-ethyl-c-hexylsulfonylamino, 1-methyl-c-pentylsulfonylamino, 2-methyl-c-pentylsulfonylamino, 3-methyl-c-pentylsulfonylamino or the like may be mentioned.

A C₁₋₆ alkoxy group may be linear, branched or a C₃₋₁₀ cycloalkoxy group, and methoxy, ethoxy, n-propoxy, i-propoxy, c-propoxy, n-butoxy, i-butoxy, s-butoxy, t-butoxy, c-butoxy, 1-methyl-c-propoxy, 2-methyl-c-propoxy, n-pentyloxy, 1-methyl-n-butoxy, 2-methyl-n-butoxy, 3-methyl-n-butoxy, 1,1-dimethyl-n-propoxy, 1,2-dimethyl-n-propoxy, 2,2-dimethyl-n-propoxy, 1-ethyl-n-propoxy, c-pentyloxy, 1-methyl-c-butoxy, 2-methyl-c-butoxy, 3-methyl-c-butoxy, 1,2-dimethyl-c-propoxy, 2,3-dimethyl-c-propoxy, 1-ethyl-c-propoxy, 2-ethyl-c-propoxy, n-hexyloxy, 1-methyl-n-pentyloxy, 2-methyl-n-pentyloxy, 3-methyl-n-pentyloxy, 4-methyl-n-pentyloxy, 1,1-dimethyl-n-butoxy, 1,2-dimethyl-n-butoxy, 1,3-dimethyl-n-butoxy, 2,2-dimethyl-n-butoxy, 2,3-dimethyl-n-butoxy, 3,3-dimethyl-n-butoxy, 1-ethyl-n-butoxy, 2-ethyl-n-butoxy, 1,1,2-trimethyl-n-propoxy, 1,2,2-trimethyl-n-propoxy, ethyl-1-methyl-n-propoxy, 1-ethyl-2-methyl-n-propoxy, c-hexyloxy, 1-methyl-c-pentyloxy, 2-methyl-c-pentyloxy, 3-methyl-c-pentyloxy, 1-ethyl-c-butoxy, 2-ethyl-c-butoxy, 3-ethyl-c-butoxy, 1,2-dimethyl-c-butoxy, 1,3-dimethyl-c-butoxy, 2,2-dimethyl-c-butoxy, 2,3-dimethyl-c-butoxy, 2,4-dimethyl-c-butoxy, 3,3-dimethyl-c-butoxy, 1-n-propyl-c-propoxy, 2-n-propyl-c-propoxy, 1-i-propyl-c-propoxy, 2-1-propyl-c-propoxy, 1,2,2-trimethyl-c-propoxy, 1,2,3-trimethyl-c-propoxy, 2,2,3-trimethyl-c-propoxy, 1-ethyl-2-methyl-c-propoxy, 2-ethyl-1-methyl-c-propoxy, 2-ethyl-2-methyl-c-propoxy, 2-ethyl-3-methyl-c-propoxy or the like may be mentioned.

A C₁₋₁₀ alkoxy group may be linear, branched or a C₃₋₁₀ cycloalkoxy group, and methoxy, ethoxy, n-propoxy, i-propoxy, c-propoxy, n-butoxy, i-butoxy, s-butoxy, t-butoxy, c-butoxy, 1-methyl-c-propoxy, 2-methyl-c-propoxy, n-pentyloxy, 1-methyl-n-butoxy, 2-methyl-n-butoxy, 3-methyl-n-butoxy, 1,1-dimethyl-n-propoxy, 1,2-dimethyl-n-propoxy, 2,2-dimethyl-n-propoxy, 1-ethyl-n-propoxy, c-pentyloxy, 1-methyl-c-butoxy, 2-methyl-c-butoxy, 3-methyl-c-butoxy, 1,2-dimethyl-c-propoxy, 2,3-dimethyl-c-propoxy, 1-ethyl-c-propoxy, 2-ethyl-c-propoxy, n-hexyloxy, 1-methyl-n-pentyloxy, 2-methyl-n-pentyloxy, 3-methyl-n-pentyloxy, 4-methyl-n-pentyloxy, 1,1-dimethyl-n-butoxy, 1,2-dimethyl-n-butoxy, 1,3-dimethyl-n-butoxy, 2,2-dimethyl-n-butoxy, 2,3-dimethyl-n-butoxy, 3,3-dimethyl-n-butoxy, 1-ethyl-n-butoxy, 2-ethyl-n-butoxy, 1,1,2-trimethyl-n-propoxy, 1,2,2-trimethyl-n-propoxy, 1-ethyl-1-methyl-n-propoxy, 1-ethyl-2-methyl-n-propoxy, c-hexyloxy, 1-methyl-c-pentyloxy, 2-methyl-c-pentyloxy, 3-methyl-c-pentyloxy, 1-ethyl-c-butoxy, 2-ethyl-c-butoxy, 3-ethyl-c-butoxy, 1,2-dimethyl-c-butoxy, 1,3-dimethyl-c-butoxy, 2,2-dimethyl-c-butoxy, 2,3-dimethyl-c-butoxy, 2,4-dimethyl-c-butoxy, 3,3-dimethyl-c-butoxy, 1-n-propyl-c-propoxy, 2-n-propyl-c-propoxy, 1-i-propyl-c-propoxy, 2-1-propyl-c-propoxy, 1,2,2-trimethyl-c-propoxy, 1,2,3-trimethyl-c-propoxy, 2,2,3-trimethyl-c-propoxy, 1-ethyl-2-methyl-c-propoxy, 2-ethyl-1-methyl-c-propoxy, 2-ethyl-2-methyl-c-propoxy, 2-ethyl-3-methyl-c-propoxy, 1-methyl-1-ethyl-n-pentyloxy, 1-heptyloxy, 2-heptyloxy, 1-ethyl-1,2-dimethyl-n-propyloxy, 1-ethyl-2,2-dimethyl-n-propyloxy, 1-octyloxy, 3-octyloxy, 4-methyl-3-n-heptyloxy, 6-methyl-2-n-heptyloxy, 2-propyl-1-n-heptyloxy, 2,4,4-trimethyl-1-n-pentyloxy, 1-nonyloxy, 2-nonyloxy, 2,6-dimethyl-4-n-heptyloxy, 3-ethyl-2,2-dimethyl-3-n-pentyloxy, 3,5,5-trimethyl-1-n-hexyloxy, 1 decyloxy, 2-decyloxy, 4-decyloxy, 3,7-dimethyl-1-n-octyloxy, 3,7-dimethyl-3-n-octyloxy or the like may be mentioned.

A C₁₋₆ alkylthiocarbonyl group is a C₁₋₆ alkylcarbonyl group having a sulfur atom instead of an oxygen atom and may be linear, branched or a C₃₋₆ cycloalkylthiocarbonyl group Methyl(thiocarbonyl)ethyl(thiocarbonyl), n-propyl(thiocarbonyl), i-propyl(thiocarbonyl), c-propyl (thiocarbonyl), n-butyl(thiocarbonyl), i-butyl(thiocarbonyl), s-butyl(thiocarbonyl), t-butyl(thiocarbonyl), c-butyl(thiocarbonyl), 1-methyl-c-propyl(thiocarbonyl), 2-methyl-c-propyl(thiocarbonyl), n-pentyl(thiocarbonyl), 1-methyl-n-butyl(thiocarbonyl), 2-methyl-n-butyl(thiocarbonyl), 3-methyl-n-butyl(thiocarbonyl), 1,1-dimethyl-n-propyl(thiocarbonyl), 1,2-dimethyl-n-propyl(thiocarbonyl), 2,2-dimethyl-n-propyl(thiocarbonyl), 1-ethyl-n-propyl(thiocarbonyl), c-pentyl(thiocarbonyl), 1-methyl-c-butyl(thiocarbonyl), 2-methyl-c-butyl(thiocarbonyl), 3-methyl-c-butyl(thiocarbonyl), 1,2-dimethyl-c-propyl(thiocarbonyl), 2,3-dimethyl-c-propyl(thiocarbonyl), 1-ethyl-c-propyl(thiocarbonyl), 2-ethyl-c-propyl(thiocarbonyl), n-hexyl(thiocarbonyl), 1-methyl-n-pentyl(thiocarbonyl), 2-methyl-n-pentyl(thiocarbonyl), 3-methyl-n-pentyl(thiocarbonyl), 4-methyl-n-pentyl(thiocarbonyl), 1,1-dimethyl-n-butyl(thiocarbonyl), 1,2-dimethyl-n-butyl(thiocarbonyl), 1,3-dimethyl-n-butyl(thiocarbonyl), 2,2-dimethyl-n-butyl(thiocarbonyl), 2,3-dimethyl-n-butyl(thiocarbonyl), 3,3-dimethyl-n-butyl(thiocarbonyl), 1-ethyl-n-butyl(thiocarbonyl), 2-ethyl-n-butyl(thiocarbonyl) 1,1,2-trimethyl-n-propyl(thiocarbonyl), 1,2,2-trimethyl-n-propyl(thiocarbonyl), 1-ethyl-1-methyl-n-propyl(thiocarbonyl), 1-ethyl-2-methyl-n-propyl(thiocarbonyl), c-hexyl(thiocarbonyl), 1-methyl-c-pentyl(thiocarbonyl), 2-methyl-c-pentyl(thiocarbonyl), 3-methyl-c-pentyl(thiocarbonyl), 1-ethyl-c-butyl(thiocarbonyl), 2-ethyl-c-butyl(thiocarbonyl), 3-ethyl-c-butyl(thiocarbonyl), 1,2-dimethyl-c-butyl(thiocarbonyl), 1,3-dimethyl-c-butyl(thiocarbonyl), 2,2-dimethyl-c-butyl(thiocarbonyl), 2,3-dimethyl-c-butyl(thiocarbonyl), 2,4-dimethyl-c-butyl(thiocarbonyl), 3,3-dimethyl-c-butyl(thiocarbonyl), 1-n-propyl-c-propyl(thiocarbonyl), 2-n-propyl-c-propyl(thiocarbonyl), 1-i-propyl-c-propyl(thiocarbonyl), 2-i-propyl-c-propyl(thiocarbonyl), 1,2,2-trimethyl-c-propyl(thiocarbonyl), 1,2,3-trimethyl-c-propyl(thiocarbonyl), 2,2,3-trimethyl-c-propyl(thiocarbonyl), 1-ethyl-2-methyl-c-propyl (thiocarbonyl), 2-ethyl-1-methyl-c-propyl(thiocarbonyl), 2-ethyl-2-methyl-c-propyl(thiocarbonyl), 2-ethyl-3-methyl-c-propyl(thiocarbonyl) and the like may be mentioned.

A C₁₋₁₀ alkylthiocarbonyl group may be linear, branched or a C₃₋₁₀ cycloalkylthiocarbonyl group, and in addition to those mentioned above, 1-methyl-1-ethyl-n-pen-yl(thiocarbonyl), 1-heptyl(thiocarbonyl), 2-heptyl(thiocarbonyl), 1-ethyl-1,2-dimethyl-n-propyl(thiocarbonyl), 1-ethyl-2,2-dimethyl-n-propyl(thiocarbonyl), 1-octyl(thiocarbonyl), 3-octyl(thiocarbonyl), 4-methyl-3-n-heptyl(thiocarbonyl), 6-methyl-2-n-heptyl(thiocarbonyl), 2-propyl-1-n-heptyl(thiocarbonyl), 2,4,4-trimethyl-1-n-pentyl(thiocarbonyl), 1-nonyl(thiocarbonyl), 2-nonyl(thiocarbonyl), 2,6-dimethyl-4-n-heptyl(thiocarbonyl), 3-ethyl-2,2-dimethyl-3-n-pentyl (thiocarbonyl), 3,5,5-trimethyl-1-n-hexyl(thiocarbonyl), 1-decyl(thiocarbonyl), 2-decyl(thiocarbonyl), 4-decyl(thiocarbonyl), 3,7-dimethyl-1-n-octyl(thiocarbonyl), 3,7-dimethyl-3-n-octyl(thiocarbonyl) or the like may be mentioned.

A C₁₋₆ alkylsulfonyl group may be linear, branched or a C₃₋₆ cycloalkylsulfonyl group, and methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, 4-propylsulfonyl, c-propylsulfonyl, n-butylsulfonyl, i-butylsulfonyl, s-butylsulfonyl, t-butylsulfonyl, c-butylsulfonyl, 1-methyl-c-propylsulfonyl, 2-methyl-c-propylsulfonyl, n-pentylsulfonyl, 1-methyl-n-butylsulfonyl, 2-methyl-n-butylsulfonyl, 3-methyl-n-butylsulfonyl, 1,1-dimethyl-n-propylsulfonyl, 1,2-dimethyl-n-propylsulfonyl, 2,2-dimethyl-n-propylsulfonyl, 1-ethyl-n-propylsulfonyl, c-pentylsulfonyl, 1-methyl-c-butylsulfonyl, 2-methyl-c-butylsulfonyl, 3-methyl-c-butylsulfonyl, 1,2-dimethyl-c-propylsulfonyl, 2,3-dimethyl-c-propylsulfonyl, 1-ethyl-c-propylsulfonyl, 2-ethyl-c-propylsulfonyl, n-hexylsulfonyl, 1-methyl-n-pentylsulfonyl, 2-methyl-n-pentylsulfonyl, 3-methyl-n-pentylsulfonyl, 4-methyl-n-pentylsulfonyl, 1,1-dimethyl-n-butylsulfonyl, 1,2-dimethyl-n-butylsulfonyl, 1,3-dimethyl-n-butylsulfonyl, 2,2-dimethyl-n-butylsulfonyl, 2,3-dimethyl-n-butylsulfonyl, 3,3-dimethyl-n-butylsulfonyl, 1-ethyl-n-butylsulfonyl, 2-ethyl-n-butylsulfonyl, 1,1,2-trimethyl-n-propylsulfonyl, 1,2,2-trimethyl-n-propylsulfonyl, 1-ethyl-1-methyl-n-propylsulfonyl, 1-ethyl-2-methyl-n-propylsulfonyl, c-hexylsulfonyl, 1-methyl-c-pentylsulfonyl, 2-methyl-c-pentylsulfonyl, 3-methyl-c-pentylsulfonyl, 1-ethyl-c-butylsulfonyl, 2-ethyl-c-butylsulfonyl, 3-ethyl-c-butylsulfonyl, 1,2-dimethyl-c-butylsulfonyl, 3-dimethyl-c-butylsulfonyl, 2,2-dimethyl-c-butylsulfonyl, 2,3-dimethyl-c-butylsulfonyl, 2,4-dimethyl-c-butylsulfonyl, 3,3-dimethyl-c-butylsulfonyl, 1-n-propyl-c-propylsulfonyl, 2-n-propyl-c-propylsulfonyl, 1-i-propyl-c-propylsulfonyl, 2-i-propyl-c-propylsulfonyl, 1,2,2-trimethyl-c-propylsulfonyl, 1,2,3-trimethyl-c-propylsulfonyl, 2,2,3-trimethyl-c-propylsulfonyl, 1-ethyl-2-methyl-c-propylsulfonyl, 2-ethyl-1-methyl-c-propylsulfonyl, 2-ethyl-2-methyl-c-propylsulfonyl, 2-ethyl-3-methyl-c-propylsulfonyl or the like may be mentioned.

A C₁₋₁₀ alkylsulfonyl group may be linear, branched or a C₃₋₁₀ cycloalkylsulfonyl group, and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentylsulfonyl, 1-heptylsulfonyl, 2-heptylsulfonyl, 1-ethyl-1,2-dimethyl-n-propylsulfonyl, 1-ethyl-2,2-dimethyl-n-propylsulfonyl, 1-octylsulfonyl, 3-octylsulfonyl, 4-methyl-3-n-heptylsulfonyl, 6-methyl-2-n-heptylsulfonyl, 2-propyl-1-n-n-heptylsulfonyl, 2,4,4-trimethyl-1-n-pentylsulfonyl, 1-nonylsulfonyl, 2-nonylsulfonyl, 2,6-dimethyl-4-n-heptylsulfonyl, 3-ethyl-2,2-dimethyl-3-n-pentylsulfonyl, 3,5,5-trimethyl-1-n-hexylsulfonyl, 1-decylsulfonyl, 2-decylsulfonyl, 4-decylsulfonyl, 3,7-dimethyl-1-n-octylsulfonyl, 3,7-dimethyl-3-n-octylsulfonyl, c-heptylsulfonyl, c-octylsulfonyl, 1-methyl-c-hexylsulfonyl, 2-methyl-c-hexylsulfonyl, 3-methyl-c-hexylsulfonyl, 1,2-dimethyl-c-hexylsulfonyl, 1-ethyl-c-hexylsulfonyl, 1-methyl-c-pentylsulfonyl, 2-methyl-c-pentylsulfonyl, 3-methyl-c-pentylsulfonyl or the like may be mentioned.

A C₁₋₆ alkoxycarbonyl group may be linear, branched or a C₃₋₆ cycloalkoxycarbonyl group, and methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, i-propoxycarbonyl, c-propoxylcarbonyl, n-butoxycarbonyl, i-butoxycarbonyl, s-butoxycarbonyl, t-butoxycarbonyl, c-butoxycarbonyl, 1-methyl-c-propoxycarbonyl, 2-methyl-c-propoxycarbonyl, n-pentyloxycarbonyl, 1-methyl-n-butoxycarbonyl, 2-methyl-n-butoxycarbonyl, 3-methyl-n-butoxycarbonyl, 1,1-dimethyl-n-propoxycarbonyl, 1,2-dimethyl-n-propoxycarbonyl, 2,2-dimethyl-n-propoxycarbonyl, 1-ethyl-n-propoxycarbonyl, c-pentyloxycarbonyl, 1-methyl-c-butoxycarbonyl, 2-methyl-c-butoxycarbonyl, 3-methyl-c-butoxycarbonyl, 1,2-dimethyl-c-propoxycarbonyl, 2,3-dimethyl-c-propoxycarbonyl, 1-ethyl-c-propoxycarbonyl, 2-ethyl-c-propoxycarbonyl, n-hexyloxycarbonyl, 1-methyl-n-pentyloxycarbonyl, 2-methyl-n-pentyloxycarbonyl, 3-methyl-n-pentyloxycarbonyl, 4-methyl-n-pentyloxycarbonyl, 1,1-dimethyl-n-butoxycarbonyl, 1,2-dimethyl-n-butoxycarbonyl, 1,3-dimethyl-n-butoxycarbonyl, 2,2-dimethyl-n-butoxycarbonyl, 2,3-dimethyl-n-butoxycarbonyl, 3,3-dimethyl-n-butoxycarbonyl, 1-ethyl-n-butoxycarbonyl, 2-ethyl-n-butoxycarbonyl, 1,1,2-trimethyl-n-propoxycarbonyl, 1,2,2-trimethyl-n-propoxycarbonyl, 1-ethyl-1-methyl-n-propoxycarbonyl, 1-ethyl-2-methyl-n-propoxycarbonyl, c-hexyloxycarbonyl, 1-methyl-c-pentyloxycarbonyl, 2-methyl-c-pentyloxycarbonyl, 3-methyl-c-pentyloxycarbonyl, 1-ethyl-c-butoxycarbonyl, 2-ethyl-c-butoxycarbonyl, 3-ethyl-c-butoxycarbonyl, 1,2-dimethyl-c-butoxycarbonyl, 1,3-dimethyl-c-butoxycarbonyl, 2,2-dimethyl-c-butoxycarbonyl, 2,3-dimethyl-c-butoxycarbonyl, 2,4-dimethyl-c-butoxycarbonyl, 3,3-dimethyl-c-butoxycarbonyl, 1-n-propyl-c-propoxycarbonyl, 2-n-propyl-c-propoxycarbonyl, 1-i-propyl-c-propoxycarbonyl, 2-i-propyl-c-propoxycarbonyl, 1,2,2-trimethyl-c-propoxycarbonyl, 1,2,3-trimethyl-c-propoxycarbonyl, 2,2,3-trimethyl-c-propoxycarbonyl, 1-ethyl-2-methyl-c-propoxycarbonyl, 2-ethyl-1-methyl-c-propoxycarbonyl, 2-ethyl-2-methyl-c-propoxycarbonyl, 2-ethyl-3-methyl-c-propoxycarbonyl or the like may be mentioned.

A C₁₋₁₀ alkoxycarbonyl group may be linear, branched or a C₃₋₁₀ cycloalkoxycarbonyl group, and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentyloxycarbonyl, 1-heptyloxycarbonyl, 2-heptyloxycarbonyl, 1-ethyl-1,2-dimethyl-n-propyloxycarbonyl, 1-ethyl-2,2-dimethyl-n-propyloxycarbonyl, 1-octyloxycarbonyl, 3-octyloxycarbonyl, 4-methyl-3-n-heptyloxycarbonyl, 6-methyl-2-n-heptyloxycarbonyl, 2-propyl-1-n-heptyloxycarbonyl, 2,4,4-trimethyl-1-n-pentyloxycarbonyl, 1-nonyloxycarbonyl, 2-nonyloxycarbonyl, 2,6-dimethyl-4-n-heptyloxycarbonyl, 3-ethyl-2,2-dimethyl-3-n-pentyloxycarbonyl, 3,5,5-trimethyl-1-n-hexyloxycarbonyl, 1-decyloxycarbonyl-2-decyloxycarbonyl, 4-decyloxycarbonyl, 3,7-dimethyl-1-n-octyloxycarbonyl, 3,7-dimethyl-3-n-octyloxycarbonyl or the like may be mentioned.

A C₁₋₁₀ alkylcarbonyloxy group may be linear, branched or a C₃₋₁₀ cycloalkylcarbonyloxy group, and methylcarbonyloxy, ethylcarbonyloxy, n-propylcarbonyloxy, i-propylcarbonyloxy, c-propylcarbonyloxy, n-butylcarbonyloxy, i-butylcarbonyloxy, s-butylcarbonyloxy, t-butylcarbonyloxy, c-butylcarbonyloxy, 1-methyl-c-propylcarbonyloxy, 2-methyl-c-propylcarbonyloxy, n-pentylcarbonyloxy, 1-methyl-n-butylcarbonyloxy, 2-methyl-n-butylcarbonyloxy, 3-methyl-n-butylcarbonyloxy, 1,1-dimethyl-n-propylcarbonyloxy, 1,2-dimethyl-n-propylcarbonyloxy, 2,2-dimethyl-n-propylcarbonyloxy, 1-ethyl-n-propylcarbonyloxy, c-pentylcarbonyloxy, 1-methyl-c-butylcarbonyloxy, 2-methyl-c-butylcarbonyloxy, 3-methyl-c-butylcarbonyloxy, 1,2-dimethyl-c-propylcarbonyloxy, 2,3-dimethyl-c-propylcarbonyloxy, 1-ethyl-c-propylcarbonyloxy, 2-ethyl-c-propylcarbonyloxy, n-hexylcarbonyloxy, 1-methyl-n-pentylcarbonyloxy, 2-methyl-n-pentylcarbonyloxy, 3-methyl-n-pentylcarbonyloxy, 4-methyl-n-pentylcarbonyloxy, 1,1-dimethyl-n-butylcarbonyloxy, 1,2-dimethyl-n-butylcarbonyloxy, 1,3-dimethyl-n-butylcarbonyloxy, 2,2-dimethyl-n-butylcarbonyloxy, 2,3-dimethyl-n-butylcarbonyloxy, 3,3-dimethyl-n-butylcarbonyloxy, 1-ethyl-n-butylcarbonyloxy, 2-ethyl-n-butylcarbonyloxy, 1,1,2-trimethyl-n-propylcarbonyloxy, 1,2,2-tri-methyl-n-propylcarbonyloxy, 1-ethyl-1-methyl-n-propylcarbonyloxy, 1-ethyl-2-methyl-n-propylcarbonyloxy, c-hexylcarbonyloxy, 1-methyl-c-pentylcarbonyloxy, 2-methyl-c-pentylcarbonyloxy, 3-methyl-c-pentylcarbonyloxy, 1-ethyl-c-butylcarbonyloxy, 2-ethyl-c-butylcarbonyloxy, 3-ethyl-c-butylcarbonyloxy, 1,2-dimethyl-c-butylcarbonyloxy, 1,3-dimethyl-c-butylcarbonyloxy, 2,2-dimethyl-c-butylcarbonyloxy, 2,3-dimethyl-c-butylcarbonyloxy, 2,4-dimethyl-c-butylcarbonyloxy, 3,3-dimethyl-c-butylcarbonyloxy, 1-n-propyl-c-propylcarbonyloxy, 2-n-propyl-c-propylcarbonyloxy, 1-i-propyl-c-propylcarbonyloxy, 2-i-propyl-c-propylcarbonyloxy, 1,2,2-trimethyl-c-propylcarbonyloxy, 1,2,3-trimethyl-c-propylcarbonyloxy, 2,2,3-trimethyl-c-propylcarbonyloxy, 1-ethyl-2-methyl-c-propylcarbonyloxy, 2-ethyl-1-methyl-c-propylcarbonyloxy, 2-ethyl-2-methyl-c-propylcarbonyloxy, 2-ethyl-3-methyl-c-propylcarbonyloxy, 1-methyl-1-ethyl-n-pentylcarbonyloxy, 1-heptylcarbonyloxy, 2-heptylcarbonyloxy, 1-ethyl-1,2-dimethyl-n-propylcarbonyloxy, 1-ethyl-2,2-dimethyl-n-propylcarbonyloxy, 1-octylcarbonyloxy, 3-octylcarbonyloxy, 4-methyl-3-n-heptylcarbonyloxy, 6-methyl-2-n-heptylcarbonyloxy, 2-propyl-1-n-heptylcarbonyloxy, 2,4,4-trimethyl-1-n-pentylcarbonyloxy, 1-nonylcarbonyloxy, 2-nonylcarbonyloxy, 2,6-dimethyl-4-n-heptylcarbonyloxy, 3-ethyl-2,2-dimethyl-3-n-pentylcarbonyloxy, 3,5,5-trimethyl-1-n-hexylcarbonyloxy, 1-decylcarbonyloxy, 2-decylcarbonyloxy, 4-decylcarbonyloxy, 3,7-dimethyl-1-n-octylcarbonyloxy, 3,7-dimethyl-3-n-octylcarbonyloxy or the like may be mentioned.

A C₁₋₁₀ alkylcarbonylamino group may be linear, branched or a C₃₋₁₀ cycloalkylcarbonylamino group, and methylcarbonylamino, ethylcarbonylamino, n-propylcarbonylamino, i-propylcarbonylamino, c-propylcarbonylamino, n-butylcarbonylamino, i-butylcarbonylamino, s-butylcarbonylamino, t-butylcarbonylamino, c-butylcarbonylamino, 1-methyl-c-propylcarbonylamino, 2-methyl-c-propylcarbonylamino, n-pentylcarbonylamino, 1-methyl-n-butylcarbonylamino, 2-methyl-n-butylcarbonylamino, 3-methyl-n-butylcarbonylamino, 1,1-dimethyl-n-propylcarbonylamino, 1,2-dimethyl-n-propylcarbonylamino, 2,2-dimethyl-n-propylcarbonylamino, 1-ethyl-n-propylcarbonylamino, c-pentylcarbonylamino, 1-methyl-c-butylcarbonylamino, 2-methyl-c-butylcarbonylamino, 3-methyl-c-butylcarbonylamino, 1,2-dimethyl-c-propylcarbonylamino, 2,3-dimethyl-c-propylcarbonylamino, 1-ethyl-c-propylcarbonylamino, 2-ethyl-c-propylcarbonylamino, n-hexylcarbonylamino, 1-methyl-n-pentylcarbonylamino, 2-methyl-n-pentylcarbonylamino, 3-methyl-n-pentylcarbonylamino, 4-methyl-n-pentylcarbonylamino, 1,1-dimethyl-n-butylcarbonylamino, 1,2-dimethyl-n-butylcarbonylamino, 1,3-dimethyl-n-butylcarbonylamino, 2,2-dimethyl-n-butylcarbonylamino, 2,3-dimethyl-n-butylcarbonylamino, 3,3-dimethyl-n-butylcarbonylamino, 1-ethyl-n-butylcarbonylamino, 2-ethyl-n-butylcarbonylamino, 1,1,2-trimethyl-n-propylcarbonylamino, 1,2,2-trimethyl-n-propylcarbonylamino, 1-ethyl-1-methyl-n-propylcarbonylamino, 1-ethyl-2-methyl-n-propylcarbonylamino, c-hexylcarbonylamino, 1-methyl-c-pentylcarbonylamino, 2-methyl-c-pentylcarbonylamino, 3-methyl-c-pentylcarbonylamino, 1-ethyl-c-butylcarbonylamino, 2-ethyl-c-butylcarbonylamino, 3-ethyl-c-butylcarbonylamino, 1,2-dimethyl-c-butylcarbonylamino, 1,3-dimethyl-c-butylcarbonylamino, 2,2-dimethyl-c-butylcarbonylamino, 2,3-dimethyl-c-butylcarbonylamino, 2,4-dimethyl-c-butylcarbonylamino, 3,3-dimethyl-c-butylcarbonylamino, 1-n-propyl-c-propylcarbonylamino 2-n-propyl-c-propylcarbonylamino, 1-i-propyl-c-propylcarbonylamino, 2-i-propyl-c-propylcarbonylamino, 1,2,2-trimethyl-c-propyl-carbonylamino, 1,2,3-trimethyl-c-propylcarbonylamino, 2,2,3-trimethyl-c-propylcarbonylamino, 1-ethyl-2-methyl-c-propylcarbonylamino, 2-ethyl-1-methyl-c-propylcarbonylamino, 2-ethyl-2-methyl-c-propylcarbonylamino, 2-ethyl-3-methyl-c-propylcarbonylamino, 1-methyl-1-ethyl-n-pentylcarbonylamino, 1-heptylcarbonylamino, 2-heptylcarbonylamino, 1-ethyl-1,2-dimethyl-n-propylcarbonylamino, 1-ethyl-2,2-dimethyl-n-propylcarbonylamino, 1-octylcarbonylamino, 3-octylcarbonylamino, 4-methyl-3-n-heptylcarbonylamino, 6-methyl-2-n-heptylcarbonylamino, 2-propyl-1-n-heptylcarbonylamino, 2,4,4-trimethyl-1-n-pentylcarbonylamino, 1-nonylcarbonylamino, 2-nonylcarbonylamino, 2,6-dimethyl-4-n-heptylcarbonylamino, 3-ethyl-2,2-dimethyl-3-n-pentylcarbonylamino, 3,5,5-trimethyl-1-n-hexylcarbonylamino, 1-decylcarbonylamino, 2-decylcarbonylamino, 4-decylcarbonylamino, 3,7-dimethyl-1-n-octylcarbonylamino, 3,7-dimethyl-3-n-octylcarbonylamino or the like may be mentioned.

A C₁₋₁₀ monoalkylamino group may be linear, branched or a C₃₋₁₀ cycloalkylamino group and methylamino, ethylamino, n-propylamino, i-propylamino, c-propylamino, n-butylamino, i-butylamino, s-butylamino, t-butylamino, c-butylamino, 1-methyl-c-propylamino, 2-methyl-c-propylamino, n-pentylamino, 1-methyl-n-butylamino, 2-methyl-n-butylamino, 3-methyl-n-butylamino, 1,1-dimethyl-n-propylamino, 1,2-dimethyl-n-propylamino, 2,2-dimethyl-n-propylamino, 1-ethyl-n-propylamino, c-pentylamino, 1-methyl-c-butylamino, 2-methyl-c-butylamino, 3-methyl-c-butylamino, 1,2-dimethyl-c-propylamino, 2,3-dimethyl-c-propylamino, 1-ethyl-c-propylamino, 2-ethyl-c-propylamino, n-hexylamino, 1-methyl-n-pentylamino, 2-methyl-n-pentylamino, 3-methyl-n-pentylamino, 4-methyl-n-pentylamino, 1,1-dimethyl-n-butylamino, 1,2-dimethyl-n-butylamino, 1,3-dimethyl-n-butylamino, 2,2-dimethyl-n-butylamino, 2,3-dimethyl-n-butylamino, 3,3-dimethyl-n-butylamino, 1-ethyl-n-butylamino, 2-ethyl-n-butylamino, 1,1,2-trimethyl-n-propylamino, 1,2,2-trimethyl-n-propylamino, 1-ethyl-1-methyl-n-propylamino, 1-ethyl-2-methyl-n-propylamino, c-hexylamino, 1-methyl-c-pentylamino, 2-methyl-c-pentylamino, 3-methyl-c-pentylamino, 1-ethyl-c-butylamino, 2-ethyl-c-butylamino, 3-ethyl-c-butylamino, 1,2-dimethyl-c-butylamino, 1,3-dimethyl-c-butylamino, 2,2-dimethyl-c-butylamino, 2,3-dimethyl-c-butylamino, 2,4-dimethyl-c-butylamino, 3,3-dimethyl-c-butylamino, 1-n-propyl-c-propylamino, 2-n-propyl-c-propylamino, 1-i-propyl-c-propylamino, 2-i-propyl-c-propylamino, 1,2,2-trimethyl-c-propylamino, 1,2,3-trimethyl-c-propylamino, 2,2,3-trimethyl-c-propylamino, 1-ethyl-2-methyl-c-propylamino, 2-ethyl-1-methyl-c-propylamino, 2-ethyl-2-methyl-c-propylamino, 2 ethyl-3-methyl-c-propylamino, 1-methyl-1-ethyl-n-pentylamino, 1-heptylamino, 2-heptylamino, 1-ethyl-1,2-dimethyl-n-propylamino, 1-ethyl-2,2-dimethyl-n-propylamino, 1-octylamino, 3-octylamino, 4-methyl-3-n-heptylamino, 6-methyl-2-n-heptylamino, 2-propyl-1-n-heptylamino, 2,4,4-trimethyl-1-n-pentylamino, 1-nonylamino, 2-nonylamino, 2,6-dimethyl-4-n-heptylamino, 3-ethyl-2,2-dimethyl-3-n-pentylamino, 3,5,5-trimethyl-1-n-hexylamino, 1-decylamino, 2-decylamino, 4-decylamino, 3,7-dimethyl-1-n-octylamino, 3,7-dimethyl-3-n-octylamino or the like may be mentioned.

A C₁₋₁₀ dialkylamino group may be symmetric or asymmetric. A symmetric C₁₋₁₀ dialkylamino group may be linear, branched or a C₃₋₁₀ cycloalkylamino group, and dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-c-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, di-c-butylamino, di-(1-methyl-c-propyl)amino, di-(2-methyl-c-propyl)amino, di-n-pentylamino, di-(1-methyl-n-butyl)amino, di-(2-methyl-n-butyl)amino, di-(3-methyl-n-butyl)amino, di-(1,1-dimethyl-n-propyl)amino, di-(1,2-dimethyl-n-propyl)amino, di-(2,2-dimethyl-n-propyl)amino, di-(1-ethyl-n-propyl)amino, di-c-pentylamino, di-(1-methyl-c-butyl)amino, di-(2-methyl-c-butyl)amino, di-(3-methyl-c-butyl)amino, di-(1,2-dimethyl-c-propyl)amino, di-(2,3-dimethyl-c-propyl)amino, di-(1-ethyl-c-propyl)amino, di-(2-ethyl-c-propyl)amino, di-n-hexylamino, di-(1-methyl-n-pentyl)amino, di-(2-methyl-n-pentyl)amino, di-(3-methyl-n-pentyl)amino, di-(4-methyl-n-pentyl)amino, di-(1,1-dimethyl-n-butyl)amino, di-(1,2-dimethyl-n-butyl)amino, di-(3,3-dimethyl-n-butyl)amino, di-(2,2-dimethyl-n-butyl)amino, di-(2,3-dimethyl-n-butyl)amino, di-(3,3-dimethyl-n-butyl)amino, di-(1-ethyl-n-butyl)amino, di-(2-ethyl-n-butyl)amino, di-(1,1,2-trimethyl-n-propyl)amino, di-(1,2,2-trimethyl-n-propyl)amino, di-(1-ethyl-1-methyl-n-propyl)amino, di-(1-ethyl-2-methyl-n-propyl)amino, di-c-hexylamino, di-(1-methyl-c-pentyl)amino, di-(2-methyl-c-pentyl)amino, di-(3-methyl-c-pentyl)amino, di-(1-ethyl-c-butyl)amino, di-(2-ethyl-c-butyl)amino, di-(3-ethyl-c-butyl)amino, di-(1,2-dimethyl-c-butyl)amino, di-(1,3-dimethyl-c-butyl)amino, di-(2,2-dimethyl-c-butyl)amino, di-(2,3-dimethyl-c-butyl)amino, di-(2,4-dimethyl-c-butyl)amino, di-(3,3-dimethyl-c-butyl)amino, di-(1-n-propyl-c-propyl)amino, di-(2-n-propyl-c-propyl)amino, di-(1-i-propyl-c-propyl)amino, di-(2-i-propyl-c-propyl)amino, di-(1,2,2-trimethyl-c-propyl)amino, di-(1,2,3-trimethyl-c-propyl)amino, di-(2,2,3-trimethyl-c-propyl)amino, di-(1-ethyl-2-methyl-c-propyl)amino, di-(2-ethyl-1-methyl-c-propyl)amino, di-(2-ethyl-2-methyl-c-propyl)amino, di-(2-ethyl-3-methyl-c-propyl)amino, di-(1-methyl-1-ethyl-n-pentyl)amino, di-(1-heptyl)amino, di-(2-heptyl)amino, di-(1-ethyl-1,2-dimethyl-n-propyl)amino, di-(1-ethyl-2,2-dimethyl-n-propyl)amino, di-(1-octyl)amino, di-(3-octyl)amino, di-(4-methyl-3-n-heptyl)amino, di-(6-methyl-2-n-heptyl)amino, di-(2-propyl-1-n-heptyl)amino, di-(2,4,4-trimethyl-1-n-pentyl)amino, di-(1-nonyl)amino, di-(2-nonyl)amino, di-(2,6-dimethyl-4-n-heptyl)amino, di-(3-ethyl-2,2-dimethyl-3-n-pentyl)amino, di-(3,5,5-trimethyl-1-n-hexyl)amino, di-(1-decyl)amino, di-(2-decyl)amino, di-(4-decyl)amino, di-(3,7-dimethyl-1-n-octyl)amino, di-(3,7-dimethyl-3-n-octyl)amino or the like may be mentioned.

An asymmetric C₁₋₁₀ dialkylamino group may be linear, branched or a C₃₋₁₀ cycloalkylamino group and (methyl, ethyl)amino, (methyl, n-propyl)amino, (methyl, i-propyl)amino, (methyl, c-propyl)amino, (methyl, n-butyl)amino, (methyl, i-butyl)amino, (methyl, s-butyl)amino, (methyl, t-butyl)amino, (methyl, n-pentyl)amino, (methyl, c-pentyl)amino, (methyl, n-hexyl)amino, (methyl, c-hexyl)amino, (ethyl, n-propyl)amino, (ethyl, i-propyl)amino, (ethyl, c-propyl)amino, (ethyl, n-butyl)amino, (ethyl, i-butyl)amino, (ethyl, s-butyl)amino, (ethyl, t-butyl)amino, (ethyl, n-pentyl)amino, (ethyl, c-pentyl)amino, (ethyl, n-hexyl)amino, (ethyl, c-hexyl)amino, (n-propyl, i-propyl)amino, (n-propyl, c-propyl)amino, (n-propyl, n-butyl)amino, (n-propyl, i-butyl)amino, (n-propyl, s-butyl)amino, (n-propyl, t-butyl)amino, (n-propyl, n-pentyl)amino, (n-propyl, c-pentyl)amino, (n-propyl, n-hexyl)amino, (n-propyl, c-hexyl)amino, (i-propyl, c-propyl)amino, (i-propyl, n-butyl)amino, (i-propyl, i-butyl)amino, (i-propyl, s-butyl)amino, (i-propyl, t-butyl)amino, (i-propyl, n-pentyl)amino, (i-propyl, c-pentyl)amino, (i-propyl, n-hexyl)amino, (i-propyl, c-hexyl)amino, (C-propyl, n-butyl)amino, (c-propyl, i-butyl)amino, (c-propyl, s-butyl)amino, (C-propyl, t-butyl)amino, (c-propyl, n-pentyl)amino, (c-propyl, c-pentyl)amino, (c-propyl, n-hexyl)amino, (C-propyl, c-hexyl)amino, (n-butyl, i-butyl)amino, (n-butyl, s-butyl)amino, (n-butyl, t-butyl)amino, (n-butyl, n-pentyl)amino, (n-butyl, c-pentyl)amino, (n-butyl, n-hexyl)amino, (n-butyl, c-hexyl)amino, (i-butyl, s-butyl)amino, (i-butyl, t-butyl)amino, (i-butyl, n-pentyl)amino, (i-butyl, c-pentyl)amino, (i-butyl, n-hexyl)amino, (i-butyl, c-hexyl)amino, (s-butyl, t-butyl)amino, (s-butyl, n-pentyl)amino, (s-butyl, c-pentyl)amino, (s-butyl, n-hexyl)amino, (s-butyl, c-hexyl)amino, (t-butyl, n-pentyl)amino, (t-butyl, c-pentyl)amino, (t-butyl, n-hexyl)amino, (t-butyl, c-hexyl)amino, (n-pentyl, c-pentyl)amino, (n-pentyl, n-hexyl)amino, (n-pentyl, hexyl)amino, (c-pentyl, n-hexyl)amino, (c-pentyl, c-hexyl)amino, (n-hexyl, c-hexyl)amino, (methyl, n-heptyl)amino, (methyl, n-octyl)amino, (methyl, n-nonyl)amino, (methyl, n-decyl)amino, (methyl, n-heptyl)amino, (ethyl, n-octyl)amino, (ethyl, n-nonyl)amino, (ethyl, n-decyl)amino or the like may be mentioned.

A C₁₋₁₀ alkylaminocarbonyl group may be linear, branched or a C₃₋₁₀ alkylaminocarbonyl group, and methylaminocarbonyl, ethylaminocarbonyl, n-propylaminocarbonyl, i-propylaminocarbonyl, c-propylaminocarbonyl, n-butylaminocarbonyl, i-butylaminocarbonyl, s-butylaminocarbonyl, t-butylaminocarbonyl, c-butylaminocarbonyl, 1-methyl-c-propylaminocarbonyl, 2-methyl-c-propylaminocarbonyl, n-pentylaminocarbonyl, 1-methyl-n-butylaminocarbonyl, 2-methyl-n-butylaminocarbonyl, 3-methyl-n-butylaminocarbonyl, 1,1-dimethyl-n-propylaminocarbonyl, 1,2-dimethyl-n-propylaminocarbonyl, 2,2-dimethyl-n-propylaminocarbonyl, 1-ethyl-n-propylaminocarbonyl, c-pentylaminocarbonyl, 1-methyl-c-butylaminocarbonyl, 2-methyl-c-butylaminocarbonyl, 3-methyl-c-butylaminocarbonyl, 1,2-dimethyl-c-propylaminocarbonyl, 2,3-dimethyl-c-propylaminocarbonyl, 1-ethyl-c-propylaminocarbonyl, 2-ethyl-c-propylaminocarbonyl, n-hexylaminocarbonyl, 1-methyl-n-pentylaminocarbonyl, 2-methyl-n-pentylaminocarbonyl, 3-methyl-n-pentylaminocarbonyl, 4-methyl-n-pentylaminocarbonyl, 1,1-dimethyl-n-butylaminocarbonyl, 1,2-dimethyl-n-butylaminocarbonyl, 1,3-dimethyl-n-butylaminocarbonyl, 2,2-dimethyl-n-butylaminocarbonyl, 2,3-dimethyl-n-butylaminocarbonyl, 3,3-dimethyl-n-butylaminocarbonyl, ethyl-n-butylaminocarbonyl, 2-ethyl-n-butylaminocarbonyl, 1,1,2-trimethyl-n-propylaminocarbonyl, 1,2,2-trimethyl-n-propylaminocarbonyl, 1-ethyl-1-methyl-n-propylaminocarbonyl, 1-ethyl-2-methyl-n-propylaminocarbonyl, c-hexylaminocarbonyl, 1-methyl-c-pentylaminocarbonyl, 2-methyl-c-pentylaminocarbonyl, 3-methyl-c-pentylaminocarbonyl, 1-ethyl-c-butylaminocarbonyl, 2-ethyl-c-butylaminocarbonyl, 3-ethyl-c-butylaminocarbonyl, 1,2-dimethyl-c-butylaminocarbonyl, 1,3-dimethyl-c-butylaminocarbonyl, 2,2-dimethyl-c-butylaminocarbonyl, 2,3-dimethyl-c-butylaminocarbonyl, 2,4-dimethyl-c-butylaminocarbonyl, 3,3-dimethyl-c-butylaminocarbonyl, 1-n-propyl-c-propylaminocarbonyl, 2-n-propyl-c-propylaminocarbonyl, 1-i-propyl-c-propylaminocarbonyl, 2-i-propyl-c-propylaminocarbonyl, 1,2,2-trimethyl-c-propylaminocarbonyl, 1,2,3-trimethyl-c-propylaminocarbonyl, 2,2,3-trimethyl-c-propylaminocarbonyl, 1-ethyl-2-methyl-c-propylaminocarbonyl, 2-ethyl-1-methyl-c-propylaminocarbonyl, 2-ethyl-2-methyl-c-propylaminocarbonyl, 2-ethyl-3-methyl-c-propylaminocarbonyl, 1-methyl-1-ethyl-n-pentylaminocarbonyl, 1-heptylaminocarbonyl, 2-heptylaminocarbonyl, 1-ethyl-1,2-dimethyl-n-propylaminocarbonyl, 1-ethyl-2,2-dimethyl-n-propylaminocarbonyl, 1-octylaminocarbonyl, 3-octylaminocarbonyl, 4-methyl-3-n-heptylaminocarbonyl, 6-methyl-2-n-heptylaminocarbonyl, 2-propyl-1-n-heptylaminocarbonyl, 2,4,4-trimethyl-1-n-pentylaminocarbonyl, 1-nonylaminocarbonyl, 2-nonylaminocarbonyl, 2,6-dimethyl-4-n-heptylaminocarbonyl, 3-ethyl-2,2-dimethyl-3-n-pentylaminocarbonyl, 3,5,5-trimethyl-1-n-hexylaminocarbonyl, 1-decylaminocarbonyl, 2-decylaminocarbonyl, 4-decylaminocarbonyl, 3,7-dimethyl-1-n-octylaminocarbonyl, 3,7-dimethyl-3-n-octylaminocarbonyl or the like may be mentioned.

A C₁₋₁₀ dialkylaminocarbonyl group may be symmetric or asymmetric. A symmetric C₁₋₁₀ dialkylaminocarbonyl group may be linear, branched or a C₃₋₁₀ cycloalkylaminocarbonyl group, and dimethylaminocarbonyl, diethylaminocarbonyl, di-n-propylaminocarbonyl, di-i-propylaminocarbonyl, di-c-propylaminocarbonyl, di-n-butylaminocarbonyl, di-i-butylaminocarbonyl, di-s-butylaminocarbonyl, di-t-butylaminocarbonyl, di-c-butylaminocarbonyl, di-(1-methyl-c-propylaminocarbonyl, di-(2-methyl-c-propyl)aminocarbonyl, di-n-pentylaminocarbonyl, di-(1-methyl-n-butyl)aminocarbonyl, di-(2-methyl-n-butyl)aminocarbonyl, di-(3-methyl-n-butyl)aminocarbonyl, di-(1,1-dimethyl-n-propylaminocarbonyl, di-(1,2-dimethyl-n-propyl)aminocarbonyl, di-(2,2-dimethyl-n-propyl)aminocarbonyl, di-(1-ethyl-n-propyl)aminocarbonyl di-c-pentylaminocarbonyl, di-(1-methyl-c-butyl)aminocarbonyl, di-(2-methyl-c-butyl)aminocarbonyl, di-(3-methyl-c-butyl)aminocarbonyl, di-(1,2-dimethyl-c-propyl)aminocarbonyl, di-(2,3-dimethyl-c-propyl)aminocarbonyl, di-(1-ethyl-c-propyl)aminocarbonyl, di-(2-ethyl-c-propyl)aminocarbonyl, di-n-hexylaminocarbonyl, di-(1-methyl-n-pentyl)aminocarbonyl, di-4-(2-methyl-n-pentyl)aminocarbonyl, di-(3-methyl-n-pentyl)aminocarbonyl, di-(4-methyl-n-pentyl)aminocarbonyl, di-(1,1-dimethyl-n-butyl)aminocarbonyl, di-(1,2-dimethyl-n-butyl)aminocarbonyl, di-(1,3-dimethyl-n-butyl)aminocarbonyl, di-(2,2-dimethyl-n-butyl)aminocarbonyl, di-(2,3-dimethyl-n-butyl)aminocarbonyl, di-(3,3-dimethyl-n-butyl)aminocarbonyl, di-(1-ethyl-n-butyl)aminocarbonyl, di-(2-ethyl-n-butyl)aminocarbonyl, di-(1,1,2-trimethyl-n-propyl)aminocarbonyl, di-(1,2,2-trimethyl-n-propyl)aminocarbonyl, di-(1-ethyl-1-methyl-n-propyl)aminocarbonyl, di-(1-ethyl-2-methyl-n-propyl)aminocarbonyl, di-c-hexylaminocarbonyl, di-(1-methyl-c-pentyl)aminocarbonyl, di-(2-methyl-c-pentyl)aminocarbonyl, di-(3-methyl-c-pentyl)aminocarbonyl, di-(1-ethyl-c-butyl)aminocarbonyl, di-(2-ethyl-c-butyl)aminocarbonyl, di-(3-ethyl-c-butyl)aminocarbonyl, di-(1,2-dimethyl-c-butyl)aminocarbonyl, di-(1,3-dimethyl-c-butyl)aminocarbonyl, di-(2,2-dimethyl-c-butyl)aminocarbonyl, di-(2,3-dimethyl-c-butyl)aminocarbonyl, di-(2,4-dimethyl-c-butyl)aminocarbonyl, di-(3,3-dimethyl-c-butyl)aminocarbonyl, di-(1-n-propyl-c-propyl)aminocarbonyl, di-(2-n-propyl-c-propyl)aminocarbonyl di-(1-i-propyl-c-propyl)aminocarbonyl, di-(2-i-propyl-c-propyl)aminocarbonyl, di-(1,2,2-trimethyl-c-propyl)aminocarbonyl, di-(1,2,3-trimethyl-c-propyl)aminocarbonyl, di-(2,2,3-trimethyl-c-propyl)aminocarbonyl, di-(1-ethyl-2-methyl-c-propyl)aminocarbonyl, di-(2-ethyl-1-methyl-c-propyl)aminocarbonyl, di-(2-ethyl-2-methyl-c-propyl)aminocarbonyl, di-(2-ethyl-3-methyl-c-propyl)aminocarbonyl, di-(1-methyl-1-ethyl-n-pentyl)aminocarbonyl, di-(1-heptyl)aminocarbonyl, di-(2-heptyl)aminocarbonyl, di-(1-ethyl-1,2-dimethyl-n-propyl)aminocarbonyl, di-(1-ethyl-2,2-dimethyl-n-propyl)aminocarbonyl, di-(1-octyl)aminocarbonyl, di-(3-octyl)aminocarbonyl, di-(4-methyl-3-n-heptyl)aminocarbonyl, di-(6-methyl-2-n-heptyl)aminocarbonyl, di-(2-propyl-1-n-heptyl)aminocarbonyl, di-(2,4,4-trimethyl-1-n-pentyl)aminocarbonyl, di-(1-nonyl)aminocarbonyl, di-(2-nonylaminocarbonyl, di-(2,6-dimethyl-4-n-heptyl)aminocarbonyl, di-(3-ethyl-2,2-dimethyl-3-n-pentyl)aminocarbonyl, di-(3,55-trimethyl-1-n-hexyl)aminocarbonyl, di-(1-decyl)aminocarbonyl, di-(2-decyl)aminocarbonyl, di-(4-decyl)aminocarbonyl, di-(3,7-dimethyl-1-n-octyl)aminocarbonyl, di-(3,7-dimethyl-3-n-octyl)aminocarbonyl or the like may be mentioned.

An asymmetric C₁₋₁₀ dialkylaminocarbonyl group may be linear, branched or a C₃₋₁₀ cycloalkylaminocarbonyl group, and (methyl, ethyl)aminocarbonyl, (methyl, n-propyl)aminocarbonyl, (methyl, i-propyl)aminocarbonyl, (methyl, c-propyl)aminocarbonyl, (methyl, n-butyl)aminocarbonyl, (methyl, i-butyl)aminocarbonyl, (methyl, s-butyl)aminocarbonyl, (methyl, t-butyl)aminocarbonyl, (methyl, n-pentyl)aminocarbonyl, (methyl, c-pentyl)aminocarbonyl, (methyl, n-hexyl)aminocarbonyl, (methyl, c-hexyl)aminocarbonyl, (ethyl, n-propyl)aminocarbonyl, (ethyl, i-propyl)aminocarbonyl, (ethyl, c-propyl)aminocarbonyl, (ethyl, n-butyl)aminocarbonyl, (ethyl, i-butyl)aminocarbonyl, (ethyl, s-butyl)aminocarbonyl, (ethyl, t-butyl)aminocarbonyl, (ethyl, n-pentyl)aminocarbonyl, (ethyl, c-pentyl)aminocarbonyl, (ethyl, n-hexyl)aminocarbonyl, (ethyl, c-hexyl)aminocarbonyl, (n-propyl, i-propyl)aminocarbonyl, (n-propyl, c-propyl)aminocarbonyl, (n-propyl, n-butyl)aminocarbonyl, (n-propyl, i-butyl)aminocarbonyl, (n-propyl, s-butyl)aminocarbonyl, (n-propyl, t-butyl)aminocarbonyl, (n-propyl, n-pentyl)aminocarbonyl, (n-propyl, c-pentyl)aminocarbonyl, (n-propyl, n-hexyl)aminocarbonyl, (n-propyl, c-hexyl)aminocarbonyl, (i-propyl, c-propyl)aminocarbonyl, (i-propyl, n-butyl)aminocarbonyl, (i-propyl, i-butyl)aminocarbonyl, (i-propyl, s-butyl)aminocarbonyl, (i-propyl, t-butyl)aminocarbonyl, (i-propyl, n-pentyl)aminocarbonyl, (i-propyl, c-pentyl)aminocarbonyl, (i-propyl, n-hexyl)aminocarbonyl, (i-propyl, c-hexyl)aminocarbonyl, (c-propyl, n-butyl)aminocarbonyl, (c-propyl, i-butyl)aminocarbonyl, (c-propyl, s-butyl)aminocarbonyl, (c-propyl, t-butyl)aminocarbonyl, (c-propyl, n-pentyl)aminocarbonyl, (c-propyl, c-pentyl)aminocarbonyl, (c-propyl, n-hexyl)aminocarbonyl, (c-propyl, c-hexyl)aminocarbonyl, (n-butyl, i-butyl)aminocarbonyl, (n-butyl, s-butyl)aminocarbonyl, (n-butyl, t-butyl)aminocarbonyl, (n-butyl, n-pentyl)aminocarbonyl, (n-butyl, c-pentyl)aminocarbonyl, (n-butyl, n-hexyl)aminocarbonyl, (n-butyl, c-hexyl)aminocarbonyl, (i-butyl, s-butyl)aminocarbonyl, (i-butyl, t-butyl)aminocarbonyl, (i-butyl, n-pentyl)aminocarbonyl, (i-butyl, c-pentyl)aminocarbonyl, (i-butyl, n-hexyl)aminocarbonyl, (i-butyl, c-hexyl)aminocarbonyl, (s-butyl, t-butyl)aminocarbonyl, (s-butyl, n-pentyl)aminocarbonyl, (s-butyl, c-pentyl)aminocarbonyl, (s-butyl, n-hexyl)aminocarbonyl, (s-butyl, c-hexyl)aminocarbonyl, (t-butyl, n-pentyl)aminocarbonyl, (t-butyl, c-pentyl)aminocarbonyl, (t-butyl, n-hexyl)aminocarbonyl, (t-butyl, c-hexyl)aminocarbonyl, (n-pentyl, c-pentyl)aminocarbonyl, (n-pentyl, n-hexyl)aminocarbonyl, (n-pentyl, c-hexyl)aminocarbonyl, (c-pentyl, n-hexyl)aminocarbonyl, (c-pentyl, c-hexyl)aminocarbonyl, (n-hexyl, c-hexyl)aminocarbonyl, (methyl, n-heptyl)aminocarbonyl, (methyl, n-octyl)aminocarbonyl, (methyl, n-nonyl)aminocarbonyl, (methyl, n-decyl)aminocarbonyl, (methyl, n-heptyl)aminocarbonyl, (ethyl, n-octyl)aminocarbonyl, (ethyl, n-nonyl)aminocarbonyl, (ethyl, n-decyl)aminocarbonyl or the like may be mentioned.

A C₁₋₆ alkylaminosulfonyl group may be linear, branched or a C₃₋₆ cycloalkylaminosulfonyl group, and methylaminosulfonyl, ethylaminosulfonyl, n-propylaminosulfonyl, i-propylaminosulfonyl, c-propylaminosulfonyl, n-butylaminosulfonyl, i-butylaminosulfonyl, s-butylaminosulfonyl, t-butylaminosulfonyl, c-butylaminosulfonyl, 1-methyl-c-propylaminosulfonyl, 2-methyl-c-propylaminosulfonyl, n-pentylaminosulfonyl, 1-methyl-n-butylaminosulfonyl, 2-methyl-n-butylaminosulfonyl, 3-methyl-n-butylaminosulfonyl, 1,1-dimethyl-n-propylaminosulfonyl, 1,2-dimethyln-propylaminosulfonyl, 2,2-dimethyln-propylaminosulfonyl, 1-ethyl-n-propylaminosulfonyl, c-pentylaminosulfonyl, 1-methyl-c-butylaminosulfonyl, 2-methyl-c-butylaminosulfonyl, 3-methyl-c-butylaminosulfonyl, 1,2-dimethyl-c-propylaminosulfonyl, 2,3-dimethyl-c-propylaminosulfonyl, 1-ethyl-c-propylaminosulfonyl, 2-ethyl-c-propylaminosulfonyl, n-hexylaminosulfonyl, 1-methyl-n-pentylaminosulfonyl, 2-methyl-n-pentylaminosulfonyl, 3-methyl-n-pentylaminosulfonyl, 4-methyl-n-pentylaminosulfonyl, 1,1-dimethyl-n-butylaminosulfonyl, 1,2-dimethyl-n-butylaminosulfonyl, 1,3-dimethyl-n-butylaminosulfonyl, 2,2-dimethyl-n-butylaminosulfonyl, 2,3-dimethyl-n-butylaminosulfonyl, 3,3-dimethyl-n-butylaminosulfonyl, 1 ethyl-n-butylaminosulfonyl, 2-ethyl-n-butylaminosulfonyl, 1,1,2-trimethyl-n-propylaminosulfonyl, 1,2,2-trimethyl-n-propylaminosulfonyl, 1-ethyl-1-methyl-n-propylaminosulfonyl, 1-ethyl-2-methyl-n-propylaminosulfonyl, c-hexylaminosulfonyl, 1-methyl-c-pentylaminosulfonyl, 2-methyl-c-pentylaminosulfonyl, 3-methyl-c-pentylaminosulfonyl, 1-ethyl-c-butylaminosulfonyl, 2-ethyl-c-butylaminosulfonyl, 3-ethyl-c-butylaminosulfonyl, 1,2-dimethyl-c-butylaminosulfonyl, 1,3-dimethyl-c-butylaminosulfonyl, 2,2-dimethyl-c-butylaminosulfonyl, 2,3-dimethyl-c-butylaminosulfonyl, 2,4-dimethyl-c-butylaminosulfonyl, 3,3-dimethyl-c-butylaminosulfonyl, 1-n-propyl-c-propylaminosulfonyl, 2-n-propyl-c-propylaminosulfonyl, 1-i-propyl-c-propylaminosulfonyl, 2-i-propyl-c-propylaminosulfonyl, 1,2,2-trimethyl-c-propylaminosulfonyl, 1,2,3-trimethyl-c-propylaminosulfonyl, 2,2,3-trimethyl-c-propylaminosulfonyl, 1-ethyl-2-methyl-c-propylaminosulfonyl, 2-ethyl-1-methyl-c-propylaminosulfonyl, 2-ethyl-2-methyl-c-propylaminosulfonyl, 2-ethyl-3-methyl-c-propylaminosulfonyl or the like may be mentioned.

A C₁₋₁₀ alkylaminosulfonyl group may be linear, branched or a C₃₋₁₀ cycloalkylsulfonylamino group, and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentylaminosulfonyl, 1-heptylaminosulfonyl, 2-heptylaminosulfonyl, 1-ethyl-1,2-dimethyl-n-propylaminosulfonyl, 1-ethyl-2,2-dimethyl-n-propylaminosulfonyl, 1-octylaminosulfonyl, 3-octylaminosulfonyl, 4-methyl-3-n-heptylaminosulfonyl, 6-methyl-2-n-heptylaminosulfonyl, 2-propyl-1-n-heptylaminosulfonyl, 2,4,4-trimethyl-1-n-pentylaminosulfonyl, 1-nonylaminosulfonyl, 2-nonylaminosulfonyl, 2,6-dimethyl-4-n-heptylaminosulfonyl, 3-ethyl-2,2-dimethyl-3-n-pentylaminosulfonyl, 3,5,5-trimethyl-1-n-hexylaminosulfonyl, 1-decylaminosulfonyl, 2-decylaminosulfonyl, 4-decylaminosulfonyl, 3,7-dimethyl-1-n-octylaminosulfonyl, 3,7-dimethyl-3-n-octylaminosulfonyl, c-heptylaminosulfonyl, c-octylaminosulfonyl, 1-methyl-c-hexylaminosulfonyl, 2-methyl-c-hexylaminosulfonyl, 3-methyl-c-hexylaminosulfonyl, 1,2-dimethyl-c-hexylaminosulfonyl, 1-ethyl-c-hexylaminosulfonyl, 1-methyl-c-pentylaminosulfonyl, 2-methyl-c-pentylaminosulfonyl, 3-methyl-c-pentylaminosulfonyl or the like may be mentioned.

The protecting group in a protected hydroxyl group may be a C₁₋₄ alkoxymethyl group (such as MOM: methoxymethyl, MEM: 2-methoxyethoxymethyl ethoxymethyl, n-propoxymethyl, i-propoxymethyl, n-butoxymethyl, iBM: isobutyloxymethyl, BUM: t-butoxymethyl, POM: pivaloyloxytethyl, SEM: trimethylsilylethoxymethyl and the like, preferably a C₁₋₂ alkoxymethyl or the like), an aryloxymethyl (such as BOM: benzyloxymethyl, PMBM: P-methoxybenzyloxymethyl, p-AOM: p-anisyloxymethyl and the like, preferably benzyloxymethyl), a C₁₋₄ alkylaminomethyl group (such as dimethylaminomethyl), a substituted acetamidomethyl group (such as Acm: acetamidomethyl Tacm: trimethylacetamidomethyl and the like) a substituted thiomethyl group (such as MTM: methylthiomethyl PTM: phenylthiomethyl, Btm: benzylthiomethyl and the like), a carboxyl group, a C₁₋₇ acyl group (such as formyl, acetyl, fluoroacetyl, difluoroacetyl, trifluoroacetyl, chloroacetyl dichloroacetyl, trichloroacetyl, propionyl, Pv: pivaloyl, tigloyl and the like), an arylcarbonyl group (such as benzoyl, p-bromobenzoyl, 2,3-dinitrobenzoyl, benzoylformyl, benzoylpropionyl, phenylpropionyl and the like), a C₁₋₄ alkoxycarbonyl group (such as methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, 1-propoxycarbonyl, n-butoxycarbonyl, i-butoxycarbonyl, BOC: t-butoxycarbonyl, AOC: t-amyloxycarbonyl, VOC: vinyloxycarbonyl, AOC: allyloxycarbonyl, Teoc: 2-(trimethylsilyl)ethoxycarbonyl, Troc: 2,2,2-trichloroethoxycarbonyl and the like, preferably BOC and the like), an aryloxycarbonyl group (such as Z: benzyloxycarbonyl, p-nitrobenzyloxycarbonyl, MOZ: p-methoxybenzyloxycarbonyl and the like), a C₁₋₄ alkylaminocarbonyl group (such as methylcarbamoyl, Ec: ethylcarbamoyl, n-propylcarbamoyl and the like), an arylaminocarbonyl group (such as phenylcarbamoyl and the like), a trialkylsilyl group (such as TMS: trimethylsilyl, TES: triethylsilyl, TIPS: triisopropylsilyl, DEIPS: diethylisopropylsilyl, DMIPS: dimethylisopropylsilyl, DTBMS: di-t-butylmethylsilyl, IPDMS: isopropyldimethylsilyl, TEDMS: t-butyldimethylsilyl, TDS: thexyldimethylsilyl and the like, preferably t-butyldimethylsilyl and the like), a trialkylarylsilyl group (such as DPMS: diphenylmethylsilyl, TBDPS: t-butyldiphenylsilyl, TEMPS: t-butyldimethoxyphenylsilyl, TPS: triphenylsilyl and the like), an alkylsulfonyl group, (such as Ms: methanesulfonyl, ethanesulfonyl and the like) or an arylsulfonyl group (such as benzenesulfonyl, Ts: p-toluenesulfonyl, p-chlorobenzenesulfonyl, MS: p-methoxybenzenesulfonyl, m-nitrobenzenesulfonyl, o-nitrobenzenesulfonyl, p-nitrobenzenesulfonyl, 2,4-nitrobenzenesulfonyl, iMds: 2,6-dimethoxy-4-methylbenzenesulfonyl, Mds: 2,6-dimethyl-4-methoxybenzenesulfonyl, Mtb: 2,4,6-trimethoxybenzenesulfonyl, Mte: 2,3,5,6-tetramethyl-4-methoxybenzenesulfonyl, Mtr: 2,3,6-trimethyl-4-methoxybenzenesulfonyl, Mts: 2,4,6-trimethylbenzenesulfonyl, Pme: pentamethylbenzenesulfonyl and the like).

In addition, a 1-methyl-1-methoxyethyl group, a 1-ethoxyethylgroup, a 2,22-trichloroethyl group, a 2-trimethylsilylethoxy group, a t-butyl group, an allyl group, a benzyl group, a p-methoxybenzyl group, a 2,4-dinitrophenyl group, a p-chlorophenyl group, a p-methoxyphenyl group, a tetrahydropyranyl group and a tetrahydrofuranyl group may be mentioned.

Specific preferred examples of the substituent R¹ are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group, and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more of the following substituents.

Substituents a C₁₋₁₀ alkyl group, a halogen atom, a C₁₋₁₀ alkyl group substituted with one or more halogen atoms, a nitro group, an amino group, an amino group substituted with one or two C₁₋₁₀ alkyl groups, an amino group substituted with a C₁₋₁₀ alkylcarbonyl group, a thiol group substituted with a C₁₋₁₀ alkyl group, a thiol group substituted with a C₁₋₁₀ alkylcarbonyl group, a hydroxyl group, a C₁₋₆ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group and a C₁₋₁₀ alkylcarbonyl group.

Particularly preferred examples of the substituent R¹ are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more of the following substituents.

Substituents: a methyl group, a t-butyl group, a trifluoromethyl group, a chlorine atom, a fluorine atom, a bromine atom, a trifluoromethoxy group, a methoxy group, a methylamino group, a dimethylamino group, a t-butyloxy group and a t-butylamino group.

Still further preferred specific examples of the substituent are a 3-methyl-phenyl group, a 4-methyl-phenyl group, a 3,4-dimethyl-phenyl group, a 4-bromo-phenyl group, a 4-trifluoromethoxy-phenyl group, a 3-t-butyl-phenyl group, a 4-t-butyl-phenyl group, a 3-trifluoromethyl-phenyl group, a 4-trifluoromethyl-phenyl group, a 4-trifluoromethoxy-phenyl group, a 3,4-ditrifluoromethyl-phenyl group, a 3-chloro-phenyl group, a 4-chloro-phenyl group, a 3-fluoro-phenyl group, a 4-fluoro-phenyl group, a 3,4-dichloro-phenyl group, a 4-methoxy-phenyl group, a 4-methylamino-phenyl group, a 3-methyl-thienyl group, a 4-methyl-thienyl group, a 3,4-dimethyl-thienyl group, a 3-t-butyl-thienyl group, a 4-t-butyl-thienyl group, a 3-trifluoromethyl-thienyl group, a 4-trifluoromethyl-thienyl group, a 3,4-ditrifluoromethyl-thienyl group, a 3-chloro-thienyl group, a 4-chloro-thienyl group, a 3-fluoro-thienyl group, a 4-fluoro-thienyl group, a 3,4-dichloro-thienyl group, a 4-methoxy-thienyl group, a 4-methylamino-thienyl group, a 3-methyl-furyl group, a 4-methyl-furyl group, a 3,4-dimethyl-furyl group, a 3-t-butyl-furyl group, a 4-t-butyl-furyl group, a 3-trifluoromethyl-furyl group, a 4-trifluoromethyl-furyl group, a 3,4-ditrifluoromethyl-furyl group, a 3-chloro-furyl group, a 4-chloro-furyl group, a 3-fluoro-furyl group, a 4-fluoro-furyl group, a 3,4-dichloro-furyl group, a 4-methoxy-furyl group, a 4-methylamino-furyl group, a 5-chloro-pyridazinyl group, a 5-methyl-pyridazinyl group, a 5-methoxy-pyridazinyl group, a 4-chloro-pyridazinyl group, a 4-methylpyridazinyl group, a 4-methoxy-pyridazinyl group, a 4-t-butoxy-pyridazinyl group and the like.

Specific preferable examples of L¹ are a bond, CH₂, an oxygen atom, a sulfur atom, NH, N-Me, N—CHO, CHMe, CMe₂, N—CH₂Ph and the like, and particularly preferable examples are a bond, CH₂, an oxygen atom, a sulfur atom, NH, NMe and the like.

Specific preferable examples of the substituent R² are hydrogen, a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a t-butyl group and a phenyl group (the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the t-butyl group and the phenyl group may be optionally substituted with an amino group, a monomethylamino group, a dimethylamino group, a monoethylamino group, a diethylamino group, a methoxy group, an ethoxy group, a methoxycarbonyl group, an ethoxycarbonyl group, a methylcarbonyloxy group, an ethylcarbonyloxy group, a methylcarbonylamino group or an ethylcarbonylamino group), and particularly preferable examples are hydrogen, a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a t-butyl group, a phenyl group and the like.

Specific preferable examples of L² are a bond, CH₂, an oxygen atom, a sulfur atom, NH, N-Me, N—CHO, CHMe, CMe₂, N—CH₂Ph and the like, and particularly preferable examples are a bond, CH₂, an oxygen atom, a sulfur atom, NH, NMe and the like.

Specific preferable examples of L³ are a bond, CH₂, an oxygen atom, a sulfur atom, NH, NH—OH, N-Me, N—CHO, CHMe, CMe₂, N—CH₂PH and the like, and particularly preferred examples are a bond, CH₂, an oxygen atom, a sulfur atom, NH, NMe and the like.

Specific preferable examples of the substituent R³ are a C₂₋₁₄ aryl group which is optionally substituted with one or more substituents selected from the following substituent set A and may be optionally substituted with one or more substituents independently selected from the following substituent set B and a C₂₋₁₄ substituted aryl group which may be optionally substituted with one or more substituents selected from the following substituent set B.

Substituent Set A:

—W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom, a hydroxyl group, an amino group, a C₁₋₆ alkyl group or a C₁₋₆ alkoxy group (the C₁₋₆ alkyl group and the C₁₋₆ alkoxy group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3) an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), and R³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group, a C₂₋₉ heterocyclyl group (the amino group, the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₄ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) and with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfo groups, sulfamoyl groups and C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or R²⁹ and R³⁰ mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is CR³¹R³² (wherein R³¹ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group (the C₁₋₁₀ alkyl group, the C₂₋₁₄ aryl group, the C₁₋₁₀ alkoxy group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group, a protected hydroxyl group, and R³² is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group, a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), or NR³³ (wherein R³³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group, a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5), or NR²⁹R³⁰, as a whole, means a nitrogen-containing C₂₋₉ cyclyl group (the nitrogen-containing C₂₋₉ cyclyl group may be optionally substituted with one or more hydrogen atoms and is substituted with two or three substituents independently selected from the group consisting of: hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylsulfonylamino groups, the C₁₋₁₀ thioalkyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or a substituted C₂₋₉ heterocyclyl group (the substituted C₂₋₉ heterocyclyl group may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylsulfonylamino groups, the C₁₋₁₀ thioalkyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halo-en atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)))), and C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups are optionally substituted with one or more substituents selected from the group consisting of: hydroxyl groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups and C₁₋₆ alkoxy groups (the mono- or di-C₁₋₁₀ alkylamino groups and the C₁₋₆ alkoxy groups may be substituted with one or more halogen atoms), with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylaminosulfo groups, C₁₋₁₀ alkylaminocarbonyl groups C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylaminosulfo groups, the C₁₋₁₀ alkylaminocarbonyl groups, the C₁₋₁₀ alkylsulfonylamino groups and the C₁₋₁₀ thioalkyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) and with —W⁵ (wherein W⁵ is SO₂R⁴², SOR⁴², COR⁴² (wherein R⁴² is a hydrogen atom, a hydroxyl group or NR⁴³R⁴⁴, and each of R⁴³ and R⁴⁴ is independently a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), or R⁴³ and R⁴⁴ mean, together with each other, —(CH₂)_(m1)-E-(CH₂)_(m2)— (wherein E is an oxygen atom, a sulfur atom, CR²⁶R²⁷ (wherein each of R²⁰ and R²⁷ is independently a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR⁸ (wherein R⁸ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alk-ylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)) or W⁴, and W⁴ is the same as defined above)) may be mentioned.

Substituent Set B

Hydrogen atoms, hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylaminosulfonyl groups, the C₁₋₁₀ alkylaminocarbonyl groups, the C₁₋₁₀ alkylsulfonylamino groups and the C₁₋₁₀ thioalkyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) may be mentioned.

Specific particularly preferable examples of the substituent R³ are C₂₋₁₄ aryl groups which are optionally substituted with one or more substituents selected from the following substituent set A and may be optionally substituted with one or more substituents independently selected from the following substituent set B.

Substituent Set A:

C₁₋₆ alkyl groups, C₂₋₆ alkenyl groups and C₂₋₆ alkynyl groups (the C₁₋₆ alkyl groups, the C₂₋₆ alkenyl groups and the C₂₋₆ alkynyl groups are optionally substituted with one or more substituents selected from the group consisting of: hydroxyl groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups and C₁₋₆ alkoxy groups (the mono- or di-C₁₋₁₀ alkylamino groups and the C₁₋₆ alkoxy groups may be substituted with one or more halogen atoms), with one or more substituents independently represented by —V² (wherein V² is the same as V¹, and V¹ is the same as defined above) and with —W⁵ (wherein W⁵ is SO₂R⁴², SOR⁴², COR⁴² (wherein R⁴² is a hydrogen atom, a hydroxyl group or NR⁴³R⁴⁴, R⁴³ is the same as R⁶, R⁴⁴ is the same as R⁷, and R⁶ and R⁷ are the same as defined above) or W⁴, and W⁴ is the same as defined above)), C₁₋₆ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylthiocarbonyl groups and C₁₋₁₀ alkylsulfonyl groups (the C₁₋₆ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylthiocarbonyl groups and the C₁₋₁₀ alkylsulfonyl groups are optionally substituted with one or more substituents independently represented by —V² (Wherein V² is the same as V¹, and V¹ is the same as defined above) and with one or more substituents selected from C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups are optionally substituted with one or more substituents independently represented by —V³ (wherein V³ is the same as V¹, and V¹ is the same as defined above))), C₁₋₆ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylthiocarbonyl groups and C₁₋₁₀ alkylsulfonyl groups (the C₁₋₆ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylthiocarbonyl groups and the C₁₋₁₀ alkylsulfonyl groups are optionally substituted with one or more substituents independently represented by —V² (wherein V² is the same as V¹ and V¹ is the same as defined above) and with one or more substituents selected from the group consisting of: amino groups (the amino groups are substituted with a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group is optionally substituted with one or more substituents independently represented by —V³ (wherein V³ is the same as V¹ and V¹ is the same as defined above)) and with a C₂₋₉ heterocyclyl group or a C₂₋₁₄ aryl group (the C₂₋₉ heterocyclyl group and the C₂₋₁₄ aryl group are optionally substituted with one or more substituents independently represented by —V⁴ (wherein V⁴ is the same as V¹, and V¹ is the same as defined above))), amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ thioalkyl groups, C₁₋₁₀ alkylsulfonyl groups, sulfonyl groups, sulfinyl groups and thiol groups (the amino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ thioalkyl groups, the C₁₋₁₀ alkylsulfonyl groups, the sulfonyl groups, the sulfinyl groups and the thiol groups are optionally substituted with one or more C₂₋₉ heterocyclyl groups or one or more C₂₋₁₄ aryl groups (the C₂₋₉ heterocyclyl groups and the C₂₋₁₄ aryl groups are optionally substituted with one or more substituents independently represented by —V⁵ (wherein V⁵ is the same as V¹, and V¹ is the same as defined above)))) may be mentioned.

Substituent Set B:

Hydrogen atoms, hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkoxy groups C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylaminosulfonyl groups, the C₁₋₁₀ alkylaminocarbonyl groups, the C₁₋₁₀ alkylsulfonylamino groups and the C₁₋₁₀ thioalkyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups, may be mentioned.

Still further specific preferable examples of the substituent R³ are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) which are substituted with one or more substituents selected from the following substituent set A and may be optionally substituted with one or more substituents independently selected from the following substituent set B and the following structures which may be optionally substituted with one or more substituents selected from the following substituent set B.

Substituent Set A:

SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²¹ is NR²⁹R³⁰ (wherein R²⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), and R³⁰ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group, a C₂₋₉ heterocyclyl group (the amino group, the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) and with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfo groups, sulfamoyl groups and C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₉ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or R²⁹ and R³⁰ mean together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is CR³¹R³² (wherein R³¹ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group (the C₁₋₁₀ alkyl group, the C₂₋₁₄ aryl group, the C₁₋₁₀ alkoxy group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group, a protected hydroxyl group, and R³² is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl so group, a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or NR³³ (wherein R³³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group, a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₁₋₁₀ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5), or NR²⁹R³⁰, as a whole, means a nitrogen-containing C₂₋₉ cyclyl group (the nitrogen-containing C₂₋₉ cyclyl group may be optionally substituted with one or more hydrogen atoms and is substituted with two or three substituents independently selected from the group consisting of: hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylsulfonylamino groups, the C₁₋₁₀ alkyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or a substituted C₂₋₉ heterocyclyl group (the substituted C₂₋₉ heterocyclyl group may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylsulfonylamino groups, the C₁₋₁₀ thioalkyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), and C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups are optionally substituted with one or more substituents selected from the group consisting of: hydroxyl groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups and C₁₋₆ alkoxy groups (the mono- or di-C₁₋₁₀ alkylamino groups and the C₁₋₆ alkoxy groups may be substituted with one or more halogen atoms), with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylaminosulfonyl groups, the C₁₋₁₀ alkylaminocarbonyl groups, the C₁₋₁₀ alkylsulfonylamino groups and the C₁₋₁₀ thioalkyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) and with —W⁵ (wherein W⁵ is SO₂R⁴², SOR⁴², COR⁴² (wherein R⁴² is a hydrogen atom, a hydroxyl group or NR⁴³R⁴⁴, and each of R⁴³ and R⁴⁴ is independently a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), or R⁴³ and R⁴⁴ mean, together with each other, —(CH₂)_(m1)-E-(CH₂)_(m2)— (wherein E is an oxygen atom, a sulfur atom, CR²⁶R²⁷ (wherein each of R²⁶ and R²⁷ is independently a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR⁸ (wherein R⁸ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)), SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is the same as defined above))) may be mentioned.

Substituent Set B:

Hydrogen atoms, hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, formyl groups, Clay alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkoxy groups C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylaminosulfonyl groups, the C₁₋₁₀ alkylaminocarbonyl groups, the C₁₋₁₀ alkylsulfonylamino groups and the C₁₋₁₀ thioalkyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) may be mentioned.

Specific preferable examples of L⁴ are a bond, CH₂, an oxygen atom, a sulfur atom, NH, N-Me, N—CHO, CHMe, CMe₂, N—CH₂Ph and the like, and particularly preferred examples are a bond, CH₂, an oxygen atom, a sulfur atom, NH, NMe and the like.

Specific preferable examples of X are OH, SH, NH₂, OMe, SMe, NHMe, NHEt, NH—CHO, NH—CH₂Ph, OCH₂Ph, SCH₂Ph, OC(═O)CH₃, SC(═O)CH₃, NHC(═O)CH₃ and the like, and particularly preferable examples are OH, SH, NH₂ and the like.

Specific preferable examples of Y are an oxygen atom, a sulfur atom, NH, N—OH, N—CHO, N-Me, N—CH₂Ph, N—OMe, N—OCH₂Ph an the like, and particularly preferred examples are an oxygen atom, a sulfur atom, NH, N—OH and the like.

Favorable compounds as the thrombopoietin receptor activator, the preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective and the platelet increasing agent of the present invention are as follows.

1) Compounds represented by the formula II) wherein A is a nitrogen atom, and B is a sulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

2) Compounds represented by the formula (1) wherein A is a nitrogen atom, and B is an oxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

3) Compounds represented by the formula (1) wherein A is a nitrogen atom, and B is NR⁹ other than NH (wherein R⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of; carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

4) Compounds represented by the formula (1) wherein A is CR⁴ (wherein R⁴ is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C₂₋₆ alkenyl group or a C₂₋₆ alkynyl group), a thiol group (the thiol group may be substituted with a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C₂₋₆ alkenyl groups or one or two C₂₋₆ alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group and the C₁₋₁₀ alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), SO₂R⁵, SOR⁵ or COR⁵ (wherein R⁵ is a hydroxyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group and the C₁₋₁₀ alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) or NR⁶R⁷ (wherein each of R⁶ and R⁷ is independently a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) or R⁶ and R⁷ mean, together with each other, —(CH₂)_(m1)-E-(CH₂)_(m2)— wherein E is an oxygen atom, a sulfur atom, CR²⁶R²⁷ (wherein each of R²⁶ and R²⁷ is independently a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR⁸ (wherein 8 is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is an oxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

5) Compounds represented by the formula (1) wherein A is CR⁴ (wherein R⁴ is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C₂₋₆ alkenyl group or a C₂₋₆ alkynyl group), a thiol group (the thiol group may be substituted with a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C₂₋₆ alkenyl groups or one or two C₂₋₆ alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group and the C₁₋₁₀ alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, clay alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), SO₂R⁵ SOR⁵ or COR⁵ (wherein R is a hydroxyl group, a C₁₋₁₀ alkyl group, a C₂₋₅ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group and the C₁₋₁₀ alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) or NR⁶R⁷ (wherein each of R⁶ and R⁷ is independently a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) or R⁶ and R⁷ mean, together with each other, —(CH₂)_(m1)-E-(CH₂)_(m2)— (wherein E is an oxygen atom, a sulfur atom, CR²⁶R²⁷ (wherein each of R²⁶ and R²⁷ is independently a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR⁸ (wherein R⁸ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), and each of m1 and m2 is independently an integer of from 3 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is a sulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

6) Compounds represented by the formula (1) wherein A is CR⁴ (wherein R⁴ is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C₂₋₆ alkenyl group or a C₂₋₆ alkynyl group), a thiol group (the thiol group may be substituted with a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C₂₋₆ alkenyl groups or one or two C₂₋₆ alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C₁₋₁₀ alkyl group a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group and the C₁₋₁₀ alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), SO₂R⁵, SOR⁵ or COR⁵ (wherein R⁵ is a hydroxyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group and the C₁₋₁₀ alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) or NR⁶R⁷ (wherein each of R⁶ and R⁷ is independently a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), or R⁶ and R⁷ mean, together with each other, —(CH₂)_(m1)-E-(CH₂)_(m2)— (wherein E is an oxygen atom, a sulfur atom, CR²⁶R²⁷ (wherein each of R²⁶ and R²⁷ is independently a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR⁸ (wherein R⁸ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is NR⁹ (wherein R⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

7) The compounds represented by the formula (1) according to 4), 5) or 6), wherein A is CR³⁷ (wherein R³⁷ is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C₂₋₆ alkenyl or a C₂₋₆ alkynyl group), a thiol group (the thiol group may be substituted with a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group) an amino group (the amino group may be substituted with one or two C₂₋₆ alkenyl groups or one or two C₂₋₆ alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonylamino group and the mono- or di-C₁₋₁₀ alkylamino group may be substituted with one or more substituents selected from the group consisting of: halogen atoms, carboxyl groups, nitro groups and cyano groups), SO₂R³⁸, SOR³⁸ or COR³⁸ (wherein R³⁸ is a hydroxyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group and the C₁₋₁₀ alkoxy group may be substituted with one or more substituents selected from the group consisting of: halogen atoms, carboxyl groups, nitro groups and cyano groups), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The terms in the respective substituents R³⁷ and R³⁸ are the same as those in the respective substituents R¹ to R³⁶.

8) The compounds represented by the formula (1) according to 3) or 6), wherein B is NR³⁹ (wherein R³⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be substituted with one or more substituents selected from the group consisting of: carboxyl groups, halogen atoms, nitro groups and cyano groups), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substituted with one or more substituents selected from the group consisting of: C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups and halogen atoms)), tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The terms in the substituent R³⁹ are the same as those in the respective substituents R¹ to R³⁶.

9) The compounds represented by the formula (1) according to 1), 2), 3), 4), 5), 6), 7) or 8), wherein L¹ is a bond, tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

10) The compounds represented by the formula (1) according to 1), 2), 3), 4), 5), 6), 7), 8) or 9), wherein L² is a bond, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

11) The compounds represented by the formula (1) according to 1), 2), 3), 4), 5), 6) 7), 8), 9) or 10), wherein L³ is NR¹⁹ (wherein R¹⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

12) The compounds according to 1), 2), 3), 4), 5), 6), 7), 8), 9) or 10), wherein L³ is NH, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

13) The compounds according to 1), 2), 3), 4), 5), 6) 7) 8), 9) or 10), wherein L³ is CH₂, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

14) The compounds according to 11), 12) or 13), wherein L⁴ is a bond, tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

15) The compounds according to 11), 12, or 13), wherein L⁴ is NR²² (wherein R²² is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

16) The compounds according to 11), 12) or 13), wherein L⁴ is NH, tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

17) The compounds according to 11), 12) or 13), wherein L⁴ is CH₂, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

18) The compounds according to 14), 15), 16) or 17), wherein R² is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group and the C₁₋₁₀ alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

19) The compounds according to 14), 15), 16) or 17), wherein R² is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₃ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group and the C₁₋₃ alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, phenyl groups and phenyloxyl groups (the phenyl groups and the phenyloxyl groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms), a phenyl group or a phenyloxy group (the phenyl group and the phenyloxy group may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

20) The compounds according to 14), 15), 16) or 17), wherein R² is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group or a C₂₋₆ alkynyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group and the C₂₋₆ alkynyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups and protected hydroxyl groups), tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

21) The compounds according to 14), 15) 16) or 17), wherein R² is a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups and protected hydroxyl groups), tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

22) The compounds according to 14), 15), 16) or 17), wherein R² is a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups and protected hydroxyl groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

23) The compounds according to 18), 19), 20) 21) or 22), wherein R¹ is a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups, C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms), thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or more substituents selected from the group consisting of formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups and C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

24) The compounds according to 18), 19), 20) 21) or 22), wherein R¹ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of: halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonyloxy groups and the C₁₋₁₀ alkoxycarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or more substituents selected from the group consisting of: formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups and C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

25) The compounds according to 18), 19), 20) 21) or 22), wherein R¹ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of: halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: halogen atoms, carboxyl groups, nitro groups and cyano groups), C₂₋₁₄ aryl groups, C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms), thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or more substituents selected from the group consisting of: formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups and C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: halogen atoms, carboxyl groups, nitro groups, cyano groups, hydroxyl groups and protected hydroxyl groups))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

26) The compounds according to 18), 19), 20) 21) or 22), wherein R¹ is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of: halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or more substituents selected from the group consisting of: formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups and C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl group-s nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

27) The compounds according to 18), 19), 20) 21) or 22), wherein R¹ is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of: halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: halogen atoms, carboxyl groups, nitro groups and cyano groups), C₂₋₁₄ aryl groups, C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms), thiol groups and amino groups (the thiol groups and the amino groups may be optionally substituted with one or more substituents selected from the group consisting of: formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups and C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: halogen atoms, carboxyl groups, nitro groups, cyano groups, hydroxyl groups and protected hydroxyl groups))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

28) The compounds according to 23), 24), 25), 26) or 27), wherein Y is an oxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

29) The compounds according to 23), 24), 25), 26) or 27), wherein Y is a sulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

30) The compounds according to 28) or 29), wherein X is a hydroxyl group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

31) The compounds according to 28) 29) or 30), wherein R³ is a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group is optionally substituted with one or more substituents independently represented by —V¹ (wherein V¹ is a hydrogen atom, a hydroxyl group, a protected hydroxyl group, an amino group, a thiol group, a nitro group, a cyano group, a halogen atom, a carboxyl group, a carbamoyl group, a sulfamoyl group, a sulfo group a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylaminosulfonyl group, a C₁₋₁₀ alkylaminocarbonyl group, a C₁₋₁₀ alkylsulfonylamino group, a C₁₋₁₀ thioalkyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyl group, the C₁₋₁₀ alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylaminosulfonyl group, the C₁₋₁₀ alkylaminocarbonyl group, the C₁₋₁₀ alkylsulfonylamino group and the C₁₋₁₀ thioalkyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)) and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (—R²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom, a hydroxyl group, an amino group, a C₁₋₆ alkyl group or a C₁₋₆ alkoxy group (the C₁₋₆ alkyl group and the C₁₋₆ alkoxy group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁶ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), and R³⁰ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group, a C₂₋₉ heterocyclyl group (the amino group, the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) and with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfo groups, sulfamoyl groups and C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or R²⁹ and R³⁰ mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is CR³¹R³² (wherein R³¹ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group (the C₁₋₁₀ alkyl group, the C₂₋₁₄ aryl group, the C₁₋₁₀ alkoxy group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R³² is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or NR³³ (wherein R³³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting off hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5), or NR²⁹R³⁰, as a whole, means a nitrogen-containing C₂₋₉ cyclyl group (the nitrogen-containing C₂₋₉ cyclyl group may be optionally substituted with one or more hydrogen atoms and is substituted with two or three substituents independently selected from the group consisting of: hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylsulfonylamino groups, Cl₁₁ thioalkyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylsulfonylamino groups, the C₁₋₁₀ thioalkyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or a substituted C₂₋₉ heterocyclyl group (the substituted C₂₋₉ heterocyclyl group may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkylsulfonylamino groups, the C₁₋₁₀ thioalkyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))))), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group is optionally substituted with one or more substituents independently represented by —V¹ (wherein V¹ is the same as defined above) and with one or more substituents selected from the group consisting of: C₁₋₆ alkyl groups, C₂₋₆ alkenyl groups and C₂₋₆ alkynyl groups (the C₁₋₆ alkyl groups, the C₂₋₆ alkenyl groups and the C₂₋₆ alkynyl groups are optionally substituted with one or more substituents selected from the group consisting of: hydroxyl groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups and C₁₋₆ alkoxy groups (the mono- or di-C₁₋₁₀ alkylamino groups and the C₁₋₆ alkoxy groups may be substituted with one or more halogen atoms), with one or more substituents independently represented by —V² (wherein V² is the same as V¹, and V¹ is the same as defined above) and with —W⁵ (wherein W⁵ is SO₂R⁴², SOR⁴², COR⁴² wherein R² is a hydrogen atom, a hydroxyl group or NR⁴³R⁴⁴, R⁴¹ is the same as R⁶, R⁴⁴ is the same as R⁷, and R⁶ and R⁷ are the same as defined above) or W⁴ and W⁴ is the same as defined above))), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group is optionally substituted with one or more substituents independently represented by —V¹ (wherein V¹ is the same as defined above) and with one or more substituents selected from the group consisting of: C₁₋₆ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylthiocarbonyl groups and C₁₋₁₀ alkylsulfonyl groups (the C₁₋₆ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylthiocarbonyl groups and the C₁₋₁₀ alkylsulfonyl groups are optionally substituted with one or more substituents independently represented by —V² (wherein V² is the same as V¹, and V¹ is the same as defined above) and with one or more substituents selected from C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups are optionally substituted with one or more substituents independently represented by —V³ (wherein V³ is the same as V¹, and V¹ is the same as defined above)))), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group is optionally substituted with one or more substituents independently represented by —V¹ (wherein V¹ is the same as defined above) and with one or more substituents selected from the group consisting of: C₁₋₆ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylthiocarbonyl groups and C₁₋₁₀ alkylsulfonyl groups (the C₁₋₆ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylthiocarbonyl groups and the C₁₋₁₀ alkylsulfonyl groups are optionally substituted with one or more substituents independently represented by —V² (wherein V² is the same as V¹, and V¹ is the same as defined above) and with one or more substituents selected from the group consisting of: amino groups (the amino groups are substituted with a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group is optionally substituted with one or more substituents independently represented by —V³ (wherein V³ is the same as V¹, and V¹ is the same as defined above)) and with a C₂₋₉ heterocyclyl group or a C₂₋₁₄ aryl group (the C₂₋₉ heterocyclyl group and the C₂₋₁₄ aryl group are optionally substituted with one or more substituents independently represented by —V⁴ (wherein V⁴ is the same as V¹, and V¹ is the same as defined above))), amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ thioalkyl groups, C₁₋₁₀ alkylsulfonyl groups, sulfonyl groups, sulfinyl groups and thiol groups (the amino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ thioalkyl groups, the C₁₋₁₀ alkylsulfonyl groups, the sulfonyl groups, the sulfinyl groups and the thiol groups are optionally substituted with one or more C₂₋₉ heterocyclyl groups or one or more C₂₋₁₄ aryl groups (the C₂₋₉ heterocyclyl groups and the C₂₋₁₄ aryl groups are optionally substituted with one or more substituents independently represented by —V⁵ (wherein V⁵ is the same as V¹, and V¹ is the same as defined above))))) or a C₂₋₁₄ substituted aryl group (the C₂₋₁₄ substituted aryl group may be optionally substituted with one or more substituents independently represented by —V¹ (wherein V¹ is the same as defined above)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

32) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ fluoroalkyl groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom, a hydroxyl group, an amino group, a C₁₋₆ alkyl group or a C₁₋₆ alkoxy group (the C₁₋₆ alkyl group and the C₁₋₆ alkoxy group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²¹, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), and R³⁰ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group, a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) and with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfo groups, sulfamoyl groups and C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

33) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group (the phenyl group is optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ fluoroalkyl groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom, a hydroxyl group, an amino group, a C₁₋₆ alkyl group or a C₁₋₆ alkoxy group (the C₁₋₆ alkyl group and the C₁₋₆ alkoxy group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), and R³⁰ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group, a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms. C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) and with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfo groups, sulfamoyl groups and C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₁₀ alkyl groups (the C₂₋₁₄ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

34) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ fluoroalkyl groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom, a hydroxyl group, an amino group, a C₁₋₆ alkyl group or a C₁₋₆ alkoxy group (the C₁₋₆ alkyl group and the C₁₋₆ alkoxy group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ and R³⁰ mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is CR³¹R³² (wherein R³¹ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group (the C₁₋₁₀ alkyl group, the C₂₋₁₄ aryl group, the C₁₋₁₀ alkoxy group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R³² is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or NR³³ (wherein R³³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups; C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups; nitro groups; cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), and each of m3 and m4 is independently an integer of from Q to 5, provided that m3+m4 is 3, 4 or 5))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

35) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ fluoroalkyl groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups are optionally substituted with one or more substituents selected from the group consisting of: hydroxyl groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups and C₁₋₆ alkoxy groups (the mono- or di-C₁₋₁₀ alkylamino groups and the C₁₋₆ alkoxy groups may be substituted with one or more halogen atoms), with one or more substituents independently represented by —V¹ (wherein V¹ is the same as defined in Claim 1) and with —W⁵ (wherein W⁵ is SO₂R⁴², SOR⁴², COR⁴² (wherein R⁴² is a hydroxyl group or NR⁴³R⁴⁴, and R⁴³ and R⁴⁴ are the same as defined in Claim 1) or W⁴ (wherein W⁴ is the same as defined in Claim 1))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

36) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group/the pyridyl group, the quinolyl group and the Isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ fluoroalkyl groups, C₁₋₁₀ fluoroalkoxy groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents selected from the group consisting of: C₁₋₆ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylthiocarbonyl groups and C₁₋₁₀ alkylsulfonyl groups (the C₁₋₆ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylthiocarbonyl groups and the C₁₋₁₀ alkylsulfonyl groups are optionally substituted with one or more substituents selected from the group consisting of: amino groups (the amino groups are substituted with a C₁₋₁₀ alkyl group and with a C₂₋₉ heterocyclyl group or a C₂₋₁₄ aryl group (the C₂₋₉ heterocyclyl group and the C₂₋₁₄ aryl group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups, C₁₋₁₀ alkoxy groups (the C₁₋₁₀ alkyl groups and the C₁₋₁₀ alkoxy groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ thioalkyl groups, C₁₋₁₀ alkylsulfonyl groups, sulfonyl groups, sulfinyl groups and thiol groups (the amino groups, the mono- or di-C₁₋₁₀ alkylamino groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ thioalkyl groups, the C₁₋₁₀ alkylsulfonyl groups, the sulfonyl groups, the sulfinyl groups and the thiol groups are optionally substituted one or more C₂₋₉ heterocyclyl groups or one or more C₂₋₁₄ aryl groups (the C₂₋₉ heterocyclyl groups and the C₂₋₁₄ aryl groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups, C₁₋₁₀ alkoxy groups (the C₁₋₁₀ alkyl groups and the C₁₋₁₀ alkoxy groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

37) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group (the phenyl group is optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ fluoroalkyl groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom, a hydroxyl group an amino group, a C₁₋₆ alkyl group or a C₁₋₆ alkoxy group (the C₁₋₆ alkyl group and the C₁₋₆ alkoxy group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group) each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ and R³⁰ mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is CR³²R³² (wherein R³¹ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group (the C₁₋₁₀ alkyl group, the C₂₋₁₄ aryl group, the C₁₋₁₀ alkoxy group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R³² is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or NR³³ (wherein R³³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))))), tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

38) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ fluoroalkyl groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom, a hydroxyl group, an amino group, a C₁₋₆ alkyl group or a C₁₋₆ alkoxy group (the C₁₋₆ alkyl group and the C₁₋₆ alkoxy group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein 36 is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein NR²³R³⁰, as a whole, means a nitrogen-containing C₂₋₉ cyclyl group (the nitrogen-containing C₂₋₉ cyclyl group may be optionally substituted with one or more hydrogen atoms and is substituted with two or three substituents independently selected from the group consisting of: hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

39) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group (the phenyl group is optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ fluoroalkyl groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR³⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein NR²⁹R³⁰, as a whole, means a nitrogen-containing C₂₋₉ cyclyl group (the nitrogen-containing C₂₋₉ cyclyl group may be optionally substituted with one or more hydrogen atoms and is substituted with two or three substituents independently selected from the group consisting of: hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

40) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of: nitro groups, cyano groups, halogen atoms, C₁₋₁₀ fluoroalkyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), and R³⁰ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group and the C₁₋₁₀ alkylaminocarbonyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₂₋₆ alkylcarbonyl group are substituted with one or more C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be substituted with one or more substituents selected from the group consisting of: hydroxyl groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

41) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group (the phenyl group is optionally substituted with one or more substituents selected from the group consisting of: nitro groups, cyano groups, halogen atoms, C₁₋₁₀ fluoroalkyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group) each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms) m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), and R³⁰ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group and the C₁₋₁₀ alkylaminocarbonyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group are substituted with one or more C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

42) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of: nitro groups, cyano groups, halogen atoms, C₁₋₁₀ fluoroalkyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ and R³⁰ mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is CR³¹R³² (wherein R³¹ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group (the C₁₋₁₀ alkyl group, the C₂₋₁₄ aryl group, the C₁₋₁₀ alkoxy group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R³² is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group and the C₁₋₁₀ alkylaminocarbonyl group may be substituted with one or more substituents selected from the group consisting of: hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or NR³³ (wherein R³³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group and the C₁₋₁₀ alkylaminocarbonyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups; the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups; the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

43) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group (the phenyl group is optionally substituted with one or more substituents selected from the group consisting of: nitro groups, cyano groups, halogen atoms, C₁₋₁₀ fluoroalkyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ and R³⁰ mean, together with each other —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is CR³¹R³² (wherein R³¹ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group (the C₁₋₁₀ alkyl group, the C₂₋₁₄ aryl group, the C₁₋₁₀ alkoxy group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R³² is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group and the C₁₋₁₀ alkylaminocarbonyl group may be substituted with one or more substituents selected from the group consisting of: hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halo-en atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or NR³³ (wherein R³³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group and the C₁₋₁₀ alkylaminocarbonyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

44) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of: nitro groups, cyano groups, halogen atoms, C₁₋₁₀ fluoroalkyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₁₀ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein NR²⁹R³⁰, as a whole, means a nitrogen-containing C₂₋₉ cyclyl group (the nitrogen-containing C₂₋₉ cyclyl group may be optionally substituted with one or more hydrogen atoms and is substituted with two or three substituents independently selected from the group consisting of: hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)))))), tautomers; prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

45) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group (the phenyl group is optionally substituted with one or more substituents selected from the group consisting of: nitro groups, cyano groups, halogen atoms, C₁₋₁₀ fluoroalkyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3 and W⁴ is SO₂R²⁸, SOR²⁸ or CR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein NR²⁹R³⁰, as a whole, means a nitrogen-containing C₂₋₉ cyclyl group (the nitrogen-containing C₂₋₉ cyclyl group may be optionally substituted with one or more hydrogen atoms and is substituted with two or three substituents independently selected from the group consisting of: hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, C₁₋₁₀ amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

46) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or H) an oxygen atom, a sulfur atom or NR³⁶ (wherein R² is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₁₀ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3 and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), and R³⁰ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group and the C₁₋₁₀ alkylaminocarbonyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group are substituted with one or more C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

47) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group (the phenyl group is optionally substituted with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein 36 is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁶ is NR²⁹R³⁰ (wherein R²⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups, and R³⁰ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group and the C₁₋₁₀ alkylaminocarbonyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group are substituted with one or more C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

48) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms)), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group)_(r) each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3 and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ and R³⁰ mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is CR³¹R³² (wherein R³¹ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group (the C₁₋₁₀ alkyl group, the C₂₋₁₄ aryl group, the C₁₋₁₀ alkoxy group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R³² is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group and the C₁₋₁₀ alkylaminocarbonyl group may be substituted with one or more substituents selected from the group consisting of: hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or NR³³ (wherein R³³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group and the C₁₋₁₀ alkylaminocarbonyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

49) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group (the phenyl group is optionally substituted with one or more substituents independently represented by W¹(CW²W³)_(m)W⁴ (wherein W¹ is CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms) m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ and R³⁰ mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is CR³¹R³² (wherein R³¹ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group (the C₁₋₁₀ alkyl group, the C₂₋₁₄ aryl group, the C₁₋₁₀ alkoxy group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R³² is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group and the C₁₋₁₀ alkylaminocarbonyl group may be substituted with one or more substituents selected from the group consisting of: hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or NR³³ (wherein R³³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group and the C₁₋₁₀ alkylaminocarbonyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

50) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an Isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents independently represented by —W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3/and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein NR²⁹R³⁰ as a whole, means a nitrogen-containing C₂₋₉ cyclyl group (the nitrogen-containing C₂₋₉ cyclyl group may be optionally substituted with one or more hydrogen atoms and is substituted with two or three substituents independently selected from the group consisting of: hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

51) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group (the phenyl group is optionally substituted with one or more substituents independently represented by W¹(CW²W³)_(m)W⁴ (wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ is independently a hydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is a hydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆ alkylcarbonyl group), each of W² and W³ is independently a hydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R² is NR²⁹R³⁰ wherein NR²⁹R³⁰, as a whole, means a nitrogen-containing C₂₋₉ cyclyl group (the nitrogen-containing C₂₋₉ cyclyl group may be optionally substituted with one or more hydrogen atoms and is substituted with two or three substituents independently selected from the group consisting of: hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

52) The compounds according to 28) 29) or 30), wherein 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with —W⁴ (wherein W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), and R³⁰ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group, a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) and with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfo groups, sulfamoyl groups and C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

53) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group (the phenyl group is substituted with —W⁴ (wherein W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is R²⁹NR³⁰ (wherein R²⁹ is a hydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups), and R³⁰ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group, a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups) and with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfo groups, sulfamoyl groups and C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups, C₂₋₉ heterocyclyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkylcarbonyl groups and the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

54) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with —W⁴ (wherein W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein R²⁹ and R³⁰ mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is CR³¹R³² (wherein R³¹ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group (the C₁₋₁₀ alkyl group, the C₂₋₁₄ aryl group, the C₁₋₁₀ alkoxy group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms), a hydroxyl group or a protected hydroxyl group, and R³² is an amino group, a mono- or di-C₁₋₁₀) alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or NR³³ (wherein R³³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

55) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group (the phenyl group is optionally substituted with one or more substituents independently represented by —W⁴ (wherein W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ wherein R²⁹ and R³⁰ mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is CR³¹R³² (wherein R³¹ is a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group (the C₁₋₁₀ alkyl group, the C₂₋₁₄ aryl group, the C₁₋₁₀ alkoxy group and the C₂₋₁₄ aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R³² is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₁₋₁₀ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))) or NR³³ (wherein R³³ is an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀ alkylcarbonylamino group, a C₂₋₉ alkylaminocarbonyl group or a C₂₋₉ heterocyclyl group (the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylcarbonylamino group, the C₁₋₁₀ alkylaminocarbonyl group and the C₂₋₉ heterocyclyl group may be substituted with one or more substituents selected from the group consisting of: hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

56) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents independently represented by W⁴ (wherein W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein NR²⁹R³⁰, as a whole, means a nitrogen-containing C₂₋₉ cyclyl group (the nitrogen-containing C₂₋₉ cyclyl group may be optionally substituted with one or more hydrogen atoms and is substituted with two or three substituents independently selected from the group consisting of: hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkyl carbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

57) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group (the phenyl group is optionally substituted with one or more substituents independently represented by —W⁴ (wherein W⁴ is SO₂R²⁸, SOR²⁸ or COR²⁸ (wherein R²⁸ is NR²⁹R³⁰ (wherein NR²⁹R³⁰, as a whole, means a nitrogen-containing C₂₋₉ cyclyl group (the nitrogen-containing C₂₋₉ cyclyl group may be optionally substituted with one or more hydrogen atoms and is substituted with two or three substituents independently selected from the group consisting of: hydroxyl groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups and the C₁₋₁₀ alkylcarbonyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)))))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

58) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents optionally selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ fluoroalkyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups are optionally substituted with one or more substituents selected from the group consisting of: hydroxyl groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups and C₁₋₆ alkoxy groups (the mono- or di-C₁₋₁₀ alkylamino groups and the C₁₋₆ alkoxy groups may be substituted with one or more halogen atoms), with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylaminosulfonyl group, the C₁₋₁₀ alkylaminocarbonyl groups, the C₁₋₁₀ alkylsulfonylamino groups and the C₁₋₁₀ thioalkyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkyl carbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)) and with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfamoyl groups and sulfo groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

59) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups are optionally substituted with one or more substituents selected from the group consisting of: hydroxyl groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups and C₁₋₆ alkoxy groups (the mono- or di-C₁₋₁₀ alkylamino groups and the C₁₋₆ alkoxy groups may be substituted with one or more halogen atoms) and with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfamoyl groups and sulfo groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

60) The compounds according to 28) 29) or 30), wherein R³ is a C₂₋₁₄ substituted aryl group (the C₂₋₁₄ substituted aryl group may be optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylaminosulfonyl group, the C₁₋₁₀ alkylaminocarbonyl groups, the C₁₋₁₀ alkylsulfonylamino groups and the C₁₋₁₀ thioalkyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

61) The compounds according to 28) 29) or 30), wherein R³ is any of the following structures (the following structures are optionally substituted with one or more substitutents selected from the group consisting of: hydrogen atoms, hydroxyl groups, amino groups, thiol groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, formyl groups, C₁₋₁₀ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, mono- or di-C₁₋₁₀ alkylamino groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylsulfonylamino groups, C₁₋₁₀ thioalkyl groups (the C₁₋₁₀ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyloxy groups, the C₁₋₁₀ alkoxycarbonyl groups, the C₁₋₁₀ alkoxy groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylcarbonylamino groups, the mono- or di-C₁₋₁₀ alkylamino group, the C₁₋₁₀ alkylaminosulfonyl group, the C₁₋₁₀ alkylaminocarbonyl groups, the C₁₋₁₀ alkylsulfonylamino groups and the C₁₋₁₀ thioalkyl groups may be optionally substituted with one or more substituents selected from the group consisting of: carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl groups may be substituted with one or more halogen atoms) or one or more halogen atoms)), C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups (the C₂₋₁₄ aryl groups and the C₂₋₁₄ aryloxy groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups (the C₁₋₁₀ alkyl groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkoxy groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

62) The compounds according to 28) 29) or 30), wherein R³ is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C₁₋₁₀ alkylaminocarbonyl groups, C₁₋₁₀ alkylaminosulfonyl groups, C₁₋₁₀ fluoroalkyl groups, C₁₋₁₀ fluoroalkoxy groups, sulfamoyl groups, carbamoyl groups and C₁₋₁₀ alkylcarbonylamino groups and with one or more substituents selected from the group consisting of: C₁₋₆ alkyl groups, C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylthiocarbonyl groups and C₁₋₁₀ alkylsulfonyl groups (the C₁₋₆ alkyl groups, the C₂₋₆ alkenyl groups, the C₂₋₆ alkynyl groups, the C₁₋₁₀ alkylcarbonyl groups, the C₁₋₁₀ alkylthiocarbonyl groups and the C₁₋₁₀ alkylsulfonyl groups are optionally substituted with one or more substituents selected from the group consisting of: hydrogen atoms, C₁₋₁₀ alkyl groups, C₁₋₁₀ alkoxy groups (the C₁₋₁₀ alkyl groups and the C₁₋₁₀ alkoxy groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups and with one or more substituents selected from C₂₋₉ heterocyclyl groups (the C₂₋₉ heterocyclyl groups may be optionally substituted with one or more substituents selected from the group consisting of: C₁₋₁₀ alkyl groups, C₁₋₁₀ alkoxy groups (the C₁₋₁₀ alkyl groups and the C₁₋₁₀ alkoxy groups may be substituted with one or more halogen atoms), C₂₋₆ alkenyl groups, C₂₋₆ alkynyl groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C₁₋₁₀ alkylcarbonyl groups, C₁₋₁₀ alkylcarbonyloxy groups, C₁₋₁₀ alkoxycarbonyl groups, C₁₋₁₀ alkylcarbonylamino groups, amino groups, mono- or di-C₁₋₁₀ alkylamino groups, hydroxyl groups, protected hydroxyl groups, C₂₋₁₄ aryl groups and C₂₋₁₄ aryloxy groups))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

63) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 1 denote the flowing substituents.

TABLE 1 No A B R¹ L¹ R² L² L³ Y L⁴ R³ X 1 N NMe Q1a a bond Me a bond NH S NH T3a OH 2 N NMe Q1a a bond Me a bond NH S NH T3b OH 3 N NMe Q1a a bond Me a bond NH S NH T3c OH 4 N NMe Q1a a bond Me a bond NH S NH T3d OH 5 N NMe Q1a a bond Me a bond NH S NH T3e OH 6 N NMe Q1a a bond Me a bond NH S NH T3f OH 7 N NMe Q1a a bond Me a bond NH S NH T3g OH 8 N NMe Q1a a bond Me a bond NH S NH T3h OH 9 N NMe Q1a a bond Me a bond NH S NH T3i OH 10 N NMe Q1a a bond Me a bond NH S NH T3j OH 11 N NMe Q1a a bond Me a bond NH S a bond T3a OH 12 N NMe Q1a a bond Me a bond NH S a bond T3b OH 13 N NMe Q1a a bond Me a bond NH S a bond T3c OH 14 N NMe Q1a a bond Me a bond NH S a bond T3d OH 15 N NMe Q1a a bond Me a bond NH S a bond T3e OH 16 N NMe Q1a a bond Me a bond NH S a bond T3f OH 17 N NMe Q1a a bond Me a bond NH S a bond T3g OH 18 N NMe Q1a a bond Me a bond NH S a bond T3h OH 19 N NMe Q1a a bond Me a bond NH S a bond T3i OH 20 N NMe Q1a a bond Me a bond NH S a bond T3j OH 21 N NMe Q1a a bond Me a bond NH O NH T3a OH 22 N NMe Q1a a bond Me a bond NH O NH T3b OH 23 N NMe Q1a a bond Me a bond NH O NH T3c OH 24 N NMe Q1a a bond Me a bond NH O NH T3d OH 25 N NMe Q1a a bond Me a bond NH O NH T3e OH 26 N NMe Q1a a bond Me a bond NH O NH T3f OH 27 N NMe Q1a a bond Me a bond NH O NH T3g OH 28 N NMe Q1a a bond Me a bond NH O NH T3h OH 29 N NMe Q1a a bond Me a bond NH O NH T3i OH 30 N NMe Q1a a bond Me a bond NH O NH T3j OH 31 N NMe Q1a a bond Me a bond NH O a bond T3a OH 32 N NMe Q1a a bond Me a bond NH O a bond T3b OH 33 N NMe Q1a a bond Me a bond NH O a bond T3c OH 34 N NMe Q1a a bond Me a bond NH O a bond T3d OH 35 N NMe Q1a a bond Me a bond NH O a bond T3e OH 36 N NMe Q1a a bond Me a bond NH O a bond T3f OH 37 N NMe Q1a a bond Me a bond NH O a bond T3g OH 38 N NMe Q1a a bond Me a bond NH O a bond T3h OH 39 N NMe Q1a a bond Me a bond NH O a bond T3i OH 40 N NMe Q1a a bond Me a bond NH O a bond T3j OH 41 N NMe Q1a a bond H a bond NH S NH T3a OH 42 N NMe Q1a a bond H a bond NH S NH T3b OH 43 N NMe Q1a a bond H a bond NH S NH T3c OH 44 N NMe Q1a a bond H a bond NH S NH T3d OH 45 N NMe Q1a a bond H a bond NH 3 NH T3e OH 46 N NMe Q1a a bond H a bond NH S NH T3f OH 47 N NMe Q1a a bond H a bond NH S NH T3g OH 48 N NMe Q1a a bond H a bond NH S NH T3h OH 49 N NMe Q1a a bond H a bond NH S NH T3i OH 50 N NMe Q1a a bond H a bond NH S NH T3j OH 51 N NMe Q1a a bond H a bond NH S a bond T3a OH 52 N NMe Q1a a bond H a bond NH S a bond T3b OH 53 N NMe Q1a a bond H a bond NH S a bond T3c OH 54 N NMe Q1a a bond H a bond NH S a bond T3d OH 55 N NMe Q1a a bond H a bond NH S a bond T3e OH 56 N NMe Q1a a bond H a bond NH S a bond T3f OH 57 N NMe Q1a a bond H a bond NH S a bond T3g OH 58 N NMe Q1a a bond H a bond NH S a bond T3h OH 59 N NMe Q1a a bond H a bond NH S a bond T3i OH 60 N NMe Q1a a bond H a bond NH S a bond T3j OH 61 N NMe Q1a a bond H a bond NH O NH T3a OH 62 N NMe Q1a a bond H a bond NH O NH T3b OH 63 N NMe Q1a a bond H a bond NH O NH T3c OH 64 N NMe Q1a a bond H a bond NH O NH T3d OH 65 N NMe Q1a a bond H a bond NH O NH T3e OH 66 N NMe Q1a a bond H a bond NH O NH T3f OH 67 N NMe Q1a a bond H a bond NH O NH T3g OH 68 N NMe Q1a a bond H a bond NH O NH T3h OH 69 N NMe Q1a a bond H a bond NH O NH T3i OH 70 N NMe Q1a a bond H a bond NH O NH T3j OH 71 N NMe Q1a a bond H a bond NH O a bond T3a OH 72 N NMe Q1a a bond H a bond NH O a bond T3b OH 73 N NMe Q1a a bond H a bond NH O a bond T3c OH 74 N NMe Q1a a bond H a bond NH O a bond T3d OH 75 N NMe Q1a a bond H a bond NH O a bond T3e OH 76 N NMe Q1a a bond H a bond NH O a bond T3f OH 77 N NMe Q1a a bond H a bond NH O a bond T3g OH 78 N NMe Q1a a bond H a bond NH O a bond T3h OH 79 N NMe Q1a a bond H a bond NH O a bond T3i OH 80 N NMe Q1a a bond H a bond NH O a bond T3j OH 81 N NMe Q1b a bond Me a bond NH S NH T3a OH 82 N NMe Q1b a bond Me a bond NH S NH T3b OH 83 N NMe Q1b a bond Me a bond NH S NH T3c OH 84 N NMe Q1b a bond Me a bond NH S NH T3d OH 85 N NMe Q1b a bond Me a bond NH S NH T3e OH 86 N NMe Q1b a bond Me a bond NH S NH T3f OH 87 N NMe Q1b a bond Me a bond NH S NH T3g OH 88 N NMe Q1b a bond Me a bond NH S NH T3h OH 89 N NMe Q1b a bond Me a bond NH S NH T3i OH 90 N NMe Q1b a bond Me a bond NH S NH T3j OH 91 N NMe Q1b a bond Me a bond NH S a bond T3a OH 92 N NMe Q1b a bond Me a bond NH S a bond T3b OH 93 N NMe Q1b a bond Me a bond NH S a bond T3c OH 94 N NMe Q1b a bond Me a bond NH S a bond T3d OH 95 N NMe Q1b a bond Me a bond NH S a bond T3e OH 96 N NMe Q1b a bond Me a bond NH S a bond T3f OH 97 N NMe Q1b a bond Me a bond NH S a bond T3g OH 98 N NMe Q1b a bond Me a bond NH S a bond T3h OH 99 N NMe Q1b a bond Me a bond NH S a bond T3i OH 100 N NMe Q1b a bond Me a bond NH S a bond T3j OH 101 N NMe Q1b a bond Me a bond NH O NH T3a OH 102 N NMe Q1b a bond Me a bond NH O NH T3b OH 103 N NMe Q1b a bond Me a bond NH O NH T3c OH 104 N NMe Q1b a bond Me a bond NH O NH T3d OH 105 N NMe Q1b a bond Me a bond NH O NH T3e OH 106 N NMe Q1b a bond Me a bond NH O NH T3f OH 107 N NMe Q1b a bond Me a bond NH O NH T3g OH 108 N NMe Q1b a bond Me a bond NH O NH T3h OH 109 N NMe Q1b a bond Me a bond NH O NH T3i OH 110 N NMe Q1b a bond Me a bond NH O NH T3j OH 111 N NMe Q1b a bond Me a bond NH O a bond T3a OH 112 N NMe Q1b a bond Me a bond NH O a bond T3b OH 113 N NMe Q1b a bond Me a bond NH O a bond T3c OH 114 N NMe Q1b a bond Me a bond NH O a bond T3d OH 115 N NMe Q1b a bond Me a bond NH O a bond T3e OH 116 N NMe Q1b a bond Me a bond NH O a bond T3f OH 117 N NMe Q1b a bond Me a bond NH O a bond T3g OH 118 N NMe Q1b a bond Me a bond NH O a bond T3h OH 119 N NMe Q1b a bond Me a bond NH O a bond T3i OH 120 N NMe Q1b a bond Me a bond NH O a bond T3j OH 121 N NMe Q1b a bond H a bond NH S NH T3a OH 122 N NMe Q1b a bond H a bond NH S NH T3b OH 123 N NMe Q1b a bond H a bond NH S NH T3c OH 124 N NMe Q1b a bond H a bond NH S NH T3d OH 125 N NMe Q1b a bond H a bond NH S NH T3e OH 126 N NMe Q1b a bond H a bond NH S NH T3f OH 127 N NMe Q1b a bond H a bond NH S NH T3g OH 128 N NMe Q1b a bond H a bond NH S NH T3h OH 129 N NMe Q1b a bond H a bond NH S NH T3i OH 130 N NMe Q1b a bond H a bond NH S NH T3j OH 131 N NMe Q1b a bond H a bond NH S a bond T3a OH 132 N NMe Q1b a bond H a bond NH S a bond T3b OH 133 N NMe Q1b a bond H a bond NH S a bond T3c OH 134 N NMe Q1b a bond H a bond NH S a bond T3d OH 135 N NMe Q1b a bond H a bond NH S a bond T3e OH 136 N NMe Q1b a bond H a bond NH S a bond T3f OH 137 N NMe Q1b a bond H a bond NH S a bond T3g OH 138 N NMe Q1b a bond H a bond NH S a bond T3h OH 139 N NMe Q1b a bond H a bond NH S a bond T3i OH 140 N NMe Q1b a bond H a bond NH S a bond T3j OH 141 N NMe Q1b a bond H a bond NH O NH T3a OH 142 N NMe Q1b a bond H a bond NH O NH T3b OH 143 N NMe Q1b a bond H a bond NH O NH T3c OH 144 N NMe Q1b a bond H a bond NH O NH T3d OH 145 N NMe Q1b a bond H a bond NH O NH T3e OH 146 N NMe Q1b a bond H a bond NH O NH T3f OH 147 N NMe Q1b a bond H a bond NH O NH T3g OH 148 N NMe Q1b a bond H a bond NH O NH T3h OH 149 N NMe Q1b a bond H a bond NH O NH T3i OH 150 N NMe Q1b a bond H a bond NH O NH T3j OH 151 N NMe Q1b a bond H a bond NH O a bond T3a OH 152 N NMe Q1b a bond H a bond NH O a bond T3b OH 153 N NMe Q1b a bond H a bond NH O a bond T3c OH 154 N NMe Q1b a bond H a bond NH O a bond T3d OH 155 N NMe Q1b a bond H a bond NH O a bond T3e OH 156 N NMe Q1b a bond H a bond NH O a bond T3f OH 157 N NMe Q1b a bond H a bond NH O a bond T3g OH 158 N NMe Q1b a bond H a bond NH O a bond T3h OH 159 N NMe Q1b a bond H a bond NH O a bond T3i OH 160 N NMe Q1b a bond H a bond NH O a bond T3j OH 161 N NMe Q1c a bond Me a bond NH S NH T3a OH 162 N NMe Q1c a bond Me a bond NH S NH T3b OH 163 N NMe Q1c a bond Me a bond NH S NH T3c OH 164 N NMe Q1c a bond Me a bond NH S NH T3d OH 165 N NMe Q1c a bond Me a bond NH S NH T3e OH 166 N NMe Q1c a bond Me a bond NH S NH T3f OH 167 N NMe Q1c a bond Me a bond NH S NH T3g OH 168 N NMe Q1c a bond Me a bond NH S NH T3h OH 169 N NMe Q1c a bond Me a bond NH S NH T3i OH 170 N NMe Q1c a bond Me a bond NH S NH T3j OH 171 N NMe Q1c a bond Me a bond NH S a bond T3a OH 172 N NMe Q1c a bond Me a bond NH S a bond T3b OH 173 N NMe Q1c a bond Me a bond NH S a bond T3c OH 174 N NMe Q1c a bond Me a bond NH S a bond T3d OH 175 N NMe Q1c a bond Me a bond NH S a bond T3e OH 176 N NMe Q1c a bond Me a bond NH S a bond T3f OH 177 N NMe Q1c a bond Me a bond NH S a bond T3g OH 178 N NMe Q1c a bond Me a bond NH S a bond T3h OH 179 N NMe Q1c a bond Me a bond NH S a bond T3i OH 180 N NMe Q1c a bond Me a bond NH S a bond T3j OH 181 N NMe Q1c a bond Me a bond NH O NH T3a OH 182 N NMe Q1c a bond Me a bond NH O NH T3b OH 183 N NMe Q1c a bond Me a bond NH O NH T3c OH 184 N NMe Q1c a bond Me a bond NH O NH T3d OH 185 N NMe Q1c a bond Me a bond NH O NH T3e OH 186 N NMe Q1c a bond Me a bond NH O NH T3f OH 187 N NMe Q1c a bond Me a bond NH O NH T3g OH 188 N NMe Q1c a bond Me a bond NH O NH T3h OH 189 N NMe Q1c a bond Me a bond NH O NH T3i OH 190 N NMe Q1c a bond Me a bond NH O NH T3j OH 191 N NMe Q1c a bond Me a bond NH O a bond T3a OH 192 N NMe Q1c a bond Me a bond NH O a bond T3b OH 193 N NMe Q1c a bond Me a bond NH O a bond T3c OH 194 N NMe Q1c a bond Me a bond NH O a bond T3d OH 195 N NMe Q1c a bond Me a bond NH O a bond T3e OH 196 N NMe Q1c a bond Me a bond NH O a bond T3f OH 197 N NMe Q1c a bond Me a bond NH O a bond T3g OH 198 N NMe Q1c a bond Me a bond NH O a bond T3h OH 199 N NMe Q1c a bond Me a bond NH O a bond T3i OH 200 N NMe Q1c a bond Me a bond NH O a bond T3j OH 201 N NMe Q1c a bond H a bond NH S NH T3a OH 202 N NMe Q1c a bond H a bond NH S NH T3b OH 203 N NMe Q1c a bond H a bond NH S NH T3c OH 204 N NMe Q1c a bond H a bond NH S NH T3d OH 205 N NMe Q1c a bond H a bond NH S NH T3e OH 206 N NMe Q1c a bond H a bond NH S NH T3f OH 207 N NMe Q1c a bond H a bond NH S NH T3g OH 208 N NMe Q1c a bond H a bond NH S NH T3h OH 209 N NMe Q1c a bond H a bond NH S NH T3i OH 210 N NMe Q1c a bond H a bond NH S NH T3j OH 211 N NMe Q1c a bond H a bond NH S a bond T3a OH 212 N NMe Q1c a bond H a bond NH S a bond T3b OH 213 N NMe Q1c a bond H a bond NH S a bond T3c OH 214 N NMe Q1c a bond H a bond NH S a bond T3d OH 215 N NMe Q1c a bond H a bond NH S a bond T3e OH 216 N NMe Q1c a bond H a bond NH S a bond T3f OH 217 N NMe Q1c a bond H a bond NH S a bond T3g OH 218 N NMe Q1c a bond H a bond NH S a bond T3h OH 219 N NMe Q1c a bond H a bond NH S a bond T3i OH 220 N NMe Q1c a bond H a bond NH S a bond T3j OH 221 N NMe Q1c a bond H a bond NH O NH T3a OH 222 N NMe Q1c a bond H a bond NH O NH T3b OH 223 N NMe Q1c a bond H a bond NH O NH T3c OH 224 N NMe Q1c a bond H a bond NH O NH T3d OH 225 N NMe Q1c a bond H a bond NH O NH T3e OH 226 N NMe Q1c a bond H a bond NH O NH T3f OH 227 N NMe Q1c a bond H a bond NH O NH T3g OH 228 N NMe Q1c a bond H a bond NH O NH T3h OH 229 N NMe Q1c a bond H a bond NH O NH T3i OH 230 N NMe Q1c a bond H a bond NH O NH T3j OH 231 N NMe Q1c a bond H a bond NH O a bond T3a OH 232 N NMe Q1c a bond H a bond NH O a bond T3b OH 233 N NMe Q1c a bond H a bond NH O a bond T3c OH 234 N NMe Q1c a bond H a bond NH O a bond T3d OH 235 N NMe Q1c a bond H a bond NH O a bond T3e OH 236 N NMe Q1c a bond H a bond NH O a bond T3f OH 237 N NMe Q1c a bond H a bond NH O a bond T3g OH 238 N NMe Q1c a bond H a bond NH O a bond T3h OH 239 N NMe Q1c a bond H a bond NH O a bond T3i OH 240 N NMe Q1c a bond H a bond NH O a bond T3j OH 241 N NMe Q1i a bond Me a bond NH S NH T3a OH 242 N NMe Q1i a bond Me a bond NH S NH T3b OH 243 N NMe Q1i a bond Me a bond NH S NH T3c OH 244 N NMe Q1i a bond Me a bond NH S NH T3d OH 245 N NMe Q1i a bond Me a bond NH S NH T3e OH 246 N NMe Q1i a bond Me a bond NH S NH T3f OH 247 N NMe Q1i a bond Me a bond NH S NH T3g OH 248 N NMe Q1i a bond Me a bond NH S NH T3h OH 249 N NMe Q1i a bond Me a bond NH S NH T3i OH 250 N NMe Q1i a bond Me a bond NH S NH T3j OH 251 N NMe Q1i a bond Me a bond NH S a bond T3a OH 252 N NMe Q1i a bond Me a bond NH S a bond T3b OH 253 N NMe Q1i a bond Me a bond NH S a bond T3c OH 254 N NMe Q1i a bond Me a bond NH S a bond T3d OH 255 N NMe Q1i a bond Me a bond NH S a bond T3e OH 256 N NMe Q1i a bond Me a bond NH S a bond T3f OH 257 N NMe Q1i a bond Me a bond NH S a bond T3g OH 258 N NMe Q1i a bond Me a bond NH S a bond T3h OH 259 N NMe Q1i a bond Me a bond NH S a bond T3i OH 260 N NMe Q1i a bond Me a bond NH S a bond T3j OH 261 N NMe Q1i a bond Me a bond NH O NH T3a OH 262 N NMe Q1i a bond Me a bond NH O NH T3b OH 263 N NMe Q1i a bond Me a bond NH O NH T3c OH 264 N NMe Q1i a bond Me a bond NH O NH T3d OH 265 N NMe Q1i a bond Me a bond NH O NH T3e OH 266 N NMe Q1i a bond Me a bond NH O NH T3f OH 267 N NMe Q1i a bond Me a bond NH O NH T3g OH 268 N NMe Q1i a bond Me a bond NH O NH T3h OH 269 N NMe Q1i a bond Me a bond NH O NH T3i OH 270 N NMe Q1i a bond Me a bond NH O NH T3j OH 271 N NMe Q1i a bond Me a bond NH O a bond T3a OH 272 N NMe Q1i a bond Me a bond NH O a bond T3b OH 273 N NMe Q1i a bond Me a bond NH O a bond T3c OH 274 N NMe Q1i a bond Me a bond NH O a bond T3d OH 275 N NMe Q1i a bond Me a bond NH O a bond T3e OH 276 N NMe Q1i a bond Me a bond NH O a bond T3f OH 277 N NMe Q1i a bond Me a bond NH O a bond T3g OH 278 N NMe Q1i a bond Me a bond NH O a bond T3h OH 279 N NMe Q1i a bond Me a bond NH O a bond T3i OH 280 N NMe Q1i a bond Me a bond NH O a bond T3j OH 281 N NMe Q1i a bond H a bond NH S NH T3a OH 282 N NMe Q1i a bond H a bond NH S NH T3b OH 283 N NMe Q1i a bond H a bond NH S NH T3c OH 284 N NMe Q1i a bond H a bond NH S NH T3d OH 285 N NMe Q1i a bond H a bond NH S NH T3e OH 286 N NMe Q1i a bond H a bond NH S NH T3f OH 287 N NMe Q1i a bond H a bond NH S NH T3g OH 288 N NMe Q1i a bond H a bond NH S NH T3h OH 289 N NMe Q1i a bond H a bond NH S NH T3i OH 290 N NMe Q1i a bond H a bond NH S NH T3j OH 291 N NMe Q1i a bond H a bond NH S a bond T3a OH 292 N NMe Q1i a bond H a bond NH S a bond T3b OH 293 N NMe Q1i a bond H a bond NH S a bond T3c OH 294 N NMe Q1i a bond H a bond NH S a bond T3d OH 295 N NMe Q1i a bond H a bond NH S a bond T3e OH 296 N NMe Q1i a bond H a bond NH S a bond T3f OH 297 N NMe Q1i a bond H a bond NH S a bond T3g OH 298 N NMe Q1i a bond H a bond NH S a bond T3h OH 299 N NMe Q1i a bond H a bond NH S a bond T3i OH 300 N NMe Q1i a bond H a bond NH S a bond T3j OH 301 N NMe Q1i a bond H a bond NH O NH T3a OH 302 N NMe Q1i a bond H a bond NH O NH T3b OH 303 N NMe Q1i a bond H a bond NH O NH T3c OH 304 N NMe Q1i a bond H a bond NH O NH T3d OH 305 N NMe Q1i a bond H a bond NH O NH T3e OH 306 N NMe Q1i a bond H a bond NH O NH T3f OH 307 N NMe Q1i a bond H a bond NH O NH T3g OH 308 N NMe Q1i a bond H a bond NH O NH T3h OH 309 N NMe Q1i a bond H a bond NH O NH T3i OH 310 N NMe Q1i a bond H a bond NH O NH T3j OH 311 N NMe Q1i a bond H a bond NH O a bond T3a OH 312 N NMe Q1i a bond H a bond NH O a bond T3b OH 313 N NMe Q1i a bond H a bond NH O a bond T3c OH 314 N NMe Q1i a bond H a bond NH O a bond T3d OH 315 N NMe Q1i a bond H a bond NH O a bond T3e OH 316 N NMe Q1i a bond H a bond NH O a bond T3f OH 317 N NMe Q1i a bond H a bond NH O a bond T3g OH 318 N NMe Q1i a bond H a bond NH O a bond T3h OH 319 N NMe Q1i a bond H a bond NH O a bond T3i OH 320 N NMe Q1i a bond H a bond NH O a bond T3j OH 321 N NMe Q1j a bond Me a bond NH S NH T3a OH 322 N NMe Q1j a bond Me a bond NH S NH T3b OH 323 N NMe Q1j a bond Me a bond NH S NH T3c OH 324 N NMe Q1j a bond Me a bond NH S NH T3d OH 325 N NMe Q1j a bond Me a bond NH S NH T3e OH 326 N NMe Q1j a bond Me a bond NH S NH T3f OH 327 N NMe Q1j a bond Me a bond NH S NH T3g OH 328 N NMe Q1j a bond Me a bond NH S NH T3h OH 329 N NMe Q1j a bond Me a bond NH S NH T3i OH 330 N NMe Q1j a bond Me a bond NH S NH T3j OH 331 N NMe Q1j a bond Me a bond NH S a bond T3a OH 332 N NMe Q1j a bond Me a bond NH S a bond T3b OH 333 N NMe Q1j a bond Me a bond NH S a bond T3c OH 334 N NMe Q1j a bond Me a bond NH S a bond T3d OH 335 N NMe Q1j a bond Me a bond NH S a bond T3e OH 336 N NMe Q1j a bond Me a bond NH S a bond T3f OH 337 N NMe Q1j a bond Me a bond NH S a bond T3g OH 338 N NMe Q1j a bond Me a bond NH S a bond T3h OH 339 N NMe Q1j a bond Me a bond NH S a bond T3i OH 340 N NMe Q1j a bond Me a bond NH S a bond T3j OH 341 N NMe Q1j a bond Me a bond NH O NH T3a OH 342 N NMe Q1j a bond Me a bond NH O NH T3b OH 343 N NMe Q1j a bond Me a bond NH O NH T3c OH 344 N NMe Q1j a bond Me a bond NH O NH T3d OH 345 N NMe Q1j a bond Me a bond NH O NH T3e OH 346 N NMe Q1j a bond Me a bond NH O NH T3f OH 347 N NMe Q1j a bond Me a bond NH O NH T3g OH 348 N NMe Q1j a bond Me a bond NH O NH T3h OH 349 N NMe Q1j a bond Me a bond NH O NH T3i OH 350 N NMe Q1j a bond Me a bond NH O NH T3j OH 351 N NMe Q1j a bond Me a bond NH O a bond T3a OH 352 N NMe Q1j a bond Me a bond NH O a bond T3b OH 353 N NMe Q1j a bond Me a bond NH O a bond T3c OH 354 N NMe Q1j a bond Me a bond NH O a bond T3d OH 355 N NMe Q1j a bond Me a bond NH O a bond T3e OH 356 N NMe Q1j a bond Me a bond NH O a bond T3f OH 357 N NMe Q1j a bond Me a bond NH O a bond T3g OH 358 N NMe Q1j a bond Me a bond NH O a bond T3h OH 359 N NMe Q1j a bond Me a bond NH O a bond T3i OH 360 N NMe Q1j a bond Me a bond NH O a bond T3j OH 361 N NMe Q1j a bond H a bond NH S NH T3a OH 362 N NMe Q1j a bond H a bond NH S NH T3b OH 363 N NMe Q1j a bond H a bond NH S NH T3c OH 364 N NMe Q1j a bond H a bond NH S NH T3d OH 365 N NMe Q1j a bond H a bond NH S NH T3e OH 366 N NMe Q1j a bond H a bond NH S NH T3f OH 367 N NMe Q1j a bond H a bond NH S NH T3g OH 368 N NMe Q1j a bond H a bond NH S NH T3h OH 369 N NMe Q1j a bond H a bond NH S NH T3i OH 370 N NMe Q1j a bond H a bond NH S NH T3j OH 371 N NMe Q1j a bond H a bond NH S a bond T3a OH 372 N NMe Q1j a bond H a bond NH S a bond T3b OH 373 N NMe Q1j a bond H a bond NH S a bond T3c OH 374 N NMe Q1j a bond H a bond NH S a bond T3d OH 375 N NMe Q1j a bond H a bond NH S a bond T3e OH 376 N NMe Q1j a bond H a bond NH S a bond T3f OH 377 N NMe Q1j a bond H a bond NH S a bond T3g OH 378 N NMe Q1j a bond H a bond NH S a bond T3h OH 379 N NMe Q1j a bond H a bond NH S a bond T3i OH 380 N NMe Q1j a bond H a bond NH S a bond T3j OH 381 N NMe Q1j a bond H a bond NH O NH T3a OH 382 N NMe Q1j a bond H a bond NH O NH T3b OH 383 N NMe Q1j a bond H a bond NH O NH T3c OH 384 N NMe Q1j a bond H a bond NH O NH T3d OH 385 N NMe Q1j a bond H a bond NH O NH T3e OH 386 N NMe Q1j a bond H a bond NH O NH T3f OH 387 N NMe Q1j a bond H a bond NH O NH T3g OH 388 N NMe Q1j a bond H a bond NH O NH T3h OH 389 N NMe Q1j a bond H a bond NH O NH T3i OH 390 N NMe Q1j a bond H a bond NH O NH T3j OH 391 N NMe Q1j a bond H a bond NH O a bond T3a OH 392 N NMe Q1j a bond H a bond NH O a bond T3b OH 393 N NMe Q1j a bond H a bond NH O a bond T3c OH 394 N NMe Q1j a bond H a bond NH O a bond T3d OH 395 N NMe Q1j a bond H a bond NH O a bond T3e OH 396 N NMe Q1j a bond H a bond NH O a bond T3f OH 397 N NMe Q1j a bond H a bond NH O a bond T3g OH 398 N NMe Q1j a bond H a bond NH O a bond T3h OH 399 N NMe Q1j a bond H a bond NH O a bond T3i OH 400 N NMe Q1j a bond H a bond NH O a bond T3j OH 401 N S Q1a a bond Me a bond NH S NH T3a OH 402 N S Q1a a bond Me a bond NH S NH T3b OH 403 N S Q1a a bond Me a bond NH S NH T3c OH 404 N S Q1a a bond Me a bond NH S NH T3d OH 405 N S Q1a a bond Me a bond NH S NH T3e OH 406 N S Q1a a bond Me a bond NH S NH T3f OH 407 N S Q1a a bond Me a bond NH S NH T3g OH 408 N S Q1a a bond Me a bond NH S NH T3h OH 409 N S Q1a a bond Me a bond NH S NH T3i OH 410 N S Q1a a bond Me a bond NH S NH T3j OH 411 N S Q1a a bond Me a bond NH S a bond T3a OH 412 N S Q1a a bond Me a bond NH S a bond T3b OH 413 N S Q1a a bond Me a bond NH S a bond T3c OH 414 N S Q1a a bond Me a bond NH S a bond T3d OH 415 N S Q1a a bond Me a bond NH S a bond T3e OH 416 N S Q1a a bond Me a bond NH S a bond T3f OH 417 N S Q1a a bond Me a bond NH S a bond T3g OH 418 N S Q1a a bond Me a bond NH S a bond T3h OH 419 N S Q1a a bond Me a bond NH S a bond T3i OH 420 N S Q1a a bond Me a bond NH S a bond T3j OH 421 N S Q1a a bond Me a bond NH O NH T3a OH 422 N S Q1a a bond Me a bond NH O NH T3b OH 423 N S Q1a a bond Me a bond NH O NH T3c OH 424 N S Q1a a bond Me a bond NH O NH T3d OH 425 N S Q1a a bond Me a bond NH O NH T3e OH 426 N S Q1a a bond Me a bond NH O NH T3f OH 427 N S Q1a a bond Me a bond NH O NH T3g OH 428 N S Q1a a bond Me a bond NH O NH T3h OH 429 N S Q1a a bond Me a bond NH O NH T3i OH 430 N S Q1a a bond Me a bond NH O NH T3j OH 431 N S Q1a a bond Me a bond NH O a bond T3a OH 432 N S Q1a a bond Me a bond NH O a bond T3b OH 433 N S Q1a a bond Me a bond NH O a bond T3c OH 434 N S Q1a a bond Me a bond NH O a bond T3d OH 435 N S Q1a a bond Me a bond NH O a bond T3e OH 436 N S Q1a a bond Me a bond NH O a bond T3f OH 437 N S Q1a a bond Me a bond NH O a bond T3g OH 438 N S Q1a a bond Me a bond NH O a bond T3h OH 439 N S Q1a a bond Me a bond NH O a bond T3i OH 440 N S Q1a a bond Me a bond NH O a bond T3j OH 441 N S Q1a a bond H a bond NH S NH T3a OH 442 N S Q1a a bond H a bond NH S NH T3b OH 443 N S Q1a a bond H a bond NH S NH T3c OH 444 N S Q1a a bond H a bond NH S NH T3d OH 445 N S Q1a a bond H a bond NH S NH T3e OH 446 N S Q1a a bond H a bond NH S NH T3f OH 447 N S Q1a a bond H a bond NH S NH T3g OH 448 N S Q1a a bond H a bond NH S NH T3h OH 449 N S Q1a a bond H a bond NH S NH T3i OH 450 N S Q1a a bond H a bond NH S NH T3j OH 451 N S Q1a a bond H a bond NH S a bond T3a OH 452 N S Q1a a bond H a bond NH S a bond T3b OH 453 N S Q1a a bond H a bond NH S a bond T3c OH 454 N S Q1a a bond H a bond NH S a bond T3d OH 455 N S Q1a a bond H a bond NH S a bond T3e OH 456 N S Q1a a bond H a bond NH S a bond T3f OH 457 N S Q1a a bond H a bond NH S a bond T3g OH 458 N S Q1a a bond H a bond NH S a bond T3h OH 459 N S Q1a a bond H a bond NH S a bond T3i OH 460 N S Q1a a bond H a bond NH S a bond T3j OH 461 N S Q1a a bond H a bond NH O NH T3a OH 462 N S Q1a a bond H a bond NH O NH T3b OH 463 N S Q1a a bond H a bond NH O NH T3c OH 464 N S Q1a a bond H a bond NH O NH T3d OH 465 N S Q1a a bond H a bond NH O NH T3e OH 466 N S Q1a a bond H a bond NH O NH T3f OH 467 N S Q1a a bond H a bond NH O NH T3g OH 468 N S Q1a a bond H a bond NH O NH T3h OH 469 N S Q1a a bond H a bond NH O NH T3i OH 470 N S Q1a a bond H a bond NH O NH T3j OH 471 N S Q1a a bond H a bond NH O a bond T3a OH 472 N S Q1a a bond H a bond NH O a bond T3b OH 473 N S Q1a a bond H a bond NH O a bond T3c OH 474 N S Q1a a bond H a bond NH O a bond T3d OH 475 N S Q1a a bond H a bond NH O a bond T3e OH 476 N S Q1a a bond H a bond NH O a bond T3f OH 477 N S Q1a a bond H a bond NH O a bond T3g OH 478 N S Q1a a bond H a bond NH O a bond T3h OH 479 N S Q1a a bond H a bond NH O a bond T3i OH 480 N S Q1a a bond H a bond NH O a bond T3j OH 481 N S Q1b a bond Me a bond NH S NH T3a OH 482 N S Q1b a bond Me a bond NH S NH T3b OH 483 N S Q1b a bond Me a bond NH S NH T3c OH 484 N S Q1b a bond Me a bond NH S NH T3d OH 485 N S Q1b a bond Me a bond NH S NH T3e OH 486 N S Q1b a bond Me a bond NH S NH T3f OH 487 N S Q1b a bond Me a bond NH S NH T3g OH 488 N S Q1b a bond Me a bond NH S NH T3h OH 489 N S Q1b a bond Me a bond NH S NH T3i OH 490 N S Q1b a bond Me a bond NH S NH T3j OH 491 N S Q1b a bond Me a bond NH S a bond T3a OH 492 N S Q1b a bond Me a bond NH S a bond T3b OH 493 N S Q1b a bond Me a bond NH S a bond T3c OH 494 N S Q1b a bond Me a bond NH S a bond T3d OH 495 N S Q1b a bond Me a bond NH S a bond T3e OH 496 N S Q1b a bond Me a bond NH S a bond T3f OH 497 N S Q1b a bond Me a bond NH S a bond T3g OH 498 N S Q1b a bond Me a bond NH S a bond T3h OH 499 N S Q1b a bond Me a bond NH S a bond T3i OH 500 N S Q1b a bond Me a bond NH S a bond T3j OH 501 N S Q1b a bond Me a bond NH O NH T3a OH 502 N S Q1b a bond Me a bond NH O NH T3b OH 503 N S Q1b a bond Me a bond NH O NH T3c OH 504 N S Q1b a bond Me a bond NH O NH T3d OH 505 N S Q1b a bond Me a bond NH O NH T3e OH 506 N S Q1b a bond Me a bond NH O NH T3f OH 507 N S Q1b a bond Me a bond NH O NH T3g OH 508 N S Q1b a bond Me a bond NH O NH T3h OH 509 N S Q1b a bond Me a bond NH O NH T3i OH 510 N S Q1b a bond Me a bond NH O NH T3j OH 511 N S Q1b a bond Me a bond NH O a bond T3a OH 512 N S Q1b a bond Me a bond NH O a bond T3b OH 513 N S Q1b a bond Me a bond NH O a bond T3c OH 514 N S Q1b a bond Me a bond NH O a bond T3d OH 515 N S Q1b a bond Me a bond NH O a bond T3e OH 516 N S Q1b a bond Me a bond NH O a bond T3f OH 517 N S Q1b a bond Me a bond NH O a bond T3g OH 518 N S Q1b a bond Me a bond NH O a bond T3h OH 519 N S Q1b a bond Me a bond NH O a bond T3i OH 520 N S Q1b a bond Me a bond NH O a bond T3j OH 521 N S Q1b a bond H a bond NH S NH T3a OH 522 N S Q1b a bond H a bond NH S NH T3b OH 523 N S Q1b a bond H a bond NH S NH T3c OH 524 N S Q1b a bond H a bond NH S NH T3d OH 525 N S Q1b a bond H a bond NH S NH T3e OH 526 N S Q1b a bond H a bond NH S NH T3f OH 527 N S Q1b a bond H a bond NH S NH T3g OH 528 N S Q1b a bond H a bond NH S NH T3h OH 529 N S Q1b a bond H a bond NH S NH T3i OH 530 N S Q1b a bond H a bond NH S NH T3j OH 531 N S Q1b a bond H a bond NH S a bond T3a OH 532 N S Q1b a bond H a bond NH S a bond T3b OH 533 N S Q1b a bond H a bond NH S a bond T3c OH 534 N S Q1b a bond H a bond NH S a bond T3d OH 535 N S Q1b a bond H a bond NH S a bond T3e OH 536 N S Q1b a bond H a bond NH S a bond T3f OH 537 N S Q1b a bond H a bond NH S a bond T3g OH 538 N S Q1b a bond H a bond NH S a bond T3h OH 539 N S Q1b a bond H a bond NH S a bond T3i OH 540 N S Q1b a bond H a bond NH S a bond T3j OH 541 N S Q1b a bond H a bond NH O NH T3a OH 542 N S Q1b a bond H a bond NH O NH T3b OH 543 N S Q1b a bond H a bond NH O NH T3c OH 544 N S Q1b a bond H a bond NH O NH T3d OH 545 N S Q1b a bond H a bond NH O NH T3e OH 546 N S Q1b a bond H a bond NH O NH T3f OH 547 N S Q1b a bond H a bond NH O NH T3g OH 548 N S Q1b a bond H a bond NH O NH T3h OH 549 N S Q1b a bond H a bond NH O NH T3i OH 550 N S Q1b a bond H a bond NH O NH T3j OH 551 N S Q1b a bond H a bond NH O a bond T3a OH 552 N S Q1b a bond H a bond NH O a bond T3b OH 553 N S Q1b a bond H a bond NH O a bond T3c OH 554 N S Q1b a bond H a bond NH O a bond T3d OH 555 N S Q1b a bond H a bond NH O a bond T3e OH 556 N S Q1b a bond H a bond NH O a bond T3f OH 557 N S Q1b a bond H a bond NH O a bond T3g OH 558 N S Q1b a bond H a bond NH O a bond T3h OH 559 N S Q1b a bond H a bond NH O a bond T3i OH 560 N S Q1b a bond H a bond NH O a bond T3j OH 561 N S Q1c a bond Me a bond NH S NH T3a OH 562 N S Q1c a bond Me a bond NH S NH T3b OH 563 N S Q1c a bond Me a bond NH S NH T3c OH 564 N S Q1c a bond Me a bond NH S NH T3d OH 565 N S Q1c a bond Me a bond NH S NH T3e OH 566 N S Q1c a bond Me a bond NH S NH T3f OH 567 N S Q1c a bond Me a bond NH S NH T3g OH 568 N S Q1c a bond Me a bond NH S NH T3h OH 569 N S Q1c a bond Me a bond NH S NH T3i OH 570 N S Q1c a bond Me a bond NH S NH T3j OH 571 N S Q1c a bond Me a bond NH S a bond T3a OH 572 N S Q1c a bond Me a bond NH S a bond T3b OH 573 N S Q1c a bond Me a bond NH S a bond T3c OH 574 N S Q1c a bond Me a bond NH S a bond T3d OH 575 N S Q1c a bond Me a bond NH S a bond T3e OH 576 N S Q1c a bond Me a bond NH S a bond T3f OH 577 N S Q1c a bond Me a bond NH S a bond T3g OH 578 N S Q1c a bond Me a bond NH S a bond T3h OH 579 N S Q1c a bond Me a bond NH S a bond T3i OH 580 N S Q1c a bond Me a bond NH S a bond T3j OH 581 N S Q1c a bond Me a bond NH O NH T3a OH 582 N S Q1c a bond Me a bond NH O NH T3b OH 583 N S Q1c a bond Me a bond NH O NH T3c OH 584 N S Q1c a bond Me a bond NH O NH T3d OH 585 N S Q1c a bond Me a bond NH O NH T3e OH 586 N S Q1c a bond Me a bond NH O NH T3f OH 587 N S Q1c a bond Me a bond NH O NH T3g OH 588 N S Q1c a bond Me a bond NH O NH T3h OH 589 N S Q1c a bond Me a bond NH O NH T3i OH 590 N S Q1c a bond Me a bond NH O NH T3j OH 591 N S Q1c a bond Me a bond NH O a bond T3a OH 592 N S Q1c a bond Me a bond NH O a bond T3b OH 593 N S Q1c a bond Me a bond NH O a bond T3c OH 594 N S Q1c a bond Me a bond NH O a bond T3d OH 595 N S Q1c a bond Me a bond NH O a bond T3e OH 596 N S Q1c a bond Me a bond NH O a bond T3f OH 597 N S Q1c a bond Me a bond NH O a bond T3g OH 598 N S Q1c a bond Me a bond NH O a bond T3h OH 599 N S Q1c a bond Me a bond NH O a bond T3i OH 600 N S Q1c a bond Me a bond NH O a bond T3j OH 601 N S Q1c a bond H a bond NH S NH T3a OH 602 N S Q1c a bond H a bond NH S NH T3b OH 603 N S Q1c a bond H a bond NH S NH T3c OH 604 N S Q1c a bond H a bond NH S NH T3d OH 605 N S Q1c a bond H a bond NH S NH T3e OH 606 N S Q1c a bond H a bond NH S NH T3f OH 607 N S Q1c a bond H a bond NH S NH T3g OH 608 N S Q1c a bond H a bond NH S NH T3h OH 609 N S Q1c a bond H a bond NH S NH T3i OH 610 N S Q1c a bond H a bond NH S NH T3j OH 611 N S Q1c a bond H a bond NH S a bond T3a OH 612 N S Q1c a bond H a bond NH S a bond T3b OH 613 N S Q1c a bond H a bond NH S a bond T3c OH 614 N S Q1c a bond H a bond NH S a bond T3d OH 615 N S Q1c a bond H a bond NH S a bond T3e OH 616 N S Q1c a bond H a bond NH S a bond T3f OH 617 N S Q1c a bond H a bond NH S a bond T3g OH 618 N S Q1c a bond H a bond NH S a bond T3h OH 619 N S Q1c a bond H a bond NH S a bond T3i OH 620 N S Q1c a bond H a bond NH S a bond T3j OH 621 N S Q1c a bond H a bond NH O NH T3a OH 622 N S Q1c a bond H a bond NH O NH T3b OH 623 N S Q1c a bond H a bond NH O NH T3c OH 624 N S Q1c a bond H a bond NH O NH T3d OH 625 N S Q1c a bond H a bond NH O NH T3e OH 626 N S Q1c a bond H a bond NH O NH T3f OH 627 N S Q1c a bond H a bond NH O NH T3g OH 628 N S Q1c a bond H a bond NH O NH T3h OH 629 N S Q1c a bond H a bond NH O NH T3i OH 630 N S Q1c a bond H a bond NH O NH T3j OH 631 N S Q1c a bond H a bond NH O a bond T3a OH 632 N S Q1c a bond H a bond NH O a bond T3b OH 633 N S Q1c a bond H a bond NH O a bond T3c OH 634 N S Q1c a bond H a bond NH O a bond T3d OH 635 N S Q1c a bond H a bond NH O a bond T3e OH 636 N S Q1c a bond H a bond NH O a bond T3f OH 637 N S Q1c a bond H a bond NH O a bond T3g OH 638 N S Q1c a bond H a bond NH O a bond T3h OH 639 N S Q1c a bond H a bond NH O a bond T3i OH 640 N S Q1c a bond H a bond NH O a bond T3j OH 641 N S Q1i a bond Me a bond NH S NH T3a OH 642 N S Q1i a bond Me a bond NH S NH T3b OH 643 N S Q1i a bond Me a bond NH S NH T3c OH 644 N S Q1i a bond Me a bond NH S NH T3d OH 645 N S Q1i a bond Me a bond NH S NH T3e OH 646 N S Q1i a bond Me a bond NH S NH T3f OH 647 N S Q1i a bond Me a bond NH S NH T3g OH 648 N S Q1i a bond Me a bond NH S NH T3h OH 649 N S Q1i a bond Me a bond NH S NH T3i OH 650 N S Q1i a bond Me a bond NH S NH T3j OH 651 N S Q1i a bond Me a bond NH S a bond T3a OH 652 N S Q1i a bond Me a bond NH S a bond T3b OH 653 N S Q1i a bond Me a bond NH S a bond T3c OH 654 N S Q1i a bond Me a bond NH S a bond T3d OH 655 N S Q1i a bond Me a bond NH S a bond T3e OH 656 N S Q1i a bond Me a bond NH S a bond T3f OH 657 N S Q1i a bond Me a bond NH S a bond T3g OH 658 N S Q1i a bond Me a bond NH S a bond T3h OH 659 N S Q1i a bond Me a bond NH S a bond T3i OH 660 N S Q1i a bond Me a bond NH S a bond T3j OH 661 N S Q1i a bond Me a bond NH O NH T3a OH 662 N S Q1i a bond Me a bond NH O NH T3b OH 663 N S Q1i a bond Me a bond NH O NH T3c OH 664 N S Q1i a bond Me a bond NH O NH T3d OH 665 N S Q1i a bond Me a bond NH O NH T3e OH 666 N S Q1i a bond Me a bond NH O NH T3f OH 667 N S Q1i a bond Me a bond NH O NH T3g OH 668 N S Q1i a bond Me a bond NH O NH T3h OH 669 N S Q1i a bond Me a bond NH O NH T3i OH 670 N S Q1i a bond Me a bond NH O NH T3j OH 671 N S Q1i a bond Me a bond NH O a bond T3a OH 672 N S Q1i a bond Me a bond NH O a bond T3b OH 673 N S Q1i a bond Me a bond NH O a bond T3c OH 674 N S Q1i a bond Me a bond NH O a bond T3d OH 675 N S Q1i a bond Me a bond NH O a bond T3e OH 676 N S Q1i a bond Me a bond NH O a bond T3f OH 677 N S Q1i a bond Me a bond NH O a bond T3g OH 678 N S Q1i a bond Me a bond NH O a bond T3h OH 679 N S Q1i a bond Me a bond NH O a bond T3i OH 680 N S Q1i a bond Me a bond NH O a bond T3j OH 681 N S Q1i a bond H a bond NH S NH T3a OH 682 N S Q1i a bond H a bond NH S NH T3b OH 683 N S Q1i a bond H a bond NH S NH T3c OH 684 N S Q1i a bond H a bond NH S NH T3d OH 685 N S Q1i a bond H a bond NH S NH T3e OH 686 N S Q1i a bond H a bond NH S NH T3f OH 687 N S Q1i a bond H a bond NH S NH T3g OH 688 N S Q1i a bond H a bond NH S NH T3h OH 689 N S Q1i a bond H a bond NH S NH T3i OH 690 N S Q1i a bond H a bond NH S NH T3j OH 691 N S Q1i a bond H a bond NH S a bond T3a OH 692 N S Q1i a bond H a bond NH S a bond T3b OH 693 N S Q1i a bond H a bond NH S a bond T3c OH 694 N S Q1i a bond H a bond NH S a bond T3d OH 695 N S Q1i a bond H a bond NH S a bond T3e OH 696 N S Q1i a bond H a bond NH S a bond T3f OH 697 N S Q1i a bond H a bond NH S a bond T3g OH 698 N S Q1i a bond H a bond NH S a bond T3h OH 699 N S Q1i a bond H a bond NH S a bond T3i OH 700 N S Q1i a bond H a bond NH S a bond T3j OH 701 N S Q1i a bond H a bond NH O NH T3a OH 702 N S Q1i a bond H a bond NH O NH T3b OH 703 N S Q1i a bond H a bond NH O NH T3c OH 704 N S Q1i a bond H a bond NH O NH T3d OH 705 N S Q1i a bond H a bond NH O NH T3e OH 706 N S Q1i a bond H a bond NH O NH T3f OH 707 N S Q1i a bond H a bond NH O NH T3g OH 708 N S Q1i a bond H a bond NH O NH T3h OH 709 N S Q1i a bond H a bond NH O NH T3i OH 710 N S Q1i a bond H a bond NH O NH T3j OH 711 N S Q1i a bond H a bond NH O a bond T3a OH 712 N S Q1i a bond H a bond NH O a bond T3b OH 713 N S Q1i a bond H a bond NH O a bond T3c OH 714 N S Q1i a bond H a bond NH O a bond T3d OH 715 N S Q1i a bond H a bond NH O a bond T3e OH 716 N S Q1i a bond H a bond NH O a bond T3f OH 717 N S Q1i a bond H a bond NH O a bond T3g OH 718 N S Q1i a bond H a bond NH O a bond T3h OH 719 N S Q1i a bond H a bond NH O a bond T3i OH 720 N S Q1i a bond H a bond NH O a bond T3j OH 721 N S Q1j a bond Me a bond NH S NH T3a OH 722 N S Q1j a bond Me a bond NH S NH T3b OH 723 N S Q1j a bond Me a bond NH S NH T3c OH 724 N S Q1j a bond Me a bond NH S NH T3d OH 725 N S Q1j a bond Me a bond NH S NH T3e OH 726 N S Q1j a bond Me a bond NH S NH T3f OH 727 N S Q1j a bond Me a bond NH S NH T3g OH 728 N S Q1j a bond Me a bond NH S NH T3h OH 729 N S Q1j a bond Me a bond NH S NH T3i OH 730 N S Q1j a bond Me a bond NH S NH T3j OH 731 N S Q1j a bond Me a bond NH S a bond T3a OH 732 N S Q1j a bond Me a bond NH S a bond T3b OH 733 N S Q1j a bond Me a bond NH S a bond T3c OH 734 N S Q1j a bond Me a bond NH S a bond T3d OH 735 N S Q1j a bond Me a bond NH S a bond T3e OH 736 N S Q1j a bond Me a bond NH S a bond T3f OH 737 N S Q1j a bond Me a bond NH S a bond T3g OH 738 N S Q1j a bond Me a bond NH S a bond T3h OH 739 N S Q1j a bond Me a bond NH S a bond T3i OH 740 N S Q1j a bond Me a bond NH S a bond T3j OH 741 N S Q1j a bond Me a bond NH O NH T3a OH 742 N S Q1j a bond Me a bond NH O NH T3b OH 743 N S Q1j a bond Me a bond NH O NH T3c OH 744 N S Q1j a bond Me a bond NH O NH T3d OH 745 N S Q1j a bond Me a bond NH O NH T3e OH 746 N S Q1j a bond Me a bond NH O NH T3f OH 747 N S Q1j a bond Me a bond NH O NH T3g OH 748 N S Q1j a bond Me a bond NH O NH T3h OH 749 N S Q1j a bond Me a bond NH O NH T3i OH 750 N S Q1j a bond Me a bond NH O NH T3j OH 751 N S Q1j a bond Me a bond NH O a bond T3a OH 752 N S Q1j a bond Me a bond NH O a bond T3b OH 753 N S Q1j a bond Me a bond NH O a bond T3c OH 754 N S Q1j a bond Me a bond NH O a bond T3d OH 755 N S Q1j a bond Me a bond NH O a bond T3e OH 756 N S Q1j a bond Me a bond NH O a bond T3f OH 757 N S Q1j a bond Me a bond NH O a bond T3g OH 758 N S Q1j a bond Me a bond NH O a bond T3h OH 759 N S Q1j a bond Me a bond NH O a bond T3i OH 760 N S Q1j a bond Me a bond NH O a bond T3j OH 761 N S Q1j a bond H a bond NH S NH T3a OH 762 N S Q1j a bond H a bond NH S NH T3b OH 763 N S Q1j a bond H a bond NH S NH T3c OH 764 N S Q1j a bond H a bond NH S NH T3d OH 765 N S Q1j a bond H a bond NH S NH T3e OH 766 N S Q1j a bond H a bond NH S NH T3f OH 767 N S Q1j a bond H a bond NH S NH T3g OH 768 N S Q1j a bond H a bond NH S NH T3h OH 769 N S Q1j a bond H a bond NH S NH T3i OH 770 N S Q1j a bond H a bond NH S NH T3j OH 771 N S Q1j a bond H a bond NH S a bond T3a OH 772 N S Q1j a bond H a bond NH S a bond T3b OH 773 N S Q1j a bond H a bond NH S a bond T3c OH 774 N S Q1j a bond H a bond NH S a bond T3d OH 775 N S Q1j a bond H a bond NH S a bond T3e OH 776 N S Q1j a bond H a bond NH S a bond T3f OH 777 N S Q1j a bond H a bond NH S a bond T3g OH 778 N S Q1j a bond H a bond NH S a bond T3h OH 779 N S Q1j a bond H a bond NH S a bond T3i OH 780 N S Q1j a bond H a bond NH S a bond T3j OH 781 N S Q1j a bond H a bond NH O NH T3a OH 782 N S Q1j a bond H a bond NH O NH T3b OH 783 N S Q1j a bond H a bond NH O NH T3c OH 784 N S Q1j a bond H a bond NH O NH T3d OH 785 N S Q1j a bond H a bond NH O NH T3e OH 786 N S Q1j a bond H a bond NH O NH T3f OH 787 N S Q1j a bond H a bond NH O NH T3g OH 788 N S Q1j a bond H a bond NH O NH T3h OH 789 N S Q1j a bond H a bond NH O NH T3i OH 790 N S Q1j a bond H a bond NH O NH T3j OH 791 N S Q1j a bond H a bond NH O a bond T3a OH 792 N S Q1j a bond H a bond NH O a bond T3b OH 793 N S Q1j a bond H a bond NH O a bond T3c OH 794 N S Q1j a bond H a bond NH O a bond T3d OH 795 N S Q1j a bond H a bond NH O a bond T3e OH 796 N S Q1j a bond H a bond NH O a bond T3f OH 797 N S Q1j a bond H a bond NH O a bond T3g OH 798 N S Q1j a bond H a bond NH O a bond T3h OH 799 N S Q1j a bond H a bond NH O a bond T3i OH 800 N S Q1j a bond H a bond NH O a bond T3j OH 801 N O Q1a a bond Me a bond NH S NH T3a OH 802 N O Q1a a bond Me a bond NH S NH T3b OH 803 N O Q1a a bond Me a bond NH S NH T3c OH 804 N O Q1a a bond Me a bond NH S NH T3d OH 805 N O Q1a a bond Me a bond NH S NH T3e OH 806 N O Q1a a bond Me a bond NH S NH T3f OH 807 N O Q1a a bond Me a bond NH S NH T3g OH 808 N O Q1a a bond Me a bond NH S NH T3h OH 809 N O Q1a a bond Me a bond NH S NH T3i OH 810 N O Q1a a bond Me a bond NH S NH T3j OH 811 N O Q1a a bond Me a bond NH S a bond T3a OH 812 N O Q1a a bond Me a bond NH S a bond T3b OH 813 N O Q1a a bond Me a bond NH S a bond T3c OH 814 N O Q1a a bond Me a bond NH S a bond T3d OH 815 N O Q1a a bond Me a bond NH S a bond T3e OH 816 N O Q1a a bond Me a bond NH S a bond T3f OH 817 N O Q1a a bond Me a bond NH S a bond T3g OH 818 N O Q1a a bond Me a bond NH S a bond T3h OH 819 N O Q1a a bond Me a bond NH S a bond T3i OH 820 N O Q1a a bond Me a bond NH S a bond T3j OH 821 N O Q1a a bond Me a bond NH O NH T3a OH 822 N O Q1a a bond Me a bond NH O NH T3b OH 823 N O Q1a a bond Me a bond NH O NH T3c OH 824 N O Q1a a bond Me a bond NH O NH T3d OH 825 N O Q1a a bond Me a bond NH O NH T3e OH 826 N O Q1a a bond Me a bond NH O NH T3f OH 827 N O Q1a a bond Me a bond NH O NH T3g OH 828 N O Q1a a bond Me a bond NH O NH T3h OH 829 N O Q1a a bond Me a bond NH O NH T3i OH 830 N O Q1a a bond Me a bond NH O NH T3j OH 831 N O Q1a a bond Me a bond NH O a bond T3a OH 832 N O Q1a a bond Me a bond NH O a bond T3b OH 833 N O Q1a a bond Me a bond NH O a bond T3c OH 834 N O Q1a a bond Me a bond NH O a bond T3d OH 835 N O Q1a a bond Me a bond NH O a bond T3e OH 836 N O Q1a a bond Me a bond NH O a bond T3f OH 837 N O Q1a a bond Me a bond NH O a bond T3g OH 838 N O Q1a a bond Me a bond NH O a bond T3h OH 839 N O Q1a a bond Me a bond NH O a bond T3i OH 840 N O Q1a a bond Me a bond NH O a bond T3j OH 841 N O Q1a a bond H a bond NH S NH T3a OH 842 N O Q1a a bond H a bond NH S NH T3b OH 843 N O Q1a a bond H a bond NH S NH T3c OH 844 N O Q1a a bond H a bond NH S NH T3d OH 845 N O Q1a a bond H a bond NH S NH T3e OH 846 N O Q1a a bond H a bond NH S NH T3f OH 847 N O Q1a a bond H a bond NH S NH T3g OH 848 N O Q1a a bond H a bond NH S NH T3h OH 849 N O Q1a a bond H a bond NH S NH T3i OH 850 N O Q1a a bond H a bond NH S NH T3j OH 851 N O Q1a a bond H a bond NH S a bond T3a OH 852 N O Q1a a bond H a bond NH S a bond T3b OH 853 N O Q1a a bond H a bond NH S a bond T3c OH 854 N O Q1a a bond H a bond NH S a bond T3d OH 855 N O Q1a a bond H a bond NH S a bond T3e OH 856 N O Q1a a bond H a bond NH S a bond T3f OH 857 N O Q1a a bond H a bond NH S a bond T3g OH 858 N O Q1a a bond H a bond NH S a bond T3h OH 859 N O Q1a a bond H a bond NH S a bond T3i OH 860 N O Q1a a bond H a bond NH S a bond T3j OH 861 N O Q1a a bond H a bond NH O NH T3a OH 862 N O Q1a a bond H a bond NH O NH T3b OH 863 N O Q1a a bond H a bond NH O NH T3c OH 864 N O Q1a a bond H a bond NH O NH T3d OH 865 N O Q1a a bond H a bond NH O NH T3e OH 866 N O Q1a a bond H a bond NH O NH T3f OH 867 N O Q1a a bond H a bond NH O NH T3g OH 868 N O Q1a a bond H a bond NH O NH T3h OH 869 N O Q1a a bond H a bond NH O NH T3i OH 870 N O Q1a a bond H a bond NH O NH T3j OH 871 N O Q1a a bond H a bond NH O a bond T3a OH 872 N O Q1a a bond H a bond NH O a bond T3b OH 873 N O Q1a a bond H a bond NH O a bond T3c OH 874 N O Q1a a bond H a bond NH O a bond T3d OH 875 N O Q1a a bond H a bond NH O a bond T3e OH 876 N O Q1a a bond H a bond NH O a bond T3f OH 877 N O Q1a a bond H a bond NH O a bond T3g OH 878 N O Q1a a bond H a bond NH O a bond T3h OH 879 N O Q1a a bond H a bond NH O a bond T3i OH 880 N O Q1a a bond H a bond NH O a bond T3j OH 881 N O Q1b a bond Me a bond NH S NH T3a OH 882 N O Q1b a bond Me a bond NH S NH T3b OH 883 N O Q1b a bond Me a bond NH S NH T3c OH 884 N O Q1b a bond Me a bond NH S NH T3d OH 885 N O Q1b a bond Me a bond NH S NH T3e OH 886 N O Q1b a bond Me a bond NH S NH T3f OH 887 N O Q1b a bond Me a bond NH S NH T3g OH 888 N O Q1b a bond Me a bond NH S NH T3h OH 889 N O Q1b a bond Me a bond NH S NH T3i OH 890 N O Q1b a bond Me a bond NH S NH T3j OH 891 N O Q1b a bond Me a bond NH S a bond T3a OH 892 N O Q1b a bond Me a bond NH S a bond T3b OH 893 N O Q1b a bond Me a bond NH S a bond T3c OH 894 N O Q1b a bond Me a bond NH S a bond T3d OH 895 N O Q1b a bond Me a bond NH S a bond T3e OH 896 N O Q1b a bond Me a bond NH S a bond T3f OH 897 N O Q1b a bond Me a bond NH S a bond T3g OH 898 N O Q1b a bond Me a bond NH S a bond T3h OH 899 N O Q1b a bond Me a bond NH S a bond T3i OH 900 N O Q1b a bond Me a bond NH S a bond T3j OH 901 N O Q1b a bond Me a bond NH O NH T3a OH 902 N O Q1b a bond Me a bond NH O NH T3b OH 903 N O Q1b a bond Me a bond NH O NH T3c OH 904 N O Q1b a bond Me a bond NH O NH T3d OH 905 N O Q1b a bond Me a bond NH O NH T3e OH 906 N O Q1b a bond Me a bond NH O NH T3f OH 907 N O Q1b a bond Me a bond NH O NH T3g OH 908 N O Q1b a bond Me a bond NH O NH T3h OH 909 N O Q1b a bond Me a bond NH O NH T3i OH 910 N O Q1b a bond Me a bond NH O NH T3j OH 911 N O Q1b a bond Me a bond NH O a bond T3a OH 912 N O Q1b a bond Me a bond NH O a bond T3b OH 913 N O Q1b a bond Me a bond NH O a bond T3c OH 914 N O Q1b a bond Me a bond NH O a bond T3d OH 915 N O Q1b a bond Me a bond NH O a bond T3e OH 916 N O Q1b a bond Me a bond NH O a bond T3f OH 917 N O Q1b a bond Me a bond NH O a bond T3g OH 918 N O Q1b a bond Me a bond NH O a bond T3h OH 919 N O Q1b a bond Me a bond NH O a bond T3i OH 920 N O Q1b a bond Me a bond NH O a bond T3j OH 921 N O Q1b a bond H a bond NH S NH T3a OH 922 N O Q1b a bond H a bond NH S NH T3b OH 923 N O Q1b a bond H a bond NH S NH T3c OH 924 N O Q1b a bond H a bond NH S NH T3d OH 925 N O Q1b a bond H a bond NH S NH T3e OH 926 N O Q1b a bond H a bond NH S NH T3f OH 927 N O Q1b a bond H a bond NH S NH T3g OH 928 N O Q1b a bond H a bond NH S NH T3h OH 929 N O Q1b a bond H a bond NH S NH T3i OH 930 N O Q1b a bond H a bond NH S NH T3j OH 931 N O Q1b a bond H a bond NH S a bond T3a OH 932 N O Q1b a bond H a bond NH S a bond T3b OH 933 N O Q1b a bond H a bond NH S a bond T3c OH 934 N O Q1b a bond H a bond NH S a bond T3d OH 935 N O Q1b a bond H a bond NH S a bond T3e OH 936 N O Q1b a bond H a bond NH S a bond T3f OH 937 N O Q1b a bond H a bond NH S a bond T3g OH 938 N O Q1b a bond H a bond NH S a bond T3h OH 939 N O Q1b a bond H a bond NH S a bond T3i OH 940 N O Q1b a bond H a bond NH S a bond T3j OH 941 N O Q1b a bond H a bond NH O NH T3a OH 942 N O Q1b a bond H a bond NH O NH T3b OH 943 N O Q1b a bond H a bond NH O NH T3c OH 944 N O Q1b a bond H a bond NH O NH T3d OH 945 N O Q1b a bond H a bond NH O NH T3e OH 946 N O Q1b a bond H a bond NH O NH T3f OH 947 N O Q1b a bond H a bond NH O NH T3g OH 948 N O Q1b a bond H a bond NH O NH T3h OH 949 N O Q1b a bond H a bond NH O NH T3i OH 950 N O Q1b a bond H a bond NH O NH T3j OH 951 N O Q1b a bond H a bond NH O a bond T3a OH 952 N O Q1b a bond H a bond NH O a bond T3b OH 953 N O Q1b a bond H a bond NH O a bond T3c OH 954 N O Q1b a bond H a bond NH O a bond T3d OH 955 N O Q1b a bond H a bond NH O a bond T3e OH 956 N O Q1b a bond H a bond NH O a bond T3f OH 957 N O Q1b a bond H a bond NH O a bond T3g OH 958 N O Q1b a bond H a bond NH O a bond T3h OH 959 N O Q1b a bond H a bond NH O a bond T3i OH 960 N O Q1b a bond H a bond NH O a bond T3j OH 961 N O Q1c a bond Me a bond NH S NH T3a OH 962 N O Q1c a bond Me a bond NH S NH T3b OH 963 N O Q1c a bond Me a bond NH S NH T3c OH 964 N O Q1c a bond Me a bond NH S NH T3d OH 965 N O Q1c a bond Me a bond NH S NH T3e OH 966 N O Q1c a bond Me a bond NH S NH T3f OH 967 N O Q1c a bond Me a bond NH S NH T3g OH 968 N O Q1c a bond Me a bond NH S NH T3h OH 969 N O Q1c a bond Me a bond NH S NH T3i OH 970 N O Q1c a bond Me a bond NH S NH T3j OH 971 N O Q1c a bond Me a bond NH S a bond T3a OH 972 N O Q1c a bond Me a bond NH S a bond T3b OH 973 N O Q1c a bond Me a bond NH S a bond T3c OH 974 N O Q1c a bond Me a bond NH S a bond T3d OH 975 N O Q1c a bond Me a bond NH S a bond T3e OH 976 N O Q1c a bond Me a bond NH S a bond T3f OH 977 N O Q1c a bond Me a bond NH S a bond T3g OH 978 N O Q1c a bond Me a bond NH S a bond T3h OH 979 N O Q1c a bond Me a bond NH S a bond T3i OH 980 N O Q1c a bond Me a bond NH S a bond T3j OH 981 N O Q1c a bond Me a bond NH O NH T3a OH 982 N O Q1c a bond Me a bond NH O NH T3b OH 983 N O Q1c a bond Me a bond NH O NH T3c OH 984 N O Q1c a bond Me a bond NH O NH T3d OH 985 N O Q1c a bond Me a bond NH O NH T3e OH 986 N O Q1c a bond Me a bond NH O NH T3f OH 987 N O Q1c a bond Me a bond NH O NH T3g OH 988 N O Q1c a bond Me a bond NH O NH T3h OH 989 N O Q1c a bond Me a bond NH O NH T3i OH 990 N O Q1c a bond Me a bond NH O NH T3j OH 991 N O Q1c a bond Me a bond NH O a bond T3a OH 992 N O Q1c a bond Me a bond NH O a bond T3b OH 993 N O Q1c a bond Me a bond NH O a bond T3c OH 994 N O Q1c a bond Me a bond NH O a bond T3d OH 995 N O Q1c a bond Me a bond NH O a bond T3e OH 996 N O Q1c a bond Me a bond NH O a bond T3f OH 997 N O Q1c a bond Me a bond NH O a bond T3g OH 998 N O Q1c a bond Me a bond NH O a bond T3h OH 999 N O Q1c a bond Me a bond NH O a bond T3i OH 1000 N O Q1c a bond Me a bond NH O a bond T3j OH 1001 N O Q1c a bond H a bond NH S NH T3a OH 1002 N O Q1c a bond H a bond NH S NH T3b OH 1003 N O Q1c a bond H a bond NH S NH T3c OH 1004 N O Q1c a bond H a bond NH S NH T3d OH 1005 N O Q1c a bond H a bond NH S NH T3e OH 1006 N O Q1c a bond H a bond NH S NH T3f OH 1007 N O Q1c a bond H a bond NH S NH T3g OH 1008 N O Q1c a bond H a bond NH S NH T3h OH 1009 N O Q1c a bond H a bond NH S NH T3i OH 1010 N O Q1c a bond H a bond NH S NH T3j OH 1011 N O Q1c a bond H a bond NH S a bond T3a OH 1012 N O Q1c a bond H a bond NH S a bond T3b OH 1013 N O Q1c a bond H a bond NH S a bond T3c OH 1014 N O Q1c a bond H a bond NH S a bond T3d OH 1015 N O Q1c a bond H a bond NH S a bond T3e OH 1016 N O Q1c a bond H a bond NH S a bond T3f OH 1017 N O Q1c a bond H a bond NH S a bond T3g OH 1018 N O Q1c a bond H a bond NH S a bond T3h OH 1019 N O Q1c a bond H a bond NH S a bond T3i OH 1020 N O Q1c a bond H a bond NH S a bond T3j OH 1021 N O Q1c a bond H a bond NH O NH T3a OH 1022 N O Q1c a bond H a bond NH O NH T3b OH 1023 N O Q1c a bond H a bond NH O NH T3c OH 1024 N O Q1c a bond H a bond NH O NH T3d OH 1025 N O Q1c a bond H a bond NH O NH T3e OH 1026 N O Q1c a bond H a bond NH O NH T3f OH 1027 N O Q1c a bond H a bond NH O NH T3g OH 1028 N O Q1c a bond H a bond NH O NH T3h OH 1029 N O Q1c a bond H a bond NH O NH T3i OH 1030 N O Q1c a bond H a bond NH O NH T3j OH 1031 N O Q1c a bond H a bond NH O a bond T3a OH 1032 N O Q1c a bond H a bond NH O a bond T3b OH 1033 N O Q1c a bond H a bond NH O a bond T3c OH 1034 N O Q1c a bond H a bond NH O a bond T3d OH 1035 N O Q1c a bond H a bond NH O a bond T3e OH 1036 N O Q1c a bond H a bond NH O a bond T3f OH 1037 N O Q1c a bond H a bond NH O a bond T3g OH 1038 N O Q1c a bond H a bond NH O a bond T3h OH 1039 N O Q1c a bond H a bond NH O a bond T3i OH 1040 N O Q1c a bond H a bond NH O a bond T3j OH 1041 N O Q1i a bond Me a bond NH S NH T3a OH 1042 N O Q1i a bond Me a bond NH S NH T3b OH 1043 N O Q1i a bond Me a bond NH S NH T3c OH 1044 N O Q1i a bond Me a bond NH S NH T3d OH 1045 N O Q1i a bond Me a bond NH S NH T3e OH 1046 N O Q1i a bond Me a bond NH S NH T3f OH 1047 N O Q1i a bond Me a bond NH S NH T3g OH 1048 N O Q1i a bond Me a bond NH S NH T3h OH 1049 N O Q1i a bond Me a bond NH S NH T3i OH 1050 N O Q1i a bond Me a bond NH S NH T3j OH 1051 N O Q1i a bond Me a bond NH S a bond T3a OH 1052 N O Q1i a bond Me a bond NH S a bond T3b OH 1053 N O Q1i a bond Me a bond NH S a bond T3c OH 1054 N O Q1i a bond Me a bond NH S a bond T3d OH 1055 N O Q1i a bond Me a bond NH S a bond T3e OH 1056 N O Q1i a bond Me a bond NH S a bond T3f OH 1057 N O Q1i a bond Me a bond NH S a bond T3g OH 1058 N O Q1i a bond Me a bond NH S a bond T3h OH 1059 N O Q1i a bond Me a bond NH S a bond T3i OH 1060 N O Q1i a bond Me a bond NH S a bond T3j OH 1061 N O Q1i a bond Me a bond NH O NH T3a OH 1062 N O Q1i a bond Me a bond NH O NH T3b OH 1063 N O Q1i a bond Me a bond NH O NH T3c OH 1064 N O Q1i a bond Me a bond NH O NH T3d OH 1065 N O Q1i a bond Me a bond NH O NH T3e OH 1066 N O Q1i a bond Me a bond NH O NH T3f OH 1067 N O Q1i a bond Me a bond NH O NH T3g OH 1068 N O Q1i a bond Me a bond NH O NH T3h OH 1069 N O Q1i a bond Me a bond NH O NH T3i OH 1070 N O Q1i a bond Me a bond NH O NH T3j OH 1071 N O Q1i a bond Me a bond NH O a bond T3a OH 1072 N O Q1i a bond Me a bond NH O a bond T3b OH 1073 N O Q1i a bond Me a bond NH O a bond T3c OH 1074 N O Q1i a bond Me a bond NH O a bond T3d OH 1075 N O Q1i a bond Me a bond NH O a bond T3e OH 1076 N O Q1i a bond Me a bond NH O a bond T3f OH 1077 N O Q1i a bond Me a bond NH O a bond T3g OH 1078 N O Q1i a bond Me a bond NH O a bond T3h OH 1079 N O Q1i a bond Me a bond NH O a bond T3i OH 1080 N O Q1i a bond Me a bond NH O a bond T3j OH 1081 N O Q1i a bond H a bond NH S NH T3a OH 1082 N O Q1i a bond H a bond NH S NH T3b OH 1083 N O Q1i a bond H a bond NH S NH T3c OH 1084 N O Q1i a bond H a bond NH S NH T3d OH 1085 N O Q1i a bond H a bond NH S NH T3e OH 1086 N O Q1i a bond H a bond NH S NH T3f OH 1087 N O Q1i a bond H a bond NH S NH T3g OH 1088 N O Q1i a bond H a bond NH S NH T3h OH 1089 N O Q1i a bond H a bond NH S NH T3i OH 1090 N O Q1i a bond H a bond NH S NH T3j OH 1091 N O Q1i a bond H a bond NH S a bond T3a OH 1092 N O Q1i a bond H a bond NH S a bond T3b OH 1093 N O Q1i a bond H a bond NH S a bond T3c OH 1094 N O Q1i a bond H a bond NH S a bond T3d OH 1095 N O Q1i a bond H a bond NH S a bond T3e OH 1096 N O Q1i a bond H a bond NH S a bond T3f OH 1097 N O Q1i a bond H a bond NH S a bond T3g OH 1098 N O Q1i a bond H a bond NH S a bond T3h OH 1099 N O Q1i a bond H a bond NH S a bond T3i OH 1100 N O Q1i a bond H a bond NH S a bond T3j OH 1101 N O Q1i a bond H a bond NH O NH T3a OH 1102 N O Q1i a bond H a bond NH O NH T3b OH 1103 N O Q1i a bond H a bond NH O NH T3c OH 1104 N O Q1i a bond H a bond NH O NH T3d OH 1105 N O Q1i a bond H a bond NH O NH T3e OH 1106 N O Q1i a bond H a bond NH O NH T3f OH 1107 N O Q1i a bond H a bond NH O NH T3g OH 1108 N O Q1i a bond H a bond NH O NH T3h OH 1109 N O Q1i a bond H a bond NH O NH T3i OH 1110 N O Q1i a bond H a bond NH O NH T3j OH 1111 N O Q1i a bond H a bond NH O a bond T3a OH 1112 N O Q1i a bond H a bond NH O a bond T3b OH 1113 N O Q1i a bond H a bond NH O a bond T3c OH 1114 N O Q1i a bond H a bond NH O a bond T3d OH 1115 N O Q1i a bond H a bond NH O a bond T3e OH 1116 N O Q1i a bond H a bond NH O a bond T3f OH 1117 N O Q1i a bond H a bond NH O a bond T3g OH 1118 N O Q1i a bond H a bond NH O a bond T3h OH 1119 N O Q1i a bond H a bond NH O a bond T3i OH 1120 N O Q1i a bond H a bond NH O a bond T3j OH 1121 N O Q1j a bond Me a bond NH S NH T3a OH 1122 N O Q1j a bond Me a bond NH S NH T3b OH 1123 N O Q1j a bond Me a bond NH S NH T3c OH 1124 N O Q1j a bond Me a bond NH S NH T3d OH 1125 N O Q1j a bond Me a bond NH S NH T3e OH 1126 N O Q1j a bond Me a bond NH S NH T3f OH 1127 N O Q1j a bond Me a bond NH S NH T3g OH 1128 N O Q1j a bond Me a bond NH S NH T3h OH 1129 N O Q1j a bond Me a bond NH S NH T3i OH 1130 N O Q1j a bond Me a bond NH S NH T3j OH 1131 N O Q1j a bond Me a bond NH S a bond T3a OH 1132 N O Q1j a bond Me a bond NH S a bond T3b OH 1133 N O Q1j a bond Me a bond NH S a bond T3c OH 1134 N O Q1j a bond Me a bond NH S a bond T3d OH 1135 N O Q1j a bond Me a bond NH S a bond T3e OH 1136 N O Q1j a bond Me a bond NH S a bond T3f OH 1137 N O Q1j a bond Me a bond NH S a bond T3g OH 1138 N O Q1j a bond Me a bond NH S a bond T3h OH 1139 N O Q1j a bond Me a bond NH S a bond T3i OH 1140 N O Q1j a bond Me a bond NH S a bond T3j OH 1141 N O Q1j a bond Me a bond NH O NH T3a OH 1142 N O Q1j a bond Me a bond NH O NH T3b OH 1143 N O Q1j a bond Me a bond NH O NH T3c OH 1144 N O Q1j a bond Me a bond NH O NH T3d OH 1145 N O Q1j a bond Me a bond NH O NH T3e OH 1146 N O Q1j a bond Me a bond NH O NH T3f OH 1147 N O Q1j a bond Me a bond NH O NH T3g OH 1148 N O Q1j a bond Me a bond NH O NH T3h OH 1149 N O Q1j a bond Me a bond NH O NH T3i OH 1150 N O Q1j a bond Me a bond NH O NH T3j OH 1151 N O Q1j a bond Me a bond NH O a bond T3a OH 1152 N O Q1j a bond Me a bond NH O a bond T3b OH 1153 N O Q1j a bond Me a bond NH O a bond T3c OH 1154 N O Q1j a bond Me a bond NH O a bond T3d OH 1155 N O Q1j a bond Me a bond NH O a bond T3e OH 1156 N O Q1j a bond Me a bond NH O a bond T3f OH 1157 N O Q1j a bond Me a bond NH O a bond T3g OH 1158 N O Q1j a bond Me a bond NH O a bond T3h OH 1159 N O Q1j a bond Me a bond NH O a bond T3i OH 1160 N O Q1j a bond Me a bond NH O a bond T3j OH 1161 N O Q1j a bond H a bond NH S NH T3a OH 1162 N O Q1j a bond H a bond NH S NH T3b OH 1163 N O Q1j a bond H a bond NH S NH T3c OH 1164 N O Q1j a bond H a bond NH S NH T3d OH 1165 N O Q1j a bond H a bond NH S NH T3e OH 1166 N O Q1j a bond H a bond NH S NH T3f OH 1167 N O Q1j a bond H a bond NH S NH T3g OH 1168 N O Q1j a bond H a bond NH S NH T3h OH 1169 N O Q1j a bond H a bond NH S NH T3i OH 1170 N O Q1j a bond H a bond NH S NH T3j OH 1171 N O Q1j a bond H a bond NH S a bond T3a OH 1172 N O Q1j a bond H a bond NH S a bond T3b OH 1173 N O Q1j a bond H a bond NH S a bond T3c OH 1174 N O Q1j a bond H a bond NH S a bond T3d OH 1175 N O Q1j a bond H a bond NH S a bond T3e OH 1176 N O Q1j a bond H a bond NH S a bond T3f OH 1177 N O Q1j a bond H a bond NH S a bond T3g OH 1178 N O Q1j a bond H a bond NH S a bond T3h OH 1179 N O Q1j a bond H a bond NH S a bond T3i OH 1180 N O Q1j a bond H a bond NH S a bond T3j OH 1181 N O Q1j a bond H a bond NH O NH T3a OH 1182 N O Q1j a bond H a bond NH O NH T3b OH 1183 N O Q1j a bond H a bond NH O NH T3c OH 1184 N O Q1j a bond H a bond NH O NH T3d OH 1185 N O Q1j a bond H a bond NH O NH T3e OH 1186 N O Q1j a bond H a bond NH O NH T3f OH 1187 N O Q1j a bond H a bond NH O NH T3g OH 1188 N O Q1j a bond H a bond NH O NH T3h OH 1189 N O Q1j a bond H a bond NH O NH T3i OH 1190 N O Q1j a bond H a bond NH O NH T3j OH 1191 N O Q1j a bond H a bond NH O a bond T3a OH 1192 N O Q1j a bond H a bond NH O a bond T3b OH 1193 N O Q1j a bond H a bond NH O a bond T3c OH 1194 N O Q1j a bond H a bond NH O a bond T3d OH 1195 N O Q1j a bond H a bond NH O a bond T3e OH 1196 N O Q1j a bond H a bond NH O a bond T3f OH 1197 N O Q1j a bond H a bond NH O a bond T3g OH 1198 N O Q1j a bond H a bond NH O a bond T3h OH 1199 N O Q1j a bond H a bond NH O a bond T3i OH 1200 N O Q1j a bond H a bond NH O a bond T3j OH 1201 CH NMe Q1a a bond Me a bond NH S NH T3a OH 1202 CH NMe Q1a a bond Me a bond NH S NH T3b OH 1203 CH NMe Q1a a bond Me a bond NH S NH T3c OH 1204 CH NMe Q1a a bond Me a bond NH S NH T3d OH 1205 CH NMe Q1a a bond Me a bond NH S NH T3e OH 1206 CH NMe Q1a a bond Me a bond NH S NH T3f OH 1207 CH NMe Q1a a bond Me a bond NH S NH T3g OH 1208 CH NMe Q1a a bond Me a bond NH S NH T3h OH 1209 CH NMe Q1a a bond Me a bond NH S NH T3i OH 1210 CH NMe Q1a a bond Me a bond NH S NH T3j OH 1211 CH NMe Q1a a bond Me a bond NH S a bond T3a OH 1212 CH NMe Q1a a bond Me a bond NH S a bond T3b OH 1213 CH NMe Q1a a bond Me a bond NH S a bond T3c OH 1214 CH NMe Q1a a bond Me a bond NH S a bond T3d OH 1215 CH NMe Q1a a bond Me a bond NH S a bond T3e OH 1216 CH NMe Q1a a bond Me a bond NH S a bond T3f OH 1217 CH NMe Q1a a bond Me a bond NH S a bond T3g OH 1218 CH NMe Q1a a bond Me a bond NH S a bond T3h OH 1219 CH NMe Q1a a bond Me a bond NH S a bond T3i OH 1220 CH NMe Q1a a bond Me a bond NH S a bond T3j OH 1221 CH NMe Q1a a bond Me a bond NH O NH T3a OH 1222 CH NMe Q1a a bond Me a bond NH O NH T3b OH 1223 CH NMe Q1a a bond Me a bond NH O NH T3c OH 1224 CH NMe Q1a a bond Me a bond NH O NH T3d OH 1225 CH NMe Q1a a bond Me a bond NH O NH T3e OH 1226 CH NMe Q1a a bond Me a bond NH O NH T3f OH 1227 CH NMe Q1a a bond Me a bond NH O NH T3g OH 1228 CH NMe Q1a a bond Me a bond NH O NH T3h OH 1229 CH NMe Q1a a bond Me a bond NH O NH T3i OH 1230 CH NMe Q1a a bond Me a bond NH O NH T3j OH 1231 CH NMe Q1a a bond Me a bond NH O a bond T3a OH 1232 CH NMe Q1a a bond Me a bond NH O a bond T3b OH 1233 CH NMe Q1a a bond Me a bond NH O a bond T3c OH 1234 CH NMe Q1a a bond Me a bond NH O a bond T3d OH 1235 CH NMe Q1a a bond Me a bond NH O a bond T3e OH 1236 CH NMe Q1a a bond Me a bond NH O a bond T3f OH 1237 CH NMe Q1a a bond Me a bond NH O a bond T3g OH 1238 CH NMe Q1a a bond Me a bond NH O a bond T3h OH 1239 CH NMe Q1a a bond Me a bond NH O a bond T3i OH 1240 CH NMe Q1a a bond Me a bond NH O a bond T3j OH 1241 CH NMe Q1a a bond H a bond NH S NH T3a OH 1242 CH NMe Q1a a bond H a bond NH S NH T3b OH 1243 CH NMe Q1a a bond H a bond NH S NH T3c OH 1244 CH NMe Q1a a bond H a bond NH S NH T3d OH 1245 CH NMe Q1a a bond H a bond NH S NH T3e OH 1246 CH NMe Q1a a bond H a bond NH S NH T3f OH 1247 CH NMe Q1a a bond H a bond NH S NH T3g OH 1248 CH NMe Q1a a bond H a bond NH S NH T3h OH 1249 CH NMe Q1a a bond H a bond NH S NH T3i OH 1250 CH NMe Q1a a bond H a bond NH S NH T3j OH 1251 CH NMe Q1a a bond H a bond NH S a bond T3a OH 1252 CH NMe Q1a a bond H a bond NH S a bond T3b OH 1253 CH NMe Q1a a bond H a bond NH S a bond T3c OH 1254 CH NMe Q1a a bond H a bond NH S a bond T3d OH 1255 CH NMe Q1a a bond H a bond NH S a bond T3e OH 1256 CH NMe Q1a a bond H a bond NH S a bond T3f OH 1257 CH NMe Q1a a bond H a bond NH S a bond T3g OH 1258 CH NMe Q1a a bond H a bond NH S a bond T3h OH 1259 CH NMe Q1a a bond H a bond NH S a bond T3i OH 1260 CH NMe Q1a a bond H a bond NH S a bond T3j OH 1261 CH NMe Q1a a bond H a bond NH O NH T3a OH 1262 CH NMe Q1a a bond H a bond NH O NH T3b OH 1263 CH NMe Q1a a bond H a bond NH O NH T3c OH 1264 CH NMe Q1a a bond H a bond NH O NH T3d OH 1265 CH NMe Q1a a bond H a bond NH O NH T3e OH 1266 CH NMe Q1a a bond H a bond NH O NH T3f OH 1267 CH NMe Q1a a bond H a bond NH O NH T3g OH 1268 CH NMe Q1a a bond H a bond NH O NH T3h OH 1269 CH NMe Q1a a bond H a bond NH O NH T3i OH 1270 CH NMe Q1a a bond H a bond NH O NH T3j OH 1271 CH NMe Q1a a bond H a bond NH O a bond T3a OH 1272 CH NMe Q1a a bond H a bond NH O a bond T3b OH 1273 CH NMe Q1a a bond H a bond NH O a bond T3c OH 1274 CH NMe Q1a a bond H a bond NH O a bond T3d OH 1275 CH NMe Q1a a bond H a bond NH O a bond T3e OH 1276 CH NMe Q1a a bond H a bond NH O a bond T3f OH 1277 CH NMe Q1a a bond H a bond NH O a bond T3g OH 1278 CH NMe Q1a a bond H a bond NH O a bond T3h OH 1279 CH NMe Q1a a bond H a bond NH O a bond T3i OH 1280 NH NMe Q1a a bond H a bond NH O a bond T3j OH 1281 CH NMe Q1b a bond Me a bond NH S NH T3a OH 1282 CH NMe Q1b a bond Me a bond NH S NH T3b OH 1283 CH NMe Q1b a bond Me a bond NH S NH T3c OH 1284 CH NMe Q1b a bond Me a bond NH S NH T3d OH 1285 CH NMe Q1b a bond Me a bond NH S NH T3e OH 1286 CH NMe Q1b a bond Me a bond NH S NH T3f OH 1287 CH NMe Q1b a bond Me a bond NH S NH T3g OH 1288 CH NMe Q1b a bond Me a bond NH S NH T3h OH 1289 CH NMe Q1b a bond Me a bond NH S NH T3i OH 1290 CH NMe Q1b a bond Me a bond NH S NH T3j OH 1291 CH NMe Q1b a bond Me a bond NH S a bond T3a OH 1292 CH NMe Q1b a bond Me a bond NH S a bond T3b OH 1293 CH NMe Q1b a bond Me a bond NH S a bond T3c OH 1294 CH NMe Q1b a bond Me a bond NH S a bond T3d OH 1295 CH NMe Q1b a bond Me a bond NH S a bond T3e OH 1296 CH NMe Q1b a bond Me a bond NH S a bond T3f OH 1297 CH NMe Q1b a bond Me a bond NH S a bond T3g OH 1298 CH NMe Q1b a bond Me a bond NH S a bond T3h OH 1299 CH NMe Q1b a bond Me a bond NH S a bond T3i OH 1300 CH NMe Q1b a bond Me a bond NH S a bond T3j OH 1301 CH NMe Q1b a bond Me a bond NH O NH T3a OH 1302 CH NMe Q1b a bond Me a bond NH O NH T3b OH 1303 CH NMe Q1b a bond Me a bond NH O NH T3c OH 1304 CH NMe Q1b a bond Me a bond NH O NH T3d OH 1305 CH NMe Q1b a bond Me a bond NH O NH T3e OH 1306 CH NMe Q1b a bond Me a bond NH O NH T3f OH 1307 CH NMe Q1b a bond Me a bond NH O NH T3g OH 1308 CH NMe Q1b a bond Me a bond NH O NH T3h OH 1309 CH NMe Q1b a bond Me a bond NH O NH T3i OH 1310 CH NMe Q1b a bond Me a bond NH O NH T3j OH 1311 CH NMe Q1b a bond Me a bond NH O a bond T3a OH 1312 CH NMe Q1b a bond Me a bond NH O a bond T3b OH 1313 CH NMe Q1b a bond Me a bond NH O a bond T3c OH 1314 CH NMe Q1b a bond Me a bond NH O a bond T3d OH 1315 CH NMe Q1b a bond Me a bond NH O a bond T3e OH 1316 CH NMe Q1b a bond Me a bond NH O a bond T3f OH 1317 CH NMe Q1b a bond Me a bond NH O a bond T3g OH 1318 CH NMe Q1b a bond Me a bond NH O a bond T3h OH 1319 CH NMe Q1b a bond Me a bond NH O a bond T3i OH 1320 CH NMe Q1b a bond Me a bond NH O a bond T3j OH 1321 CH NMe Q1b a bond H a bond NH S NH T3a OH 1322 CH NMe Q1b a bond H a bond NH S NH T3b OH 1323 CH NMe Q1b a bond H a bond NH S NH T3c OH 1324 CH NMe Q1b a bond H a bond NH S NH T3d OH 1325 CH NMe Q1b a bond H a bond NH S NH T3e OH 1326 CH NMe Q1b a bond H a bond NH S NH T3f OH 1327 CH NMe Q1b a bond H a bond NH S NH T3g OH 1328 CH NMe Q1b a bond H a bond NH S NH T3h OH 1329 CH NMe Q1b a bond H a bond NH S NH T3i OH 1330 CH NMe Q1b a bond H a bond NH S NH T3j OH 1331 CH NMe Q1b a bond H a bond NH S a bond T3a OH 1332 CH NMe Q1b a bond H a bond NH S a bond T3b OH 1333 CH NMe Q1b a bond H a bond NH S a bond T3c OH 1334 CH NMe Q1b a bond H a bond NH S a bond T3d OH 1335 CH NMe Q1b a bond H a bond NH S a bond T3e OH 1336 CH NMe Q1b a bond H a bond NH S a bond T3f OH 1337 CH NMe Q1b a bond H a bond NH S a bond T3g OH 1338 CH NMe Q1b a bond H a bond NH S a bond T3h OH 1339 CH NMe Q1b a bond H a bond NH S a bond T3i OH 1340 CH NMe Q1b a bond H a bond NH S a bond T3j OH 1341 CH NMe Q1b a bond H a bond NH O NH T3a OH 1342 CH NMe Q1b a bond H a bond NH O NH T3b OH 1343 CH NMe Q1b a bond H a bond NH O NH T3c OH 1344 CH NMe Q1b a bond H a bond NH O NH T3d OH 1345 CH NMe Q1b a bond H a bond NH O NH T3e OH 1346 CH NMe Q1b a bond H a bond NH O NH T3f OH 1347 CH NMe Q1b a bond H a bond NH O NH T3g OH 1348 CH NMe Q1b a bond H a bond NH O NH T3h OH 1349 CH NMe Q1b a bond H a bond NH O NH T3i OH 1350 CH NMe Q1b a bond H a bond NH O NH T3j OH 1351 CH NMe Q1b a bond H a bond NH O a bond T3a OH 1352 CH NMe Q1b a bond H a bond NH O a bond T3b OH 1353 CH NMe Q1b a bond H a bond NH O a bond T3c OH 1354 CH NMe Q1b a bond H a bond NH O a bond T3d OH 1355 CH NMe Q1b a bond H a bond NH O a bond T3e OH 1356 CH NMe Q1b a bond H a bond NH O a bond T3f OH 1357 CH NMe Q1b a bond H a bond NH O a bond T3g OH 1358 CH NMe Q1b a bond H a bond NH O a bond T3h OH 1359 CH NMe Q1b a bond H a bond NH O a bond T3i OH 1360 CH NMe Q1b a bond H a bond NH O a bond T3j OH 1361 CH NMe Q1c a bond Me a bond NH S NH T3a OH 1362 CH NMe Q1c a bond Me a bond NH S NH T3b OH 1363 CH NMe Q1c a bond Me a bond NH S NH T3c OH 1364 CH NMe Q1c a bond Me a bond NH S NH T3d OH 1365 CH NMe Q1c a bond Me a bond NH S NH T3e OH 1366 CH NMe Q1c a bond Me a bond NH S NH T3f OH 1367 CH NMe Q1c a bond Me a bond NH S NH T3g OH 1368 CH NMe Q1c a bond Me a bond NH S NH T3h OH 1369 CH NMe Q1c a bond Me a bond NH S NH T3i OH 1370 CH NMe Q1c a bond Me a bond NH S NH T3j OH 1371 CH NMe Q1c a bond Me a bond NH S a bond T3a OH 1372 CH NMe Q1c a bond Me a bond NH S a bond T3b OH 1373 CH NMe Q1c a bond Me a bond NH S a bond T3c OH 1374 CH NMe Q1c a bond Me a bond NH S a bond T3d OH 1375 CH NMe Q1c a bond Me a bond NH S a bond T3e OH 1376 CH NMe Q1c a bond Me a bond NH S a bond T3f OH 1377 CH NMe Q1c a bond Me a bond NH S a bond T3g OH 1378 CH NMe Q1c a bond Me a bond NH S a bond T3h OH 1379 CH NMe Q1c a bond Me a bond NH S a bond T3i OH 1380 CH NMe Q1c a bond Me a bond NH S a bond T3j OH 1381 CH NMe Q1c a bond Me a bond NH O NH T3a OH 1382 CH NMe Q1c a bond Me a bond NH O NH T3b OH 1383 CH NMe Q1c a bond Me a bond NH O NH T3c OH 1384 CH NMe Q1c a bond Me a bond NH O NH T3d OH 1385 CH NMe Q1c a bond Me a bond NH O NH T3e OH 1386 CH NMe Q1c a bond Me a bond NH O NH T3f OH 1387 CH NMe Q1c a bond Me a bond NH O NH T3g OH 1388 CH NMe Q1c a bond Me a bond NH O NH T3h OH 1389 CH NMe Q1c a bond Me a bond NH O NH T3i OH 1390 CH NMe Q1c a bond Me a bond NH O NH T3j OH 1391 CH NMe Q1c a bond Me a bond NH O a bond T3a OH 1392 CH NMe Q1c a bond Me a bond NH O a bond T3b OH 1393 CH NMe Q1c a bond Me a bond NH O a bond T3c OH 1394 CH NMe Q1c a bond Me a bond NH O a bond T3d OH 1395 CH NMe Q1c a bond Me a bond NH O a bond T3e OH 1396 CH NMe Q1c a bond Me a bond NH O a bond T3f OH 1397 CH NMe Q1c a bond Me a bond NH O a bond T3g OH 1398 CH NMe Q1c a bond Me a bond NH O a bond T3h OH 1399 CH NMe Q1c a bond Me a bond NH O a bond T3i OH 1400 CH NMe Q1c a bond Me a bond NH O a bond T3j OH 1401 CH NMe Q1c a bond H a bond NH S NH T3a OH 1402 CH NMe Q1c a bond H a bond NH S NH T3b OH 1403 CH NMe Q1c a bond H a bond NH S NH T3c OH 1404 CH NMe Q1c a bond H a bond NH S NH T3d OH 1405 CH NMe Q1c a bond H a bond NH S NH T3e OH 1406 CH NMe Q1c a bond H a bond NH S NH T3f OH 1407 CH NMe Q1c a bond H a bond NH S NH T3g OH 1408 CH NMe Q1c a bond H a bond NH S NH T3h OH 1409 CH NMe Q1c a bond H a bond NH S NH T3i OH 1410 CH NMe Q1c a bond H a bond NH S NH T3j OH 1411 CH NMe Q1c a bond H a bond NH S a bond T3a OH 1412 CH NMe Q1c a bond H a bond NH S a bond T3b OH 1413 CH NMe Q1c a bond H a bond NH S a bond T3c OH 1414 CH NMe Q1c a bond H a bond NH S a bond T3d OH 1415 CH NMe Q1c a bond H a bond NH S a bond T3e OH 1416 CH NMe Q1c a bond H a bond NH S a bond T3f OH 1417 CH NMe Q1c a bond H a bond NH S a bond T3g OH 1418 CH NMe Q1c a bond H a bond NH S a bond T3h OH 1419 CH NMe Q1c a bond H a bond NH S a bond T3i OH 1420 CH NMe Q1c a bond H a bond NH S a bond T3j OH 1421 CH NMe Q1c a bond H a bond NH O NH T3a OH 1422 CH NMe Q1c a bond H a bond NH O NH T3b OH 1423 CH NMe Q1c a bond H a bond NH O NH T3c OH 1424 CH NMe Q1c a bond H a bond NH O NH T3d OH 1425 CH NMe Q1c a bond H a bond NH O NH T3e OH 1426 CH NMe Q1c a bond H a bond NH O NH T3f OH 1427 CH NMe Q1c a bond H a bond NH O NH T3g OH 1428 CH NMe Q1c a bond H a bond NH O NH T3h OH 1429 CH NMe Q1c a bond H a bond NH O NH T3i OH 1430 CH NMe Q1c a bond H a bond NH O NH T3j OH 1431 CH NMe Q1c a bond H a bond NH O a bond T3a OH 1432 CH NMe Q1c a bond H a bond NH O a bond T3b OH 1433 CH NMe Q1c a bond H a bond NH O a bond T3c OH 1434 CH NMe Q1c a bond H a bond NH O a bond T3d OH 1435 CH NMe Q1c a bond H a bond NH O a bond T3e OH 1436 CH NMe Q1c a bond H a bond NH O a bond T3f OH 1437 CH NMe Q1c a bond H a bond NH O a bond T3g OH 1438 CH NMe Q1c a bond H a bond NH O a bond T3h OH 1439 CH NMe Q1c a bond H a bond NH O a bond T3i OH 1440 CH NMe Q1c a bond H a bond NH O a bond T3j OH 1441 CH NMe Q1i a bond Me a bond NH S NH T3a OH 1442 CH NMe Q1i a bond Me a bond NH S NH T3b OH 1443 CH NMe Q1i a bond Me a bond NH S NH T3c OH 1444 CH NMe Q1i a bond Me a bond NH S NH T3d OH 1445 CH NMe Q1i a bond Me a bond NH S NH T3e OH 1446 CH NMe Q1i a bond Me a bond NH S NH T3f OH 1447 CH NMe Q1i a bond Me a bond NH S NH T3g OH 1448 CH NMe Q1i a bond Me a bond NH S NH T3h OH 1449 CH NMe Q1i a bond Me a bond NH S NH T3i OH 1450 CH NMe Q1i a bond Me a bond NH S NH T3j OH 1451 CH NMe Q1i a bond Me a bond NH S a bond T3a OH 1452 CH NMe Q1i a bond Me a bond NH S a bond T3b OH 1453 CH NMe Q1i a bond Me a bond NH S a bond T3c OH 1454 CH NMe Q1i a bond Me a bond NH S a bond T3d OH 1455 CH NMe Q1i a bond Me a bond NH S a bond T3e OH 1456 CH NMe Q1i a bond Me a bond NH S a bond T3f OH 1457 CH NMe Q1i a bond Me a bond NH S a bond T3g OH 1458 CH NMe Q1i a bond Me a bond NH S a bond T3h OH 1459 CH NMe Q1i a bond Me a bond NH S a bond T3i OH 1460 CH NMe Q1i a bond Me a bond NH S a bond T3j OH 1461 CH NMe Q1i a bond Me a bond NH O NH T3a OH 1462 CH NMe Q1i a bond Me a bond NH O NH T3b OH 1463 CH NMe Q1i a bond Me a bond NH O NH T3c OH 1464 CH NMe Q1i a bond Me a bond NH O NH T3d OH 1465 CH NMe Q1i a bond Me a bond NH O NH T3e OH 1466 CH NMe Q1i a bond Me a bond NH O NH T3f OH 1467 CH NMe Q1i a bond Me a bond NH O NH T3g OH 1468 CH NMe Q1i a bond Me a bond NH O NH T3h OH 1469 CH NMe Q1i a bond Me a bond NH O NH T3i OH 1470 CH NMe Q1i a bond Me a bond NH O NH T3j OH 1471 CH NMe Q1i a bond Me a bond NH O a bond T3a OH 1472 CH NMe Q1i a bond Me a bond NH O a bond T3b OH 1473 CH NMe Q1i a bond Me a bond NH O a bond T3c OH 1474 CH NMe Q1i a bond Me a bond NH O a bond T3d OH 1475 CH NMe Q1i a bond Me a bond NH O a bond T3e OH 1476 CH NMe Q1i a bond Me a bond NH O a bond T3f OH 1477 CH NMe Q1i a bond Me a bond NH O a bond T3g OH 1478 CH NMe Q1i a bond Me a bond NH O a bond T3h OH 1479 CH NMe Q1i a bond Me a bond NH O a bond T3i OH 1480 CH NMe Q1i a bond Me a bond NH O a bond T3j OH 1481 CH NMe Q1i a bond H a bond NH S NH T3a OH 1482 CH NMe Q1i a bond H a bond NH S NH T3b OH 1483 CH NMe Q1i a bond H a bond NH S NH T3c OH 1484 CH NMe Q1i a bond H a bond NH S NH T3d OH 1485 CH NMe Q1i a bond N a bond NH S NH T3e OH 1486 CH NMe Q1i a bond H a bond NH S NH T3f OH 1487 CH NMe Q1i a bond H a bond NH S NH T3g OH 1488 CH NMe Q1i a bond H a bond NH S NH T3h OH 1489 CH NMe Q1i a bond H a bond NH S NH T3i OH 1490 CH NMe Q1i a bond H a bond NH S NH T3j OH 1491 CH NMe Q1i a bond H a bond NH S a bond T3a OH 1492 CH NMe Q1i a bond H a bond NH S a bond T3b OH 1493 CH NMe Q1i a bond H a bond NH S a bond T3c OH 1494 CH NMe Q1i a bond H a bond NH S a bond T3d OH 1495 CH NMe Q1i a bond H a bond NH S a bond T3e OH 1496 CH NMe Q1i a bond H a bond NH S a bond T3f OH 1497 CH NMe Q1i a bond H a bond NH S a bond T3g OH 1498 CH NMe Q1i a bond H a bond NH S a bond T3h OH 1499 CH NMe Q1i a bond H a bond NH S a bond T3i OH 1500 CH NMe Q1i a bond H a bond NH S a bond T3j OH 1501 CH NMe Q1i a bond H a bond NH O NH T3a OH 1502 CH NMe Q1i a bond H a bond NH O NH T3b OH 1503 CH NMe Q1i a bond H a bond NH O NH T3c OH 1504 CH NMe Q1i a bond H a bond NH O NH T3d OH 1505 CH NMe Q1i a bond H a bond NH O NH T3e OH 1506 CH NMe Q1i a bond H a bond NH O NH T3f OH 1507 CH NMe Q1i a bond H a bond NH O NH T3g OH 1508 CH NMe Q1i a bond H a bond NH O NH T3h OH 1509 CH NMe Q1i a bond H a bond NH O NH T3i OH 1510 CH NMe Q1i a bond H a bond NH O NH T3j OH 1511 CH NMe Q1i a bond H a bond NH O a bond T3a OH 1512 CH NMe Q1i a bond H a bond NH O a bond T3b OH 1513 CH NMe Q1i a bond H a bond NH O a bond T3c OH 1514 CH NMe Q1i a bond H a bond NH O a bond T3d OH 1515 CH NMe Q1i a bond H a bond NH O a bond T3e OH 1516 CH NMe Q1i a bond H a bond NH O a bond T3f OH 1517 CH NMe Q1i a bond H a bond NH O a bond T3g OH 1518 CH NMe Q1i a bond H a bond NH O a bond T3h OH 1519 CH NMe Q1i a bond H a bond NH O a bond T3i OH 1520 CH NMe Q1i a bond H a bond NH O a bond T3j OH 1521 CH NMe Q1j a bond Me a bond NH S NH T3a OH 1522 CH NMe Q1j a bond Me a bond NH S NH T3b OH 1523 CH NMe Q1j a bond Me a bond NH S NH T3c OH 1524 CH NMe Q1j a bond Me a bond NH S NH T3d OH 1525 CH NMe Q1j a bond Me a bond NH S NH T3e OH 1526 CH NMe Q1j a bond Me a bond NH S NH T3f OH 1527 CH NMe Q1j a bond Me a bond NH S NH T3g OH 1528 CH NMe Q1j a bond Me a bond NH S NH T3h OH 1529 CH NMe Q1j a bond Me a bond NH S NH T3i OH 1530 CH NMe Q1j a bond Me a bond NH S NH T3j OH 1531 CH NMe Q1j a bond Me a bond NH S a bond T3a OH 1532 CH NMe Q1j a bond Me a bond NH S a bond T3b OH 1533 CH NMe Q1j a bond Me a bond NH S a bond T3c OH 1534 CH NMe Q1j a bond Me a bond NH S a bond T3d OH 1535 CH NMe Q1j a bond Me a bond NH S a bond T3e OH 1536 CH NMe Q1j a bond Me a bond NH S a bond T3f OH 1537 CH NMe Q1j a bond Me a bond NH S a bond T3g OH 1538 CH NMe Q1j a bond Me a bond NH S a bond T3h OH 1539 CH NMe Q1j a bond Me a bond NH S a bond T3i OH 1540 CH NMe Q1j a bond Me a bond NH S a bond T3j OH 1541 CH NMe Q1j a bond Me a bond NH O NH T3a OH 1542 CH NMe Q1j a bond Me a bond NH O NH T3b OH 1543 CH NMe Q1j a bond Me a bond NH O NH T3c OH 1544 CH NMe Q1j a bond Me a bond NH O NH T3d OH 1545 CH NMe Q1j a bond Me a bond NH O NH T3e OH 1546 CH NMe Q1j a bond Me a bond NH O NH T3f OH 1547 CH NMe Q1j a bond Me a bond NH O NH T3g OH 1548 CH NMe Q1j a bond Me a bond NH O NH T3h OH 1549 CH NMe Q1j a bond Me a bond NH O NH T3i OH 1550 CH NMe Q1j a bond Me a bond NH O NH T3j OH 1551 CH NMe Q1j a bond Me a bond NH O a bond T3a OH 1552 CH NMe Q1j a bond Me a bond NH O a bond T3b OH 1553 CH NMe Q1j a bond Me a bond NH O a bond T3c OH 1554 CH NMe Q1j a bond Me a bond NH O a bond T3d OH 1555 CH NMe Q1j a bond Me a bond NH O a bond T3e OH 1556 CH NMe Q1j a bond Me a bond NH O a bond T3f OH 1557 CH NMe Q1j a bond Me a bond NH O a bond T3g OH 1558 CH NMe Q1j a bond Me a bond NH O a bond T3h OH 1559 CH NMe Q1j a bond Me a bond NH O a bond T3i OH 1560 CH NMe Q1j a bond Me a bond NH O a bond T3j OH 1561 CH NMe Q1j a bond H a bond NH S NH T3a OH 1562 CH NMe Q1j a bond H a bond NH S NH T3b OH 1563 CH NMe Q1j a bond H a bond NH S NH T3c OH 1564 CH NMe Q1j a bond H a bond NH S NH T3d OH 1565 CH NMe Q1j a bond H a bond NH S NH T3e OH 1566 CH NMe Q1j a bond H a bond NH S NH T3f OH 1567 CH NMe Q1j a bond H a bond NH S NH T3g OH 1568 CH NMe Q1j a bond H a bond NH S NH T3h OH 1569 CH NMe Q1j a bond H a bond NH S NH T3i OH 1570 CH NMe Q1j a bond H a bond NH S NH T3j OH 1571 CH NMe Q1j a bond H a bond NH S a bond T3a OH 1572 CH NMe Q1j a bond H a bond NH S a bond T3b OH 1573 CH NMe Q1j a bond H a bond NH S a bond T3c OH 1574 CH NMe Q1j a bond H a bond NH S a bond T3d OH 1575 CH NMe Q1j a bond H a bond NH S a bond T3e OH 1576 CH NMe Q1j a bond H a bond NH S a bond T3f OH 1577 CH NMe Q1j a bond H a bond NH S a bond T3g OH 1578 CH NMe Q1j a bond H a bond NH S a bond T3h OH 1579 CH NMe Q1j a bond H a bond NH S a bond T3i OH 1580 CH NMe Q1j a bond H a bond NH S a bond T3j OH 1581 CH NMe Q1j a bond H a bond NH O NH T3a OH 1582 CH NMe Q1j a bond H a bond NH O NH T3b OH 1583 CH NMe Q1j a bond H a bond NH O NH T3c OH 1584 CH NMe Q1j a bond H a bond NH O NH T3d OH 1585 CH NMe Q1j a bond H a bond NH O NH T3e OH 1586 CH NMe Q1j a bond H a bond NH O NH T3f OH 1587 CH NMe Q1j a bond H a bond NH O NH T3g OH 1588 CH NMe Q1j a bond H a bond NH O NH T3h OH 1589 CH NMe Q1j a bond H a bond NH O NH T3i OH 1590 CH NMe Q1j a bond H a bond NH O NH T3j OH 1591 CH NMe Q1j a bond H a bond NH O a bond T3a OH 1592 CH NMe Q1j a bond H a bond NH O a bond T3b OH 1593 CH NMe Q1j a bond H a bond NH O a bond T3c OH 1594 CH NMe Q1j a bond H a bond NH O a bond T3d OH 1595 CH NMe Q1j a bond H a bond NH O a bond T3e OH 1596 CH NMe Q1j a bond H a bond NH O a bond T3f OH 1597 CH NMe Q1j a bond H a bond NH O a bond T3g OH 1598 CH NMe Q1j a bond H a bond NH O a bond T3h OH 1599 CH NMe Q1j a bond H a bond NH O a bond T3i OH 1600 CH NMe Q1j a bond H a bond NH O a bond T3j OH 1601 CH S Q1a a bond Me a bond NH S NH T3a OH 1602 CH S Q1a a bond Me a bond NH S NH T3b OH 1603 CH S Q1a a bond Me a bond NH S NH T3c OH 1604 CH S Q1a a bond Me a bond NH S NH T3d OH 1605 CH S Q1a a bond Me a bond NH S NH T3e OH 1606 CH S Q1a a bond Me a bond NH S NH T3f OH 1607 CH S Q1a a bond Me a bond NH S NH T3g OH 1608 CH S Q1a a bond Me a bond NH S NH T3h OH 1609 CH S Q1a a bond Me a bond NH S NH T3i OH 1610 CH S Q1a a bond Me a bond NH S NH T3j OH 1611 CH S Q1a a bond Me a bond NH S a bond T3a OH 1612 CH S Q1a a bond Me a bond NH S a bond T3b OH 1613 CH S Q1a a bond Me a bond NH S a bond T3c OH 1614 CH S Q1a a bond Me a bond NH S a bond T3d OH 1615 CH S Q1a a bond Me a bond NH S a bond T3e OH 1616 CH S Q1a a bond Me a bond NH S a bond T3f OH 1617 CH S Q1a a bond Me a bond NH S a bond T3g OH 1618 CH S Q1a a bond Me a bond NH S a bond T3h OH 1619 CH S Q1a a bond Me a bond NH S a bond T3i OH 1620 CH S Q1a a bond Me a bond NH S a bond T3j OH 1621 CH S Q1a a bond Me a bond NH O NH T3a OH 1622 CH S Q1a a bond Me a bond NH O NH T3b OH 1623 CH S Q1a a bond Me a bond NH O NH T3c OH 1624 CH S Q1a a bond Me a bond NH O NH T3d OH 1625 CH S Q1a a bond Me a bond NH O NH T3e OH 1626 CH S Q1a a bond Me a bond NH O NH T3f OH 1627 CH S Q1a a bond Me a bond NH O NH T3g OH 1628 CH S Q1a a bond Me a bond NH O NH T3h OH 1629 CH S Q1a a bond Me a bond NH O NH T3i OH 1630 CH S Q1a a bond Me a bond NH O NH T3j OH 1631 CH S Q1a a bond Me a bond NH O a bond T3a OH 1632 CH S Q1a a bond Me a bond NH O a bond T3b OH 1633 CH S Q1a a bond Me a bond NH O a bond T3c OH 1634 CH S Q1a a bond Me a bond NH O a bond T3d OH 1635 CH S Q1a a bond Me a bond NH O a bond T3e OH 1636 CH S Q1a a bond Me a bond NH O a bond T3f OH 1637 CH S Q1a a bond Me a bond NH O a bond T3g OH 1638 CH S Q1a a bond Me a bond NH O a bond T3h OH 1639 CH S Q1a a bond Me a bond NH O a bond T3i OH 1640 CH S Q1a a bond Me a bond NH O a bond T3j OH 1641 CH S Q1a a bond H a bond NH S NH T3a OH 1642 CH S Q1a a bond H a bond NH S NH T3b OH 1643 CH S Q1a a bond H a bond NH S NH T3c OH 1644 CH S Q1a a bond H a bond NH S NH T3d OH 1645 CH S Q1a a bond H a bond NH S NH T3e OH 1646 CH S Q1a a bond H a bond NH S NH T3f OH 1647 CH S Q1a a bond H a bond NH S NH T3g OH 1648 CH S Q1a a bond H a bond NH S NH T3h OH 1649 CH S Q1a a bond H a bond NH S NH T3i OH 1650 CH S Q1a a bond H a bond NH S NH T3j OH 1651 CH S Q1a a bond H a bond NH S a bond T3a OH 1652 CH S Q1a a bond H a bond NH S a bond T3b OH 1653 CH S Q1a a bond H a bond NH S a bond T3c OH 1654 CH S Q1a a bond H a bond NH S a bond T3d OH 1655 CH S Q1a a bond H a bond NH S a bond T3e OH 1656 CH S Q1a a bond H a bond NH S a bond T3f OH 1657 CH S Q1a a bond H a bond NH S a bond T3g OH 1658 CH S Q1a a bond H a bond NH S a bond T3h OH 1659 CH S Q1a a bond H a bond NH S a bond T3i OH 1660 CH S Q1a a bond H a bond NH S a bond T3j OH 1661 CH S Q1a a bond H a bond NH O NH T3a OH 1662 CH S Q1a a bond H a bond NH O NH T3b OH 1663 CH S Q1a a bond H a bond NH O NH T3c OH 1664 CH S Q1a a bond H a bond NH O NH T3d OH 1665 CH S Q1a a bond H a bond NH O NH T3e OH 1666 CH S Q1a a bond H a bond NH O NH T3f OH 1667 CH S Q1a a bond H a bond NH O NH T3g OH 1668 CH S Q1a a bond H a bond NH O NH T3h OH 1669 CH S Q1a a bond H a bond NH O NH T3i OH 1670 CH S Q1a a bond H a bond NH O NH T3j OH 1671 CH S Q1a a bond H a bond NH O a bond T3a OH 1672 CH S Q1a a bond H a bond NH O a bond T3b OH 1673 CH S Q1a a bond H a bond NH O a bond T3c OH 1674 CH S Q1a a bond H a bond NH O a bond T3d OH 1675 CH S Q1a a bond H a bond NH O a bond T3e OH 1676 CH S Q1a a bond H a bond NH O a bond T3f OH 1677 CH S Q1a a bond H a bond NH O a bond T3g OH 1678 CH S Q1a a bond H a bond NH O a bond T3h OH 1679 CH S Q1a a bond H a bond NH O a bond T3i OH 1680 CH S Q1a a bond H a bond NH O a bond T3j OH 1681 CH S Q1b a bond Me a bond NH S NH T3a OH 1682 CH S Q1b a bond Me a bond NH S NH T3b OH 1683 CH S Q1b a bond Me a bond NH S NH T3c OH 1684 CH S Q1b a bond Me a bond NH S NH T3d OH 1685 CH S Q1b a bond Me a bond NH S NH T3e OH 1686 CH S Q1b a bond Me a bond NH S NH T3f OH 1687 CH S Q1b a bond Me a bond NH S NH T3g OH 1688 CH S Q1b a bond Me a bond NH S NH T3h OH 1689 CH S Q1b a bond Me a bond NH S NH T3i OH 1690 CH S Q1b a bond Me a bond NH S NH T3j OH 1691 CH S Q1b a bond Me a bond NH S a bond T3a OH 1692 CH S Q1b a bond Me a bond NH S a bond T3b OH 1693 CH S Q1b a bond Me a bond NH S a bond T3c OH 1694 CH S Q1b a bond Me a bond NH S a bond T3d OH 1695 CH S Q1b a bond Me a bond NH S a bond T3e OH 1696 CH S Q1b a bond Me a bond NH S a bond T3f OH 1697 CH S Q1b a bond Me a bond NH S a bond T3g OH 1698 CH S Q1b a bond Me a bond NH S a bond T3h OH 1699 CH S Q1b a bond Me a bond NH S a bond T3i OH 1700 CH S Q1b a bond Me a bond NH S a bond T3j OH 1701 CH S Q1b a bond Me a bond NH O NH T3a OH 1702 CH S Q1b a bond Me a bond NH O NH T3b OH 1703 CH S Q1b a bond Me a bond NH O NH T3c OH 1704 CH S Q1b a bond Me a bond NH O NH T3d OH 1705 CH S Q1b a bond Me a bond NH O NH T3e OH 1706 CH S Q1b a bond Me a bond NH O NH T3f OH 1707 CH S Q1b a bond Me a bond NH O NH T3g OH 1708 CH S Q1b a bond Me a bond NH O NH T3h OH 1709 CH S Q1b a bond Me a bond NH O NH T3i OH 1710 CH S Q1b a bond Me a bond NH O NH T3j OH 1711 CH S Q1b a bond Me a bond NH O a bond T3a OH 1712 CH S Q1b a bond Me a bond NH O a bond T3b OH 1713 CH S Q1b a bond Me a bond NH O a bond T3c OH 1714 CH S Q1b a bond Me a bond NH O a bond T3d OH 1715 CH S Q1b a bond Me a bond NH O a bond T3e OH 1716 CH S Q1b a bond Me a bond NH O a bond T3f OH 1717 CH S Q1b a bond Me a bond NH O a bond T3g OH 1718 CH S Q1b a bond Me a bond NH O a bond T3h OH 1719 CH S Q1b a bond Me a bond NH O a bond T3i OH 1720 CH S Q1b a bond Me a bond NH O a bond T3j OH 1721 CH S Q1b a bond H a bond NH S NH T3a OH 1722 CH S Q1b a bond H a bond NH S NH T3b OH 1723 CH S Q1b a bond H a bond NH S NH T3c OH 1724 CH S Q1b a bond H a bond NH S NH T3d OH 1725 CH S Q1b a bond H a bond NH S NH T3e OH 1726 CH S Q1b a bond H a bond NH S NH T3f OH 1727 CH S Q1b a bond H a bond NH S NH T3g OH 1728 CH S Q1b a bond H a bond NH S NH T3h OH 1729 CH S Q1b a bond H a bond NH S NH T3i OH 1730 CH S Q1b a bond H a bond NH S NH T3j OH 1731 CH S Q1b a bond H a bond NH S a bond T3a OH 1732 CH S Q1b a bond H a bond NH S a bond T3b OH 1733 CH S Q1b a bond H a bond NH S a bond T3c OH 1734 CH S Q1b a bond H a bond NH S a bond T3d OH 1735 CH S Q1b a bond H a bond NH S a bond T3e OH 1736 CH S Q1b a bond H a bond NH S a bond T3f OH 1737 CH S Q1b a bond H a bond NH S a bond T3g OH 1738 CH S Q1b a bond H a bond NH S a bond T3h OH 1739 CH S Q1b a bond H a bond NH S a bond T3i OH 1740 CH S Q1b a bond H a bond NH S a bond T3j OH 1741 CH S Q1b a bond H a bond NH O NH T3a OH 1742 CH S Q1b a bond H a bond NH O NH T3b OH 1743 CH S Q1b a bond H a bond NH O NH T3c OH 1744 CH S Q1b a bond H a bond NH O NH T3d OH 1745 CH S Q1b a bond H a bond NH O NH T3e OH 1746 CH S Q1b a bond H a bond NH O NH T3f OH 1747 CH S Q1b a bond H a bond NH O NH T3g OH 1748 CH S Q1b a bond H a bond NH O NH T3h OH 1749 CH S Q1b a bond H a bond NH O NH T3i OH 1750 CH S Q1b a bond H a bond NH O NH T3j OH 1751 CH S Q1b a bond H a bond NH O a bond T3a OH 1752 CH S Q1b a bond H a bond NH O a bond T3b OH 1753 CH S Q1b a bond H a bond NH O a bond T3c OH 1754 CH S Q1b a bond H a bond NH O a bond T3d OH 1755 CH S Q1b a bond H a bond NH O a bond T3e OH 1756 CH S Q1b a bond H a bond NH O a bond T3f OH 1757 CH S Q1b a bond H a bond NH O a bond T3g OH 1758 CH S Q1b a bond H a bond NH O a bond T3h OH 1759 CH S Q1b a bond H a bond NH O a bond T3i OH 1760 CH S Q1b a bond H a bond NH O a bond T3j OH 1761 CH S Q1c a bond Me a bond NH S NH T3a OH 1762 CH S Q1c a bond Me a bond NH S NH T3b OH 1763 CH S Q1c a bond Me a bond NH S NH T3c OH 1764 CH S Q1c a bond Me a bond NH S NH T3d OH 1765 CH S Q1c a bond Me a bond NH S NH T3e OH 1766 CH S Q1c a bond Me a bond NH S NH T3f OH 1767 CH S Q1c a bond Me a bond NH S NH T3g OH 1768 CH S Q1c a bond Me a bond NH S NH T3h OH 1769 CH S Q1c a bond Me a bond NH S NH T3i OH 1770 CH S Q1c a bond Me a bond NH S NH T3j OH 1771 CH S Q1c a bond Me a bond NH S a bond T3a OH 1772 CH S Q1c a bond Me a bond NH S a bond T3b OH 1773 CH S Q1c a bond Me a bond NH S a bond T3c OH 1774 CH S Q1c a bond Me a bond NH S a bond T3d OH 1775 CH S Q1c a bond Me a bond NH S a bond T3e OH 1776 CH S Q1c a bond Me a bond NH S a bond T3f OH 1777 CH S Q1c a bond Me a bond NH S a bond T3g OH 1778 CH S Q1c a bond Me a bond NH S a bond T3h OH 1779 CH S Q1c a bond Me a bond NH S a bond T3i OH 1780 CH S Q1c a bond Me a bond NH S a bond T3j OH 1781 CH S Q1c a bond Me a bond NH O NH T3a OH 1782 CH S Q1c a bond Me a bond NH O NH T3b OH 1783 CH S Q1c a bond Me a bond NH O NH T3c OH 1784 CH S Q1c a bond Me a bond NH O NH T3d OH 1785 CH S Q1c a bond Me a bond NH O NH T3e OH 1786 CH S Q1c a bond Me a bond NH O NH T3f OH 1787 CH S Q1c a bond Me a bond NH O NH T3g OH 1788 CH S Q1c a bond Me a bond NH O NH T3h OH 1789 CH S Q1c a bond Me a bond NH O NH T3i OH 1790 CH S Q1c a bond Me a bond NH O NH T3j OH 1791 CH S Q1c a bond Me a bond NH O a bond T3a OH 1792 CH S Q1c a bond Me a bond NH O a bond T3b OH 1793 CH S Q1c a bond Me a bond NH O a bond T3c OH 1794 CH S Q1c a bond Me a bond NH O a bond T3d OH 1795 CH S Q1c a bond Me a bond NH O a bond T3e OH 1796 CH S Q1c a bond Me a bond NH O a bond T3f OH 1797 CH S Q1c a bond Me a bond NH O a bond T3g OH 1798 CH S Q1c a bond Me a bond NH O a bond T3h OH 1799 CH S Q1c a bond Me a bond NH O a bond T3i OH 1800 CH S Q1c a bond Me a bond NH O a bond T3j OH 1801 CH S Q1c a bond H a bond NH S NH T3a OH 1802 CH S Q1c a bond H a bond NH S NH T3b OH 1803 CH S Q1c a bond H a bond NH S NH T3c OH 1804 CH S Q1c a bond H a bond NH S NH T3d OH 1805 CH S Q1c a bond H a bond NH S NH T3e OH 1806 CH S Q1c a bond H a bond NH S NH T3f OH 1807 CH S Q1c a bond H a bond NH S NH T3g OH 1808 CH S Q1c a bond H a bond NH S NH T3h OH 1809 CH S Q1c a bond H a bond NH S NH T3i OH 1810 CH S Q1c a bond H a bond NH S NH T3j OH 1811 CH S Q1c a bond H a bond NH S a bond T3a OH 1812 CH S Q1c a bond H a bond NH S a bond T3b OH 1813 CH S Q1c a bond H a bond NH S a bond T3c OH 1814 CH S Q1c a bond H a bond NH S a bond T3d OH 1815 CH S Q1c a bond H a bond NH S a bond T3e OH 1816 CH S Q1c a bond H a bond NH S a bond T3f OH 1817 CH S Q1c a bond H a bond NH S a bond T3g OH 1818 CH S Q1c a bond H a bond NH S a bond T3h OH 1819 CH S Q1c a bond H a bond NH S a bond T3i OH 1820 CH S Q1c a bond H a bond NH S a bond T3j OH 1821 CH S Q1c a bond H a bond NH O NH T3a OH 1822 CH S Q1c a bond H a bond NH O NH T3b OH 1823 CH S Q1c a bond H a bond NH O NH T3c OH 1824 CH S Q1c a bond H a bond NH O NH T3d OH 1825 CH S Q1c a bond H a bond NH O NH T3e OH 1826 CH S Q1c a bond H a bond NH O NH T3f OH 1827 CH S Q1c a bond H a bond NH O NH T3g OH 1828 CH S Q1c a bond H a bond NH O NH T3h OH 1829 CH S Q1c a bond H a bond NH O NH T3i OH 1830 CH S Q1c a bond H a bond NH O NH T3j OH 1831 CH S Q1c a bond H a bond NH O a bond T3a OH 1832 CH S Q1c a bond H a bond NH O a bond T3b OH 1833 CH S Q1c a bond H a bond NH O a bond T3c OH 1834 CH S Q1c a bond H a bond NH O a bond T3d OH 1835 CH S Q1c a bond H a bond NH O a bond T3e OH 1836 CH S Q1c a bond H a bond NH O a bond T3f OH 1837 CH S Q1c a bond H a bond NH O a bond T3g OH 1838 CH S Q1c a bond H a bond NH O a bond T3h OH 1839 CH S Q1c a bond H a bond NH O a bond T3i OH 1840 CH S Q1c a bond H a bond NH O a bond T3j OH 1841 CH S Q1i a bond Me a bond NH S NH T3a OH 1842 CH S Q1i a bond Me a bond NH S NH T3b OH 1843 CH S Q1i a bond Me a bond NH S NH T3c OH 1844 CH S Q1i a bond Me a bond NH S NH T3d OH 1845 CH S Q1i a bond Me a bond NH S NH T3e OH 1846 CH S Q1i a bond Me a bond NH S NH T3f OH 1847 CH S Q1i a bond Me a bond NH S NH T3g OH 1848 CH S Q1i a bond Me a bond NH S NH T3h OH 1849 CH S Q1i a bond Me a bond NH S NH T3i OH 1850 CH S Q1i a bond Me a bond NH S NH T3j OH 1851 CH S Q1i a bond Me a bond NH S a bond T3a OH 1852 CH S Q1i a bond Me a bond NH S a bond T3b OH 1853 CH S Q1i a bond Me a bond NH S a bond T3c OH 1854 CH S Q1i a bond Me a bond NH S a bond T3d OH 1855 CH S Q1i a bond Me a bond NH S a bond T3e OH 1856 CH S Q1i a bond Me a bond NH S a bond T3f OH 1857 CH S Q1i a bond Me a bond NH S a bond T3g OH 1858 CH S Q1i a bond Me a bond NH S a bond T3h OH 1859 CH S Q1i a bond Me a bond NH S a bond T3i OH 1860 CH S Q1i a bond Me a bond NH S a bond T3j OH 1861 CH S Q1i a bond Me a bond NH O NH T3a OH 1862 CH S Q1i a bond Me a bond NH O NH T3b OH 1863 CH S Q1i a bond Me a bond NH O NH T3c OH 1864 CH S Q1i a bond Me a bond NH O NH T3d OH 1865 CH S Q1i a bond Me a bond NH O NH T3e OH 1866 CH S Q1i a bond Me a bond NH O NH T3f OH 1867 CH S Q1i a bond Me a bond NH O NH T3g OH 1868 CH S Q1i a bond Me a bond NH O NH T3h OH 1869 CH S Q1i a bond Me a bond NH O NH T3i OH 1870 CH S Q1i a bond Me a bond NH O NH T3j OH 1871 CH S Q1i a bond Me a bond NH O a bond T3a OH 1872 CH S Q1i a bond Me a bond NH O a bond T3b OH 1873 CH S Q1i a bond Me a bond NH O a bond T3c OH 1874 CH S Q1i a bond Me a bond NH O a bond T3d OH 1875 CH S Q1i a bond Me a bond NH O a bond T3e OH 1876 CH S Q1i a bond Me a bond NH O a bond T3f OH 1877 CH S Q1i a bond Me a bond NH O a bond T3g OH 1878 CH S Q1i a bond Me a bond NH O a bond T3h OH 1879 CH S Q1i a bond Me a bond NH O a bond T3i OH 1880 CH S Q1i a bond Me a bond NH O a bond T3j OH 1881 CH S Q1i a bond H a bond NH S NH T3a OH 1882 CH S Q1i a bond H a bond NH S NH T3b OH 1883 CH S Q1i a bond H a bond NH S NH T3c OH 1884 CH S Q1i a bond H a bond NH S NH T3d OH 1885 CH S Q1i a bond H a bond NH S NH T3e OH 1886 CH S Q1i a bond H a bond NH S NH T3f OH 1887 CH S Q1i a bond H a bond NH S NH T3g OH 1888 CH S Q1i a bond H a bond NH S NH T3h OH 1889 CH S Q1i a bond H a bond NH S NH T3i OH 1890 CH S Q1i a bond H a bond NH S NH T3j OH 1891 CH S Q1i a bond H a bond NH S a bond T3a OH 1892 CH S Q1i a bond H a bond NH S a bond T3b OH 1893 CH S Q1i a bond H a bond NH S a bond T3c OH 1894 CH S Q1i a bond H a bond NH S a bond T3d OH 1895 CH S Q1i a bond H a bond NH S a bond T3e OH 1896 CH S Q1i a bond H a bond NH S a bond T3f OH 1897 CH S Q1i a bond H a bond NH S a bond T3g OH 1898 CH S Q1i a bond H a bond NH S a bond T3h OH 1899 CH S Q1i a bond H a bond NH S a bond T3i OH 1900 CH S Q1i a bond H a bond NH S a bond T3j OH 1901 CH S Q1i a bond H a bond NH O NH T3a OH 1902 CH S Q1i a bond H a bond NH O NH T3b OH 1903 CH S Q1i a bond H a bond NH O NH T3c OH 1904 CH S Q1i a bond H a bond NH O NH T3d OH 1905 CH S Q1i a bond H a bond NH O NH T3e OH 1906 CH S Q1i a bond H a bond NH O NH T3f OH 1907 CH S Q1i a bond H a bond NH O NH T3g OH 1908 CH S Q1i a bond H a bond NH O NH T3h OH 1909 CH S Q1i a bond H a bond NH O NH T3i OH 1910 CH S Q1i a bond H a bond NH O NH T3j OH 1911 CH S Q1i a bond H a bond NH O a bond T3a OH 1912 CH S Q1i a bond H a bond NH O a bond T3b OH 1913 CH S Q1i a bond H a bond NH O a bond T3c OH 1914 CH S Q1i a bond H a bond NH O a bond T3d OH 1915 CH S Q1i a bond H a bond NH O a bond T3e OH 1916 CH S Q1i a bond H a bond NH O a bond T3f OH 1917 CH S Q1i a bond H a bond NH O a bond T3g OH 1918 CH S Q1i a bond H a bond NH O a bond T3h OH 1919 CH S Q1i a bond H a bond NH O a bond T3i OH 1920 CH S Q1i a bond H a bond NH O a bond T3j OH 1921 CH S Q1j a bond Me a bond NH S NH T3a OH 1922 CH S Q1j a bond Me a bond NH S NH T3b OH 1923 CH S Q1j a bond Me a bond NH S NH T3c OH 1924 CH S Q1j a bond Me a bond NH S NH T3d OH 1925 CH S Q1j a bond Me a bond NH S NH T3e OH 1926 CH S Q1j a bond Me a bond NH S NH T3f OH 1927 CH S Q1j a bond Me a bond NH S NH T3g OH 1928 CH S Q1j a bond Me a bond NH S NH T3h OH 1929 CH S Q1j a bond Me a bond NH S NH T3i OH 1930 CH S Q1j a bond Me a bond NH S NH T3j OH 1931 CH S Q1j a bond Me a bond NH S a bond T3a OH 1932 CH S Q1j a bond Me a bond NH S a bond T3b OH 1933 CH S Q1j a bond Me a bond NH S a bond T3c OH 1934 CH S Q1j a bond Me a bond NH S a bond T3d OH 1935 CH S Q1j a bond Me a bond NH S a bond T3e OH 1936 CH S Q1j a bond Me a bond NH S a bond T3f OH 1937 CH S Q1j a bond Me a bond NH S a bond T3g OH 1938 CH S Q1j a bond Me a bond NH S a bond T3h OH 1939 CH S Q1j a bond Me a bond NH S a bond T3i OH 1940 CH S Q1j a bond Me a bond NH S a bond T3j OH 1941 CH S Q1j a bond Me a bond NH O NH T3a OH 1942 CH S Q1j a bond Me a bond NH O NH T3b OH 1943 CH S Q1j a bond Me a bond NH O NH T3c OH 1944 CH S Q1j a bond Me a bond NH O NH T3d OH 1945 CH S Q1j a bond Me a bond NH O NH T3e OH 1946 CH S Q1j a bond Me a bond NH O NH T3f OH 1947 CH S Q1j a bond Me a bond NH O NH T3g OH 1948 CH S Q1j a bond Me a bond NH O NH T3h OH 1949 CH S Q1j a bond Me a bond NH O NH T3i OH 1950 CH S Q1j a bond Me a bond NH O NH T3j OH 1951 CH S Q1j a bond Me a bond NH O a bond T3a OH 1952 CH S Q1j a bond Me a bond NH O a bond T3b OH 1953 CH S Q1j a bond Me a bond NH O a bond T3c OH 1954 CH S Q1j a bond Me a bond NH O a bond T3d OH 1955 CH S Q1j a bond Me a bond NH O a bond T3e OH 1956 CH S Q1j a bond Me a bond NH O a bond T3f OH 1957 CH S Q1j a bond Me a bond NH O a bond T3g OH 1958 CH S Q1j a bond Me a bond NH O a bond T3h OH 1959 CH S Q1j a bond Me a bond NH O a bond T3i OH 1960 CH S Q1j a bond Me a bond NH O a bond T3j OH 1961 CH S Q1j a bond H a bond NH S NH T3a OH 1962 CH S Q1j a bond H a bond NH S NH T3b OH 1963 CH S Q1j a bond H a bond NH S NH T3c OH 1964 CH S Q1j a bond H a bond NH S NH T3d OH 1965 CH S Q1j a bond H a bond NH S NH T3e OH 1966 CH S Q1j a bond H a bond NH S NH T3f OH 1967 CH S Q1j a bond H a bond NH S NH T3g OH 1968 CH S Q1j a bond H a bond NH S NH T3h OH 1969 CH S Q1j a bond H a bond NH S NH T3i OH 1970 CH S Q1j a bond H a bond NH S NH T3j OH 1971 CH S Q1j a bond H a bond NH S a bond T3a OH 1972 CH S Q1j a bond H a bond NH S a bond T3b OH 1973 CH S Q1j a bond H a bond NH S a bond T3c OH 1974 CH S Q1j a bond H a bond NH S a bond T3d OH 1975 CH S Q1j a bond H a bond NH S a bond T3e OH 1976 CH S Q1j a bond H a bond NH S a bond T3f OH 1977 CH S Q1j a bond H a bond NH S a bond T3g OH 1978 CH S Q1j a bond H a bond NH S a bond T3h OH 1979 CH S Q1j a bond H a bond NH S a bond T3i OH 1980 CH S Q1j a bond H a bond NH S a bond T3j OH 1981 CH S Q1j a bond H a bond NH O NH T3a OH 1982 CH S Q1j a bond H a bond NH O NH T3b OH 1983 CH S Q1j a bond H a bond NH O NH T3c OH 1984 CH S Q1j a bond H a bond NH O NH T3d OH 1985 CH S Q1j a bond H a bond NH O NH T3e OH 1986 CH S Q1j a bond H a bond NH O NH T3f OH 1987 CH S Q1j a bond H a bond NH O NH T3g OH 1988 CH S Q1j a bond H a bond NH O NH T3h OH 1989 CH S Q1j a bond H a bond NH O NH T3i OH 1990 CH S Q1j a bond H a bond NH O NH T3j OH 1991 CH S Q1j a bond H a bond NH O a bond T3a OH 1992 CH S Q1j a bond H a bond NH O a bond T3b OH 1993 CH S Q1j a bond H a bond NH O a bond T3c OH 1994 CH S Q1j a bond H a bond NH O a bond T3d OH 1995 CH S Q1j a bond H a bond NH O a bond T3e OH 1996 CH S Q1j a bond H a bond NH O a bond T3f OH 1997 CH S Q1j a bond H a bond NH O a bond T3g OH 1998 CH S Q1j a bond H a bond NH O a bond T3h OH 1999 CH S Q1j a bond H a bond NH O a bond T3i OH 2000 CH S Q1j a bond H a bond NH O a bond T3j OH 2001 CH O Q1a a bond Me a bond NH S NH T3a OH 2002 CH O Q1a a bond Me a bond NH S NH T3b OH 2003 CH O Q1a a bond Me a bond NH S NH T3c OH 2004 CH O Q1a a bond Me a bond NH S NH T3d OH 2005 CH O Q1a a bond Me a bond NH S NH T3e OH 2006 CH O Q1a a bond Me a bond NH S NH T3f OH 2007 CH O Q1a a bond Me a bond NH S NH T3g OH 2008 CH O Q1a a bond Me a bond NH S NH T3h OH 2009 CH O Q1a a bond Me a bond NH S NH T3i OH 2010 CH O Q1a a bond Me a bond NH S NH T3j OH 2011 CH O Q1a a bond Me a bond NH S a bond T3a OH 2012 CH O Q1a a bond Me a bond NH S a bond T3b OH 2013 CH O Q1a a bond Me a bond NH S a bond T3c OH 2014 CH O Q1a a bond Me a bond NH S a bond T3d OH 2015 CH O Q1a a bond Me a bond NH S a bond T3e OH 2016 CH O Q1a a bond Me a bond NH S a bond T3f OH 2017 CH O Q1a a bond Me a bond NH S a bond T3g OH 2018 CH O Q1a a bond Me a bond NH S a bond T3h OH 2019 CH O Q1a a bond Me a bond NH S a bond T3i OH 2020 CH O Q1a a bond Me a bond NH S a bond T3j OH 2021 CH O Q1a a bond Me a bond NH O NH T3a OH 2022 CH O Q1a a bond Me a bond NH O NH T3b OH 2023 CH O Q1a a bond Me a bond NH O NH T3c OH 2024 CH O Q1a a bond Me a bond NH O NH T3d OH 2025 CH O Q1a a bond Me a bond NH O NH T3e OH 2026 CH O Q1a a bond Me a bond NH O NH T3f OH 2027 CH O Q1a a bond Me a bond NH O NH T3g OH 2028 CH O Q1a a bond Me a bond NH O NH T3h OH 2029 CH O Q1a a bond Me a bond NH O NH T3i OH 2030 CH O Q1a a bond Me a bond NH O NH T3j OH 2031 CH O Q1a a bond Me a bond NH O a bond T3a OH 2032 CH O Q1a a bond Me a bond NH O a bond T3b OH 2033 CH O Q1a a bond Me a bond NH O a bond T3c OH 2034 CH O Q1a a bond Me a bond NH O a bond T3d OH 2035 CH O Q1a a bond Me a bond NH O a bond T3e OH 2036 CH O Q1a a bond Me a bond NH O a bond T3f OH 2037 CH O Q1a a bond Me a bond NH O a bond T3g OH 2038 CH O Q1a a bond Me a bond NH O a bond T3h OH 2039 CH O Q1a a bond Me a bond NH O a bond T3i OH 2040 CH O Q1a a bond Me a bond NH O a bond T3j OH 2041 CH O Q1a a bond H a bond NH S NH T3a OH 2042 CH O Q1a a bond H a bond NH S NH T3b OH 2043 CH O Q1a a bond H a bond NH S NH T3c OH 2044 CH O Q1a a bond H a bond NH S NH T3d OH 2045 CH O Q1a a bond H a bond NH S NH T3e OH 2046 CH O Q1a a bond H a bond NH S NH T3f OH 2047 CH O Q1a a bond H a bond NH S NH T3g OH 2048 CH O Q1a a bond H a bond NH S NH T3h OH 2049 CH O Q1a a bond H a bond NH S NH T3i OH 2050 CH O Q1a a bond H a bond NH S NH T3j OH 2051 CH O Q1a a bond H a bond NH S a bond T3a OH 2052 CH O Q1a a bond H a bond NH S a bond T3b OH 2053 CH O Q1a a bond H a bond NH S a bond T3c OH 2054 CH O Q1a a bond H a bond NH S a bond T3d OH 2055 CH O Q1a a bond H a bond NH S a bond T3e OH 2056 CH O Q1a a bond H a bond NH S a bond T3f OH 2057 CH O Q1a a bond H a bond NH S a bond T3g OH 2058 CH O Q1a a bond H a bond NH S a bond T3h OH 2059 CH O Q1a a bond H a bond NH S a bond T3i OH 2060 CH O Q1a a bond H a bond NH S a bond T3j OH 2061 CH O Q1a a bond H a bond NH O NH T3a OH 2062 CH O Q1a a bond H a bond NH O NH T3b OH 2063 CH O Q1a a bond H a bond NH O NH T3c OH 2064 CH O Q1a a bond H a bond NH O NH T3d OH 2065 CH O Q1a a bond H a bond NH O NH T3e OH 2066 CH O Q1a a bond H a bond NH O NH T3f OH 2067 CH O Q1a a bond H a bond NH O NH T3g OH 2068 CH O Q1a a bond H a bond NH O NH T3h OH 2069 CH O Q1a a bond H a bond NH O NH T3i OH 2070 CH O Q1a a bond H a bond NH O NH T3j OH 2071 CH O Q1a a bond H a bond NH O a bond T3a OH 2072 CH O Q1a a bond H a bond NH O a bond T3b OH 2073 CH O Q1a a bond H a bond NH O a bond T3c OH 2074 CH O Q1a a bond H a bond NH O a bond T3d OH 2075 CH O Q1a a bond H a bond NH O a bond T3e OH 2076 CH O Q1a a bond H a bond NH O a bond T3f OH 2077 CH O Q1a a bond H a bond NH O a bond T3g OH 2078 CH O Q1a a bond H a bond NH O a bond T3h OH 2079 CH O Q1a a bond H a bond NH O a bond T3i OH 2080 CH O Q1a a bond H a bond NH O a bond T3j OH 2081 CH O Q1b a bond Me a bond NH S NH T3a OH 2082 CH O Q1b a bond Me a bond NH S NH T3b OH 2083 CH O Q1b a bond Me a bond NH S NH T3c OH 2084 CH O Q1b a bond Me a bond NH S NH T3d OH 2085 CH O Q1b a bond Me a bond NH S NH T3e OH 2086 CH O Q1b a bond Me a bond NH S NH T3f OH 2087 CH O Q1b a bond Me a bond NH S NH T3g OH 2088 CH O Q1b a bond Me a bond NH S NH T3h OH 2089 CH O Q1b a bond Me a bond NH S NH T3i OH 2090 CH O Q1b a bond Me a bond NH S NH T3j OH 2091 CH O Q1b a bond Me a bond NH S a bond T3a OH 2092 CH O Q1b a bond Me a bond NH S a bond T3b OH 2093 CH O Q1b a bond Me a bond NH S a bond T3c OH 2094 CH O Q1b a bond Me a bond NH S a bond T3d OH 2095 CH O Q1b a bond Me a bond NH S a bond T3e OH 2096 CH O Q1b a bond Me a bond NH S a bond T3f OH 2097 CH O Q1b a bond Me a bond NH S a bond T3g OH 2098 CH O Q1b a bond Me a bond NH S a bond T3h OH 2099 CH O Q1b a bond Me a bond NH S a bond T3i OH 2100 CH O Q1b a bond Me a bond NH S a bond T3j OH 2101 CH O Q1b a bond Me a bond NH O NH T3a OH 2102 CH O Q1b a bond Me a bond NH O NH T3b OH 2103 CH O Q1b a bond Me a bond NH O NH T3c OH 2104 CH O Q1b a bond Me a bond NH O NH T3d OH 2105 CH O Q1b a bond Me a bond NH O NH T3e OH 2106 CH O Q1b a bond Me a bond NH O NH T3f OH 2107 CH O Q1b a bond Me a bond NH O NH T3g OH 2108 CH O Q1b a bond Me a bond NH O NH T3h OH 2109 CH O Q1b a bond Me a bond NH O NH T3i OH 2110 CH O Q1b a bond Me a bond NH O NH T3j OH 2111 CH O Q1b a bond Me a bond NH O a bond T3a OH 2112 CH O Q1b a bond Me a bond NH O a bond T3b OH 2113 CH O Q1b a bond Me a bond NH O a bond T3c OH 2114 CH O Q1b a bond Me a bond NH O a bond T3d OH 2115 CH O Q1b a bond Me a bond NH O a bond T3e OH 2116 CH O Q1b a bond Me a bond NH O a bond T3f OH 2117 CH O Q1b a bond Me a bond NH O a bond T3g OH 2118 CH O Q1b a bond Me a bond NH O a bond T3h OH 2119 CH O Q1b a bond Me a bond NH O a bond T3i OH 2120 CH O Q1b a bond Me a bond NH O a bond T3j OH 2121 CH O Q1b a bond H a bond NH S NH T3a OH 2122 CH O Q1b a bond H a bond NH S NH T3b OH 2123 CH O Q1b a bond H a bond NH S NH T3c OH 2124 CH O Q1b a bond H a bond NH S NH T3d OH 2125 CH O Q1b a bond H a bond NH S NH T3e OH 2126 CH O Q1b a bond H a bond NH S NH T3f OH 2127 CH O Q1b a bond H a bond NH S NH T3g OH 2128 CH O Q1b a bond H a bond NH S NH T3h OH 2129 CH O Q1b a bond H a bond NH S NH T3i OH 2130 CH O Q1b a bond H a bond NH S NH T3j OH 2131 CH O Q1b a bond H a bond NH S a bond T3a OH 2132 CH O Q1b a bond H a bond NH S a bond T3b OH 2133 CH O Q1b a bond H a bond NH S a bond T3c OH 2134 CH O Q1b a bond H a bond NH S a bond T3d OH 2135 CH O Q1b a bond H a bond NH S a bond T3e OH 2136 CH O Q1b a bond H a bond NH S a bond T3f OH 2137 CH O Q1b a bond H a bond NH S a bond T3g OH 2138 CH O Q1b a bond H a bond NH S a bond T3h OH 2139 CH O Q1b a bond H a bond NH S a bond T3i OH 2140 CH O Q1b a bond H a bond NH S a bond T3j OH 2141 CH O Q1b a bond H a bond NH O NH T3a OH 2142 CH O Q1b a bond H a bond NH O NH T3b OH 2143 CH O Q1b a bond H a bond NH O NH T3c OH 2144 CH O Q1b a bond H a bond NH O NH T3d OH 2145 CH O Q1b a bond H a bond NH O NH T3e OH 2146 CH O Q1b a bond H a bond NH O NH T3f OH 2147 CH O Q1b a bond H a bond NH O NH T3g OH 2148 CH O Q1b a bond H a bond NH O NH T3h OH 2149 CH O Q1b a bond H a bond NH O NH T3i OH 2150 CH O Q1b a bond H a bond NH O NH T3j OH 2151 CH O Q1b a bond H a bond NH O a bond T3a OH 2152 CH O Q1b a bond H a bond NH O a bond T3b OH 2153 CH O Q1b a bond H a bond NH O a bond T3c OH 2154 CH O Q1b a bond H a bond NH O a bond T3d OH 2155 CH O Q1b a bond H a bond NH O a bond T3e OH 2156 CH O Q1b a bond H a bond NH O a bond T3f OH 2157 CH O Q1b a bond H a bond NH O a bond T3g OH 2158 CH O Q1b a bond H a bond NH O a bond T3h OH 2159 CH O Q1b a bond H a bond NH O a bond T3i OH 2160 CH O Q1b a bond H a bond NH O a bond T3j OH 2161 CH O Q1c a bond Me a bond NH S NH T3a OH 2162 CH O Q1c a bond Me a bond NH S NH T3b OH 2163 CH O Q1c a bond Me a bond NH S NH T3c OH 2164 CH O Q1c a bond Me a bond NH S NH T3d OH 2165 CH O Q1c a bond Me a bond NH S NH T3e OH 2166 CH O Q1c a bond Me a bond NH S NH T3f OH 2167 CH O Q1c a bond Me a bond NH S NH T3g OH 2168 CH O Q1c a bond Me a bond NH S NH T3h OH 2169 CH O Q1c a bond Me a bond NH S NH T3i OH 2170 CH O Q1c a bond Me a bond NH S NH T3j OH 2171 CH O Q1c a bond Me a bond NH S a bond T3a OH 2172 CH O Q1c a bond Me a bond NH S a bond T3b OH 2173 CH O Q1c a bond Me a bond NH S a bond T3c OH 2174 CH O Q1c a bond Me a bond NH S a bond T3d OH 2175 CH O Q1c a bond Me a bond NH S a bond T3e OH 2176 CH O Q1c a bond Me a bond NH S a bond T3f OH 2177 CH O Q1c a bond Me a bond NH S a bond T3g OH 2178 CH O Q1c a bond Me a bond NH S a bond T3h OH 2179 CH O Q1c a bond Me a bond NH S a bond T3i OH 2180 CH O Q1c a bond Me a bond NH S a bond T3j OH 2181 CH O Q1c a bond Me a bond NH O NH T3a OH 2182 CH O Q1c a bond Me a bond NH O NH T3b OH 2183 CH O Q1c a bond Me a bond NH O NH T3c OH 2184 CH O Q1c a bond Me a bond NH O NH T3d OH 2185 CH O Q1c a bond Me a bond NH O NH T3e OH 2186 CH O Q1c a bond Me a bond NH O NH T3f OH 2187 CH O Q1c a bond Me a bond NH O NH T3g OH 2188 CH O Q1c a bond Me a bond NH O NH T3h OH 2189 CH O Q1c a bond Me a bond NH O NH T3i OH 2190 CH O Q1c a bond Me a bond NH O NH T3j OH 2191 CH O Q1c a bond Me a bond NH O a bond T3a OH 2192 CH O Q1c a bond Me a bond NH O a bond T3b OH 2193 CH O Q1c a bond Me a bond NH O a bond T3c OH 2194 CH O Q1c a bond Me a bond NH O a bond T3d OH 2195 CH O Q1c a bond Me a bond NH O a bond T3e OH 2196 CH O Q1c a bond Me a bond NH O a bond T3f OH 2197 CH O Q1c a bond Me a bond NH O a bond T3g OH 2198 CH O Q1c a bond Me a bond NH O a bond T3h OH 2199 CH O Q1c a bond Me a bond NH O a bond T3i OH 2200 CH O Q1c a bond Me a bond NH O a bond T3j OH 2201 CH O Q1c a bond H a bond NH S NH T3a OH 2202 CH O Q1c a bond H a bond NH S NH T3b OH 2203 CH O Q1c a bond H a bond NH S NH T3c OH 2204 CH O Q1c a bond H a bond NH S NH T3d OH 2205 CH O Q1c a bond H a bond NH S NH T3e OH 2206 CH O Q1c a bond H a bond NH S NH T3f OH 2207 CH O Q1c a bond H a bond NH S NH T3g OH 2208 CH O Q1c a bond H a bond NH S NH T3h OH 2209 CH O Q1c a bond H a bond NH S NH T3i OH 2210 CH O Q1c a bond H a bond NH S NH T3j OH 2211 CH O Q1c a bond H a bond NH S a bond T3a OH 2212 CH O Q1c a bond H a bond NH S a bond T3b OH 2213 CH O Q1c a bond H a bond NH S a bond T3c OH 2214 CH O Q1c a bond H a bond NH S a bond T3d OH 2215 CH O Q1c a bond H a bond NH S a bond T3e OH 2216 CH O Q1c a bond H a bond NH S a bond T3f OH 2217 CH O Q1c a bond H a bond NH S a bond T3g OH 2218 CH O Q1c a bond H a bond NH S a bond T3h OH 2219 CH O Q1c a bond H a bond NH S a bond T3i OH 2220 CH O Q1c a bond H a bond NH S a bond T3j OH 2221 CH O Q1c a bond H a bond NH O NH T3a OH 2222 CH O Q1c a bond H a bond NH O NH T3b OH 2223 CH O Q1c a bond H a bond NH O NH T3c OH 2224 CH O Q1c a bond H a bond NH O NH T3d OH 2225 CH O Q1c a bond H a bond NH O NH T3e OH 2226 CH O Q1c a bond H a bond NH O NH T3f OH 2227 CH O Q1c a bond H a bond NH O NH T3g OH 2228 CH O Q1c a bond H a bond NH O NH T3h OH 2229 CH O Q1c a bond H a bond NH O NH T3i OH 2230 CH O Q1c a bond H a bond NH O NH T3j OH 2231 CH O Q1c a bond H a bond NH O a bond T3a OH 2232 CH O Q1c a bond H a bond NH O a bond T3b OH 2233 CH O Q1c a bond H a bond NH O a bond T3c OH 2234 CH O Q1c a bond H a bond NH O a bond T3d OH 2235 CH O Q1c a bond H a bond NH O a bond T3e OH 2236 CH O Q1c a bond H a bond NH O a bond T3f OH 2237 CH O Q1c a bond H a bond NH O a bond T3g OH 2238 CH O Q1c a bond H a bond NH O a bond T3h OH 2239 CH O Q1c a bond H a bond NH O a bond T3i OH 2240 CH O Q1c a bond H a bond NH O a bond T3j OH 2241 CH O Q1i a bond Me a bond NH S NH T3a OH 2242 CH O Q1i a bond Me a bond NH S NH T3b OH 2243 CH O Q1i a bond Me a bond NH S NH T3c OH 2244 CH O Q1i a bond Me a bond NH S NH T3d OH 2245 CH O Q1i a bond Me a bond NH S NH T3e OH 2246 CH O Q1i a bond Me a bond NH S NH T3f OH 2247 CH O Q1i a bond Me a bond NH S NH T3g OH 2248 CH O Q1i a bond Me a bond NH S NH T3h OH 2249 CH O Q1i a bond Me a bond NH S NH T3i OH 2250 CH O Q1i a bond Me a bond NH S NH T3j OH 2251 CH O Q1i a bond Me a bond NH S a bond T3a OH 2252 CH O Q1i a bond Me a bond NH S a bond T3b OH 2253 CH O Q1i a bond Me a bond NH S a bond T3c OH 2254 CH O Q1i a bond Me a bond NH S a bond T3d OH 2255 CH O Q1i a bond Me a bond NH S a bond T3e OH 2256 CH O Q1i a bond Me a bond NH S a bond T3f OH 2257 CH O Q1i a bond Me a bond NH S a bond T3g OH 2258 CH O Q1i a bond Me a bond NH S a bond T3h OH 2259 CH O Q1i a bond Me a bond NH S a bond T3i OH 2260 CH O Q1i a bond Me a bond NH S a bond T3j OH 2261 CH O Q1i a bond Me a bond NH O NH T3a OH 2262 CH O Q1i a bond Me a bond NH O NH T3b OH 2263 CH O Q1i a bond Me a bond NH O NH T3c OH 2264 CH O Q1i a bond Me a bond NH O NH T3d OH 2265 CH O Q1i a bond Me a bond NH O NH T3e OH 2266 CH O Q1i a bond Me a bond NH O NH T3f OH 2267 CH O Q1i a bond Me a bond NH O NH T3g OH 2268 CH O Q1i a bond Me a bond NH O NH T3h OH 2269 CH O Q1i a bond Me a bond NH O NH T3i OH 2270 CH O Q1i a bond Me a bond NH O NH T3j OH 2271 CH O Q1i a bond Me a bond NH O a bond T3a OH 2272 CH O Q1i a bond Me a bond NH O a bond T3b OH 2273 CH O Q1i a bond Me a bond NH O a bond T3c OH 2274 CH O Q1i a bond Me a bond NH O a bond T3d OH 2275 CH O Q1i a bond Me a bond NH O a bond T3e OH 2276 CH O Q1i a bond Me a bond NH O a bond T3f OH 2277 CH O Q1i a bond Me a bond NH O a bond T3g OH 2278 CH O Q1i a bond Me a bond NH O a bond T3h OH 2279 CH O Q1i a bond Me a bond NH O a bond T3i OH 2280 CH O Q1i a bond Me a bond NH O a bond T3j OH 2281 CH O Q1i a bond H a bond NH S NH T3a OH 2282 CH O Q1i a bond H a bond NH S NH T3b OH 2283 CH O Q1i a bond H a bond NH S NH T3c OH 2284 CH O Q1i a bond H a bond NH S NH T3d OH 2285 CH O Q1i a bond H a bond NH S NH T3e OH 2286 CH O Q1i a bond H a bond NH S NH T3f OH 2287 CH O Q1i a bond H a bond NH S NH T3g OH 2288 CH O Q1i a bond H a bond NH S NH T3h OH 2289 CH O Q1i a bond H a bond NH S NH T3i OH 2290 CH O Q1i a bond H a bond NH S NH T3j OH 2291 CH O Q1i a bond H a bond NH S a bond T3a OH 2292 CH O Q1i a bond H a bond NH S a bond T3b OH 2293 CH O Q1i a bond H a bond NH S a bond T3c OH 2294 CH O Q1i a bond H a bond NH S a bond T3d OH 2295 CH O Q1i a bond H a bond NH S a bond T3e OH 2296 CH O Q1i a bond H a bond NH S a bond T3f OH 2297 CH O Q1i a bond H a bond NH S a bond T3g OH 2298 CH O Q1i a bond H a bond NH S a bond T3h OH 2299 CH O Q1i a bond H a bond NH S a bond T3i OH 2300 CH O Q1i a bond H a bond NH S a bond T3j OH 2301 CH O Q1i a bond H a bond NH O NH T3a OH 2302 CH O Q1i a bond H a bond NH O NH T3b OH 2303 CH O Q1i a bond H a bond NH O NH T3c OH 2304 CH O Q1i a bond H a bond NH O NH T3d OH 2305 CH O Q1i a bond H a bond NH O NH T3e OH 2306 CH O Q1i a bond H a bond NH O NH T3f OH 2307 CH O Q1i a bond H a bond NH O NH T3g OH 2308 CH O Q1i a bond H a bond NH O NH T3h OH 2309 CH O Q1i a bond H a bond NH O NH T3i OH 2310 CH O Q1i a bond H a bond NH O NH T3j OH 2311 CH O Q1i a bond H a bond NH O a bond T3a OH 2312 CH O Q1i a bond H a bond NH O a bond T3b OH 2313 CH O Q1i a bond H a bond NH O a bond T3c OH 2314 CH O Q1i a bond H a bond NH O a bond T3d OH 2315 CH O Q1i a bond H a bond NH O a bond T3e OH 2316 CH O Q1i a bond H a bond NH O a bond T3f OH 2317 CH O Q1i a bond H a bond NH O a bond T3g OH 2318 CH O Q1i a bond H a bond NH O a bond T3h OH 2319 CH O Q1i a bond H a bond NH O a bond T3i OH 2320 CH O Q1i a bond H a bond NH O a bond T3j OH 2321 CH O Q1j a bond Me a bond NH S NH T3a OH 2322 CH O Q1j a bond Me a bond NH S NH T3b OH 2323 CH O Q1j a bond Me a bond NH S NH T3c OH 2324 CH O Q1j a bond Me a bond NH S NH T3d OH 2325 CH O Q1j a bond Me a bond NH S NH T3e OH 2326 CH O Q1j a bond Me a bond NH S NH T3f OH 2327 CH O Q1j a bond Me a bond NH S NH T3g OH 2328 CH O Q1j a bond Me a bond NH S NH T3h OH 2329 CH O Q1j a bond Me a bond NH S NH T3i OH 2330 CH O Q1j a bond Me a bond NH S NH T3j OH 2331 CH O Q1j a bond Me a bond NH S a bond T3a OH 2332 CH O Q1j a bond Me a bond NH S a bond T3b OH 2333 CH O Q1j a bond Me a bond NH S a bond T3c OH 2334 CH O Q1j a bond Me a bond NH S a bond T3d OH 2335 CH O Q1j a bond Me a bond NH S a bond T3e OH 2336 CH O Q1j a bond Me a bond NH S a bond T3f OH 2337 CH O Q1j a bond Me a bond NH S a bond T3g OH 2338 CH O Q1j a bond Me a bond NH S a bond T3h OH 2339 CH O Q1j a bond Me a bond NH S a bond T3i OH 2340 CH O Q1j a bond Me a bond NH S a bond T3j OH 2341 CH O Q1j a bond Me a bond NH O NH T3a OH 2342 CH O Q1j a bond Me a bond NH O NH T3b OH 2343 CH O Q1j a bond Me a bond NH O NH T3c OH 2344 CH O Q1j a bond Me a bond NH O NH T3d OH 2345 CH O Q1j a bond Me a bond NH O NH T3e OH 2346 CH O Q1j a bond Me a bond NH O NH T3f OH 2347 CH O Q1j a bond Me a bond NH O NH T3g OH 2348 CH O Q1j a bond Me a bond NH O NH T3h OH 2349 CH O Q1j a bond Me a bond NH O NH T3i OH 2350 CH O Q1j a bond Me a bond NH O NH T3j OH 2351 CH O Q1j a bond Me a bond NH O a bond T3a OH 2352 CH O Q1j a bond Me a bond NH O a bond T3b OH 2353 CH O Q1j a bond Me a bond NH O a bond T3c OH 2354 CH O Q1j a bond Me a bond NH O a bond T3d OH 2355 CH O Q1j a bond Me a bond NH O a bond T3e OH 2356 CH O Q1j a bond Me a bond NH O a bond T3f OH 2357 CH O Q1j a bond Me a bond NH O a bond T3g OH 2358 CH O Q1j a bond Me a bond NH O a bond T3h OH 2359 CH O Q1j a bond Me a bond NH O a bond T3i OH 2360 CH O Q1j a bond Me a bond NH O a bond T3j OH 2361 CH O Q1j a bond H a bond NH S NH T3a OH 2362 CH O Q1j a bond H a bond NH S NH T3b OH 2363 CH O Q1j a bond H a bond NH S NH T3c OH 2364 CH O Q1j a bond H a bond NH S NH T3d OH 2365 CH O Q1j a bond H a bond NH S NH T3e OH 2366 CH O Q1j a bond H a bond NH S NH T3f OH 2367 CH O Q1j a bond H a bond NH S NH T3g OH 2368 CH O Q1j a bond H a bond NH S NH T3h OH 2369 CH O Q1j a bond H a bond NH S NH T3i OH 2370 CH O Q1j a bond H a bond NH S NH T3j OH 2371 CH O Q1j a bond H a bond NH S a bond T3a OH 2372 CH O Q1j a bond H a bond NH S a bond T3b OH 2373 CH O Q1j a bond H a bond NH S a bond T3c OH 2374 CH O Q1j a bond H a bond NH S a bond T3d OH 2375 CH O Q1j a bond H a bond NH S a bond T3e OH 2376 CH O Q1j a bond H a bond NH S a bond T3f OH 2377 CH O Q1j a bond H a bond NH S a bond T3g OH 2378 CH O Q1j a bond H a bond NH S a bond T3h OH 2379 CH O Q1j a bond H a bond NH S a bond T3i OH 2380 CH O Q1j a bond H a bond NH S a bond T3j OH 2381 CH O Q1j a bond H a bond NH O NH T3a OH 2382 CH O Q1j a bond H a bond NH O NH T3b OH 2383 CH O Q1j a bond H a bond NH O NH T3c OH 2384 CH O Q1j a bond H a bond NH O NH T3d OH 2385 CH O Q1j a bond H a bond NH O NH T3e OH 2386 CH O Q1j a bond H a bond NH O NH T3f OH 2387 CH O Q1j a bond H a bond NH O NH T3g OH 2388 CH O Q1j a bond H a bond NH O NH T3h OH 2389 CH O Q1j a bond H a bond NH O NH T3i OH 2390 CH O Q1j a bond H a bond NH O NH T3j OH 2391 CH O Q1j a bond H a bond NH O a bond T3a OH 2392 CH O Q1j a bond H a bond NH O a bond T3b OH 2393 CH O Q1j a bond H a bond NH O a bond T3c OH 2394 CH O Q1j a bond H a bond NH O a bond T3d OH 2395 CH O Q1j a bond H a bond NH O a bond T3e OH 2396 CH O Q1j a bond H a bond NH O a bond T3f OH 2397 CH O Q1j a bond H a bond NH O a bond T3g OH 2398 CH O Q1j a bond H a bond NH O a bond T3h OH 2399 CH O Q1j a bond H a bond NH O a bond T3i OH 2400 CH O Q1j a bond H a bond NH O a bond T3j OH 2401 CMe NMe Q1a a bond Me a bond NH S NH T3a OH 2402 CMe NMe Q1a a bond Me a bond NH S NH T3b OH 2403 CMe NMe Q1a a bond Me a bond NH S NH T3c OH 2404 CMe NMe Q1a a bond Me a bond NH S NH T3d OH 2405 CMe NMe Q1a a bond Me a bond NH S NH T3e OH 2406 CMe NMe Q1a a bond Me a bond NH S NH T3f OH 2407 CMe NMe Q1a a bond Me a bond NH S NH T3g OH 2408 CMe NMe Q1a a bond Me a bond NH S NH T3h OH 2409 CMe NMe Q1a a bond Me a bond NH S NH T3i OH 2410 CMe NMe Q1a a bond Me a bond NH S NH T3j OH 2411 CMe NMe Q1a a bond Me a bond NH S a bond T3a OH 2412 CMe NMe Q1a a bond Me a bond NH S a bond T3b OH 2413 CMe NMe Q1a a bond Me a bond NH S a bond T3c OH 2414 CMe NMe Q1a a bond Me a bond NH S a bond T3d OH 2415 CMe NMe Q1a a bond Me a bond NH S a bond T3e OH 2416 CMe NMe Q1a a bond Me a bond NH S a bond T3f OH 2417 CMe NMe Q1a a bond Me a bond NH S a bond T3g OH 2418 CMe NMe Q1a a bond Me a bond NH S a bond T3h OH 2419 CMe NMe Q1a a bond Me a bond NH S a bond T3i OH 2420 CMe NMe Q1a a bond Me a bond NH S a bond T3j OH 2421 CMe NMe Q1a a bond Me a bond NH O NH T3a OH 2422 CMe NMe Q1a a bond Me a bond NH O NH T3b OH 2423 CMe NMe Q1a a bond Me a bond NH O NH T3c OH 2424 CMe NMe Q1a a bond Me a bond NH O NH T3d OH 2425 CMe NMe Q1a a bond Me a bond NH O NH T3e OH 2426 CMe NMe Q1a a bond Me a bond NH O NH T3f OH 2427 CMe NMe Q1a a bond Me a bond NH O NH T3g OH 2428 CMe NMe Q1a a bond Me a bond NH O NH T3h OH 2429 CMe NMe Q1a a bond Me a bond NH O NH T3i OH 2430 CMe NMe Q1a a bond Me a bond NH O NH T3j OH 2431 CMe NMe Q1a a bond Me a bond NH O a bond T3a OH 2432 CMe NMe Q1a a bond Me a bond NH O a bond T3b OH 2433 CMe NMe Q1a a bond Me a bond NH O a bond T3c OH 2434 CMe NMe Q1a a bond Me a bond NH O a bond T3d OH 2435 CMe NMe Q1a a bond Me a bond NH O a bond T3e OH 2436 CMe NMe Q1a a bond Me a bond NH O a bond T3f OH 2437 CMe NMe Q1a a bond Me a bond NH O a bond T3g OH 2438 CMe NMe Q1a a bond Me a bond NH O a bond T3h OH 2439 CMe NMe Q1a a bond Me a bond NH O a bond T3i OH 2440 CMe NMe Q1a a bond Me a bond NH O a bond T3j OH 2441 CMe NMe Q1a a bond H a bond NH S NH T3a OH 2442 CMe NMe Q1a a bond H a bond NH S NH T3b OH 2443 CMe NMe Q1a a bond H a bond NH S NH T3c OH 2444 CMe NMe Q1a a bond H a bond NH S NH T3d OH 2445 CMe NMe Q1a a bond H a bond NH S NH T3e OH 2446 CMe NMe Q1a a bond H a bond NH S NH T3f OH 2447 CMe NMe Q1a a bond H a bond NH S NH T3g OH 2448 CMe NMe Q1a a bond H a bond NH S NH T3h OH 2449 CMe NMe Q1a a bond H a bond NH S NH T3i OH 2450 CMe NMe Q1a a bond H a bond NH S NH T3j OH 2451 CMe NMe Q1a a bond H a bond NH S a bond T3a OH 2452 CMe NMe Q1a a bond H a bond NH S a bond T3b OH 2453 CMe NMe Q1a a bond H a bond NH S a bond T3c OH 2454 CMe NMe Q1a a bond H a bond NH S a bond T3d OH 2455 CMe NMe Q1a a bond H a bond NH S a bond T3e OH 2456 CMe NMe Q1a a bond H a bond NH S a bond T3f OH 2457 CMe NMe Q1a a bond H a bond NH S a bond T3g OH 2458 CMe NMe Q1a a bond H a bond NH S a bond T3h OH 2459 CMe NMe Q1a a bond H a bond NH S a bond T3i OH 2460 CMe NMe Q1a a bond H a bond NH S a bond T3j OH 2461 CMe NMe Q1a a bond H a bond NH O NH T3a OH 2462 CMe NMe Q1a a bond H a bond NH O NH T3b OH 2463 CMe NMe Q1a a bond H a bond NH O NH T3c OH 2464 CMe NMe Q1a a bond H a bond NH O NH T3d OH 2465 CMe NMe Q1a a bond H a bond NH O NH T3e OH 2466 CMe NMe Q1a a bond H a bond NH O NH T3f OH 2467 CMe NMe Q1a a bond H a bond NH O NH T3g OH 2468 CMe NMe Q1a a bond H a bond NH O NH T3h OH 2469 CMe NMe Q1a a bond H a bond NH O NH T3i OH 2470 CMe NMe Q1a a bond H a bond NH O NH T3j OH 2471 CMe NMe Q1a a bond H a bond NH O a bond T3a OH 2472 CMe NMe Q1a a bond H a bond NH O a bond T3b OH 2473 CMe NMe Q1a a bond H a bond NH O a bond T3c OH 2474 CMe NMe Q1a a bond H a bond NH O a bond T3d OH 2475 CMe NMe Q1a a bond H a bond NH O a bond T3e OH 2476 CMe NMe Q1a a bond H a bond NH O a bond T3f OH 2477 CMe NMe Q1a a bond H a bond NH O a bond T3g OH 2478 CMe NMe Q1a a bond H a bond NH O a bond T3h OH 2479 CMe NMe Q1a a bond H a bond NH O a bond T3i OH 2480 CMe NMe Q1a a bond H a bond NH O a bond T3j OH 2481 CMe NMe Q1a a bond Me a bond NH S NH T3a OH 2482 CMe NMe Q1b a bond Me a bond NH S NH T3b OH 2483 CMe NMe Q1b a bond Me a bond NH S NH T3c OH 2484 CMe NMe Q1b a bond Me a bond NH S NH T3d OH 2485 CMe NMe Q1b a bond Me a bond NH S NH T3e OH 2486 CMe NMe Q1b a bond Me a bond NH S NH T3f OH 2487 CMe NMe Q1b a bond Me a bond NH S NH T3g OH 2488 CMe NMe Q1b a bond Me a bond NH S NH T3h OH 2489 CMe NMe Q1b a bond Me a bond NH S NH T3i OH 2490 CMe NMe Q1b a bond Me a bond NH S NH T3j OH 2491 CMe NMe Q1b a bond Me a bond NH S a bond T3a OH 2492 CMe NMe Q1b a bond Me a bond NH S a bond T3b OH 2493 CMe NMe Q1b a bond Me a bond NH S a bond T3c OH 2494 CMe NMe Q1b a bond Me a bond NH S a bond T3d OH 2495 CMe NMe Q1b a bond Me a bond NH S a bond T3e OH 2496 CMe NMe Q1b a bond Me a bond NH S a bond T3f OH 2497 CMe NMe Q1b a bond Me a bond NH S a bond T3g OH 2498 CMe NMe Q1b a bond Me a bond NH S a bond T3h OH 2499 CMe NMe Q1b a bond Me a bond NH S a bond T3i OH 2500 CMe NMe Q1b a bond Me a bond NH S a bond T3j OH 2501 CMe NMe Q1b a bond Me a bond NH O NH T3a OH 2502 CMe NMe Q1b a bond Me a bond NH O NH T3b OH 2503 CMe NMe Q1b a bond Me a bond NH O NH T3c OH 2504 CMe NMe Q1b a bond Me a bond NH O NH T3d OH 2505 CMe NMe Q1b a bond Me a bond NH O NH T3e OH 2506 CMe NMe Q1b a bond Me a bond NH O NH T3f OH 2507 CMe NMe Q1b a bond Me a bond NH O NH T3g OH 2508 CMe NMe Q1b a bond Me a bond NH O NH T3h OH 2509 CMe NMe Q1b a bond Me a bond NH O NH T3i OH 2510 CMe NMe Q1b a bond Me a bond NH O NH T3j OH 2511 CMe NMe Q1b a bond Me a bond NH O a bond T3a OH 2512 CMe NMe Q1b a bond Me a bond NH O a bond T3b OH 2513 CMe NMe Q1b a bond Me a bond NH O a bond T3c OH 2514 CMe NMe Q1b a bond Me a bond NH O a bond T3d OH 2515 CMe NMe Q1b a bond Me a bond NH O a bond T3e OH 2516 CMe NMe Q1b a bond Me a bond NH O a bond T3f OH 2517 CMe NMe Q1b a bond Me a bond NH O a bond T3g OH 2518 CMe NMe Q1b a bond Me a bond NH O a bond T3h OH 2519 CMe NMe Q1b a bond Me a bond NH O a bond T3i OH 2520 CMe NMe Q1b a bond Me a bond NH O a bond T3j OH 2521 CMe NMe Q1b a bond H a bond NH S NH T3a OH 2522 CMe NMe Q1b a bond H a bond NH S NH T3b OH 2523 CMe NMe Q1b a bond H a bond NH S NH T3c OH 2524 CMe NMe Q1b a bond H a bond NH S NH T3d OH 2525 CMe NMe Q1b a bond H a bond NH S NH T3e OH 2526 CMe NMe Q1b a bond H a bond NH S NH T3f OH 2527 CMe NMe Q1b a bond H a bond NH S NH T3g OH 2528 CMe NMe Q1b a bond H a bond NH S NH T3h OH 2529 CMe NMe Q1b a bond H a bond NH S NH T3i OH 2530 CMe NMe Q1b a bond H a bond NH S NH T3j OH 2531 CMe NMe Q1b a bond H a bond NH S a bond T3a OH 2532 CMe NMe Q1b a bond H a bond NH S a bond T3b OH 2533 CMe NMe Q1b a bond H a bond NH S a bond T3c OH 2534 CMe NMe Q1b a bond H a bond NH S a bond T3d OH 2535 CMe NMe Q1b a bond H a bond NH S a bond T3e OH 2536 CMe NMe Q1b a bond H a bond NH S a bond T3f OH 2537 CMe NMe Q1b a bond H a bond NH S a bond T3g OH 2538 CMe NMe Q1b a bond H a bond NH S a bond T3h OH 2539 CMe NMe Q1b a bond H a bond NH S a bond T3i OH 2540 CMe NMe Q1b a bond H a bond NH S a bond T3j OH 2541 CMe NMe Q1b a bond H a bond NH O NH T3a OH 2542 CMe NMe Q1b a bond H a bond NH O NH T3b OH 2543 CMe NMe Q1b a bond H a bond NH O NH T3c OH 2544 CMe NMe Q1b a bond H a bond NH O NH T3d OH 2545 CMe NMe Q1b a bond H a bond NH O NH T3e OH 2546 CMe NMe Q1b a bond H a bond NH O NH T3f OH 2547 CMe NMe Q1b a bond H a bond NH O NH T3g OH 2548 CMe NMe Q1b a bond H a bond NH O NH T3h OH 2549 CMe NMe Q1b a bond H a bond NH O NH T3i OH 2550 CMe NMe Q1b a bond H a bond NH O NH T3j OH 2551 CMe NMe Q1b a bond H a bond NH O a bond T3a OH 2552 CMe NMe Q1b a bond H a bond NH O a bond T3b OH 2553 CMe NMe Q1b a bond H a bond NH O a bond T3c OH 2554 CMe NMe Q1b a bond H a bond NH O a bond T3d OH 2555 CMe NMe Q1b a bond H a bond NH O a bond T3e OH 2556 CMe NMe Q1b a bond H a bond NH O a bond T3f OH 2557 CMe NMe Q1b a bond H a bond NH O a bond T3g OH 2558 CMe NMe Q1b a bond H a bond NH O a bond T3h OH 2559 CMe NMe Q1b a bond H a bond NH O a bond T3i OH 2560 CMe NMe Q1b a bond H a bond NH O a bond T3j OH 2561 CMe NMe Q1c a bond Me a bond NH S NH T3a OH 2562 CMe NMe Q1c a bond Me a bond NH S NH T3b OH 2563 CMe NMe Q1c a bond Me a bond NH S NH T3c OH 2564 CMe NMe Q1c a bond Me a bond NH S NH T3d OH 2565 CMe NMe Q1c a bond Me a bond NH S NH T3e OH 2566 CMe NMe Q1c a bond Me a bond NH S NH T3f OH 2567 CMe NMe Q1c a bond Me a bond NH S NH T3g OH 2568 CMe NMe Q1c a bond Me a bond NH S NH T3h OH 2569 CMe NMe Q1c a bond Me a bond NH S NH T3i OH 2570 CMe NMe Q1c a bond Me a bond NH S NH T3j OH 2571 CMe NMe Q1c a bond Me a bond NH S a bond T3a OH 2572 CMe NMe Q1c a bond Me a bond NH S a bond T3b OH 2573 CMe NMe Q1c a bond Me a bond NH S a bond T3c OH 2574 CMe NMe Q1c a bond Me a bond NH S a bond T3d OH 2575 CMe NMe Q1c a bond Me a bond NH S a bond T3e OH 2576 CMe NMe Q1c a bond Me a bond NH S a bond T3f OH 2577 CMe NMe Q1c a bond Me a bond NH S a bond T3g OH 2578 CMe NMe Q1c a bond Me a bond NH S a bond T3h OH 2579 CMe NMe Q1c a bond Me a bond NH S a bond T3i OH 2580 CMe NMe Q1c a bond Me a bond NH S a bond T3j OH 2581 CMe NMe Q1c a bond Me a bond NH O NH T3a OH 2582 CMe NMe Q1c a bond Me a bond NH O NH T3b OH 2583 CMe NMe Q1c a bond Me a bond NH O NH T3c OH 2584 CMe NMe Q1c a bond Me a bond NH O NH T3d OH 2585 CMe NMe Q1c a bond Me a bond NH O NH T3e OH 2586 CMe NMe Q1c a bond Me a bond NH O NH T3f OH 2587 CMe NMe Q1c a bond Me a bond NH O NH T3g OH 2588 CMe NMe Q1c a bond Me a bond NH O NH T3h OH 2589 CMe NMe Q1c a bond Me a bond NH O NH T3i OH 2590 CMe NMe Q1c a bond Me a bond NH O NH T3j OH 2591 CMe NMe Q1c a bond Me a bond NH O a bond T3a OH 2592 CMe NMe Q1c a bond Me a bond NH O a bond T3b OH 2593 CMe NMe Q1c a bond Me a bond NH O a bond T3c OH 2594 CMe NMe Q1c a bond Me a bond NH O a bond T3d OH 2595 CMe NMe Q1c a bond Me a bond NH O a bond T3e OH 2596 CMe NMe Q1c a bond Me a bond NH O a bond T3f OH 2597 CMe NMe Q1c a bond Me a bond NH O a bond T3g OH 2598 CMe NMe Q1c a bond Me a bond NH O a bond T3h OH 2599 CMe NMe Q1c a bond Me a bond NH O a bond T3i OH 2600 CMe NMe Q1c a bond Me a bond NH O a bond T3j OH 2601 CMe NMe Q1c a bond H a bond NH S NH T3a OH 2602 CMe NMe Q1c a bond H a bond NH S NH T3b OH 2603 CMe NMe Q1c a bond H a bond NH S NH T3c OH 2604 CMe NMe Q1c a bond H a bond NH S NH T3d OH 2605 CMe NMe Q1c a bond H a bond NH S NH T3e OH 2606 CMe NMe Q1c a bond H a bond NH S NH T3f OH 2607 CMe NMe Q1c a bond H a bond NH S NH T3g OH 2608 CMe NMe Q1c a bond H a bond NH S NH T3h OH 2609 CMe NMe Q1c a bond H a bond NH S NH T3i OH 2610 CMe NMe Q1c a bond H a bond NH S NH T3j OH 2611 CMe NMe Q1c a bond H a bond NH S a bond T3a OH 2612 CMe NMe Q1c a bond H a bond NH S a bond T3b OH 2613 CMe NMe Q1c a bond H a bond NH S a bond T3c OH 2614 CMe NMe Q1c a bond H a bond NH S a bond T3d OH 2615 CMe NMe Q1c a bond H a bond NH S a bond T3e OH 2616 CMe NMe Q1c a bond H a bond NH S a bond T3f OH 2617 CMe NMe Q1c a bond H a bond NH S a bond T3g OH 2618 CMe NMe Q1c a bond H a bond NH S a bond T3h OH 2619 CMe NMe Q1c a bond H a bond NH S a bond T3i OH 2620 CMe NMe Q1c a bond H a bond NH S a bond T3j OH 2621 CMe NMe Q1c a bond H a bond NH O NH T3a OH 2622 CMe NMe Q1c a bond H a bond NH O NH T3b OH 2623 CMe NMe Q1c a bond H a bond NH O NH T3c OH 2624 CMe NMe Q1c a bond H a bond NH O NH T3d OH 2625 CMe NMe Q1c a bond H a bond NH O NH T3e OH 2626 CMe NMe Q1c a bond H a bond NH O NH T3f OH 2627 CMe NMe Q1c a bond H a bond NH O NH T3g OH 2628 CMe NMe Q1c a bond H a bond NH O NH T3h OH 2629 CMe NMe Q1c a bond H a bond NH O NH T3i OH 2630 CMe NMe Q1c a bond H a bond NH O NH T3j OH 2631 CMe NMe Q1c a bond H a bond NH O a bond T3a OH 2632 CMe NMe Q1c a bond H a bond NH O a bond T3b OH 2633 CMe NMe Q1c a bond H a bond NH O a bond T3c OH 2634 CMe NMe Q1c a bond H a bond NH O a bond T3d OH 2635 CMe NMe Q1c a bond H a bond NH O a bond T3e OH 2636 CMe NMe Q1c a bond H a bond NH O a bond T3f OH 2637 CMe NMe Q1c a bond H a bond NH O a bond T3g OH 2638 CMe NMe Q1c a bond H a bond NH O a bond T3h OH 2639 CMe NMe Q1c a bond H a bond NH O a bond T3i OH 2640 CMe NMe Q1c a bond H a bond NH O a bond T3j OH 2641 CMe NMe Q1i a bond Me a bond NH S NH T3a OH 2642 CMe NMe Q1i a bond Me a bond NH S NH T3b OH 2643 CMe NMe Q1i a bond Me a bond NH S NH T3c OH 2644 CMe NMe Q1i a bond Me a bond NH S NH T3d OH 2645 CMe NMe Q1i a bond Me a bond NH S NH T3e OH 2646 CMe NMe Q1i a bond Me a bond NH S NH T3f OH 2647 CMe NMe Q1i a bond Me a bond NH S NH T3g OH 2648 CMe NMe Q1i a bond Me a bond NH S NH T3h OH 2649 CMe NMe Q1i a bond Me a bond NH S NH T3i OH 2650 CMe NMe Q1i a bond Me a bond NH S NH T3j OH 2651 CMe NMe Q1i a bond Me a bond NH S a bond T3a OH 2652 CMe NMe Q1i a bond Me a bond NH S a bond T3b OH 2653 CMe NMe Q1i a bond Me a bond NH S a bond T3c OH 2654 CMe NMe Q1i a bond Me a bond NH S a bond T3d OH 2655 CMe NMe Q1i a bond Me a bond NH S a bond T3e OH 2656 CMe NMe Q1i a bond Me a bond NH S a bond T3f OH 2657 CMe NMe Q1i a bond Me a bond NH S a bond T3g OH 2658 CMe NMe Q1i a bond Me a bond NH S a bond T3h OH 2659 CMe NMe Q1i a bond Me a bond NH S a bond T3i OH 2660 CMe NMe Q1i a bond Me a bond NH S a bond T3j OH 2661 CMe NMe Q1i a bond Me a bond NH O NH T3a OH 2662 CMe NMe Q1i a bond Me a bond NH O NH T3b OH 2663 CMe NMe Q1i a bond Me a bond NH O NH T3c OH 2664 CMe NMe Q1i a bond Me a bond NH O NH T3d OH 2665 CMe NMe Q1i a bond Me a bond NH O NH T3e OH 2666 CMe NMe Q1i a bond Me a bond NH O NH T3f OH 2667 CMe NMe Q1i a bond Me a bond NH O NH T3g OH 2668 CMe NMe Q1i a bond Me a bond NH O NH T3h OH 2669 CMe NMe Q1i a bond Me a bond NH O NH T3i OH 2670 CMe NMe Q1i a bond Me a bond NH O NH T3j OH 2671 CMe NMe Q1i a bond Me a bond NH O a bond T3a OH 2672 CMe NMe Q1i a bond Me a bond NH O a bond T3b OH 2673 CMe NMe Q1i a bond Me a bond NH O a bond T3c OH 2674 CMe NMe Q1i a bond Me a bond NH O a bond T3d OH 2675 CMe NMe Q1i a bond Me a bond NH O a bond T3e OH 2676 CMe NMe Q1i a bond Me a bond NH O a bond T3f OH 2677 CMe NMe Q1i a bond Me a bond NH O a bond T3g OH 2678 CMe NMe Q1i a bond Me a bond NH O a bond T3h OH 2679 CMe NMe Q1i a bond Me a bond NH O a bond T3i OH 2680 CMe NMe Q1i a bond Me a bond NH O a bond T3j OH 2681 CMe NMe Q1i a bond H a bond NH S NH T3a OH 2682 CMe NMe Q1i a bond H a bond NH S NH T3b OH 2683 CMe NMe Q1i a bond H a bond NH S NH T3c OH 2684 CMe NMe Q1i a bond H a bond NH S NH T3d OH 2685 CMe NMe Q1i a bond H a bond NH S NH T3e OH 2686 CMe NMe Q1i a bond H a bond NH S NH T3f OH 2687 CMe NMe Q1i a bond H a bond NH S NH T3g OH 2688 CMe NMe Q1i a bond H a bond NH S NH T3h OH 2689 CMe NMe Q1i a bond H a bond NH S NH T3i OH 2690 CMe NMe Q1i a bond H a bond NH S NH T3j OH 2691 CMe NMe Q1i a bond H a bond NH S a bond T3a OH 2692 CMe NMe Q1i a bond H a bond NH S a bond T3b OH 2693 CMe NMe Q1i a bond H a bond NH S a bond T3c OH 2694 CMe NMe Q1i a bond H a bond NH S a bond T3d OH 2695 CMe NMe Q1i a bond H a bond NH S a bond T3e OH 2696 CMe NMe Q1i a bond H a bond NH S a bond T3f OH 2697 CMe NMe Q1i a bond H a bond NH S a bond T3g OH 2698 CMe NMe Q1i a bond H a bond NH S a bond T3h OH 2699 CMe NMe Q1i a bond H a bond NH S a bond T3i OH 2700 CMe NMe Q1i a bond H a bond NH S a bond T3j OH 2701 CMe NMe Q1i a bond H a bond NH O NH T3a OH 2702 CMe NMe Q1i a bond H a bond NH O NH T3b OH 2703 CMe NMe Q1i a bond H a bond NH O NH T3c OH 2704 CMe NMe Q1i a bond H a bond NH O NH T3d OH 2705 CMe NMe Q1i a bond H a bond NH O NH T3e OH 2706 CMe NMe Q1i a bond H a bond NH O NH T3f OH 2707 CMe NMe Q1i a bond H a bond NH O NH T3g OH 2708 CMe NMe Q1i a bond H a bond NH O NH T3h OH 2709 CMe NMe Q1i a bond H a bond NH O NH T3i OH 2710 CMe NMe Q1i a bond H a bond NH O NH T3j OH 2711 CMe NMe Q1i a bond H a bond NH O a bond T3a OH 2712 CMe NMe Q1i a bond H a bond NH O a bond T3b OH 2713 CMe NMe Q1i a bond H a bond NH O a bond T3c OH 2714 CMe NMe Q1i a bond H a bond NH O a bond T3d OH 2715 CMe NMe Q1i a bond H a bond NH O a bond T3e OH 2716 CMe NMe Q1i a bond H a bond NH O a bond T3f OH 2717 CMe NMe Q1i a bond H a bond NH O a bond T3g OH 2718 CMe NMe Q1i a bond H a bond NH O a bond T3h OH 2719 CMe NMe Q1i a bond H a bond NH O a bond T3i OH 2720 CMe NMe Q1i a bond H a bond NH O a bond T3j OH 2721 CMe NMe Q1j a bond Me a bond NH S NH T3a OH 2722 CMe NMe Q1j a bond Me a bond NH S NH T3b OH 2723 CMe NMe Q1j a bond Me a bond NH S NH T3c OH 2724 CMe NMe Q1j a bond Me a bond NH S NH T3d OH 2725 CMe NMe Q1j a bond Me a bond NH S NH T3e OH 2726 CMe NMe Q1j a bond Me a bond NH S NH T3f OH 2727 CMe NMe Q1j a bond Me a bond NH S NH T3g OH 2728 CMe NMe Q1j a bond Me a bond NH S NH T3h OH 2729 CMe NMe Q1j a bond Me a bond NH S NH T3i OH 2730 CMe NMe Q1j a bond Me a bond NH S NH T3j OH 2731 CMe NMe Q1j a bond Me a bond NH S a bond T3a OH 2732 CMe NMe Q1j a bond Me a bond NH S a bond T3b OH 2733 CMe NMe Q1j a bond Me a bond NH S a bond T3c OH 2734 CMe NMe Q1j a bond Me a bond NH S a bond T3d OH 2735 CMe NMe Q1j a bond Me a bond NH S a bond T3e OH 2736 CMe NMe Q1j a bond Me a bond NH S a bond T3f OH 2737 CMe NMe Q1j a bond Me a bond NH S a bond T3g OH 2738 CMe NMe Q1j a bond Me a bond NH S a bond T3h OH 2739 CMe NMe Q1j a bond Me a bond NH S a bond T3i OH 2740 CMe NMe Q1j a bond Me a bond NH S a bond T3j OH 2741 CMe NMe Q1j a bond Me a bond NH O NH T3a OH 2742 CMe NMe Q1j a bond Me a bond NH O NH T3b OH 2743 CMe NMe Q1j a bond Me a bond NH O NH T3c OH 2744 CMe NMe Q1j a bond Me a bond NH O NH T3d OH 2745 CMe NMe Q1j a bond Me a bond NH O NH T3e OH 2746 CMe NMe Q1j a bond Me a bond NH O NH T3f OH 2747 CMe NMe Q1j a bond Me a bond NH O NH T3g OH 2748 CMe NMe Q1j a bond Me a bond NH O NH T3h OH 2749 CMe NMe Q1j a bond Me a bond NH O NH T3i OH 2750 CMe NMe Q1j a bond Me a bond NH O NH T3j OH 2751 CMe NMe Q1j a bond Me a bond NH O a bond T3a OH 2752 CMe NMe Q1j a bond Me a bond NH O a bond T3b OH 2753 CMe NMe Q1j a bond Me a bond NH O a bond T3c OH 2754 CMe NMe Q1j a bond Me a bond NH O a bond T3d OH 2755 CMe NMe Q1j a bond Me a bond NH O a bond T3e OH 2756 CMe NMe Q1j a bond Me a bond NH O a bond T3f OH 2757 CMe NMe Q1j a bond Me a bond NH O a bond T3g OH 2758 CMe NMe Q1j a bond Me a bond NH O a bond T3h OH 2759 CMe NMe Q1j a bond Me a bond NH O a bond T3i OH 2760 CMe NMe Q1j a bond Me a bond NH O a bond T3j OH 2761 CMe NMe Q1j a bond H a bond NH S NH T3a OH 2762 CMe NMe Q1j a bond H a bond NH S NH T3b OH 2763 CMe NMe Q1j a bond H a bond NH S NH T3c OH 2764 CMe NMe Q1j a bond H a bond NH S NH T3d OH 2765 CMe NMe Q1j a bond H a bond NH S NH T3e OH 2766 CMe NMe Q1j a bond H a bond NH S NH T3f OH 2767 CMe NMe Q1j a bond H a bond NH S NH T3g OH 2768 CMe NMe Q1j a bond H a bond NH S NH T3h OH 2769 CMe NMe Q1j a bond H a bond NH S NH T3i OH 2770 CMe NMe Q1j a bond H a bond NH S NH T3j OH 2771 CMe NMe Q1j a bond H a bond NH S a bond T3a OH 2772 CMe NMe Q1j a bond H a bond NH S a bond T3b OH 2773 CMe NMe Q1j a bond H a bond NH S a bond T3c OH 2774 CMe NMe Q1j a bond H a bond NH S a bond T3d OH 2775 CMe NMe Q1j a bond H a bond NH S a bond T3e OH 2776 CMe NMe Q1j a bond H a bond NH S a bond T3f OH 2777 CMe NMe Q1j a bond H a bond NH S a bond T3g OH 2778 CMe NMe Q1j a bond H a bond NH S a bond T3h OH 2779 CMe NMe Q1j a bond H a bond NH S a bond T3i OH 2780 CMe NMe Q1j a bond H a bond NH S a bond T3j OH 2781 CMe NMe Q1j a bond H a bond NH O NH T3a OH 2782 CMe NMe Q1j a bond H a bond NH O NH T3b OH 2783 CMe NMe Q1j a bond H a bond NH O NH T3c OH 2784 CMe NMe Q1j a bond H a bond NH O NH T3d OH 2785 CMe NMe Q1j a bond H a bond NH O NH T3e OH 2786 CMe NMe Q1j a bond H a bond NH O NH T3f OH 2787 CMe NMe Q1j a bond H a bond NH O NH T3g OH 2788 CMe NMe Q1j a bond H a bond NH O NH T3h OH 2789 CMe NMe Q1j a bond H a bond NH O NH T3i OH 2790 CMe NMe Q1j a bond H a bond NH O NH T3j OH 2791 CMe NMe Q1j a bond H a bond NH O a bond T3a OH 2792 CMe NMe Q1j a bond H a bond NH O a bond T3b OH 2793 CMe NMe Q1j a bond H a bond NH O a bond T3c OH 2794 CMe NMe Q1j a bond H a bond NH O a bond T3d OH 2795 CMe NMe Q1j a bond H a bond NH O a bond T3e OH 2796 CMe NMe Q1j a bond H a bond NH O a bond T3f OH 2797 CMe NMe Q1j a bond H a bond NH O a bond T3g OH 2798 CMe NMe Q1j a bond H a bond NH O a bond T3h OH 2799 CMe NMe Q1j a bond H a bond NH O a bond T3i OH 2800 CMe NMe Q1j a bond H a bond NH O a bond T3j OH 2801 CMe S Q1a a bond Me a bond NH S NH T3a OH 2802 CMe S Q1a a bond Me a bond NH S NH T3b OH 2803 CMe S Q1a a bond Me a bond NH S NH T3c OH 2804 CMe S Q1a a bond Me a bond NH S NH T3d OH 2805 CMe S Q1a a bond Me a bond NH S NH T3e OH 2806 CMe S Q1a a bond Me a bond NH S NH T3f OH 2807 CMe S Q1a a bond Me a bond NH S NH T3g OH 2808 CMe S Q1a a bond Me a bond NH S NH T3h OH 2809 CMe S Q1a a bond Me a bond NH S NH T3i OH 2810 CMe S Q1a a bond Me a bond NH S NH T3j OH 2811 CMe S Q1a a bond Me a bond NH S a bond T3a OH 2812 CMe S Q1a a bond Me a bond NH S a bond T3b OH 2813 CMe S Q1a a bond Me a bond NH S a bond T3c OH 2814 CMe S Q1a a bond Me a bond NH S a bond T3d OH 2815 CMe S Q1a a bond Me a bond NH S a bond T3e OH 2816 CMe S Q1a a bond Me a bond NH S a bond T3f OH 2817 CMe S Q1a a bond Me a bond NH S a bond T3g OH 2818 CMe S Q1a a bond Me a bond NH S a bond T3h OH 2819 CMe S Q1a a bond Me a bond NH S a bond T3i OH 2820 CMe S Q1a a bond Me a bond NH S a bond T3j OH 2821 CMe S Q1a a bond Me a bond NH O NH T3a OH 2822 CMe S Q1a a bond Me a bond NH O NH T3b OH 2823 CMe S Q1a a bond Me a bond NH O NH T3c OH 2824 CMe S Q1a a bond Me a bond NH O NH T3d OH 2825 CMe S Q1a a bond Me a bond NH O NH T3e OH 2826 CMe S Q1a a bond Me a bond NH O NH T3f OH 2827 CMe S Q1a a bond Me a bond NH O NH T3g OH 2828 CMe S Q1a a bond Me a bond NH O NH T3h OH 2829 CMe S Q1a a bond Me a bond NH O NH T3i OH 2830 CMe S Q1a a bond Me a bond NH O NH T3j OH 2831 CMe S Q1a a bond Me a bond NH O a bond T3a OH 2832 CMe S Q1a a bond Me a bond NH O a bond T3b OH 2833 CMe S Q1a a bond Me a bond NH O a bond T3c OH 2834 CMe S Q1a a bond Me a bond NH O a bond T3d OH 2835 CMe S Q1a a bond Me a bond NH O a bond T3e OH 2836 CMe S Q1a a bond Me a bond NH O a bond T3f OH 2837 CMe S Q1a a bond Me a bond NH O a bond T3g OH 2838 CMe S Q1a a bond Me a bond NH O a bond T3h OH 2839 CMe S Q1a a bond Me a bond NH O a bond T3i OH 2840 CMe S Q1a a bond Me a bond NH O a bond T3j OH 2841 CMe S Q1a a bond H a bond NH S NH T3a OH 2842 CMe S Q1a a bond H a bond NH S NH T3b OH 2843 CMe S Q1a a bond H a bond NH S NH T3c OH 2844 CMe S Q1a a bond H a bond NH S NH T3d OH 2845 CMe S Q1a a bond H a bond NH S NH T3e OH 2846 CMe S Q1a a bond H a bond NH S NH T3f OH 2847 CMe S Q1a a bond H a bond NH S NH T3g OH 2848 CMe S Q1a a bond H a bond NH S NH T3h OH 2849 CMe S Q1a a bond H a bond NH S NH T3i OH 2850 CMe S Q1a a bond H a bond NH S NH T3j OH 2851 CMe S Q1a a bond H a bond NH S a bond T3a OH 2852 CMe S Q1a a bond H a bond NH S a bond T3b OH 2853 CMe S Q1a a bond H a bond NH S a bond T3c OH 2854 CMe S Q1a a bond H a bond NH S a bond T3d OH 2855 CMe S Q1a a bond H a bond NH S a bond T3e OH 2856 CMe S Q1a a bond H a bond NH S a bond T3f OH 2857 CMe S Q1a a bond H a bond NH S a bond T3g OH 2858 CMe S Q1a a bond H a bond NH S a bond T3h OH 2859 CMe S Q1a a bond H a bond NH S a bond T3i OH 2860 CMe S Q1a a bond H a bond NH S a bond T3j OH 2861 CMe S Q1a a bond H a bond NH O NH T3a OH 2862 CMe S Q1a a bond H a bond NH O NH T3b OH 2863 CMe S Q1a a bond H a bond NH O NH T3c OH 2864 CMe S Q1a a bond H a bond NH O NH T3d OH 2865 CMe S Q1a a bond H a bond NH O NH T3e OH 2866 CMe S Q1a a bond H a bond NH O NH T3f OH 2867 CMe S Q1a a bond H a bond NH O NH T3g OH 2868 CMe S Q1a a bond H a bond NH O NH T3h OH 2869 CMe S Q1a a bond H a bond NH O NH T3i OH 2870 CMe S Q1a a bond H a bond NH O NH T3j OH 2871 CMe S Q1a a bond H a bond NH O a bond T3a OH 2872 CMe S Q1a a bond H a bond NH O a bond T3b OH 2873 CMe S Q1a a bond H a bond NH O a bond T3c OH 2874 CMe S Q1a a bond H a bond NH O a bond T3d OH 2875 CMe S Q1a a bond H a bond NH O a bond T3e OH 2876 CMe S Q1a a bond H a bond NH O a bond T3f OH 2877 CMe S Q1a a bond H a bond NH O a bond T3g OH 2878 CMe S Q1a a bond H a bond NH O a bond T3h OH 2879 CMe S Q1a a bond H a bond NH O a bond T3i OH 2880 CMe S Q1a a bond H a bond NH O a bond T3j OH 2881 CMe S Q1b a bond Me a bond NH S NH T3a OH 2882 CMe S Q1b a bond Me a bond NH S NH T3b OH 2883 CMe S Q1b a bond Me a bond NH S NH T3c OH 2884 CMe S Q1b a bond Me a bond NH S NH T3d OH 2885 CMe S Q1b a bond Me a bond NH S NH T3e OH 2886 CMe S Q1b a bond Me a bond NH S NH T3f OH 2887 CMe S Q1b a bond Me a bond NH S NH T3g OH 2888 CMe S Q1b a bond Me a bond NH S NH T3h OH 2889 CMe S Q1b a bond Me a bond NH S NH T3i OH 2890 CMe S Q1b a bond Me a bond NH S NH T3j OH 2891 CMe S Q1b a bond Me a bond NH S a bond T3a OH 2892 CMe S Q1b a bond Me a bond NH S a bond T3b OH 2893 CMe S Q1b a bond Me a bond NH S a bond T3c OH 2894 CMe S Q1b a bond Me a bond NH S a bond T3d OH 2895 CMe S Q1b a bond Me a bond NH S a bond T3e OH 2896 CMe S Q1b a bond Me a bond NH S a bond T3f OH 2897 CMe S Q1b a bond Me a bond NH S a bond T3g OH 2898 CMe S Q1b a bond Me a bond NH S a bond T3h OH 2899 CMe S Q1b a bond Me a bond NH S a bond T3i OH 2900 CMe S Q1b a bond Me a bond NH S a bond T3j OH 2901 CMe S Q1b a bond Me a bond NH O NH T3a OH 2902 CMe S Q1b a bond Me a bond NH O NH T3b OH 2903 CMe S Q1b a bond Me a bond NH O NH T3c OH 2904 CMe S Q1b a bond Me a bond NH O NH T3d OH 2905 CMe S Q1b a bond Me a bond NH O NH T3e OH 2906 CMe S Q1b a bond Me a bond NH O NH T3f OH 2907 CMe S Q1b a bond Me a bond NH O NH T3g OH 2908 CMe S Q1b a bond Me a bond NH O NH T3h OH 2909 CMe S Q1b a bond Me a bond NH O NH T3i OH 2910 CMe S Q1b a bond Me a bond NH O NH T3j OH 2911 CMe S Q1b a bond Me a bond NH O a bond T3a OH 2912 CMe S Q1b a bond Me a bond NH O a bond T3b OH 2913 CMe S Q1b a bond Me a bond NH O a bond T3c OH 2914 CMe S Q1b a bond Me a bond NH O a bond T3d OH 2915 CMe S Q1b a bond Me a bond NH O a bond T3e OH 2916 CMe S Q1b a bond Me a bond NH O a bond T3f OH 2917 CMe S Q1b a bond Me a bond NH O a bond T3g OH 2918 CMe S Q1b a bond Me a bond NH O a bond T3h OH 2919 CMe S Q1b a bond Me a bond NH O a bond T3i OH 2920 CMe S Q1b a bond Me a bond NH O a bond T3j OH 2921 CMe S Q1b a bond H a bond NH S NH T3a OH 2922 CMe S Q1b a bond H a bond NH S NH T3b OH 2923 CMe S Q1b a bond H a bond NH S NH T3c OH 2924 CMe S Q1b a bond H a bond NH S NH T3d OH 2925 CMe S Q1b a bond H a bond NH S NH T3e OH 2926 CMe S Q1b a bond H a bond NH S NH T3f OH 2927 CMe S Q1b a bond H a bond NH S NH T3g OH 2928 CMe S Q1b a bond H a bond NH S NH T3h OH 2929 CMe S Q1b a bond H a bond NH S NH T3i OH 2930 CMe S Q1b a bond H a bond NH S NH T3j OH 2931 CMe S Q1b a bond H a bond NH S a bond T3a OH 2932 CMe S Q1b a bond H a bond NH S a bond T3b OH 2933 CMe S Q1b a bond H a bond NH S a bond T3c OH 2934 CMe S Q1b a bond H a bond NH S a bond T3d OH 2935 CMe S Q1b a bond H a bond NH S a bond T3e OH 2936 CMe S Q1b a bond H a bond NH S a bond T3f OH 2937 CMe S Q1b a bond H a bond NH S a bond T3g OH 2938 CMe S Q1b a bond H a bond NH S a bond T3h OH 2939 CMe S Q1b a bond H a bond NH S a bond T3i OH 2940 CMe S Q1b a bond H a bond NH S a bond T3j OH 2941 CMe S Q1b a bond H a bond NH O NH T3a OH 2942 CMe S Q1b a bond H a bond NH O NH T3b OH 2943 CMe S Q1b a bond H a bond NH O NH T3c OH 2944 CMe S Q1b a bond H a bond NH O NH T3d OH 2945 CMe S Q1b a bond H a bond NH O NH T3e OH 2946 CMe S Q1b a bond H a bond NH O NH T3f OH 2947 CMe S Q1b a bond H a bond NH O NH T3g OH 2948 CMe S Q1b a bond H a bond NH O NH T3h OH 2949 CMe S Q1b a bond H a bond NH O NH T3i OH 2950 CMe S Q1b a bond H a bond NH O NH T3j OH 2951 CMe S Q1b a bond H a bond NH O a bond T3a OH 2952 CMe S Q1b a bond H a bond NH O a bond T3b OH 2953 CMe S Q1b a bond H a bond NH O a bond T3c OH 2954 CMe S Q1b a bond H a bond NH O a bond T3d OH 2955 CMe S Q1b a bond H a bond NH O a bond T3e OH 2956 CMe S Q1b a bond H a bond NH O a bond T3f OH 2957 CMe S Q1b a bond H a bond NH O a bond T3g OH 2958 CMe S Q1b a bond H a bond NH O a bond T3h OH 2959 CMe S Q1b a bond H a bond NH O a bond T3i OH 2960 CMe S Q1b a bond H a bond NH O a bond T3j OH 2961 CMe S Q1c a bond Me a bond NH S NH T3a OH 2962 CMe S Q1c a bond Me a bond NH S NH T3b OH 2963 CMe S Q1c a bond Me a bond NH S NH T3c OH 2964 CMe S Q1c a bond Me a bond NH S NH T3d OH 2965 CMe S Q1c a bond Me a bond NH S NH T3e OH 2966 CMe S Q1c a bond Me a bond NH S NH T3f OH 2967 CMe S Q1c a bond Me a bond NH S NH T3g OH 2968 CMe S Q1c a bond Me a bond NH S NH T3h OH 2969 CMe S Q1c a bond Me a bond NH S NH T3i OH 2970 CMe S Q1c a bond Me a bond NH S NH T3j OH 2971 CMe S Q1c a bond Me a bond NH S a bond T3a OH 2972 CMe S Q1c a bond Me a bond NH S a bond T3b OH 2973 CMe S Q1c a bond Me a bond NH S a bond T3c OH 2974 CMe S Q1c a bond Me a bond NH S a bond T3d OH 2975 CMe S Q1c a bond Me a bond NH S a bond T3e OH 2976 CMe S Q1c a bond Me a bond NH S a bond T3f OH 2977 CMe S Q1c a bond Me a bond NH S a bond T3g OH 2978 CMe S Q1c a bond Me a bond NH S a bond T3h OH 2979 CMe S Q1c a bond Me a bond NH S a bond T3i OH 2980 CMe S Q1c a bond Me a bond NH S a bond T3j OH 2981 CMe S Q1c a bond Me a bond NH O NH T3a OH 2982 CMe S Q1c a bond Me a bond NH O NH T3b OH 2983 CMe S Q1c a bond Me a bond NH O NH T3c OH 2984 CMe S Q1c a bond Me a bond NH O NH T3d OH 2985 CMe S Q1c a bond Me a bond NH O NH T3e OH 2986 CMe S Q1c a bond Me a bond NH O NH T3f OH 2987 CMe S Q1c a bond Me a bond NH O NH T3g OH 2988 CMe S Q1c a bond Me a bond NH O NH T3h OH 2989 CMe S Q1c a bond Me a bond NH O NH T3i OH 2990 CMe S Q1c a bond Me a bond NH O NH T3j OH 2991 CMe S Q1c a bond Me a bond NH O a bond T3a OH 2992 CMe S Q1c a bond Me a bond NH O a bond T3b OH 2993 CMe S Q1c a bond Me a bond NH O a bond T3c OH 2994 CMe S Q1c a bond Me a bond NH O a bond T3d OH 2995 CMe S Q1c a bond Me a bond NH O a bond T3e OH 2996 CMe S Q1c a bond Me a bond NH O a bond T3f OH 2997 CMe S Q1c a bond Me a bond NH O a bond T3g OH 2998 CMe S Q1c a bond Me a bond NH O a bond T3h OH 2999 CMe S Q1c a bond Me a bond NH O a bond T3i OH 3000 CMe S Q1c a bond Me a bond NH O a bond T3j OH 3001 CMe S Q1c a bond H a bond NH S NH T3a OH 3002 CMe S Q1c a bond H a bond NH S NH T3b OH 3003 CMe S Q1c a bond H a bond NH S NH T3c OH 3004 CMe S Q1c a bond H a bond NH S NH T3d OH 3005 CMe S Q1c a bond H a bond NH S NH T3e OH 3006 CMe S Q1c a bond H a bond NH S NH T3f OH 3007 CMe S Q1c a bond H a bond NH S NH T3g OH 3008 CMe S Q1c a bond H a bond NH S NH T3h OH 3009 CMe S Q1c a bond H a bond NH S NH T3i OH 3010 CMe S Q1c a bond H a bond NH S NH T3j OH 3011 CMe S Q1c a bond H a bond NH S a bond T3a OH 3012 CMe S Q1c a bond H a bond NH S a bond T3b OH 3013 CMe S Q1c a bond H a bond NH S a bond T3c OH 3014 CMe S Q1c a bond H a bond NH S a bond T3d OH 3015 CMe S Q1c a bond H a bond NH S a bond T3e OH 3016 CMe S Q1c a bond H a bond NH S a bond T3f OH 3017 CMe S Q1c a bond H a bond NH S a bond T3g OH 3018 CMe S Q1c a bond H a bond NH S a bond T3h OH 3019 CMe S Q1c a bond H a bond NH S a bond T3i OH 3020 CMe S Q1c a bond H a bond NH S a bond T3j OH 3021 CMe S Q1c a bond H a bond NH O NH T3a OH 3022 CMe S Q1c a bond H a bond NH O NH T3b OH 3023 CMe S Q1c a bond H a bond NH O NH T3c OH 3024 CMe S Q1c a bond H a bond NH O NH T3d OH 3025 CMe S Q1c a bond H a bond NH O NH T3e OH 3026 CMe S Q1c a bond H a bond NH O NH T3f OH 3027 CMe S Q1c a bond H a bond NH O NH T3g OH 3028 CMe S Q1c a bond H a bond NH O NH T3h OH 3029 CMe S Q1c a bond H a bond NH O NH T3i OH 3030 CMe S Q1c a bond H a bond NH O NH T3j OH 3031 CMe S Q1c a bond H a bond NH O a bond T3a OH 3032 CMe S Q1c a bond H a bond NH O a bond T3b OH 3033 CMe S Q1c a bond H a bond NH O a bond T3c OH 3034 CMe S Q1c a bond H a bond NH O a bond T3d OH 3035 CMe S Q1c a bond H a bond NH O a bond T3e OH 3036 CMe S Q1c a bond H a bond NH O a bond T3f OH 3037 CMe S Q1c a bond H a bond NH O a bond T3g OH 3038 CMe S Q1c a bond H a bond NH O a bond T3h OH 3039 CMe S Q1c a bond H a bond NH O a bond T3i OH 3040 CMe S Q1c a bond H a bond NH O a bond T3j OH 3041 CMe S Q1i a bond Me a bond NH S NH T3a OH 3042 CMe S Q1i a bond Me a bond NH S NH T3b OH 3043 CMe S Q1i a bond Me a bond NH S NH T3c OH 3044 CMe S Q1i a bond Me a bond NH S NH T3d OH 3045 CMe S Q1i a bond Me a bond NH S NH T3e OH 3046 CMe S Q1i a bond Me a bond NH S NH T3f OH 3047 CMe S Q1i a bond Me a bond NH S NH T3g OH 3048 CMe S Q1i a bond Me a bond NH S NH T3h OH 3049 CMe S Q1i a bond Me a bond NH S NH T3i OH 3050 CMe S Q1i a bond Me a bond NH S NH T3j OH 3051 CMe S Q1i a bond Me a bond NH S a bond T3a OH 3052 CMe S Q1i a bond Me a bond NH S a bond T3b OH 3053 CMe S Q1i a bond Me a bond NH S a bond T3c OH 3054 CMe S Q1i a bond Me a bond NH S a bond T3d OH 3055 CMe S Q1i a bond Me a bond NH S a bond T3e OH 3056 CMe S Q1i a bond Me a bond NH S a bond T3f OH 3057 CMe S Q1i a bond Me a bond NH S a bond T3g OH 3058 CMe S Q1i a bond Me a bond NH S a bond T3h OH 3059 CMe S Q1i a bond Me a bond NH S a bond T3i OH 3060 CMe S Q1i a bond Me a bond NH S a bond T3j OH 3061 CMe S Q1i a bond Me a bond NH O NH T3a OH 3062 CMe S Q1i a bond Me a bond NH O NH T3b OH 3063 CMe S Q1i a bond Me a bond NH O NH T3c OH 3064 CMe S Q1i a bond Me a bond NH O NH T3d OH 3065 CMe S Q1i a bond Me a bond NH O NH T3e OH 3066 CMe S Q1i a bond Me a bond NH O NH T3f OH 3067 CMe S Q1i a bond Me a bond NH O NH T3g OH 3068 CMe S Q1i a bond Me a bond NH O NH T3h OH 3069 CMe S Q1i a bond Me a bond NH O NH T3i OH 3070 CMe S Q1i a bond Me a bond NH O NH T3j OH 3071 CMe S Q1i a bond Me a bond NH O a bond T3a OH 3072 CMe S Q1i a bond Me a bond NH O a bond T3b OH 3073 CMe S Q1i a bond Me a bond NH O a bond T3c OH 3074 CMe S Q1i a bond Me a bond NH O a bond T3d OH 3075 CMe S Q1i a bond Me a bond NH O a bond T3e OH 3076 CMe S Q1i a bond Me a bond NH O a bond T3f OH 3077 CMe S Q1i a bond Me a bond NH O a bond T3g OH 3078 CMe S Q1i a bond Me a bond NH O a bond T3h OH 3079 CMe S Q1i a bond Me a bond NH O a bond T3i OH 3080 CMe S Q1i a bond Me a bond NH O a bond T3j OH 3081 CMe S Q1i a bond H a bond NH S NH T3a OH 3082 CMe S Q1i a bond H a bond NH S NH T3b OH 3083 CMe S Q1i a bond H a bond NH S NH T3c OH 3084 CMe S Q1i a bond H a bond NH S NH T3d OH 3085 CMe S Q1i a bond H a bond NH S NH T3e OH 3086 CMe S Q1i a bond H a bond NH S NH T3f OH 3087 CMe S Q1i a bond H a bond NH S NH T3g OH 3088 CMe S Q1i a bond H a bond NH S NH T3h OH 3089 CMe S Q1i a bond H a bond NH S NH T3i OH 3090 CMe S Q1i a bond H a bond NH S NH T3j OH 3091 CMe S Q1i a bond H a bond NH S a bond T3a OH 3092 CMe S Q1i a bond H a bond NH S a bond T3b OH 3093 CMe S Q1i a bond H a bond NH S a bond T3c OH 3094 CMe S Q1i a bond H a bond NH S a bond T3d OH 3095 CMe S Q1i a bond H a bond NH S a bond T3e OH 3096 CMe S Q1i a bond H a bond NH S a bond T3f OH 3097 CMe S Q1i a bond H a bond NH S a bond T3g OH 3098 CMe S Q1i a bond H a bond NH S a bond T3h OH 3099 CMe S Q1i a bond H a bond NH S a bond T3i OH 3100 CMe S Q1i a bond H a bond NH S a bond T3j OH 3101 CMe S Q1i a bond H a bond NH O NH T3a OH 3102 CMe S Q1i a bond H a bond NH O NH T3b OH 3103 CMe S Q1i a bond H a bond NH O NH T3c OH 3104 CMe S Q1i a bond H a bond NH O NH T3d OH 3105 CMe S Q1i a bond H a bond NH O NH T3e OH 3106 CMe S Q1i a bond H a bond NH O NH T3f OH 3107 CMe S Q1i a bond H a bond NH O NH T3g OH 3108 CMe S Q1i a bond H a bond NH O NH T3h OH 3109 CMe S Q1i a bond H a bond NH O NH T3i OH 3110 CMe S Q1i a bond H a bond NH O NH T3j OH 3111 CMe S Q1i a bond H a bond NH O a bond T3a OH 3112 CMe S Q1i a bond H a bond NH O a bond T3b OH 3113 CMe S Q1i a bond H a bond NH O a bond T3c OH 3114 CMe S Q1i a bond H a bond NH O a bond T3d OH 3115 CMe S Q1i a bond H a bond NH O a bond T3e OH 3116 CMe S Q1i a bond H a bond NH O a bond T3f OH 3117 CMe S Q1i a bond H a bond NH O a bond T3g OH 3118 CMe S Q1i a bond H a bond NH O a bond T3h OH 3119 CMe S Q1i a bond H a bond NH O a bond T3i OH 3120 CMe S Q1i a bond H a bond NH O a bond T3j OH 3121 CMe S Q1j a bond Me a bond NH S NH T3a OH 3122 CMe S Q1j a bond Me a bond NH S NH T3b OH 3123 CMe S Q1j a bond Me a bond NH S NH T3c OH 3124 CMe S Q1j a bond Me a bond NH S NH T3d OH 3125 CMe S Q1j a bond Me a bond NH S NH T3e OH 3126 CMe S Q1j a bond Me a bond NH S NH T3f OH 3127 CMe S Q1j a bond Me a bond NH S NH T3g OH 3128 CMe S Q1j a bond Me a bond NH S NH T3h OH 3129 CMe S Q1j a bond Me a bond NH S NH T3i OH 3130 CMe S Q1j a bond Me a bond NH S NH T3j OH 3131 CMe S Q1j a bond Me a bond NH S a bond T3a OH 3132 CMe S Q1j a bond Me a bond NH S a bond T3b OH 3133 CMe S Q1j a bond Me a bond NH S a bond T3c OH 3134 CMe S Q1j a bond Me a bond NH S a bond T3d OH 3135 CMe S Q1j a bond Me a bond NH S a bond T3e OH 3136 CMe S Q1j a bond Me a bond NH S a bond T3f OH 3137 CMe S Q1j a bond Me a bond NH S a bond T3g OH 3138 CMe S Q1j a bond Me a bond NH S a bond T3h OH 3139 CMe S Q1j a bond Me a bond NH S a bond T3i OH 3140 CMe S Q1j a bond Me a bond NH S a bond T3j OH 3141 CMe S Q1j a bond Me a bond NH O NH T3a OH 3142 CMe S Q1j a bond Me a bond NH O NH T3b OH 3143 CMe S Q1j a bond Me a bond NH O NH T3c OH 3144 CMe S Q1j a bond Me a bond NH O NH T3d OH 3145 CMe S Q1j a bond Me a bond NH O NH T3e OH 3146 CMe S Q1j a bond Me a bond NH O NH T3f OH 3147 CMe S Q1j a bond Me a bond NH O NH T3g OH 3148 CMe S Q1j a bond Me a bond NH O NH T3h OH 3149 CMe S Q1j a bond Me a bond NH O NH T3i OH 3150 CMe S Q1j a bond Me a bond NH O NH T3j OH 3151 CMe S Q1j a bond Me a bond NH O a bond T3a OH 3152 CMe S Q1j a bond Me a bond NH O a bond T3b OH 3153 CMe S Q1j a bond Me a bond NH O a bond T3c OH 3154 CMe S Q1j a bond Me a bond NH O a bond T3d OH 3155 CMe S Q1j a bond Me a bond NH O a bond T3e OH 3156 CMe S Q1j a bond Me a bond NH O a bond T3f OH 3157 CMe S Q1j a bond Me a bond NH O a bond T3g OH 3158 CMe S Q1j a bond Me a bond NH O a bond T3h OH 3159 CMe S Q1j a bond Me a bond NH O a bond T3i OH 3160 CMe S Q1j a bond Me a bond NH O a bond T3j OH 3161 CMe S Q1j a bond H a bond NH S NH T3a OH 3162 CMe S Q1j a bond H a bond NH S NH T3b OH 3163 CMe S Q1j a bond H a bond NH S NH T3c OH 3164 CMe S Q1j a bond H a bond NH S NH T3d OH 3165 CMe S Q1j a bond H a bond NH S NH T3e OH 3166 CMe S Q1j a bond H a bond NH S NH T3f OH 3167 CMe S Q1j a bond H a bond NH S NH T3g OH 3168 CMe S Q1j a bond H a bond NH S NH T3h OH 3169 CMe S Q1j a bond H a bond NH S NH T3i OH 3170 CMe S Q1j a bond H a bond NH S NH T3j OH 3171 CMe S Q1j a bond H a bond NH S a bond T3a OH 3172 CMe S Q1j a bond H a bond NH S a bond T3b OH 3173 CMe S Q1j a bond H a bond NH S a bond T3c OH 3174 CMe S Q1j a bond H a bond NH S a bond T3d OH 3175 CMe S Q1j a bond H a bond NH S a bond T3e OH 3176 CMe S Q1j a bond H a bond NH S a bond T3f OH 3177 CMe S Q1j a bond H a bond NH S a bond T3g OH 3178 CMe S Q1j a bond H a bond NH S a bond T3h OH 3179 CMe S Q1j a bond H a bond NH S a bond T3i OH 3180 CMe S Q1j a bond H a bond NH S a bond T3j OH 3181 CMe S Q1j a bond H a bond NH O NH T3a OH 3182 CMe S Q1j a bond H a bond NH O NH T3b OH 3183 CMe S Q1j a bond H a bond NH O NH T3c OH 3184 CMe S Q1j a bond H a bond NH O NH T3d OH 3185 CMe S Q1j a bond H a bond NH O NH T3e OH 3186 CMe S Q1j a bond H a bond NH O NH T3f OH 3187 CMe S Q1j a bond H a bond NH O NH T3g OH 3188 CMe S Q1j a bond H a bond NH O NH T3h OH 3189 CMe S Q1j a bond H a bond NH O NH T3i OH 3190 CMe S Q1j a bond H a bond NH O NH T3j OH 3191 CMe S Q1j a bond H a bond NH O a bond T3a OH 3192 CMe S Q1j a bond H a bond NH O a bond T3b OH 3193 CMe S Q1j a bond H a bond NH O a bond T3c OH 3194 CMe S Q1j a bond H a bond NH O a bond T3d OH 3195 CMe S Q1j a bond H a bond NH O a bond T3e OH 3196 CMe S Q1j a bond H a bond NH O a bond T3f OH 3197 CMe S Q1j a bond H a bond NH O a bond T3g OH 3198 CMe S Q1j a bond H a bond NH O a bond T3h OH 3199 CMe S Q1j a bond H a bond NH O a bond T3i OH 3200 CMe S Q1j a bond H a bond NH O a bond T3j OH 3201 CMe O Q1a a bond Me a bond NH S NH T3a OH 3202 CMe O Q1a a bond Me a bond NH S NH T3b OH 3203 CMe O Q1a a bond Me a bond NH S NH T3c OH 3204 CMe O Q1a a bond Me a bond NH S NH T3d OH 3205 CMe O Q1a a bond Me a bond NH S NH T3e OH 3206 CMe O Q1a a bond Me a bond NH S NH T3f OH 3207 CMe O Q1a a bond Me a bond NH S NH T3g OH 3208 CMe O Q1a a bond Me a bond NH S NH T3h OH 3209 CMe O Q1a a bond Me a bond NH S NH T3i OH 3210 CMe O Q1a a bond Me a bond NH S NH T3j OH 3211 CMe O Q1a a bond Me a bond NH S a bond T3a OH 3212 CMe O Q1a a bond Me a bond NH S a bond T3b OH 3213 CMe O Q1a a bond Me a bond NH S a bond T3c OH 3214 CMe O Q1a a bond Me a bond NH S a bond T3d OH 3215 CMe O Q1a a bond Me a bond NH S a bond T3e OH 3216 CMe O Q1a a bond Me a bond NH S a bond T3f OH 3217 CMe O Q1a a bond Me a bond NH S a bond T3g OH 3218 CMe O Q1a a bond Me a bond NH S a bond T3h OH 3219 CMe O Q1a a bond Me a bond NH S a bond T3i OH 3220 CMe O Q1a a bond Me a bond NH S a bond T3j OH 3221 CMe O Q1a a bond Me a bond NH O NH T3a OH 3222 CMe O Q1a a bond Me a bond NH O NH T3b OH 3223 CMe O Q1a a bond Me a bond NH O NH T3c OH 3224 CMe O Q1a a bond Me a bond NH O NH T3d OH 3225 CMe O Q1a a bond Me a bond NH O NH T3e OH 3226 CMe O Q1a a bond Me a bond NH O NH T3f OH 3227 CMe O Q1a a bond Me a bond NH O NH T3g OH 3228 CMe O Q1a a bond Me a bond NH O NH T3h OH 3229 CMe O Q1a a bond Me a bond NH O NH T3i OH 3230 CMe O Q1a a bond Me a bond NH O NH T3j OH 3231 CMe O Q1a a bond Me a bond NH O a bond T3a OH 3232 CMe O Q1a a bond Me a bond NH O a bond T3b OH 3233 CMe O Q1a a bond Me a bond NH O a bond T3c OH 3234 CMe O Q1a a bond Me a bond NH O a bond T3d OH 3235 CMe O Q1a a bond Me a bond NH O a bond T3e OH 3236 CMe O Q1a a bond Me a bond NH O a bond T3f OH 3237 CMe O Q1a a bond Me a bond NH O a bond T3g OH 3238 CMe O Q1a a bond Me a bond NH O a bond T3h OH 3239 CMe O Q1a a bond Me a bond NH O a bond T3i OH 3240 CMe O Q1a a bond Me a bond NH O a bond T3j OH 3241 CMe O Q1a a bond H a bond NH S NH T3a OH 3242 CMe O Q1a a bond H a bond NH S NH T3b OH 3243 CMe O Q1a a bond H a bond NH S NH T3c OH 3244 CMe O Q1a a bond H a bond NH S NH T3d OH 3245 CMe O Q1a a bond H a bond NH S NH T3e OH 3246 CMe O Q1a a bond H a bond NH S NH T3f OH 3247 CMe O Q1a a bond H a bond NH S NH T3g OH 3248 CMe O Q1a a bond H a bond NH S NH T3h OH 3249 CMe O Q1a a bond H a bond NH S NH T3i OH 3250 CMe O Q1a a bond H a bond NH S NH T3j OH 3251 CMe O Q1a a bond H a bond NH S a bond T3a OH 3252 CMe O Q1a a bond H a bond NH S a bond T3b OH 3253 CMe O Q1a a bond H a bond NH S a bond T3c OH 3254 CMe O Q1a a bond H a bond NH S a bond T3d OH 3255 CMe O Q1a a bond H a bond NH S a bond T3e OH 3256 CMe O Q1a a bond H a bond NH S a bond T3f OH 3257 CMe O Q1a a bond H a bond NH S a bond T3g OH 3258 CMe O Q1a a bond H a bond NH S a bond T3h OH 3259 CMe O Q1a a bond H a bond NH S a bond T3i OH 3260 CMe O Q1a a bond H a bond NH S a bond T3j OH 3261 CMe O Q1a a bond H a bond NH O NH T3a OH 3262 CMe O Q1a a bond H a bond NH O NH T3b OH 3263 CMe O Q1a a bond H a bond NH O NH T3c OH 3264 CMe O Q1a a bond H a bond NH O NH T3d OH 3265 CMe O Q1a a bond H a bond NH O NH T3e OH 3266 CMe O Q1a a bond H a bond NH O NH T3f OH 3267 CMe O Q1a a bond H a bond NH O NH T3g OH 3268 CMe O Q1a a bond H a bond NH O NH T3h OH 3269 CMe O Q1a a bond H a bond NH O NH T3i OH 3270 CMe O Q1a a bond H a bond NH O NH T3j OH 3271 CMe O Q1a a bond H a bond NH O a bond T3a OH 3272 CMe O Q1a a bond H a bond NH O a bond T3b OH 3273 CMe O Q1a a bond H a bond NH O a bond T3c OH 3274 CMe O Q1a a bond H a bond NH O a bond T3d OH 3275 CMe O Q1a a bond H a bond NH O a bond T3e OH 3276 CMe O Q1a a bond H a bond NH O a bond T3f OH 3277 CMe O Q1a a bond H a bond NH O a bond T3g OH 3278 CMe O Q1a a bond H a bond NH O a bond T3h OH 3279 CMe O Q1a a bond H a bond NH O a bond T3i OH 3280 CMe O Q1a a bond H a bond NH O a bond T3j OH 3281 CMe O Q1b a bond Me a bond NH S NH T3a OH 3282 CMe O Q1b a bond Me a bond NH S NH T3b OH 3283 CMe O Q1b a bond Me a bond NH S NH T3c OH 3284 CMe O Q1b a bond Me a bond NH S NH T3d OH 3285 CMe O Q1b a bond Me a bond NH S NH T3e OH 3286 CMe O Q1b a bond Me a bond NH S NH T3f OH 3287 CMe O Q1b a bond Me a bond NH S NH T3g OH 3288 CMe O Q1b a bond Me a bond NH S NH 73h OH 3289 CMe O Q1b a bond Me a bond NH S NH T3i OH 3290 CMe O Q1b a bond Me a bond NH S NH T3j OH 3291 CMe O Q1b a bond Me a bond NH S a bond T3a OH 3292 CMe O Q1b a bond Me a bond NH S a bond T3b OH 3293 CMe O Q1b a bond Me a bond NH S a bond T3c OH 3294 CMe O Q1b a bond Me a bond NH S a bond T3d OH 3295 CMe O Q1b a bond Me a bond NH S a bond T3e OH 3296 CMe O Q1b a bond Me a bond NH S a bond T3f OH 3297 CMe O Q1b a bond Me a bond NH S a bond T3g OH 3298 CMe O Q1b a bond Me a bond NH S a bond T3h OH 3299 CMe O Q1b a bond Me a bond NH S a bond T3i OH 3300 CMe O Q1b a bond Me a bond NH S a bond T3j OH 3301 CMe O Q1b a bond Me a bond NH O NH T3a OH 3302 CMe O Q1b a bond Me a bond NH O NH T3b OH 3303 CMe O Q1b a bond Me a bond NH O NH T3c OH 3304 CMe O Q1b a bond Me a bond NH O NH T3d OH 3305 CMe O Q1b a bond Me a bond NH O NH T3e OH 3306 CMe O Q1b a bond Me a bond NH O NH T3f OH 3307 CMe O Q1b a bond Me a bond NH O NH T3g OH 3308 CMe O Q1b a bond Me a bond NH O NH T3h OH 3309 CMe O Q1b a bond Me a bond NH O NH T3i OH 3310 CMe O Q1b a bond Me a bond NH O NH T3j OH 3311 CMe O Q1b a bond Me a bond NH O a bond T3a OH 3312 CMe O Q1b a bond Me a bond NH O a bond T3b OH 3313 CMe O Q1b a bond Me a bond NH O a bond T3c OH 3314 CMe O Q1b a bond Me a bond NH O a bond T3d OH 3315 CMe O Q1b a bond Me a bond NH O a bond T3e OH 3316 CMe O Q1b a bond Me a bond NH O a bond T3f OH 3317 CMe O Q1b a bond Me a bond NH O a bond T3g OH 3318 CMe O Q1b a bond Me a bond NH O a bond T3h OH 3319 CMe O Q1b a bond Me a bond NH O a bond T3i OH 3320 CMe O Q1b a bond Me a bond NH O a bond T3j OH 3321 CMe O Q1b a bond H a bond NH S NH T3a OH 3322 CMe O Q1b a bond H a bond NH S NH T3b OH 3323 CMe O Q1b a bond H a bond NH S NH T3c OH 3324 CMe O Q1b a bond H a bond NH S NH T3d OH 3325 CMe O Q1b a bond H a bond NH S NH T3e OH 3326 CMe O Q1b a bond H a bond NH S NH T3f OH 3327 CMe O Q1b a bond H a bond NH S NH T3g OH 3328 CMe O Q1b a bond H a bond NH S NH 73h OH 3329 CMe O Q1b a bond H a bond NH S NH T3i OH 3330 CMe O Q1b a bond H a bond NH S NH T3j OH 3331 CMe O Q1b a bond H a bond NH S a bond T3a OH 3332 CMe O Q1b a bond H a bond NH S a bond T3b OH 3333 CMe O Q1b a bond H a bond NH S a bond T3c OH 3334 CMe O Q1b a bond H a bond NH S a bond T3d OH 3335 CMe O Q1b a bond H a bond NH S a bond T3e OH 3336 CMe O Q1b a bond H a bond NH S a bond T3f OH 3337 CMe O Q1b a bond H a bond NH S a bond T3g OH 3338 CMe O Q1b a bond H a bond NH S a bond T3h OH 3339 CMe O Q1b a bond H a bond NH S a bond T3i OH 3340 CMe O Q1b a bond H a bond NH S a bond T3j OH 3341 CMe O Q1b a bond H a bond NH O NH T3a OH 3342 CMe O Q1b a bond H a bond NH O NH T3b OH 3343 CMe O Q1b a bond H a bond NH O NH T3c OH 3344 CMe O Q1b a bond H a bond NH O NH T3d OH 3345 CMe O Q1b a bond H a bond NH O NH T3e OH 3346 CMe O Q1b a bond H a bond NH O NH T3f OH 3347 CMe O Q1b a bond H a bond NH O NH T3g OH 3348 CMe O Q1b a bond H a bond NH O NH T3h OH 3349 CMe O Q1b a bond H a bond NH O NH T3i OH 3350 CMe O Q1b a bond H a bond NH O NH T3j OH 3351 CMe O Q1b a bond H a bond NH O a bond T3a OH 3352 CMe O Q1b a bond H a bond NH O a bond T3b OH 3353 CMe O Q1b a bond H a bond NH O a bond T3c OH 3354 CMe O Q1b a bond H a bond NH O a bond T3d OH 3355 CMe O Q1b a bond H a bond NH O a bond T3e OH 3356 CMe O Q1b a bond H a bond NH O a bond T3f OH 3357 CMe O Q1b a bond H a bond NH O a bond T3g OH 3358 CMe O Q1b a bond H a bond NH O a bond T3h OH 3359 CMe O Q1b a bond H a bond NH O a bond T3i OH 3360 CMe O Q1b a bond H a bond NH O a bond T3j OH 3361 CMe O Q1c a bond Me a bond NH S NH T3a OH 3362 CMe O Q1c a bond Me a bond NH S NH T3b OH 3363 CMe O Q1c a bond Me a bond NH S NH T3c OH 3364 CMe O Q1c a bond Me a bond NH S NH T3d OH 3365 CMe O Q1c a bond Me a bond NH S NH T3e OH 3366 CMe O Q1c a bond Me a bond NH S NH T3f OH 3367 CMe O Q1c a bond Me a bond NH S NH T3g OH 3368 CMe O Q1c a bond Me a bond NH S NH T3h OH 3369 CMe O Q1c a bond Me a bond NH S NH T3i OH 3370 CMe O Q1c a bond Me a bond NH S NH T3j OH 3371 CMe O Q1c a bond Me a bond NH S a bond T3a OH 3372 CMe O Q1c a bond Me a bond NH S a bond T3b OH 3373 CMe O Q1c a bond Me a bond NH S a bond T3c OH 3374 CMe O Q1c a bond Me a bond NH S a bond T3d OH 3375 CMe O Q1c a bond Me a bond NH S a bond T3e OH 3376 CMe O Q1c a bond Me a bond NH S a bond T3f OH 3377 CMe O Q1c a bond Me a bond NH S a bond T3g OH 3378 CMe O Q1c a bond Me a bond NH S a bond T3h OH 3379 CMe O Q1c a bond Me a bond NH S a bond T3i OH 3380 CMe O Q1c a bond Me a bond NH S a bond T3j OH 3381 CMe O Q1c a bond Me a bond NH O NH T3a OH 3382 CMe O Q1c a bond Me a bond NH O NH T3b OH 3383 CMe O Q1c a bond Me a bond NH O NH T3c OH 3384 CMe O Q1c a bond Me a bond NH O NH T3d OH 3385 CMe O Q1c a bond Me a bond NH O NH T3e OH 3386 CMe O Q1c a bond Me a bond NH O NH T3f OH 3387 CMe O Q1c a bond Me a bond NH O NH T3g OH 3388 CMe O Q1c a bond Me a bond NH O NH T3h OH 3389 CMe O Q1c a bond Me a bond NH O NH T3i OH 3390 CMe O Q1c a bond Me a bond NH O NH T3j OH 3391 CMe O Q1c a bond Me a bond NH O a bond T3a OH 3392 CMe O Q1c a bond Me a bond NH O a bond T3b OH 3393 CMe O Q1c a bond Me a bond NH O a bond T3c OH 3394 CMe O Q1c a bond Me a bond NH O a bond T3d OH 3395 CMe O Q1c a bond Me a bond NH O a bond T3e OH 3396 CMe O Q1c a bond Me a bond NH O a bond T3f OH 3397 CMe O Q1c a bond Me a bond NH O a bond T3g OH 3398 CMe O Q1c a bond Me a bond NH O a bond T3h OH 3399 CMe O Q1c a bond Me a bond NH O a bond T3i OH 3400 CMe O Q1c a bond Me a bond NH O a bond T3j OH 3401 CMe O Q1c a bond H a bond NH S NH T3a OH 3402 CMe O Q1c a bond H a bond NH S NH T3b OH 3403 CMe O Q1c a bond H a bond NH S NH T3c OH 3404 CMe O Q1c a bond H a bond NH S NH T3d OH 3405 CMe O Q1c a bond H a bond NH S NH T3e OH 3406 CMe O Q1c a bond H a bond NH S NH T3f OH 3407 CMe O Q1c a bond H a bond NH S NH T3g OH 3408 CMe O Q1c a bond H a bond NH S NH T3h OH 3409 CMe O Q1c a bond H a bond NH S NH T3i OH 3410 CMe O Q1c a bond H a bond NH S NH T3j OH 3411 CMe O Q1c a bond H a bond NH S a bond T3a OH 3412 CMe O Q1c a bond H a bond NH S a bond T3b OH 3413 CMe O Q1c a bond H a bond NH S a bond T3c OH 3414 CMe O Q1c a bond H a bond NH S a bond T3d OH 3415 CMe O Q1c a bond H a bond NH S a bond T3e OH 3416 CMe O Q1c a bond H a bond NH S a bond T3f OH 3417 CMe O Q1c a bond H a bond NH S a bond T3g OH 3418 CMe O Q1c a bond H a bond NH S a bond T3h OH 3419 CMe O Q1c a bond H a bond NH S a bond T3i OH 3420 CMe O Q1c a bond H a bond NH S a bond T3j OH 3421 CMe O Q1c a bond H a bond NH O NH T3a OH 3422 CMe O Q1c a bond H a bond NH O NH T3b OH 3423 CMe O Q1c a bond H a bond NH O NH T3c OH 3424 CMe O Q1c a bond H a bond NH O NH T3d OH 3425 CMe O Q1c a bond H a bond NH O NH T3e OH 3426 CMe O Q1c a bond H a bond NH O NH T3f OH 3427 CMe O Q1c a bond H a bond NH O NH T3g OH 3428 CMe O Q1c a bond H a bond NH O NH T3h OH 3429 CMe O Q1c a bond H a bond NH O NH T3i OH 3430 CMe O Q1c a bond H a bond NH O NH T3j OH 3431 CMe O Q1c a bond H a bond NH O a bond T3a OH 3432 CMe O Q1c a bond H a bond NH O a bond T3b OH 3433 CMe O Q1c a bond H a bond NH O a bond T3c OH 3434 CMe O Q1c a bond H a bond NH O a bond T3d OH 3435 CMe O Q1c a bond H a bond NH O a bond T3e OH 3436 CMe O Q1c a bond H a bond NH O a bond T3f OH 3437 CMe O Q1c a bond H a bond NH O a bond T3g OH 3438 CMe O Q1c a bond H a bond NH O a bond T3h OH 3439 CMe O Q1c a bond H a bond NH O a bond T3i OH 3440 CMe O Q1c a bond H a bond NH O a bond T3j OH 3441 CMe O Q1i a bond Me a bond NH S NH T3a OH 3442 CMe O Q1i a bond Me a bond NH S NH T3b OH 3443 CMe O Q1i a bond Me a bond NH S NH T3c OH 3444 CMe O Q1i a bond Me a bond NH S NH T3d OH 3445 CMe O Q1i a bond Me a bond NH S NH T3e OH 3446 CMe O Q1i a bond Me a bond NH S NH T3f OH 3447 CMe O Q1i a bond Me a bond NH S NH T3g OH 3448 CMe O Q1i a bond Me a bond NH S NH T3h OH 3449 CMe O Q1i a bond Me a bond NH S NH T3i OH 3450 CMe O Q1i a bond Me a bond NH S NH T3j OH 3451 CMe O Q1i a bond Me a bond NH S a bond T3a OH 3452 CMe O Q1i a bond Me a bond NH S a bond T3b OH 3453 CMe O Q1i a bond Me a bond NH S a bond T3c OH 3454 CMe O Q1i a bond Me a bond NH S a bond T3d OH 3455 CMe O Q1i a bond Me a bond NH S a bond T3e OH 3456 CMe O Q1i a bond Me a bond NH S a bond T3f OH 3457 CMe O Q1i a bond Me a bond NH S a bond T3g OH 3458 CMe O Q1i a bond Me a bond NH S a bond T3h OH 3459 CMe O Q1i a bond Me a bond NH S a bond T3i OH 3460 CMe O Q1i a bond Me a bond NH S a bond T3j OH 3461 CMe O Q1i a bond Me a bond NH O NH T3a OH 3462 CMe O Q1i a bond Me a bond NH O NH T3b OH 3463 CMe O Q1i a bond Me a bond NH O NH T3c OH 3464 CMe O Q1i a bond Me a bond NH O NH T3d OH 3465 CMe O Q1i a bond Me a bond NH O NH T3e OH 3466 CMe O Q1i a bond Me a bond NH O NH T3f OH 3467 CMe O Q1i a bond Me a bond NH O NH T3g OH 3468 CMe O Q1i a bond Me a bond NH O NH T3h OH 3469 CMe O Q1i a bond Me a bond NH O NH T3i OH 3470 CMe O Q1i a bond Me a bond NH O NH T3j OH 3471 CMe O Q1i a bond Me a bond NH O a bond T3a OH 3472 CMe O Q1i a bond Me a bond NH O a bond T3b OH 3473 CMe O Q1i a bond Me a bond NH O a bond T3c OH 3474 CMe O Q1i a bond Me a bond NH O a bond T3d OH 3475 CMe O Q1i a bond Me a bond NH O a bond T3e OH 3476 CMe O Q1i a bond Me a bond NH O a bond T3f OH 3477 CMe O Q1i a bond Me a bond NH O a bond T3g OH 3478 CMe O Q1i a bond Me a bond NH O a bond T3h OH 3479 CMe O Q1i a bond Me a bond NH O a bond T3i OH 3480 CMe O Q1i a bond Me a bond NH O a bond T3j OH 3481 CMe O Q1i a bond H a bond NH S NH T3a OH 3482 CMe O Q1i a bond H a bond NH S NH T3b OH 3483 CMe O Q1i a bond H a bond NH S NH T3c OH 3484 CMe O Q1i a bond H a bond NH S NH T3d OH 3485 CMe O Q1i a bond H a bond NH S NH T3e OH 3486 CMe O Q1i a bond H a bond NH S NH T3f OH 3487 CMe O Q1i a bond H a bond NH S NH T3g OH 3488 CMe O Q1i a bond H a bond NH S NH T3h OH 3489 CMe O Q1i a bond H a bond NH S NH T3i OH 3490 CMe O Q1i a bond H a bond NH S NH T3j OH 3491 CMe O Q1i a bond H a bond NH S a bond T3a OH 3492 CMe O Q1i a bond H a bond NH S a bond T3b OH 3493 CMe O Q1i a bond H a bond NH S a bond T3c OH 3494 CMe O Q1i a bond H a bond NH S a bond T3d OH 3495 CMe O Q1i a bond H a bond NH S a bond T3e OH 3496 CMe O Q1i a bond H a bond NH S a bond T3f OH 3497 CMe O Q1i a bond H a bond NH S a bond T3g OH 3498 CMe O Q1i a bond H a bond NH S a bond T3h OH 3499 CMe O Q1i a bond H a bond NH S a bond T3i OH 3500 CMe O Q1i a bond H a bond NH S a bond T3j OH 3501 CMe O Q1i a bond H a bond NH O NH T3a OH 3502 CMe O Q1i a bond H a bond NH O NH T3b OH 3503 CMe O Q1i a bond H a bond NH O NH T3c OH 3504 CMe O Q1i a bond H a bond NH O NH T3d OH 3505 CMe O Q1i a bond H a bond NH O NH T3e OH 3506 CMe O Q1i a bond H a bond NH O NH T3f OH 3507 CMe O Q1i a bond H a bond NH O NH T3g OH 3508 CMe O Q1i a bond H a bond NH O NH T3h OH 3509 CMe O Q1i a bond H a bond NH O NH T3i OH 3510 CMe O Q1i a bond H a bond NH O NH T3j OH 3511 CMe O Q1i a bond H a bond NH O a bond T3a OH 3512 CMe O Q1i a bond H a bond NH O a bond T3b OH 3513 CMe O Q1i a bond H a bond NH O a bond T3c OH 3514 CMe O Q1i a bond H a bond NH O a bond T3d OH 3515 CMe O Q1i a bond H a bond NH O a bond T3e OH 3516 CMe O Q1i a bond H a bond NH O a bond T3f OH 3517 CMe O Q1i a bond H a bond NH O a bond T3g OH 3518 CMe O Q1i a bond H a bond NH O a bond T3h OH 3519 CMe O Q1i a bond H a bond NH O a bond T3i OH 3520 CMe O Q1i a bond H a bond NH O a bond T3j OH 3521 CMe O Q1j a bond Me a bond NH S NH T3a OH 3522 CMe O Q1j a bond Me a bond NH S NH T3b OH 3523 CMe O Q1j a bond Me a bond NH S NH T3c OH 3524 CMe O Q1j a bond Me a bond NH S NH T3d OH 3525 CMe O Q1j a bond Me a bond NH S NH T3e OH 3526 CMe O Q1j a bond Me a bond NH S NH T3f OH 3527 CMe O Q1j a bond Me a bond NH S NH T3g OH 3528 CMe O Q1j a bond Me a bond NH S NH T3h OH 3529 CMe O Q1j a bond Me a bond NH S NH T3i OH 3530 CMe O Q1j a bond Me a bond NH S NH T3j OH 3531 CMe O Q1j a bond Me a bond NH S a bond T3a OH 3532 CMe O Q1j a bond Me a bond NH S a bond T3b OH 3533 CMe O Q1j a bond Me a bond NH S a bond T3c OH 3534 CMe O Q1j a bond Me a bond NH S a bond T3d OH 3535 CMe O Q1j a bond Me a bond NH S a bond T3e OH 3536 CMe O Q1j a bond Me a bond NH S a bond T3f OH 3537 CMe O Q1j a bond Me a bond NH S a bond T3g OH 3538 CMe O Q1j a bond Me a bond NH S a bond T3h OH 3539 CMe O Q1j a bond Me a bond NH S a bond T3i OH 3540 CMe O Q1j a bond Me a bond NH S a bond T3j OH 3541 CMe O Q1j a bond Me a bond NH O NH T3a OH 3542 CMe O Q1j a bond Me a bond NH O NH T3b OH 3543 CMe O Q1j a bond Me a bond NH O NH T3c OH 3544 CMe O Q1j a bond Me a bond NH O NH T3d OH 3545 CMe O Q1j a bond Me a bond NH O NH T3e OH 3546 CMe O Q1j a bond Me a bond NH O NH T3f OH 3547 CMe O Q1j a bond Me a bond NH O NH T3g OH 3548 CMe O Q1j a bond Me a bond NH O NH T3h OH 3549 CMe O Q1j a bond Me a bond NH O NH T3i OH 3550 CMe O Q1j a bond Me a bond NH O NH T3j OH 3551 CMe O Q1j a bond Me a bond NH O a bond T3a OH 3552 CMe O Q1j a bond Me a bond NH O a bond T3b OH 3553 CMe O Q1j a bond Me a bond NH O a bond T3c OH 3554 CMe O Q1j a bond Me a bond NH O a bond T3d OH 3555 CMe O Q1j a bond Me a bond NH O a bond T3e OH 3556 CMe O Q1j a bond Me a bond NH O a bond T3f OH 3557 CMe O Q1j a bond Me a bond NH O a bond T3g OH 3558 CMe O Q1j a bond Me a bond NH O a bond T3h OH 3559 CMe O Q1j a bond Me a bond NH O a bond T3i OH 3560 CMe O Q1j a bond Me a bond NH O a bond T3j OH 3561 CMe O Q1j a bond H a bond NH S NH T3a OH 3562 CMe O Q1j a bond H a bond NH S NH T3b OH 3563 CMe O Q1j a bond H a bond NH S NH T3c OH 3564 CMe O Q1j a bond H a bond NH S NH T3d OH 3565 CMe O Q1j a bond H a bond NH S NH T3e OH 3566 CMe O Q1j a bond H a bond NH S NH T3f OH 3567 CMe O Q1j a bond H a bond NH S NH T3g OH 3568 CMe O Q1j a bond H a bond NH S NH T3h OH 3569 CMe O Q1j a bond H a bond NH S NH T3i OH 3570 CMe O Q1j a bond H a bond NH S NH T3j OH 3571 CMe O Q1j a bond H a bond NH S a bond T3a OH 3572 CMe O Q1j a bond H a bond NH S a bond T3b OH 3573 CMe O Q1j a bond H a bond NH S a bond T3c OH 3574 CMe O Q1j a bond H a bond NH S a bond T3d OH 3575 CMe O Q1j a bond H a bond NH S a bond T3e OH 3576 CMe O Q1j a bond H a bond NH S a bond T3f OH 3577 CMe O Q1j a bond H a bond NH S a bond T3g OH 3578 CMe O Q1j a bond H a bond NH S a bond T3h OH 3579 CMe O Q1j a bond H a bond NH S a bond T3i OH 3580 CMe O Q1j a bond H a bond NH S a bond T3j OH 3581 CMe O Q1j a bond H a bond NH O NH T3a OH 3582 CMe O Q1j a bond H a bond NH O NH T3b OH 3583 CMe O Q1j a bond H a bond NH O NH T3c OH 3584 CMe O Q1j a bond H a bond NH O NH T3d OH 3585 CMe O Q1j a bond H a bond NH O NH T3e OH 3586 CMe O Q1j a bond H a bond NH O NH T3f OH 3587 CMe O Q1j a bond H a bond NH O NH T3g OH 3588 CMe O Q1j a bond H a bond NH O NH T3h OH 3589 CMe O Q1j a bond H a bond NH O NH T3i OH 3590 CMe O Q1j a bond H a bond NH O NH T3j OH 3591 CMe O Q1j a bond H a bond NH O a bond T3a OH 3592 CMe O Q1j a bond H a bond NH O a bond T3b OH 3593 CMe O Q1j a bond H a bond NH O a bond T3c OH 3594 CMe O Q1j a bond H a bond NH O a bond T3d OH 3595 CMe O Q1j a bond H a bond NH O a bond T3e OH 3596 CMe O Q1j a bond H a bond NH O a bond T3f OH 3597 CMe O Q1j a bond H a bond NH O a bond T3g OH 3598 CMe O Q1j a bond H a bond NH O a bond T3h OH 3599 CMe O Q1j a bond H a bond NH O a bond T3i OH 3600 CMe O Q1j a bond H a bond NH O a bond T3j OH 3601 N NMe Q1i a bond Me a bond NH S NH Q3e OH 3602 N NMe Q1i a bond Me a bond NH S a bond Q3e OH 3603 N NMe Q1i a bond Me a bond NH O NH Q3e OH 3604 N NMe Q1i a bond Me a bond NH O a bond Q3e OH 3605 N NMe Q1i a bond H a bond NH S NH Q3e OH 3606 N NMe Q1i a bond H a bond NH S a bond Q3e OH 3607 N NMe Q1i a bond H a bond NH O NH Q3e OH 3608 N NMe Q1i a bond H a bond NH O a bond Q3e OH 3609 N NMe Q1j a bond Me a bond NH S NH Q3e OH 3610 N NMe Q1j a bond Me a bond NH S a bond Q3e OH 3611 N NMe Q1j a bond Me a bond NH O NH Q3e OH 3612 N NMe Q1j a bond Me a bond NH O a bond Q3e OH 3613 N NMe Q1j a bond H a bond NH S NH Q3e OH 3614 N NMe Q1j a bond H a bond NH S a bond Q3e OH 3615 N NMe Q1j a bond H a bond NH O NH Q3e OH 3616 N NMe Q1j a bond H a bond NH O a bond Q3e OH 3617 N S Q1i a bond Me a bond NH S NH Q3e OH 3618 N S Q1i a bond Me a bond NH S a bond Q3e OH 3619 N S Q1i a bond Me a bond NH O NH Q3e OH 3620 N S Q1i a bond Me a bond NH O a bond Q3e OH 3621 N S Q1i a bond H a bond NH S NH Q3e OH 3622 N S Q1i a bond H a bond NH S a bond Q3e OH 3623 N S Q1i a bond H a bond NH O NH Q3e OH 3624 N S Q1i a bond H a bond NH O a bond Q3e OH 3625 N S Q1j a bond Me a bond NH S NH Q3e OH 3626 N S Q1j a bond Me a bond NH S a bond Q3e OH 3627 N S Q1j a bond Me a bond NH O NH Q3e OH 3628 N S Q1j a bond Me a bond NH O a bond Q3e OH 3629 N S Q1j a bond H a bond NH S NH Q3e OH 3630 N S Q1j a bond H a bond NH S a bond Q3e OH 3631 N S Q1j a bond H a bond NH O NH Q3e OH 3632 N S Q1j a bond H a bond NH O a bond Q3e OH 3633 N O Q1i a bond Me a bond NH S NH Q3e OH 3634 N O Q1i a bond Me a bond NH S a bond Q3e OH 3635 N O Q1i a bond Me a bond NH O NH Q3e OH 3636 N O Q1i a bond Me a bond NH O a bond Q3e OH 3637 N O Q1i a bond H a bond NH S NH Q3e OH 3638 N O Q1i a bond H a bond NH S a bond Q3e OH 3639 N O Q1i a bond H a bond NH O NH Q3e OH 3640 N O Q1i a bond H a bond NH O a bond Q3e OH 3641 N O Q1j a bond Me a bond NH S NH Q3e OH 3642 N O Q1j a bond Me a bond NH S a bond Q3e OH 3643 N O Q1j a bond Me a bond NH O NH Q3e OH 3644 N O Q1j a bond Me a bond NH O a bond Q3e OH 3645 N O Q1j a bond H a bond NH S NH Q3e OH 3646 N O Q1j a bond H a bond NH S a bond Q3e OH 3647 N O Q1j a bond H a bond NH O NH Q3e OH 3648 N O Q1j a bond H a bond NH O a bond Q3e OH 3649 CH NMe Q1i a bond Me a bond NH S NH Q3e OH 3650 CH NMe Q1i a bond Me a bond NH S a bond Q3e OH 3651 CH NMe Q1i a bond Me a bond NH O NH Q3e OH 3652 CH NMe Q1i a bond Me a bond NH O a bond Q3e OH 3653 CH NMe Q1i a bond H a bond NH S NH Q3e OH 3654 CH NMe Q1i a bond H a bond NH S a bond Q3e OH 3655 CH NMe Q1i a bond H a bond NH O NH Q3e OH 3656 CH NMe Q1i a bond H a bond NH O a bond Q3e OH 3657 CH NMe Q1j a bond Me a bond NH S NH Q3e OH 3658 CH NMe Q1j a bond Me a bond NH S a bond Q3e OH 3659 CH NMe Q1j a bond Me a bond NH O NH Q3e OH 3660 CH NMe Q1j a bond Me a bond NH O a bond Q3e OH 3661 CH NMe Q1j a bond H a bond NH S NH Q3e OH 3662 CH NMe Q1j a bond H a bond NH S a bond Q3e OH 3663 CH NMe Q1j a bond H a bond NH O NH Q3e OH 3664 CH NMe Q1j a bond H a bond NH O a bond Q3e OH 3665 CH S Q1i a bond Me a bond NH S NH Q3e OH 3666 CH S Q1i a bond Me a bond NH S a bond Q3e OH 3667 CH S Q1i a bond Me a bond NH O NH Q3e OH 3668 CH S Q1i a bond Me a bond NH O a bond Q3e OH 3669 CH S Q1i a bond H a bond NH S NH Q3e OH 3670 CH S Q1i a bond H a bond NH S a bond Q3e OH 3671 CH S Q1i a bond H a bond NH O NH Q3e OH 3672 CH S Q1i a bond H a bond NH O a bond Q3e OH 3673 CH S Q1j a bond Me a bond NH S NH Q3e OH 3674 CH S Q1j a bond Me a bond NH S a bond Q3e OH 3675 CH S Q1j a bond Me a bond NH O NH Q3e OH 3676 CH S Q1j a bond Me a bond NH O a bond Q3e OH 3677 CH S Q1j a bond H a bond NH S NH Q3e OH 3678 CH S Q1j a bond H a bond NH S a bond Q3e OH 3679 CH S Q1j a bond H a bond NH O NH Q3e OH 3680 CH S Q1j a bond H a bond NH O a bond Q3e OH 3681 CH O Q1i a bond Me a bond NH S NH Q3e OH 3682 CH O Q1i a bond Me a bond NH S a bond Q3e OH 3683 CH O Q1i a bond Me a bond NH O NH Q3e OH 3684 CH O Q1i a bond Me a bond NH O a bond Q3e OH 3685 CH O Q1i a bond H a bond NH S NH Q3e OH 3686 CH O Q1i a bond H a bond NH S a bond Q3e OH 3687 CH O Q1i a bond H a bond NH O NH Q3e OH 3688 CH O Q1i a bond H a bond NH O a bond Q3e OH 3689 CH O Q1j a bond Me a bond NH S NH Q3e OH 3690 CH O Q1j a bond Me a bond NH S a bond Q3e OH 3691 CH O Q1j a bond Me a bond NH O NH Q3e OH 3692 CH O Q1j a bond Me a bond NH O a bond Q3e OH 3693 CH O Q1j a bond H a bond NH S NH Q3e OH 3694 CH O Q1j a bond H a bond NH S a bond Q3e OH 3695 CH O Q1j a bond H a bond NH O NH Q3e OH 3696 CH O Q1j a bond H a bond NH O a bond Q3e OH 3697 CMe NMe Q1i a bond Me a bond NH S NH Q3e OH 3698 CMe NMe Q1i a bond Me a bond NH S a bond Q3e OH 3699 CMe NMe Q1i a bond Me a bond NH O NH Q3e OH 3700 CMe NMe Q1i a bond Me a bond NH O a bond Q3e OH 3701 CMe NMe Q1i a bond H a bond NH S NH Q3e OH 3702 CMe NMe Q1i a bond H a bond NH S a bond Q3e OH 3703 CMe NMe Q1i a bond H a bond NH O NH Q3e OH 3704 CMe NMe Q1i a bond H a bond NH O a bond Q3e OH 3705 CMe NMe Q1j a bond Me a bond NH S NH Q3e OH 3706 CMe NMe Q1j a bond Me a bond NH S a bond Q3e OH 3707 CMe NMe Q1j a bond Me a bond NH O NH Q3e OH 3708 CMe NMe Q1j a bond Me a bond NH O a bond Q3e OH 3709 CMe NMe Q1j a bond H a bond NH S NH Q3e OH 3710 CMe NMe Q1j a bond H a bond NH S a bond Q3e OH 3711 CMe NMe Q1j a bond H a bond NH O NH Q3e OH 3712 CMe NMe Q1j a bond H a bond NH O a bond Q3e OH 3713 CMe S Q1i a bond Me a bond NH S NH Q3e OH 3714 CMe S Q1i a bond Me a bond NH S a bond Q3e OH 3715 CMe S Q1i a bond Me a bond NH O NH Q3e OH 3716 CMe S Q1i a bond Me a bond NH O a bond Q3e OH 3717 CMe S Q1i a bond H a bond NH S NH Q3e OH 3718 CMe S Q1i a bond H a bond NH S a bond Q3e OH 3719 CMe S Q1i a bond H a bond NH O NH Q3e OH 3720 CMe S Q1i a bond H a bond NH O a bond Q3e OH 3721 CMe S Q1j a bond Me a bond NH S NH Q3e OH 3722 CMe S Q1j a bond Me a bond NH S a bond Q3e OH 3723 CMe S Q1j a bond Me a bond NH O NH Q3e OH 3724 CMe S Q1j a bond Me a bond NH O a bond Q3e OH 3725 CMe S Q1j a bond H a bond NH S NH Q3e OH 3726 CMe S Q1j a bond H a bond NH S a bond Q3e OH 3727 CMe S Q1j a bond H a bond NH O NH Q3e OH 3728 CMe S Q1j a bond H a bond NH O a bond Q3e OH 3729 CMe O Q1i a bond Me a bond NH S NH Q3e OH 3730 CMe O Q1i a bond Me a bond NH S a bond Q3e OH 3731 CMe O Q1i a bond Me a bond NH O NH Q3e OH 3732 CMe O Q1i a bond Me a bond NH O a bond Q3e OH 3733 CMe O Q1i a bond H a bond NH S NH Q3e OH 3734 CMe O Q1i a bond H a bond NH S a bond Q3e OH 3735 CMe O Q1i a bond H a bond NH O NH Q3e OH 3736 CMe O Q1i a bond H a bond NH O a bond Q3e OH 3737 CMe O Q1j a bond Me a bond NH S NH Q3e OH 3738 CMe O Q1j a bond Me a bond NH S a bond Q3e OH 3739 CMe O Q1j a bond Me a bond NH O NH Q3e OH 3740 CMe O Q1j a bond Me a bond NH O a bond Q3e OH 3741 CMe O Q1j a bond H a bond NH S NH Q3e OH 3742 CMe O Q1j a bond H a bond NH S a bond Q3e OH 3743 CMe O Q1j a bond H a bond NH O NH Q3e OH 3744 CMe O Q1j a bond H a bond NH O a bond Q3e OH

64) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 64), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

65) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 65), Q1a, Q1b, Q1c, Q1i, Q14, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

66) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 66), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

67) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 67), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

68) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 68), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

69) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 69), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

70) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 70), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

71) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 71), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

72) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the following combinations in Table 2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 2 denote the flowing substituents.

TABLE 2 No A B R¹ L¹ R² L² L³ Y L⁴ R³ X  1 N NMe Q1a NH Me a bond NH S NH Q3a OH  2 N NMe Q1a NH Me a bond NH S a bond Q3a OH  3 N NMe Q1a NH Me a bond NH O NH Q3a OH  4 N NMe Q1a NH Me a bond NH O a bond Q3a OH  5 N NMe Q1a NH H a bond NH S NH Q3a OH  6 N NMe Q1a NH H a bond NH S a bond Q3a OH  7 N NMe Q1a NH H a bond NH O NH Q3a OH  8 N NMe Q1a NH H a bond NH O a bond Q3a OH  9 N NMe Q1b NH Me a bond NH S NH Q3a OH  10 N NMe Q1b NH Me a bond NH S a bond Q3a OH  11 N NMe Q1b NH Me a bond NH O NH Q3a OH  12 N NMe Q1b NH Me a bond NH O a bond Q3a OH  13 N NMe Q1b NH H a bond NH S NH Q3a OH  14 N NMe Q1b NH H a bond NH S a bond Q3a OH  15 N NMe Q1b NH H a bond NH O NH Q3a OH  16 N NMe Q1b NH H a bond NH O a bond Q3a OH  17 N S Q1a NH Me a bond NH S NH Q3a OH  18 N S Q1a NH Me a bond NH S a bond Q3a OH  19 N S Q1a NH Me a bond NH O NH Q3a OH  20 N S Q1a NH Me a bond NH O a bond Q3a OH  21 N S Q1a NH H a bond NH S NH Q3a OH  22 N S Q1a NH H a bond NH S a bond Q3a OH  23 N S Q1a NH H a bond NH O NH Q3a OH  24 N S Q1a NH H a bond NH O a bond Q3a OH  25 N S Q1b NH Me a bond NH S NH Q3a OH  26 N S Q1b NH Me a bond NH S a bond Q3a OH  27 N S Q1b NH Me a bond NH O NH Q3a OH  28 N S Q1b NH Me a bond NH O a bond Q3a OH  29 N S Q1b NH H a bond NH S NH Q3a OH  30 N S Q1b NH H a bond NH S a bond Q3a OH  31 N S Q1b NH H a bond NH O NH Q3a OH  32 N S Q1b NH H a bond NH O a bond Q3a OH  33 N O Q1a NH Me a bond NH S NH Q3a OH  34 N O Q1a NH Me a bond NH S a bond Q3a OH  35 N O Q1a NH Me a bond NH O NH Q3a OH  36 N O Q1a NH Me a bond NH O a bond Q3a OH  37 N O Q1a NH H a bond NH S NH Q3a OH  38 N O Q1a NH H a bond NH S a bond Q3a OH  39 N O Q1a NH H a bond NH O NH Q3a OH  40 N O Q1a NH H a bond NH O a bond Q3a OH  41 N O Q1b NH Me a bond NH S NH Q3a OH  42 N O Q1b NH Me a bond NH S a bond Q3a OH  43 N O Q1b NH Me a bond NH O NH Q3a OH  44 N O Q1b NH Me a bond NH O a bond Q3a OH  45 N O Q1b NH H a bond NH S NH Q3a OH  46 N O Q1b NH H a bond NH S a bond Q3a OH  47 N O Q1b NH H a bond NH O NH Q3a OH  48 N O Q1b NH H a bond NH O a bond Q3a OH  49 CH NMe Q1a NH Me a bond NH S NH Q3a OH  50 CH NMe Q1a NH Me a bond NH S a bond Q3a OH  51 CH NMe Q1a NH Me a bond NH O NH Q3a OH  52 CH NMe Q1a NH Me a bond NH O a bond Q3a OH  53 CH NMe Q1a NH H a bond NH S NH Q3a OH  54 CH NMe Q1a NH H a bond NH S a bond Q3a OH  55 CH NMe Q1a NH H a bond NH O NH Q3a OH  56 CH NMe Q1a NH H a bond NH O a bond Q3a OH  57 CH NMe Q1b NH Me a bond NH S NH Q3a OH  58 CH NMe Q1b NH Me a bond NH S a bond Q3a OH  59 CH NMe Q1b NH Me a bond NH O NH Q3a OH  60 CH NMe Q1b NH Me a bond NH O a bond Q3a OH  61 CH NMe Q1b NH H a bond NH S NH Q3a OH  62 CH NMe Q1b NH H a bond NH S a bond Q3a OH  63 CH NMe Q1b NH H a bond NH O NH Q3a OH  64 CH NMe Q1b NH H a bond NH O a bond Q3a OH  65 CH S Q1a NH Me a bond NH S NH Q3a OH  66 CH S Q1a NH Me a bond NH S a bond Q3a OH  67 CH S Q1a NH Me a bond NH O NH Q3a OH  68 CH S Q1a NH Me a bond NH O a bond Q3a OH  69 CH S Q1a NH H a bond NH S NH Q3a OH  70 CH S Q1a NH H a bond NH S a bond Q3a OH  71 CH S Q1a NH H a bond NH O NH Q3a OH  72 CH S Q1a NH H a bond NH O a bond Q3a OH  73 CH S Q1b NH Me a bond NH S NH Q3a OH  74 CH S Q1b NH Me a bond NH S a bond Q3a OH  75 CH S Q1b NH Me a bond NH O NH Q3a OH  76 CH S Q1b NH Me a bond NH O a bond Q3a OH  77 CH S Q1b NH H a bond NH S NH Q3a OH  78 CH S Q1b NH H a bond NH S a bond Q3a OH  79 CH S Q1b NH H a bond NH O NH Q3a OH  80 CH S Q1b NH H a bond NH O a bond Q3a OH  81 CH O Q1a NH Me a bond NH S NH Q3a OH  82 CH O Q1a NH Me a bond NH S a bond Q3a OH  83 CH O Q1a NH Me a bond NH O NH Q3a OH  84 CH O Q1a NH Me a bond NH O a bond Q3a OH  85 CH O Q1a NH H a bond NH S NH Q3a OH  86 CH O Q1a NH H a bond NH S a bond Q3a OH  87 CH O Q1a NH H a bond NH O NH Q3a OH  88 CH O Q1a NH H a bond NH O a bond Q3a OH  89 CH O Q1b NH Me a bond NH S NH Q3a OH  90 CH O Q1b NH Me a bond NH S a bond Q3a OH  91 CH O Q1b NH Me a bond NH O NH Q3a OH  92 CH O Q1b NH Me a bond NH O a bond Q3a OH  93 CH O Q1b NH H a bond NH S NH Q3a OH  94 CH O Q1b NH H a bond NH S a bond Q3a OH  95 CH O Q1b NH H a bond NH O NH Q3a OH  96 CH O Q1b NH H a bond NH O a bond Q3a OH  97 CMe NMe Q1a NH Me a bond NH S NH Q3a OH  98 CMe NMe Q1a NH Me a bond NH S a bond Q3a OH  99 CMe NMe Q1a NH Me a bond NH O NH Q3a OH 100 CMe NMe Q1a NH Me a bond NH O a bond Q3a OH 101 CMe NMe Q1a NH H a bond NH S NH Q3a OH 102 CMe NMe Q1a NH H a bond NH S a bond Q3a OH 103 CMe NMe Q1a NH H a bond NH O NH Q3a OH 104 CMe NMe Q1a NH H a bond NH O a bond Q3a OH 105 CMe NMe Q1b NH Me a bond NH S NH Q3a OH 106 CMe NMe Q1b NH Me a bond NH S a bond Q3a OH 107 CMe NMe Q1b NH Me a bond NH O NH Q3a OH 108 CMe NMe Q1b NH Me a bond NH O a bond Q3a OH 109 CMe NMe Q1b NH H a bond NH S NH Q3a OH 110 CMe NMe Q1b NH H a bond NH S a bond Q3a OH 111 CMe NMe Q1b NH H a bond NH O NH Q3a OH 112 CMe NMe Q1b NH H a bond NH O a bond Q3a OH 113 CMe S Q1a NH Me a bond NH S NH Q3a OH 114 CMe S Q1a NH Me a bond NH S a bond Q3a OH 115 CMe S Q1a NH Me a bond NH O NH Q3a OH 116 CMe S Q1a NH Me a bond NH O a bond Q3a OH 117 CMe S Q1a NH H a bond NH S NH Q3a OH 118 CMe S Q1a NH H a bond NH S a bond Q3a OH 119 CMe S Q1a NH H a bond NH O NH Q3a OH 120 CMe S Q1a NH H a bond NH O a bond Q3a OH 121 CMe S Q1b NH Me a bond NH S NH Q3a OH 122 CMe S Q1b NH Me a bond NH S a bond Q3a OH 123 CMe S Q1b NH Me a bond NH O NH Q3a OH 124 CMe S Q1b NH Me a bond NH O a bond Q3a OH 125 CMe S Q1b NH H a bond NH S NH Q3a OH 126 CMe S Q1b NH H a bond NH S a bond Q3a OH 127 CMe S Q1b NH H a bond NH O NH Q3a OH 128 CMe S Q1b NH H a bond NH O a bond Q3a OH 129 CMe O Q1a NH Me a bond NH S NH Q3a OH 130 CMe O Q1a NH Me a bond NH S a bond Q3a OH 131 CMe O Q1a NH Me a bond NH O NH Q3a OH 132 CMe O Q1a NH Me a bond NH O a bond Q3a OH 133 CMe O Q1a NH H a bond NH S NH Q3a OH 134 CMe O Q1a NH H a bond NH S a bond Q3a OH 135 CMe O Q1a NH H a bond NH O NH Q3a OH 136 CMe O Q1a NH H a bond NH O a bond Q3a OH 137 CMe O Q1b NH Me a bond NH S NH Q3a OH 138 CMe O Q1b NH Me a bond NH S a bond Q3a OH 139 CMe O Q1b NH Me a bond NH O NH Q3a OH 140 CMe O Q1b NH Me a bond NH O a bond Q3a OH 141 CMe O Q1b NH H a bond NH S NH Q3a OH 142 CMe O Q1b NH H a bond NH S a bond Q3a OH 143 CMe O Q1b NH H a bond NH O NH Q3a OH 144 CMe O Q1b NH H a bond NH O a bond Q3a OH 145 N NMe Q1a O Me a bond NH S NH Q3a OH 146 N NMe Q1a O Me a bond NH S a bond Q3a OH 147 N NMe Q1a O Me a bond NH O NH Q3a OH 148 N NMe Q1a O Me a bond NH O a bond Q3a OH 149 N NMe Q1a O H a bond NH S NH Q3a OH 150 N NMe Q1a O H a bond NH S a bond Q3a OH 151 N NMe Q1a O H a bond NH O NH Q3a OH 152 N NMe Q1a O H a bond NH O a bond Q3a OH 153 N NMe Q1b O Me a bond NH S NH Q3a OH 154 N NMe Q1b O Me a bond NH S a bond Q3a OH 155 N NMe Q1b O Me a bond NH O NH Q3a OH 156 N NMe Q1b O Me a bond NH O a bond Q3a OH 157 N NMe Q1b O H a bond NH S NH Q3a OH 158 N NMe Q1b O H a bond NH S a bond Q3a OH 159 N NMe Q1b O H a bond NH O NH Q3a OH 160 N NMe Q1b O H a bond NH O a bond Q3a OH 161 N S Q1a O Me a bond NH S NH Q3a OH 162 N S Q1a O Me a bond NH S a bond Q3a OH 163 N S Q1a O Me a bond NH O NH Q3a OH 164 N S Q1a O Me a bond NH O a bond Q3a OH 165 N S Q1a O H a bond NH S NH Q3a OH 166 N S Q1a O H a bond NH S a bond Q3a OH 167 N S Q1a O H a bond NH O NH Q3a OH 168 N S Q1a O H a bond NH O a bond Q3a OH 169 N S Q1b O Me a bond NH S NH Q3a OH 170 N S Q1b O Me a bond NH S a bond Q3a OH 171 N S Q1b O Me a bond NH O NH Q3a OH 172 N S Q1b O Me a bond NH O a bond Q3a OH 173 N S Q1b O H a bond NH S NH Q3a OH 174 N S Q1b O H a bond NH S a bond Q3a OH 175 N S Q1b O H a bond NH O NH Q3a OH 176 N S Q1b O H a bond NH O a bond Q3a OH 177 N O Q1a O Me a bond NH S NH Q3a OH 178 N O Q1a O Me a bond NH S a bond Q3a OH 179 N O Q1a O Me a bond NH O NH Q3a OH 180 N O Q1a O Me a bond NH O a bond Q3a OH 181 N O Q1a O H a bond NH S NH Q3a OH 182 N O Q1a O H a bond NH S a bond Q3a OH 183 N O Q1a O H a bond NH O NH Q3a OH 184 N O Q1a O H a bond NH O a bond Q3a OH 185 N O Q1b O Me a bond NH S NH Q3a OH 186 N O Q1b O Me a bond NH S a bond Q3a OH 187 N O Q1b O Me a bond NH O NH Q3a OH 188 N O Q1b O Me a bond NH O a bond Q3a OH 189 N O Q1b O H a bond NH S NH Q3a OH 190 N O Q1b O H a bond NH S a bond Q3a OH 191 N O Q1b O H a bond NH O NH Q3a OH 192 N O Q1b O H a bond NH O a bond Q3a OH 193 CH NMe Q1a O Me a bond NH S NH Q3a OH 194 CH NMe Q1a O Me a bond NH S a bond Q3a OH 195 CH NMe Q1a O Me a bond NH O NH Q3a OH 196 CH NMe Q1a O Me a bond NH O a bond Q3a OH 197 CH NMe Q1a O H a bond NH S NH Q3a OH 198 CH NMe Q1a O H a bond NH S a bond Q3a OH 199 CH NMe Q1a O H a bond NH O NH Q3a OH 200 CH NMe Q1a O H a bond NH O a bond Q3a OH 201 CH NMe Q1b O Me a bond NH S NH Q3a OH 202 CH NMe Q1b O Me a bond NH S a bond Q3a OH 203 CH NMe Q1b O Me a bond NH O NH Q3a OH 204 CH NMe Q1b O Me a bond NH O a bond Q3a OH 205 CH NMe Q1b O H a bond NH S NH Q3a OH 206 CH NMe Q1b O H a bond NH S a bond Q3a OH 207 CH NMe Q1b O H a bond NH O NH Q3a OH 208 CH NMe Q1b O H a bond NH O a bond Q3a OH 209 CH S Q1a O Me a bond NH S NH Q3a OH 210 CH S Q1a O Me a bond NH S a bond Q3a OH 211 CH S Q1a O Me a bond NH O NH Q3a OH 212 CH S Q1a O Me a bond NH O a bond Q3a OH 213 CH S Q1a O H a bond NH S NH Q3a OH 214 CH S Q1a O H a bond NH S a bond Q3a OH 215 CH S Q1a O H a bond NH O NH Q3a OH 216 CH S Q1a O H a bond NH O a bond Q3a OH 217 CH S Q1b O Me a bond NH S NH Q3a OH 218 CH S Q1b O Me a bond NH S a bond Q3a OH 219 CH S Q1b O Me a bond NH O NH Q3a OH 220 CH S Q1b O Me a bond NH O a bond Q3a OH 221 CH S Q1b O H a bond NH S NH Q3a OH 222 CH S Q1b O H a bond NH S a bond Q3a OH 223 CH S Q1b O H a bond NH O NH Q3a OH 224 CH S Q1b O H a bond NH O a bond Q3a OH 225 CH O Q1a O Me a bond NH S NH Q3a OH 226 CH O Q1a O Me a bond NH S a bond Q3a OH 227 CH O Q1a O Me a bond NH O NH Q3a OH 228 CH O Q1a O Me a bond NH O a bond Q3a OH 229 CH O Q1a O H a bond NH S NH Q3a OH 230 CH O Q1a O H a bond NH S a bond Q3a OH 231 CH O Q1a O H a bond NH O NH Q3a OH 232 CH O Q1a O H a bond NH O a bond Q3a OH 233 CH O Q1b O Me a bond NH S NH Q3a OH 234 CH O Q1b O Me a bond NH S a bond Q3a OH 235 CH O Q1b O Me a bond NH O NH Q3a OH 236 CH O Q1b O Me a bond NH O a bond Q3a OH 237 CH O Q1b O H a bond NH S NH Q3a OH 238 CH O Q1b O H a bond NH S a bond Q3a OH 239 CH O Q1b O H a bond NH O NH Q3a OH 240 CH O Q1b O H a bond NH O a bond Q3a OH 241 CMe NMe Q1a O Me a bond NH S NH Q3a OH 242 CMe NMe Q1a O Me a bond NH S a bond Q3a OH 243 CMe NMe Q1a O Me a bond NH O NH Q3a OH 244 CMe NMe Q1a O Me a bond NH O a bond Q3a OH 245 CMe NMe Q1a O H a bond NH S NH Q3a OH 246 CMe NMe Q1a O H a bond NH S a bond Q3a OH 247 CMe NMe Q1a O H a bond NH O NH Q3a OH 248 CMe NMe Q1a O H a bond NH O a bond Q3a OH 249 CMe NMe Q1b O Me a bond NH S NH Q3a OH 250 CMe NMe Q1b O Me a bond NH S a bond Q3a OH 251 CMe NMe Q1b O Me a bond NH O NH Q3a OH 252 CMe NMe Q1b O Me a bond NH O a bond Q3a OH 253 CMe NMe Q1b O H a bond NH S NH Q3a OH 254 CMe NMe Q1b O H a bond NH S a bond Q3a OH 255 CMe NMe Q1b O H a bond NH O NH Q3a OH 256 CMe NMe Q1b O H a bond NH O a bond Q3a OH 257 CMe S Q1a O Me a bond NH S NH Q3a OH 258 CMe S Q1a O Me a bond NH S a bond Q3a OH 259 CMe S Q1a O Me a bond NH O NH Q3a OH 260 CMe S Q1a O Me a bond NH O a bond Q3a OH 261 CMe S Q1a O H a bond NH S NH Q3a OH 262 CMe S Q1a O H a bond NH S a bond Q3a OH 263 CMe S Q1a O H a bond NH O NH Q3a OH 264 CMe S Q1a O H a bond NH O a bond Q3a OH 265 CMe S Q1b O Me a bond NH S NH Q3a OH 266 CMe S Q1b O Me a bond NH S a bond Q3a OH 267 CMe S Q1b O Me a bond NH O NH Q3a OH 268 CMe S Q1b O Me a bond NH O a bond Q3a OH 269 CMe S Q1b O H a bond NH S NH Q3a OH 270 CMe S Q1b O H a bond NH S a bond Q3a OH 271 CMe S Q1b O H a bond NH O NH Q3a OH 272 CMe S Q1b O H a bond NH O a bond Q3a OH 273 CMe O Q1a O Me a bond NH S NH Q3a OH 274 CMe O Q1a O Me a bond NH S a bond Q3a OH 275 CMe O Q1a O Me a bond NH O NH Q3a OH 276 CMe O Q1a O Me a bond NH O a bond Q3a OH 277 CMe O Q1a O H a bond NH S NH Q3a OH 278 CMe O Q1a O H a bond NH S a bond Q3a OH 279 CMe O Q1a O H a bond NH O NH Q3a OH 280 CMe O Q1a O H a bond NH O a bond Q3a OH 281 CMe O Q1b O Me a bond NH S NH Q3a OH 282 CMe O Q1b O Me a bond NH S a bond Q3a OH 283 CMe O Q1b O Me a bond NH O NH Q3a OH 284 CMe O Q1b O Me a bond NH O a bond Q3a OH 285 CMe O Q1b O H a bond NH S NH Q3a OH 286 CMe O Q1b O H a bond NH S a bond Q3a OH 287 CMe O Q1b O H a bond NH O NH Q3a OH 288 CMe O Q1b O H a bond NH O a bond Q3a OH 289 N NMe Q1a CH2 Me a bond NH S NH Q3a OH 290 N NMe Q1a CH2 Me a bond NH S a bond Q3a OH 291 N NMe Q1a CH2 Me a bond NH O NH Q3a OH 292 N NMe Q1a CH2 Me a bond NH O a bond Q3a OH 293 N NMe Q1a CH2 H a bond NH S NH Q3a OH 294 N NMe Q1a CH2 H a bond NH S a bond Q3a OH 295 N NMe Q1a CH2 H a bond NH O NH Q3a OH 296 N NMe Q1a CH2 H a bond NH O a bond Q3a OH 297 N NMe Q1b CH2 Me a bond NH S NH Q3a OH 298 N NMe Q1b CH2 Me a bond NH S a bond Q3a OH 299 N NMe Q1b CH2 Me a bond NH O NH Q3a OH 300 N NMe Q1b CH2 Me a bond NH O a bond Q3a OH 301 N NMe Q1b CH2 H a bond NH S NH Q3a OH 302 N NMe Q1b CH2 H a bond NH S a bond Q3a OH 303 N NMe Q1b CH2 H a bond NH O NH Q3a OH 304 N NMe Q1b CH2 H a bond NH O a bond Q3a OH 305 N S Q1a CH2 Me a bond NH S NH Q3a OH 306 N S Q1a CH2 Me a bond NH S a bond Q3a OH 307 N S Q1a CH2 Me a bond NH O NH Q3a OH 308 N S Q1a CH2 Me a bond NH O a bond Q3a OH 309 N S Q1a CH2 H a bond NH S NH Q3a OH 310 N S Q1a CH2 H a bond NH S a bond Q3a OH 311 N S Q1a CH2 H a bond NH O NH Q3a OH 312 N S Q1a CH2 H a bond NH O a bond Q3a OH 313 N S Q1b CH2 Me a bond NH S NH Q3a OH 314 N S Q1b CH2 Me a bond NH S a bond Q3a OH 315 N S Q1b CH2 Me a bond NH O NH Q3a OH 316 N S Q1b CH2 Me a bond NH O a bond Q3a OH 317 N S Q1b CH2 H a bond NH S NH Q3a OH 318 N S Q1b CH2 H a bond NH S a bond Q3a OH 319 N S Q1b CH2 H a bond NH O NH Q3a OH 320 N S Q1b CH2 H a bond NH O a bond Q3a OH 321 N O Q1a CH2 Me a bond NH S NH Q3a OH 322 N O Q1a CH2 Me a bond NH S a bond Q3a OH 323 N O Q1a CH2 Me a bond NH O NH Q3a OH 324 N O Q1a CH2 Me a bond NH O a bond Q3a OH 325 N O Q1a CH2 H a bond NH S NH Q3a OH 326 N O Q1a CH2 H a bond NH S a bond Q3a OH 327 N O Q1a CH2 H a bond NH O NH Q3a OH 328 N O Q1a CH2 H a bond NH O a bond Q3a OH 329 N O Q1b CH2 Me a bond NH S NH Q3a OH 330 N O Q1b CH2 Me a bond NH S a bond Q3a OH 331 N O Q1b CH2 Me a bond NH O NH Q3a OH 332 N O Q1b CH2 Me a bond NH O a bond Q3a OH 333 N O Q1b CH2 H a bond NH S NH Q3a OH 334 N O Q1b CH2 H a bond NH S a bond Q3a OH 335 N O Q1b CH2 H a bond NH O NH Q3a OH 336 N O Q1b CH2 H a bond NH O a bond Q3a OH 337 CH NMe Q1a CH2 Me a bond NH S NH Q3a OH 338 CH NMe Q1a CH2 Me a bond NH S a bond Q3a OH 339 CH NMe Q1a CH2 Me a bond NH O NH Q3 OH 340 CH NMe Q1a CH2 Me a bond NH O a bond Q3a OH 341 CH NMe Q1a CH2 H a bond NH S NH Q3a OH 342 CH NMe Q1a CH2 H a bond NH S a bond Q3a OH 343 CH NMe Q1a CH2 H a bond NH O NH Q3a OH 344 CH NMe Q1a CH2 H a bond NH O a bond 3a OH 345 CH NMe Q1b CH2 Me a bond NH S NH Q3a OH 346 CH NMe Q1b CH2 Me a bond NH S a bond Q3a OH 347 CH NMe Q1b CH2 Me a bond NH O NH Q3a OH 348 CH NMe Q1b CH2 Me a bond NH O a bond Q3a OH 349 CH NMe Q1b CH2 H a bond NH S NH Q3a OH 350 CH NMe Q1b CH2 H a bond NH S a bond Q3a OH 351 CH NMe Q1b CH2 H a bond NH O NH Q3a OH 352 CH NMe Q1b CH2 H a bond NH O a bond Q3a OH 353 CH S Q1a CH2 Me a bond NH S NH Q3a OH 354 CH S Q1a CH2 Me a bond NH S a bond Q3a OH 355 CH S Q1a CH2 Me a bond NH O NH Q3a OH 356 CH S Q1a CH2 Me a bond NH O a bond Q3a OH 357 CH S Q1a CH2 H a bond NH S NH Q3a OH 358 CH S Q1a CH2 H a bond NH S a bond Q3a OH 359 CH S Q1a CH2 H a bond NH O NH Q3a OH 360 CH S Q1a CH2 H a bond NH O a bond Q3a OH 361 CH S Q1b CH2 Me a bond NH S NH Q3a OH 362 CH S Q1b CH2 Me a bond NH S a bond Q3a OH 363 CH S Q1b CH2 Me a bond NH O NH Q3a OH 364 CH S Q1b CH2 Me a bond NH O a bond Q3a OH 365 CH S Q1b CH2 H a bond NH S NH Q3a OH 366 CH S Q1b CH2 H a bond NH S a bond Q3a OH 367 CH S Q1b CH2 H a bond NH O NH Q3a OH 368 CH S Q1b CH2 H a bond NH O a bond Q3a OH 369 CH O Q1a CH2 Me a bond NH S NH Q3a OH 370 CH O Q1a CH2 Me a bond NH S a bond Q3a OH 371 CH O Q1a CH2 Me a bond NH O NH Q3a OH 372 CH O Q1a CH2 Me a bond NH O a bond Q3a OH 373 CH O Q1a CH2 H a bond NH S NH Q3a OH 374 CH O Q1a CH2 H a bond NH S a bond Q3a OH 375 CH O Q1a CH2 H a bond NH O NH Q3a OH 376 CH O Q1a CH2 H a bond NH O a bond Q3a OH 377 CH O Q1b CH2 Me a bond NH S NH Q3a OH 378 CH O Q1b CH2 Me a bond NH S a bond Q3a OH 379 CH O Q1b CH2 Me a bond NH O NH Q3a OH 380 CH O Q1b CH2 Me a bond NH O a bond Q3a OH 381 CH O Q1b CH2 H a bond NH S NH Q3a OH 382 CH O Q1b CH2 H a bond NH S a bond Q3a OH 383 CH O Q1b CH2 H a bond NH O NH Q3a OH 384 CH O Q1b CH2 H a bond NH O a bond Q3a OH 385 CMe NMe Q1a CH2 Me a bond NH S NH Q3a OH 386 CMe NMe Q1a CH2 Me a bond NH S a bond Q3a OH 387 CMe NMe Q1a CH2 Me a bond NH O NH Q3a OH 388 CMe NMe Q1a CH2 Me a bond NH O a bond Q3a OH 389 CMe NMe Q1a CH2 H a bond NH S NH Q3a OH 390 CMe NMe Q1a CH2 H a bond NH S a bond Q3a OH 391 CMe NMe Q1a CH2 H a bond NH O NH Q3a OH 392 CMe NMe Q1a CH2 H a bond NH O a bond Q3a OH 393 CMe NMe Q1b CH2 Me a bond NH S NH Q3a OH 394 CMe NMe Q1b CH2 Me a bond NH S a bond Q3a OH 395 CMe NMe Q1b CH2 Me a bond NH O NH Q3a OH 396 CMe NMe Q1b CH2 Me a bond NH O a bond Q3a OH 397 CMe NMe Q1b CH2 H a bond NH S NH Q3a OH 398 CMe NMe Q1b CH2 H a bond NH S a bond Q3a OH 399 CMe NMe Q1b CH2 H a bond NH O NH Q3a OH 400 CMe NMe Q1b CH2 H a bond NH O a bond Q3a OH 401 CMe S Q1a CH2 Me a bond NH S NH Q3a OH 402 CMe S Q1a CH2 Me a bond NH S a bond Q3a OH 403 CMe S Q1a CH2 Me a bond NH O NH Q3a OH 404 CMe S Q1a CH2 Me a bond NH O a bond Q3a OH 405 CMe S Q1a CH2 H a bond NH S NH Q3a OH 406 CMe S Q1a CH2 H a bond NH S a bond Q3a OH 407 CMe S Q1a CH2 H a bond NH O NH Q3a OH 408 CMe S Q1a CH2 H a bond NH O a bond Q3a OH 409 CMe S Q1b CH2 Me a bond NH S NH Q3a OH 410 CMe S Q1b CH2 Me a bond NH S a bond Q3a OH 411 CMe S Q1b CH2 Me a bond NH O NH Q3a OH 412 CMe S Q1b CH2 Me a bond NH O a bond Q3a OH 413 CMe S Q1b CH2 H a bond NH S NH Q3a OH 414 CMe S Q1b CH2 H a bond NH S a bond Q3a OH 415 CMe S Q1b CH2 H a bond NH O NH Q3a OH 416 CMe S Q1b CH2 H a bond NH O a bond Q3a OH 417 CMe O Q1a CH2 Me a bond NH S NH Q3a OH 418 CMe O Q1a CH2 Me a bond NH S a bond Q3a OH 419 CMe O Q1a CH2 Me a bond NH O NH Q3a OH 420 CMe O Q1a CH2 Me a bond NH O a bond Q3a OH 421 CMe O Q1a CH2 H a bond NH S NH Q3a OH 422 CMe O Q1a CH2 H a bond NH S a bond Q3a OH 423 CMe O Q1a CH2 H a bond NH O NH Q3a OH 424 CMe O Q1a CH2 H a bond NH O a bond Q3a OH 425 CMe O Q1b CH2 Me a bond NH S NH Q3a OH 426 CMe O Q1b CH2 Me a bond NH S a bond Q3a OH 427 CMe O Q1b CH2 Me a bond NH O NH Q3a OH 428 CMe O Q1b CH2 Me a bond NH O a bond Q3a OH 429 CMe O Q1b CH2 H a bond NH S NH Q3a OH 430 CMe O Q1b CH2 H a bond NH S a bond Q3a OH 431 CMe O Q1b CH2 H a bond NH O NH Q3a OH 432 CMe O Q1b CH2 H a bond NH O a bond Q3a OH 433 N NMe Q1a a bond Me a bond NH S CH2 Q3a OH 434 N NMe Q1a a bond Me a bond NH O CH2 Q3a OH 435 N NMe Q1a a bond H a bond NH S CH2 Q3a OH 436 N NMe Q1a a bond H a bond NH O CH2 Q3a OH 437 N NMe Q1b a bond Me a bond NH S CH2 Q3a OH 438 N NMe Q1b a bond Me a bond NH O CH2 Q3a OH 439 N NMe Q1b a bond H a bond NH S CH2 Q3a OH 440 N NMe Q1b a bond H a bond NH O CH2 Q3a OH 441 N S Q1a a bond Me a bond NH S CH2 Q3a OH 442 N S Q1a a bond Me a bond NH O CH2 Q3a OH 443 N S Q1a a bond H a bond NH S CH2 Q3a OH 444 N S Q1a a bond H a bond NH O CH2 Q3a OH 445 N S Q1b a bond Me a bond NH S CH2 Q3a OH 446 N S Q1b a bond Me a bond NH O CH2 Q3a OH 447 N S Q1b a bond H a bond NH S CH2 Q3a OH 448 N S Q1b a bond H a bond NH O CH2 Q3a OH 449 N O Q1a a bond Me a bond NH S CH2 Q3a OH 450 N O Q1a a bond Me a bond NH O CH2 Q3a OH 451 N O Q1a a bond H a bond NH S CH2 Q3a OH 452 N O Q1a a bond H a bond NH O CH2 Q3a OH 453 N O Q1b a bond Me a bond NH S CH2 Q3a OH 454 N O Q1b a bond Me a bond NH O CH2 Q3a OH 455 N O Q1b a bond H a bond NH S CH2 Q3a OH 456 N O Q1b a bond H a bond NH O CH2 Q3a OH 457 CH NMe Q1a a bond Me a bond NH S CH2 Q3a OH 458 CH NMe Q1a a bond Me a bond NH O CH2 Q3a OH 459 CH NMe Q1a a bond H a bond NH S CH2 Q3a OH 460 CH NMe Q1a a bond H a bond NH O CH2 Q3a OH 461 CH NMe Q1b a bond Me a bond NH S CH2 Q3a OH 462 CH NMe Q1b a bond Me a bond NH O CH2 Q3a OH 463 CH NMe Q1b a bond H a bond NH S CH2 Q3a OH 464 CH NMe Q1b a bond H a bond NH O CH2 Q3a OH 465 CH S Q1a a bond Me a bond NH S CH2 Q3a OH 466 CH S Q1a a bond Me a bond NH O CH2 Q3a OH 467 CH S Q1a a bond H a bond NH S CH2 Q3a OH 468 CH S Q1a a bond H a bond NH O CH2 Q3a OH 469 CH S Q1b a bond Me a bond NH S CH2 Q3a OH 470 CH S Q1b a bond Me a bond NH O CH2 Q3a OH 471 CH S Q1b a bond H a bond NH S CH2 Q3a OH 472 CH S Q1b a bond H a bond NH O CH2 Q3a OH 473 CH O Q1a a bond Me a bond NH S CH2 Q3a OH 474 CH O Q1a a bond Me a bond NH O CH2 Q3a OH 475 CH O Q1a a bond H a bond NH S CH2 Q3a OH 476 CH O Q1a a bond H a bond NH O CH2 Q3a OH 477 CH O Q1b a bond Me a bond NH S CH2 Q3a OH 478 CH O Q1b a bond Me a bond NH O CH2 Q3a OH 479 CH O Q1b a bond H a bond NH S CH2 Q3a OH 480 CH O Q1b a bond H a bond NH O CH2 Q3a OH 481 CMe NMe Q1a a bond Me a bond NH S CH2 Q3a OH 482 CMe NMe Q1a a bond Me a bond NH O CH2 Q3a OH 483 CMe NMe Q1a a bond H a bond NH S CH2 Q3a OH 484 CMe NMe Q1a a bond H a bond NH O CH2 Q3a OH 485 CMe NMe Q1b a bond Me a bond NH S CH2 Q3a OH 486 CMe NMe Q1b a bond Me a bond NH O CH2 Q3a OH 487 CMe NMe Q1b a bond H a bond NH S CH2 Q3a OH 488 CMe NMe Q1b a bond H a bond NH O CH2 Q3a OH 489 CMe S Q1a a bond Me a bond NH S CH2 Q3a OH 490 CMe S Q1a a bond Me a bond NH O CH2 Q3a OH 491 CMe S Q1a a bond H a bond NH S CH2 Q3a OH 492 CMe S Q1a a bond H a bond NH O CH2 Q3a OH 493 CMe S Q1b a bond Me a bond NH S CH2 Q3a OH 494 CMe S Q1b a bond Me a bond NH O CH2 Q3a OH 495 CMe S Q1b a bond H a bond NH S CH2 Q3a OH 496 CMe S Q1b a bond H a bond NH O CH2 Q3a OH 497 CMe O Q1a a bond Me a bond NH S CH2 Q3a OH 498 CMe O Q1a a bond Me a bond NH O CH2 Q3a OH 499 CMe O Q1a a bond H a bond NH S CH2 Q3a OH 500 CMe O Q1a a bond H a bond NH O CH2 Q3a OH 501 CMe O Q1b a bond Me a bond NH S CH2 Q3a OH 502 CMe O Q1b a bond Me a bond NH O CH2 Q3a OH 503 CMe O Q1b a bond H a bond NH S CH2 Q3a OH 504 CMe O Q1b a bond H a bond NH O CH2 Q3a OH 505 N NMe Q1a a bond Me a bond CH2 S a bond Q3a OH 506 N NMe Q1a a bond Me a bond CH2 S NH Q3a OH 507 N NMe Q1a a bond Me a bond CH2 O a bond Q3a OH 508 N NMe Q1a a bond Me a bond CH2 O NH Q3a OH 509 N NMe Q1a a bond H a bond CH2 S a bond Q3a OH 510 N NMe Q1a a bond H a bond CH2 S NH Q3a OH 511 N NMe Q1a a bond H a bond CH2 O a bond Q3a OH 512 N NMe Q1a a bond H a bond CH2 O NH Q3a OH 513 N NMe Q1b a bond Me a bond CH2 S a bond Q3a OH 514 N NMe Q1b a bond Me a bond CH2 S NH Q3a OH 515 N NMe Q1b a bond Me a bond CH2 O a bond Q3a OH 516 N NMe Q1b a bond Me a bond CH2 O NH Q3a OH 517 N NMe Q1b a bond H a bond CH2 S a bond Q3a OH 518 N NMe Q1b a bond H a bond CH2 S NH Q3a OH 519 N NMe Q1b a bond H a bond CH2 O a bond Q3a OH 520 N NMe Q1b a bond H a bond CH2 O NH Q3a OH 521 N S Q1a a bond Me a bond CH2 S a bond Q3a OH 522 N S Q1a a bond Me a bond CH2 S NH Q3a OH 523 N S Q1a a bond Me a bond CH2 O a bond Q3a OH 524 N S Q1a a bond Me a bond CH2 O NH Q3a OH 525 N S Q1a a bond H a bond CH2 S a bond Q3a OH 526 N S Q1a a bond H a bond CH2 S NH Q3a OH 527 N S Q1a a bond H a bond CH2 O a bond Q3a OH 528 N S Q1a a bond H a bond CH2 O NH Q3a OH 529 N S Q1b a bond Me a bond CH2 S a bond Q3a OH 530 N S Q1b a bond Me a bond CH2 S NH Q3a OH 531 N S Q1b a bond Me a bond CH2 O a bond Q3a OH 532 N S Q1b a bond Me a bond CH2 O NH Q3a OH 533 N S Q1b a bond H a bond CH2 S a bond Q3a OH 534 N S Q1b a bond H a bond CH2 S NH Q3a OH 535 N S Q1b a bond H a bond CH2 O a bond Q3a OH 536 N S Q1b a bond H a bond CH2 O NH Q3a OH 537 N O Q1a a bond Me a bond CH2 S a bond Q3a OH 538 N O Q1a a bond Me a bond CH2 S NH Q3a OH 539 N O Q1a a bond Me a bond CH2 O a bond Q3a OH 540 N O Q1a a bond Me a bond CH2 O NH Q3a OH 541 N O Q1a a bond H a bond CH2 S a bond Q3a OH 542 N O Q1a a bond H a bond CH2 S NH Q3a OH 543 N O Q1a a bond H a bond CH2 O a bond Q3a OH 544 N O Q1a a bond H a bond CH2 O NH Q3a OH 545 N O Q1b a bond Me a bond CH2 S a bond Q3a OH 546 N O Q1b a bond Me a bond CH2 S NH Q3a OH 547 N O Q1b a bond Me a bond CH2 O a bond Q3a OH 548 N O Q1b a bond Me a bond CH2 O NH Q3a OH 549 N O Q1b a bond H a bond CH2 S a bond Q3a OH 550 N O Q1b a bond H a bond CH2 S NH Q3a OH 551 N O Q1b a bond H a bond CH2 O a bond Q3a OH 552 N O Q1b a bond H a bond CH2 O NH Q3a OH 553 CH NMe Q1a a bond Me a bond CH2 S a bond Q3a OH 554 CH NMe Q1a a bond Me a bond CH2 S NH Q3a OH 555 CH NMe Q1a a bond Me a bond CH2 O a bond Q3a OH 556 CH NMe Q1a a bond Me a bond CH2 O NH Q3a OH 557 CH NMe Q1a a bond H a bond CH2 S a bond Q3a OH 558 CH NMe Q1a a bond H a bond CH2 S NH Q3a OH 559 CH NMe Q1a a bond H a bond CH2 O a bond Q3a OH 560 CH NMe Q1a a bond H a bond CH2 O NH Q3a OH 561 CH NMe Q1b a bond Me a bond CH2 S a bond Q3a OH 562 CH NMe Q1b a bond Me a bond CH2 S NH Q3a OH 563 CH NMe Q1b a bond Me a bond CH2 O a bond Q3a OH 564 CH NMe Q1b a bond Me a bond CH2 O NH Q3a OH 565 CH NMe Q1b a bond H a bond CH2 S a bond Q3a OH 566 CH NMe Q1b a bond H a bond CH2 S NH Q3a OH 567 CH NMe Q1b a bond H a bond CH2 O a bond Q3a OH 568 CH NMe Q1b a bond H a bond CH2 O NH Q3a OH 569 CH S Q1a a bond Me a bond CH2 S a bond Q3a OH 570 CH S Q1a a bond Me a bond CH2 S NH Q3a OH 571 CH S Q1a a bond Me a bond CH2 O a bond Q3a OH 572 CH S Q1a a bond Me a bond CH2 O NH Q3a OH 573 CH S Q1a a bond H a bond CH2 S a bond Q3a OH 574 CH S Q1a a bond H a bond CH2 S NH Q3a OH 575 CH S Q1a a bond H a bond CH2 O a bond Q3a OH 576 CH S Q1a a bond H a bond CH2 O NH Q3a OH 577 CH S Q1b a bond Me a bond CH2 S a bond Q3a OH 578 CH S Q1b a bond Me a bond CH2 S NH Q3a OH 579 CH S Q1b a bond Me a bond CH2 O a bond Q3a OH 580 CH S Q1b a bond Me a bond CH2 O NH Q3a OH 581 CH S Q1b a bond H a bond CH2 S a bond Q3a OH 582 CH S Q1b a bond H a bond CH2 S NH Q3a OH 583 CH S Q1b a bond H a bond CH2 O a bond Q3a OH 584 CH S Q1b a bond H a bond CH2 O NH Q3a OH 585 CH O Q1a a bond Me a bond CH2 S a bond Q3a OH 586 CH O Q1a a bond Me a bond CH2 S NH Q3a OH 587 CH O Q1a a bond Me a bond CH2 O a bond Q3a OH 588 CH O Q1a a bond Me a bond CH2 O NH Q3a OH 589 CH O Q1a a bond H a bond CH2 S a bond Q3a OH 590 CH O Q1a a bond H a bond CH2 S NH Q3a OH 591 CH O Q1a a bond H a bond CH2 O a bond Q3a OH 592 CH O Q1a a bond H a bond CH2 O NH Q3a OH 593 CH O Q1b a bond Me a bond CH2 S a bond Q3a OH 594 CH O Q1b a bond Me a bond CH2 S NH Q3a OH 595 CH O Q1b a bond Me a bond CH2 O a bond Q3a OH 596 CH O Q1b a bond Me a bond CH2 O NH Q3a OH 597 CH O Q1b a bond H a bond CH2 S a bond Q3a OH 598 CH O Q1b a bond H a bond CH2 S NH Q3a OH 599 CH O Q1b a bond H a bond CH2 O a bond Q3a OH 600 CH O Q1b a bond H a bond CH2 O NH Q3a OH 601 CMe NMe Q1a a bond Me a bond CH2 S a bond Q3a OH 602 CMe NMe Q1a a bond Me a bond CH2 S NH Q3a OH 603 CMe NMe Q1a a bond Me a bond CH2 O a bond Q3a OH 604 CMe NMe Q1a a bond Me a bond CH2 O NH Q3a OH 605 CMe NMe Q1a a bond H a bond CH2 S a bond Q3a OH 606 CMe NMe Q1a a bond H a bond CH2 S NH Q3a OH 607 CMe NMe Q1a a bond H a bond CH2 O a bond Q3a OH 608 CMe NMe Q1a a bond H a bond CH2 O NH Q3a OH 609 CMe NMe Q1b a bond Me a bond CH2 S a bond Q3a OH 610 CMe NMe Q1b a bond Me a bond CH2 S NH Q3a OH 611 CMe NMe Q1b a bond Me a bond CH2 O a bond Q3a OH 612 CMe NMe Q1b a bond Me a bond CH2 O NH Q3a OH 613 CMe NMe Q1b a bond H a bond CH2 S a bond Q3a OH 614 CMe NMe Q1b a bond H a bond CH2 S NH Q3a OH 615 CMe NMe Q1b a bond H a bond CH2 O a bond Q3a OH 616 CMe NMe Q1b a bond H a bond CH2 O NH Q3a OH 617 CMe S Q1a a bond Me a bond CH2 S a bond Q3a OH 618 CMe S Q1a a bond Me a bond CH2 S NH Q3a OH 619 CMe S Q1a a bond Me a bond CH2 O a bond Q3a OH 620 CMe S Q1a a bond Me a bond CH2 O NH Q3a OH 621 CMe S Q1a a bond H a bond CH2 S a bond Q3a OH 622 CMe S Q1a a bond H a bond CH2 S NH Q3a OH 623 CMe S Q1a a bond H a bond CH2 O a bond Q3a OH 624 CMe S Q1a a bond H a bond CH2 O NH Q3a OH 625 CMe S Q1b a bond Me a bond CH2 S a bond Q3a OH 626 CMe S Q1b a bond Me a bond CH2 S NH Q3a OH 627 CMe S Q1b a bond Me a bond CH2 O a bond Q3a OH 628 CMe S Q1b a bond Me a bond CH2 O NH Q3a OH 629 CMe S Q1b a bond H a bond CH2 S a bond Q3a OH 630 CMe S Q1b a bond H a bond CH2 S NH Q3a OH 631 CMe S Q1b a bond H a bond CH2 O a bond Q3a OH 632 CMe S Q1b a bond H a bond CH2 O NH Q3a OH 633 CMe O Q1a a bond Me a bond CH2 S a bond Q3a OH 634 CMe O Q1a a bond Me a bond CH2 S NH Q3a OH 635 CMe O Q1a a bond Me a bond CH2 O a bond Q3a OH 636 CMe O Q1a a bond Me a bond CH2 O NH Q3a OH 637 CMe O Q1a a bond H a bond CH2 S a bond Q3a OH 638 CMe O Q1a a bond H a bond CH2 S NH Q3a OH 639 CMe O Q1a a bond H a bond CH2 O a bond Q3a OH 640 CMe O Q1a a bond H a bond CH2 O NH Q3a OH 641 CMe O Q1b a bond Me a bond CH2 S a bond Q3a OH 642 CMe O Q1b a bond Me a bond CH2 S NH Q3a OH 643 CMe O Q1b a bond Me a bond CH2 O a bond Q3a OH 644 CMe O Q1b a bond Me a bond CH2 O NH Q3a OH 645 CMe O Q1b a bond H a bond CH2 S a bond Q3a OH 646 CMe O Q1b a bond H a bond CH2 S NH Q3a OH 647 CMe O Q1b a bond H a bond CH2 O a bond Q3a OH 648 CMe O Q1b a bond H a bond CH2 O NH Q3a OH 649 CMe NH Q1a NH Me a bond NH S NH Q3a OH 650 CMe NH Q1a NH Me a bond NH S a bond Q3a OH 651 CMe NH Q1a NH Me a bond NH O NH Q3a OH 652 CMe NH Q1a NH Me a bond NH O a bond Q3a OH 653 CMe NH Q1a NH H a bond NH S NH Q3a OH 654 CMe NH Q1a NH H a bond NH S a bond Q3a OH 655 CMe NH Q1a NH H a bond NH O NH Q3a OH 656 CMe NH Q1a NH H a bond NH O a bond Q3a OH 657 CMe NH Q1b NH Me a bond NH S NH Q3a OH 658 CMe NH Q1b NH Me a bond NH S a bond Q3a OH 659 CMe NH Q1b NH Me a bond NH O NH Q3a OH 660 CMe NH Q1b NH Me a bond NH O a bond Q3a OH 661 CMe NH Q1b NH H a bond NH S NH Q3a OH 662 CMe NH Q1b NH H a bond NH S a bond Q3a OH 663 CMe NH Q1b NH H a bond NH O NH Q3a OH 664 CMe NH Q1b NH H a bond NH O a bond Q3a OH 665 CMe NH Q1a O Me a bond NH S NH Q3a OH 666 CMe NH Q1a O Me a bond NH S a bond Q3a OH 667 CMe NH Q1a O Me a bond NH O NH Q3a OH 668 CMe NH Q1a O Me a bond NH O a bond Q3a OH 669 CMe NH Q1a O H a bond NH S NH Q3a OH 670 CMe NH Q1a O H a bond NH S a bond Q3a OH 671 CMe NH Q1a O H a bond NH O NH Q3a OH 672 CMe NH Q1a O H a bond NH O a bond Q3a OH 673 CMe NH Q1b O Me a bond NH S NH Q3a OH 674 CMe NH Q1b O Me a bond NH S a bond Q3a OH 675 CMe NH Q1b O Me a bond NH O NH Q3a OH 676 CMe NH Q1b O Me a bond NH O a bond Q3a OH 677 CMe NH Q1b O H a bond NH S NH Q3a OH 678 CMe NH Q1b O H a bond NH S a bond Q3a OH 679 CMe NH Q1b O H a bond NH O NH Q3a OH 680 CMe NH Q1b O H a bond NH O a bond Q3a OH 681 CMe NH Q1a CH2 Me a bond NH S NH Q3a OH 682 CMe NH Q1a CH2 Me a bond NH S a bond Q3a OH 683 CMe NH Q1a CH2 Me a bond NH O NH Q3a OH 684 CMe NH Q1a CH2 Me a bond NH O a bond Q3a OH 685 CMe NH Q1a CH2 H a bond NH S NH Q3a OH 686 CMe NH Q1a CH2 H a bond NH S a bond Q3a OH 687 CMe NH Q1a CH2 H a bond NH O NH Q3a OH 688 CMe NH Q1a CH2 H a bond NH O a bond Q3a OH 689 CMe NH Q1b CH2 Me a bond NH S NH Q3a OH 690 CMe NH Q1b CH2 Me a bond NH S a bond Q3a OH 691 CMe NH Q1b CH2 Me a bond NH O NH Q3a OH 692 CMe NH Q1b CH2 Me a bond NH O a bond Q3a OH 693 CMe NH Q1b CH2 H a bond NH S NH Q3a OH 694 CMe NH Q1b CH2 H a bond NH S a bond Q3a OH 695 CMe NH Q1b CH2 H a bond NH O NH Q3a OH 696 CMe NH Q1b CH2 H a bond NH O a bond Q3a OH 697 CMe NH Q1a a bond Me a bond NH S CH2 Q3a OH 698 CMe NH Q1a a bond Me a bond NH O CH2 Q3a OH 699 CMe NH Q1a a bond H a bond NH S CH2 Q3a OH 700 CMe NH Q1a a bond H a bond NH O CH2 Q3a OH 701 CMe NH Q1b a bond Me a bond NH S CH2 Q3a OH 702 CMe NH Q1b a bond Me a bond NH O CH2 Q3a OH 703 CMe NH Q1b a bond H a bond NH S CH2 Q3a OH 704 CMe NH Q1b a bond H a bond NH O CH2 Q3a OH 705 CMe NH Q1a a bond Me a bond CH2 S a bond Q3a OH 706 CMe NH Q1a a bond Me a bond CH2 S NH Q3a OH 707 CMe NH Q1a a bond Me a bond CH2 O a bond Q3a OH 708 CMe NH Q1a a bond Me a bond CH2 O NH Q3a OH 709 CMe NH Q1a a bond H a bond CH2 S a bond Q3a OH 710 CMe NH Q1a a bond H a bond CH2 S NH Q3a OH 711 CMe NH Q1a a bond H a bond CH2 O a bond Q3a OH 712 CMe NH Q1a a bond H a bond CH2 O NH Q3a OH 713 CMe NH Q1b a bond Me a bond CH2 S a bond Q3a OH 714 CMe NH Q1b a bond Me a bond CH2 S NH Q3a OH 715 CMe NH Q1b a bond Me a bond CH2 O a bond Q3a OH 716 CMe NH Q1b a bond Me a bond CH2 O NH Q3a OH 717 CMe NH Q1b a bond H a bond CH2 S a bond Q3a OH 718 CMe NH Q1b a bond H a bond CH2 S NH Q3a OH 719 CMe NH Q1b a bond H a bond CH2 O a bond Q3a OH 720 CMe NH Q1b a bond H a bond CH2 O NH Q3a OH

73) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 73), Q1a, Q1b and Q3a in Table 2 denote the following substituents).

74) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 74), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

75) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 75), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

76) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 76), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

77) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 77), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

78) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 78), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T1f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

79) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 79), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

80) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 80), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

81) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 81), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

82) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 82), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

83) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 83), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

84) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 84), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

85) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1 tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 85), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

86) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 86), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents.

87) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 87), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents.

88) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 88), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

89) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 89), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

90) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X are any of the above combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 90), Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 1 denote the following substituents).

91) The compounds represented by any of 63) to 90), wherein X is converted to NH₂, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

92) The compounds represented by any of 63) to 90), wherein X is converted to SH, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

93) The compounds represented by any of 63) to 90), wherein X is converted to OAc, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.

94) The thrombopoietin receptor activators represented by any of 1) to 93).

95) Preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective which contain the thrombopoietin receptor activators represented by 94) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof, as an active ingredient.

96) Platelet increasing agents containing the thrombopoietin receptor activators represented by 94) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof, as an active ingredient.

97) Medicaments containing the compounds represented by any of 1) to 93) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof as an active ingredient.

In the present invention, the compounds of the present invention represented by the formula (1) may be present in the form of tautomers or geometrical isomers which undergo endocyclic or exocyclic isomerization, mixtures of tautomers or geometric isomers or mixtures of thereof. When the compounds of the present invention have an asymmetric center, whether or not resulting from an isomerization, the compounds of the present invention may be in the form of resolved optical isomers or in the form of mixtures containing them in certain ratios.

For example, furan compounds, thiophene compounds and pyrrole compounds of the present invention may be present in the form of tetronic acid (4-hydroxy-2(5H)-furanone) analogues, thiotetronic acid (4-hydroxy-2(5H)-thiophenone) analogues and tetraminic acid (4-hydroxy-3-pyrrolin-2-one) analogues as shown below by the formulae (2), (3) and (4), mixtures thereof or mixtures of isomers thereof.

The compounds of the present invention represented by the formula (1) or pharmaceutically acceptable salts thereof may be in the form of arbitrary crystals or arbitrary hydrates, depending on the production conditions. The present invention covers these crystals, hydrates and mixtures. They may be in the form of solvates with organic solvents such as acetone, ethanol and tetrahydrofuran, and the present invention covers any of these forms.

The compounds of the present invention represented by the formula (1) may be converted to pharmaceutically acceptable salts or may be liberated from the resulting salts, if necessary. The pharmaceutically acceptable salts of the present invention may be, for example, salts with alkali metals (such as lithium, sodium and potassium) alkaline earth metals (such as magnesium and calcium), ammonium, organic bases and amino acids. They may be salts with inorganic acids (such as hydrochloric acid, hydrobromic acid, phosphoric acid and sulfuric acid) and organic acids (such as acetic acid, citric acid, maleic acid, fumaric acid, benzenesulfonic acid and p-toluenesulfonic acid).

The compounds which serve as prodrugs are derivatives of the present invention having chemically or metabolically degradable groups which give pharmacologically active compounds of the present invention upon solvolysis or under physiological conditions in vivo Methods for selecting or producing appropriate prodrugs are disclosed, for example, in Design of Prodrug (Elsevier, Amsterdam 1985). In the present invention when the compound has a hydroxyl group, acyloxy derivatives obtained by reacting the compound with appropriate acyl halides or appropriate acid anhydrides may, for example, be mentioned as prodrugs. Acyloxys particularly preferred as prodrugs include —OCOC₂H₅, —OCO(t-Bu), —OCOC₁₅H₃₁, —OCO(m-CO₂Na-Ph), —OCOCH₂CH₂CO₂Na, —OCOCH(NH₂)CH₃, —OCOCH₂N(CH₃)₂ and the like. When the compound of the present invention has an amino group, amide derivatives obtained by reacting the compound having an amino group with appropriate acid halides or appropriate mixed acid anhydrides may, for example, be mentioned as prodrugs. Amides particularly preferred as prodrugs include —NHCO(CH₂)₂₀OCH₃, —NHCOCH(NH₂)CH₃ and the like. When the compound of the present invention has a carboxyl group, carboxylic acid esters with aliphatic alcohols or carboxylic acid esters obtained by the reaction with an alcoholic free hydroxyl group of 1,2- or 1,3-digylcerides may, for example, be mentioned as prodrugs Particularly preferred prodrugs are methyl esters and ethyl esters.

The preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective or platelet increasing agents which contain the thrombopoietin receptor activators of the present invention tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof as an active ingredient may usually be administered as oral medicines such as tablets, capsules, powder, granules, pills and syrup, as rectal medicines, percutaneous medicines or injections. The agents of the present invention may be administered as a single therapeutic agent or as a mixture with other therapeutic agents. Though they may be administered as they are, they are usually administered in the form of medical compositions. These pharmaceutical preparations can be obtained by adding pharmacologically and pharmaceutically acceptable additives by conventional methods. Namely, for oral medicines, ordinary excipients, lubricants, binders, disintegrants, humectants, plasticizers and coating agents may be used. Oral liquid preparations may be in the form of aqueous or oily suspensions, solutions, emulsions, syrups or elixirs or may be supplied as dry syrups to be mixed with water or other appropriate solvents before use. Such liquid preparations may contain ordinary additives such as suspending agents, perfumes, diluents and emulsifiers. In the case of rectal administration, they may be administered as suppositories. Suppositories may use an appropriate substance such as cacao butter, laurin tallow, Macrogol, glycerogelatin, Witepsol, sodium stearate and mixtures thereof as the base and may, if necessary, contain an emulsifier, a suspending agent, a preservative and the like. For injections, pharmaceutical ingredients such as distilled water for injection, physiological saline, 5% glucose solution propylene glycol and other solvents or solubilizing agents, a pH regulator, an isotonizing agent and a stabilizer may be used to form aqueous dosage forms or dosage forms which need dissolution before use.

The dose of the agents of the present invention for administration to human is usually about from 0.1 to 1000 mg/human/day in the case of oral drugs or rectal administration and about from 0.05 mg to 500 mg/human/day in the case of injections into an adult, though it depends on the age and conditions of the patient. The above-mentioned ranges are mere examples and the dose should be determined from the conditions of the patient.

The present invention is used when the use of compounds which have thrombopoietin receptor affinity and act as thrombopoietin receptor agonists are expected to improve pathological conditions. For example, hematological disorders accompanied by abnormal platelet count may be mentioned. Specifically it is effective for therapy or prevention of human and mammalian diseases caused by abnormal megakaryopoiesis, especially those accompanied by thrombocytopenia. Examples of such diseases include thrombocytopenia accompanying chemotherapy or radiotherapy of cancer, thrombocytopenia accompanying antiviral therapy for diseases such as hepatitis C, thrombocytopenia caused by bone marrow transplantation surgery and serious infections, or gastrointestinal bleeding, but such diseases are not restricted to those mentioned. Typical thrombocytopenias such as aplastic anemia, idiopathic thrombocytopenic purpura, myelodysplastic syndrome, hepatic disease, HIV infection and thrombopoietin deficiency are also targets of the agents of the present invention. The present invention may be used as a peripheral stem cell mobilizer, a megakaryoblastic or megakaryocytic leukemia cell differentiation inducer and a platelet increasing agent for platelet donors. In addition, potential applications include therapeutic angiogenesis based on differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells, prevention and therapy of arteriosclerosis, myocardial infarction, unstable angina, peripheral artery occlusive disease, but there is no restriction.

The compounds represented by the formula (1) are prepared by the process represented by the formula (5) illustrated below.

The reaction of the compound (I) with a —NH₂ compound (II) in a solvent, if necessary in the presence of a catalyst, under heating with stirring gives a desired compound or its precursor. The precursor may be, if necessary, hydrolyzed, deprotected, reduced or oxidized to a desired compound. The compounds of the present invention usually can be purified by column chromatography, thin layer chromatography, high performance liquid chromatography (HPLC) or high performance liquid chromatography-mass spectrometry (LC-MS) and, if necessary, they may be obtained with high purity by recrystallization or washing with solvents.

For the syntheses of the intermediates (I), syntheses of the following heterocyclic compounds may be referred to.

-   1) Pyrazole (the formula (6)) -   J. Chem. Soc. Perkin. TransI, p. 81, (1985) -   2) Isothiazole (the formula (7)) -   Liebigs. Annalen. der Chemie., 10, 1534-1546 (1979) -   3) Isoxazole (the formula (8)) -   Synthesis, 10, 664-665 (1975) -   4) Thiophene (the formula (9)) -   JP-A-48-026755 -   5) Furan (the formula (10)) -   J. Org. Chem., 21, 1492-1509 (1956) and EP1253146 -   6) Pyrrole (the formula (11)) -   J. Heterocyclic Chem., 30, 1253 (1993) and Tetrahedron 50(26),     7849-56 (1994) -   7) Tetronic acid (4-hydroxy-2(5H-furanone) analogue (the formula     (12)) -   Synthesis 7, 564-566 (1988) and Yakugaku Zasshi, 96(4), 536-543     (1976) -   8) Tetraminic acid (4-hydroxy-3-pyrrolin-2-one) analogue (the     formula (13)) -   Synthesis, 2, 190-192 (1987) and Agric. Biol. Chem., 43(8),     1641-1646 (1979)

For synthesis of the —NH₂ compounds (II), for example, when L³═NH, the following may be referred to.

-   1) L⁴=a bond, Y═O -   Synthetic Commun., 28(7), 1223-1231 (1998), J. Chem. Soc.,     1225 (1948) and J. Chem. Soc., 2831 (1952) -   2) L⁴═NH, Y═O -   J. Am. Chem. Soc., 46, 2813 (1924) and J. Chem. Soc., 2654 (1952) -   3) L⁴═NH, Y═S -   Can. J. Chem 35, 834 (1957) -   4) L⁴═CH₂, Y═O -   J. Org. Chem., 30, 2487 (1965) -   5) L⁴═O, Y═O -   Bull. Soc. Chim. Belg., 68, 409, (1959)

The compounds represented by the formula (1) wherein L³ is NR¹⁹, L⁴ is NH, and Y is O or S are prepared by the process represented by the formula (14) illustrated below.

The compounds represented by the formula (1) wherein L³ is NR¹⁹, L is a bond, and Y is O or S are prepared by the process represented by the formula (15) illustrated below.

The reaction of the compound (I) with a NH₂ compound (IV) in a solvent, if necessary in the presence of a condensation agent or a catalyst, under heating with stirring gives the compound (III) as the desired product.

EXAMPLES

Now, the present invention will be described in further detail with reference to Reference Synthetic Examples, Synthetic Examples, Assay Examples and Formulation Examples. However, it should be understood that the present invention is by no means restricted by these specific Examples.

The ¹H-NMR analysis was carried out at 300 MHz, and the ¹³C-NMR analysis was carried out at 75 MHz. LC/MS was measured under the following conditions.

LC/MS Condition 1

Column: Waters SunFire C18 (3.5 μm, 4.6×30 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (10/90→30/70)

LC/MS Condition 2

Column: Waters SunFire C18 (3.5 μm, 4.6×30 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (10/90→60/40)

LC/MS Conditions 3

Column: Waters SunFire C18 (3.5 μm, 4.6×30 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (10/90→85/15)

LC/MS Conditions 4

Column: Waters Xterra MSC18 (5 μm, 4.6×50 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (10/90→30/70)

LC/MS Conditions 5

Column: Waters Xterra MSC18 (5 μm, 4.6×50 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (10/90→60/40)

LC/MS Conditions 6

Column: Waters Xterra MSC18 (5 μm, 4.6×50 mm)

Eluent acetonitrile/0.1% aqueous formic acid (10/90→85/15)

LC/MS Conditions 7

Column: Waters Xterra MSC18 (5 μm, 4.6×50 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (20/80→100/0)

LC/MS Conditions 8

Column: Waters Xterra MSC18 (3.5 μm, 2.1×20 mm)

Eluent: acetonitrile/0.2% aqueous formic acid (20/80→90/10)

LC/MS Conditions 9

Column: Waters SunFire C18 (3.5 μm, 4.6×30 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (20/80→100/0)

Reference Synthetic Example 1 5-(Hydrazinocarbonyl)thiophene-2-carboxylic acid[2-(pyrrolidin-1-yl)ethyl]-amide

Methyl 5-[2-(pyrrolidin-1-yl)ethylcarbamoyl]-thiophene-2-carboxylate (56 mg, 0.2 mmol) in ethanol (2.0 mL) was refluxed with heating with hydrazine monohydrate (0.10 mL) for 10 hours and allowed to cool to room temperature, and the precipitated solid was collected by filtration, washed with water and dried to give 21 mg of the desired product (yield 38%).

Morphology: white solid

LC/MS (ESI⁺) m/z; 297 [M+1]⁺

LC/MS (ESI⁻) m/z; 295 [M−1]⁻

Reference Synthetic Example 2 5-(Hydrazinocarbonyl)thiophene-2-carboxylic acid(tetrahydrofuran-2-ylmethyl)amide

Synthesis was carried out in the same manner as in Reference Synthetic Example 1 by using methyl 5-[(tetrahydrofuran-2-ylmethyl)carbamoyl]-thiophene-2-carboxylate to give 17 mg of the desired product (yield 32%).

Morphology: white solid

LC/MS (ESI⁺) m/z; 270 [M+1]⁺

LC/MS (ESI⁻) m/z; 268 [M−1]⁻

Reference Synthetic Example 3 5-(Hydrazinocarbonyl)thiophene-2-carboxylic acid[2-(morpholin-4-yl)ethyl]amide

Synthesis was carried out in the same manner as in Reference Synthetic Example 1 by using methyl 5-[2-(morpholin-4-yl)ethylcarbamoyl]thiophene-2-carboxylate to give 30 mg of the desired product (yield 50%).

Morphology: white solid

LC/MS (ESI⁺) m/z; 299 [M+1]⁺

LC/MS (ESI⁻) m/z; 297 [M−1]⁻

Reference Synthetic Example 4 2,5-Di(hydrazinocarbonyl)thiophene

Synthesis was carried out in the same manner as in Reference Synthetic Example 1 by using dimethyl thiophene-2,5-dicarboxylate to give 28 mg of the desired product.

Morphology: pale green solid

¹H-NMR (DMSO-d₆) δ: 4.51 (4H, s), 7.64 (2H, s), 9.88 (2H, br s).

LC/MS (ESI⁻) m/z; 199 [M−1]⁻

Reference Synthetic Example 5 N-[1-(5-Hydrazinocarbonylthiophene-2-carbonyl)-pyrrolidin-3-yl]acetamide

Synthesis was carried out in the same manner as in Reference Synthetic Example 1 by using methyl 5-[3-(acetylamino)pyrrolidine-1-carbonyl]thiophene-2-carboxylate to give 37 mg of the desired product (yield 62%).

Morphology: white solid

LC/MS (ESI⁺) m/z; 297 [M+1]⁺

LC/MS (ESI⁻) m/z; 295 [M−1]⁻

Reference Synthetic Example 6 2-(N,N-Dimethylhydrazinocarbonyl)-5-(hydrazinocarbonyl)thiophene

Methyl 5-(N,N-dimethylhydrazinocarbonyl)thiophene-2-carboxylate (46 mg, 0.2 mmol) in ethanol (2.0 mL) was refluexed with heating with hydrazine monohydrate (0.10 mL) for 10 hours and allowed to cool to room temperature. After addition of 3 mL of waster, the reaction solution was extracted with 10 mL of ethyl acetate, and the extract was dried over magnesium sulfate, filtered and concentrated to give 23 mg of the desired product (yield 50%).

Morphology: colorless oil

LC/MS (ESI⁺) m/z; 229 [M+1]⁺

LC/MS (ESI⁻) m/z; 227 [M−1]⁻

Reference Synthetic Example 7 tert-Butyl 3-{[5-(hydrazinocarbonyl)thiophene-2-carbonyl]amino}propionate

Synthesis was carried out in the same manner as in Reference Synthetic Example 1 by using methyl 5-[2-tert butoxycarbonyl)ethylcarbamoyl]thiophene-2-carboxylate to give 37 mg of the desired product (yield 62%).

Morphology: white solid

LC/MS (ESI⁺) m/z; 314 [M+1]⁺

LC/MS (ESI⁻) m/z; 312 [M−1]⁻

Reference Synthetic Example 8 tert-Butyl{[5-(hydrazinocarbonyl)thiophene-2-carbonyl]amino}acetate

Methyl 5-(tert-butoxycarbonylmethylcarbamoyl)thiophene-2-carboxylate (63 mg, 0.21 mmol) in ethanol (3.0 mL) was refluexed with heating with hydrazine monohydrate (0.13 mL) for 8 hours and allowed to cool to room temperature. The reaction mixture was concentrated under reduced pressure, and water was added. The precipitated solid was collected by filtration, washed with water and dried to give 44 mg of the desired product (yield 71%).

Morphology: white solid

LC/MS (ESI⁺) m/z; 300 [M+1]⁺

LC/MS (ESI⁻) m/z; 298 [M−1]⁻

Reference Synthetic Example 9 5-(Hydrazinocarbonyl)thiophene-2-carboxylic acid piperidin-1-ylamide

Methyl 5-piperidin-1-ylcarbamoyl)thiophene-2-carboxylate (232 mg, 0.87 mmol) in ethanol (6.0 mL) was refluexed with heating with hydrazine monohydrate (0.40 mL) for 3 hours and allowed to cool to room temperature, and the precipitated solid was collected by filtration, washed with water and dried to give 129 mg of the desired product (yield 56%).

Morphology: white solid

LC/MS (ESI⁺) m/z; 269 [M+1]⁺

LC/MS (ESI⁻) m/z; 267 [M−1]⁻

Reference Synthetic Example 10 5-(Hydrazinocarbonyl)thiophene-2-carboxylic acid (4-methylpiperazin-1-yl)amide

Methyl 5-(4-methylpiperazin-1-ylcarbamoyl)thiophene-2-carboxylate (218 mg, 0.77 mmol) in ethanol (60 mL) was refluexed with heating with hydrazine monohydrate (0.40 mL) for 6 hours and allowed to cool to room temperature, and the solvent was evaporated at 40° C. mL of diethyl ether was added to the resulting oil, and the precipitated solid was collected by filtration, washed with water and dried to give 142 mg of the desired product (yield 65%).

Morphology: pale yellow solid

LC/MS (ESI⁺) m/z; 284 [M+1]⁺

LC/MS (ESI⁻) m/z; 282 [M−1]⁻

Reference Synthetic Example 11 5-(Hydrazinocarbonyl)thiophene-2-carboxylic acid morpholin-4-ylamide

Methyl 5-(morpholin-4-ylcarbamoyl)thiophene-2-carboxylate (237 mg, 0.87 mmol) in ethanol (6.0 mL) was refluexed with heating with hydrazine monohydrate (0.40 mL) for 6 hours and allowed to cool to room temperature and the solvent was evaporated at 40° C. 5 mL of diethyl ether was added to the resulting oil, and the precipitated solid was collected by filtration, washed with water and dried to give 160 mg of the desired product (yield 68%).

Morphology: pale yellow solid

LC/MS (ESI⁺) m/z; 271 [M+1]⁺

LC/MS (ESI⁻) m/z; 269 [M−1]⁻

Reference Synthetic Example 12 5-[4-Pyrrolidin-1-yl)piperidine-1-carbonyl]thiophene-2-carbohydrazide

Methyl 5-[4-(pyrrolidin-1-yl)piperidine-1-carbonyl]thiophene-2-carboxylate (242 mg, 0.75 mmol) in ethanol (7.0 mL) was refluexed with heating with hydrazine monohydrate (0.38 mL) for 12 hours and allowed to cool to room temperature, and the solvent was evaporated at 40° C. 5 mL of diethyl ether was added to the resulting oil, and the precipitated solid was collected by filtration, washed with water and dried to give 193 mg of the desired product (yield 80%).

Morphology: pale yellow solid

LC/MS (ESI⁺) m/z; 323 [M+1]⁺

Reference Synthetic Example 13 2-(3,4-Dichlorophenyl)-4-(1-hydrazonoethyl)-thiophen-3-ol

2-(3,4-Dichlorophenyl)-3-hydroxy-4-(methylcarbonyl)thiophene (50 mg, 0.17 mmol) (prepared by the method disclosed in WO2004/108683) in isopropanol was stirred with hydrazine monohydrate (95 μL/0.19 mmol) at 90° C. for 1 hour, then allowed to cool to room temperature and stirred at 0° C. The precipitated solid was collected by filtration and dried to give 36 mg of the desired product (yield 69%).

Morphology: white solid

LC/MS (ESI⁺) m/z; 301 [M+1]⁺

LC/MS (ESI⁻) m/z; 299 [M−1]⁻

Reference Synthetic Example 14 3-(1-Hydrazonoethyl)-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-ol

1-[4-Hydroxy-1-methyl-5-[4-trifluoromethyl)phenyl]-1H-pyrazol-3-yl]ethanone (2.72 g, 9.57 mmol) (prepared by the method disclosed in WO2004/108683) was dissolved in 1,4-dioxane (82 mL), and hydrazine monohydrate (0.512 mL, 10.53 mmol) was added dropwise at 50° C. The reaction solution was stirred at the same temperature for 3 hours and then allowed to cools and ethyl acetate was added. The organic layer was washed with saturated aqueous sodium chloride three times, dried over anhydrous magnesium sulfate and filtered. The filtrate was dried by evaporating the solvent to give 2.90 g of the desired product (yield 102%).

Morphology: yellow solid

LC/MS (ESI⁺) m/z; 299 [M+1]⁺

LC/MS (ESI⁻) m/z; 297 [M−1]⁻

Reference Synthetic Example 15 Potassium 3-[4-(hydrazinocarbonyl)phenyl]-3-hydroxypropionate 15-a) Methyl 4-(2-tert-butoxycarbonyl-1-hydroxyethyl)benzoate

Diisopropylamine (0.55 mL, 3.9 mmol) was dissolved in dry tetrahydrofuran (10 mL), and 2.66 M n-butyllithium in hexane (1.4 mL, 3.6 mmol) was added dropwise at 0° C. The reaction solution was stirred at 0° C. for 10 minutes and cooled to −78° C., and after dropwise addition of tert-butyl acetate (0.58 mL, 4.3 mmol), stirred at −78° C. for 30 minutes. Methyl 4-formylbenzoate (0.70 g, 4.3 mmol) in tetrahydrofuran (6 mL) was added dropwise at −78° C. over 5 minutes, and the reaction solution was stirred at −78° C. for 10 minutes and at 0° C. for 1 hour, then adjusted to pH 7 with acetic acid (0.43 mL, 7.5 mmol) and returned to room temperature over 12 hours. The solution was concentrated by evaporating tetrahydrofuran under reduced pressure, and ethyl acetate and water were added. The organic layer was separated and dried under reduced pressure to dryness to give 1.17 g of the crude desired product. The crude desired product was purified by silica gel column chromatography (Merck silica gel 60, 22 g, n-hexane-ethyl acetate 4:1) to give 0.84 g of the desired product (yield 84%).

Morphology: colorless solid

¹H-NMR (CDCl₃) δ: 1.45 (9H, s), 2.65 (1H, dd, J=16.5&7.0 Hz), 2.66 (1H, dd, J=16.5&5.5 Hz), 3.66 (1H, d, J=3.5 Hz), 3.91 (3H, s), 5.09-5.17 (1H, m), 7.45 (1H, d, J=8.5 Hz), 8.02 (1H, d, J=8.5 Hz).

15-b) Methyl 4-(2-carboxy-1-hydroxyethyl)benzoate

Methyl 4-(2-tert-butoxycarbonyl-1-hydroxyethyl)benzoate (140 mg, 0.50 mmol) was dissolved in trifluoroacetic acid (2.0 mL), and the resulting solution was left to stand at room temperature for 3 hours and concentrated to dryness under reduced pressure to give 113 mg of the desired product (stoichiometric yield).

Morphology: colorless solid

¹H-NMR (DMSO-d₆) δ: 2.50 (1H, dd, J=15.5&8.5 Hz: overlapped with DMSO), 2.57 (1H, dd, J=15.5&5.0 Hz), 3.82 (3H, s), 5.00 (1H, dd, J=8.5&5.0 Hz) 5.4-5.8 (1H, br s), 7.50 (1H, d, J=8.0 Hz, 7.91 (1H, d, J=8.0 Hz).

15-c) Potassium 3-[4-(hydrazinocarbonyl)phenyl]-3-hydroxypropionate

Methyl 4-(2-carboxy-1-hydroxyethyl)benzoate (110 mg, 0.49 mmol) was dissolved in methanol (2.0 mL) 0.1 M potassium hydroxide in methanol (4.9 mL, 0.49 ml) was added, and then, hydrazine monohydrate (0.24 mL, 4.9 mmol) was added at room temperature. The resulting solution was left to stand at 45° C. for 1 hour and at 60° C. for 2.5 hours, but the starting materials were little consumed The solution was concentrated under reduced pressure by evaporating methanol, and left to stand with water at 80° C. for 1 hour to force the reaction to completion. The reaction solution was concentrated to dryness to give the crude desired product.

Morphology: colorless solid

¹H-NMR (DMSO-d₆) δ: 1.93 (1H, dd, 15.0&9.5 Hz), 2.19 (1H, dd, J=15.0&3.5 Hz), 4.3-4.6 (2H, br s), 4.69 (1H, dd, J=9.5&3.5 Hz), 7.35 (1H, d, J=8.0 Hz), 7.71 (1H, d, J=80 Hz), 9.67 (1H, br s).

Reference Synthetic Examples 16 to 22

Synthesis was carried out in the same manner as in Reference Synthetic Example 1, except that Reference Synthetic Example 18 was carried out in the same manner as in Reference Synthetic Example 15, and the yields and morphology of the resulting compounds, the LC/MS conditions used for their analysis and the observed peaks and retention times are shown in Table 3.

TABLE 3 Syn. Observed Observed Retention Ex. Yield LC/MS peak peak time No. (%) Morphology conditions ESI⁺ ESI⁻ (minute) 16 100 white solid 8 313 311 0.47 17 89 white solid 18 100 pale yellow solid 19 77 pale yellow, 1 300 298 0.48 amorphous 20 50 white solid 21 84 white solid 2 287 276 0.28 22 67 pale yellow, 8 272 (M − isobutene + 1) 1.30 amorphous

Reference Synthetic Examples 23 to 26

Synthesis was carried out by the method disclosed in WO2004/108683, and the yields and morphology of the resulting compounds, the LC/MS conditions used for their analysis and the observed peaks and retention times are shown in Table 4.

TABLE 4 Observed Observed Retention Syn. LC/MS peak peak time Ex. No. Morphology conditions ESI⁺ ESI⁻ (minute) 23 yellow solid 2 247 245 4.52 24 yellow solid 9 303 301 3.34 25 light brown 2 297/299 295/297 4.54 solid 26 pale green 2 253/255 251/253 4.49 solid

Reference Synthetic Example 27 3-(1-Hydrazonoethyl)-1-methyl-5-(3,4-dichlorophenyl)-1H-pyrazol-4-ol

Synthesis was carried out in the same manner as in Reference Synthetic Example 14 by using 1-[4-hydroxy-1-methyl-5-(3,4-dichlorophenyl)-1H-pyrazol-3-yl]ethanone (prepared by the method disclosed in WO2004/108683) to give 326 mg of the desired product (yield 100%).

Morphology: pale yellow solid

¹H-NMR (CDCl₃) δ: 2.23 (3H, s), 3.84 (3H, s), 5.24 (2H, s), 7.35 (1H, dd, J=8.5&2.0 Hz), 753 (1H, d, J=8.5 Hz), 7.61 (1H, d, J=2.0 Hz), 9.01 (1H, br s).

Reference Synthetic Example 28 5-[2-(4-Oxopyridin-1(4H)-yl)acetyl]thiophene-2-carboxylic acid 1) Synthesis of methyl 5-(2-bromoacetyl)thiophenecarboxylate

1.08 g (5.86 mmol) of methyl 5-acetylthiophenecarboxylate was dissolved in 40 ml of tetrahydrofuran, and the resulting solution was cooled to 0° C. and stirred with 2.31 g (6.15 mmol) of phenyltrimethylammonium tribromide at room temperature for 24 hours. 50 ml of water was added to terminate the reaction, and the reaction solution was extracted with 50 ml of ethyl acetate twice. The organic layer was dried over magnesium sulfate, then the magnesium sulfate was removed by filtration, and the solvent was evaporated to give 2.20 g of a light brown solid. It was recrystallized from hexane 40 ml-chloroform 7 ml to give 990 mg of methyl 5-(2-bromoacetyl)thiophenecarboxylate (yield 64%).

Morphology: light brown solid

LC/MS (ESI⁺) m/z; 263, 265 [M+1]⁺

Retention time 2.79 minutes (condition 6)

2) Methyl 5-[2-(4-oxopyridin-1(4H)-yl)acetyl]thiophene-2-carboxylate

263 mg (1.00 mmol) of methyl 5-(2-bromoacetyl)thiophenecarboxylate obtained in 1), 100 mg (1.05 mmol) of 4-hydroxypyridine and 151 mg (1.0 mmol) of potassium carbonate were stirred in 5 ml of methyl ethyl ketone at room temperature for 3 days After addition of 10 ml of water, the organic solvent was evaporated, and 20 ml of water was added. The precipitate was collected by filtration and dried to give 189 mg of methyl 5-[2-(4-oxopyridin-1(4H)-yl)acetyl]thiophene-2-carboxylate (yield 68%).

Morphology: pale purple solid

LC/MS (ESI⁺) m/z; 278 [M+1]⁺

LC/MS (ESI⁻) m/z; 276 [M−1]⁻

Retention time 1.53 minutes (condition 6)

¹H-NMR (CDCl₃) δ: 2.08 (3H, s), 5.12 (2H, s) 6.44 (2H, d, J=7.0 Hz), 7.20 (2H d, J=7.0 Hz) 7.76 (2H, d, J=2.0 Hz), 7.84 (2H, d, 2.0 Hz).

¹³C-NMR (DMSO-d₆) δ: 52.9, 60.8, 117.1, 133.6, 134.2, 139.1, 141.9, 144.8, 161.2, 176, 187.3.

3) 5-[2-(4-Oxopyridin-1(4H)-yl)acetyl]thiophene-2-carboxylic acid

189 mg (0.68 mmol) of methyl 5-[2-(4-oxopyridin-1(4H)-yl)acetyl]thiophene-2-carboxylate obtained in 2) was dissolved in 15 ml of methanol and stirred with 2.7 ml (4 eq) of 1M aqueous sodium hydroxide at room temperature overnight. The reaction solution was cooled to 0° C. and neutralized with 2.7 ml of 1 M hydrochloric acid, and the organic solvent was evaporated. The precipitated solid was collected by filtration, washed with 2 ml of water and dried to give 129 mg of 5-[2-(4-oxopyridin-1(4H)-yl)acetyl]thiophene-2-carboxylic acid (yield 72%).

Morphology: red solid

LC/MS (ESI⁺) m/z; 264 [M+1]⁺

LC/MS (ESI⁻) m/z; 262 [M−1]⁻

Retention time 0.47 minutes (condition 6)

¹H-NMR (DMSO-d₆) δ: 5.62 (2H, s) 6.20 (2H, d, J=7.0 Hz), 7.65 (2H, d, J=7.0 Hz), 7.87 (2H, d, J=2.0 Hz), 8.06 (2H, d, J=2.0 Hz).

The structures of the compounds obtained in Reference Synthetic Examples 16 to 28 are shown below.

Synthetic Example 1 5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carboxylic acid [2-(pyrrolidin-1-yl)ethyl]amide

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (22 mg, 0.075 mmol) in dimethyl sulfoxide (2.0 mL) was heated with 5-(hydrazinocarbonyl)thiophene-2-carboxylic acid [2-(pyrrolidin-1-yl)ethyl]-amide (21 mg, 0.075 mmol) prepared in Reference Synthetic Example 1 at 100° C. for 24 hours. Evaporation of the solvent followed by recrystallization from chloroform (1 mL)-diethyl ether (2 mL) affored 12 mg of the desired product (yield 29%).

Morphology: orange solid

LC/MS (ESI⁺) m/z; 551, 553 [M+1]⁺

LC/MS (ESI⁻) m/z; 549, 551 [M−1]⁻

Synthetic Example 2 5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carboxylic acid(tetrahydrofuran-2-ylmethyl)amide

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (22 mg, 0.075 mmol) in isopropanol (2.0 mL) was heated with 5-(hydrazinocarbonyl)thiophene-2-carboxylic acid (tetrahydrofuran-2-ylmethyl)amide (20 mg, 0.075 mmol) prepared in Reference Synthetic Example 2 and 3 mg of p-toluenesulfonic acid monohydrate at 105° C. for 17 hours and allowed to cool to room temperature. The precipitated solid was collected by filtration, washed with 1 mL of isopropanol and 1 mL of chloroform and dried to give 26 mg of the desired product (yield 72%).

Morphology: light brown solid

¹H-NMR (DMSO-d₆) δ: 1.50-1.70 (1H, m), 1.70-2.00 (4H, m), 3.50-4.10 (3H, m), 7.60-7.80 (2H, m), 7.86 (1H, d, J=4 Hz), 8.00 (1H, d, J=4 Hz), 8.05 (1H, brs), 8.12 (1H, s), 8.80 (1H, t, J=6 Hz), 11.4 (1H, s).

LC/MS (ESI⁺) m/z; 538, 540 [M+1]⁺

LC/MS (ESI⁻) m/z; 536, 538 [M−1]⁻

Synthetic Example 3 5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl)thiophene-2-carboxylic acid[2-(morpholin-4-yl)ethyl]amide

Synthesis was carried out in the same manner as in Synthetic Example 1 by using 5-(hydrazinocarbonyl)thiophene-2-carboxylic acid [2-(morpholin-4-yl)ethyl]amide prepared in Reference Synthetic Example 3 to give 12 mg of the desired product (yield 21%).

Morphology: white solid

¹H-NMR (DMSO-d₆) δ: 3.5-4.0 (4H, my 7.6-7.75 (3H, m), 7.80 (1H, d, J=4 Hz), 7.9-8.1 (2H, m), 8.09 (1H d, J=2 Hz), 11.4 (1H, s).

LC/MS (ESI⁺) m/z; 567, 569 [M+1]⁺

LC/MS (ESI⁻) m/z; 565, 567 [M−1]⁻

Synthetic Example 4 5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carbohydrazide

Synthesis was carried out in the same manner as in Synthetic Example 2 by using 2,5-di(hydrazinocarbonyl)thiophene prepared in Reference Synthetic Example 4 to give 43 mg of the desired product (yield 90%).

Morphology: pale yellow solid

¹H-NMR (DMSO-d₆) δ: 7.60-7.75 (2H, m), 7.77 (1H, d), 8.00 (1H, d), 8.05 (1H, brs), 8.13 (1H, s).

LC/MS (ESI⁺) m/z; 469, 471 [M+1]⁺

LC/MS (ESI⁻) m/z; 467, 469 [M−1]⁻

Synthetic Example 5

N-[1-{5-{1-[5-(3,4-Dichlorophenyl)4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carbonyl]pyrrolidin-3-yl]acetamide

Synthesis was carried out in the same manner as in Synthetic Example 2 by using N-[1-(5-hydrazinocarbonylthiophene-2-carbonyl)-pyrrolidin-3-yl]acetamide prepared in Reference Synthetic Example 5 to give 53 mg of the desired product (yield 93%).

Morphology: pale yellow solid

¹H-NMR (DMSO-d₆) δ: 1.81 (3H, ds), 2.0-2.3 (1H, m), 3.5-4.2 (4H, m), 4.30 (1H, brs), 7.5-7.8 (3H, m), 7.9-8.1 (2H, m), 8.12 (1H, s) 8.19 (1H, t, J=6 Hz, 11.5 (1H, s).

LC/MS (ESI⁺) m/z; 565, 567 [M+1]⁺

LC/MS (ESI⁻) m/z; 563, 565 [M−1]⁻

Synthetic Example 6 5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carboxylic acid(N,N-dimethyl)hydrazide

Synthesis was carried out in the same manner as in Synthetic Example 2 by using 2-(N,N-dimethylhydrazinocarbonyl)-5-(hydrazinocarbonyl thiophene prepared in Reference Synthetic Example 6 to give 14 mg of the desired product (yield 28%).

Morphology: pale yellow solid

(DMSO-d₆) δ: 2.60 (3H, s) 262 (3H, s), 7.6-7.75 (2H, m), 7.8-8.2 (4H, m).

LC/MS (ESI⁺) m/z; 497, 499 [M+1]⁺

LC/MS (ESI⁻) m/z; 495, 497 [M−1]⁻

Synthetic Example 7 3-[5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carbonyl)amino]propionic acid 7-a) tert-Butyl 3-[(5-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carbonyl)amino]propionate

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (24 mg, 0.083 mmol) in isopropanol (2.0 mL) was heated with tert-butyl 3-{[5-(hydrazinocarbonyl)thiophene-2-carbonyl]amino}propionate (18 mg, 0.057 mmol) prepared in Reference Synthetic Example 7 and 6 mg of p-toluenesulfonic acid monohydrate at 100° C. for 8 hours and allowed to cool to room temperature. Water was added to the reaction mixture, and the precipitated solid was collected by filtration, washed with water, methanol and chloroform and dried to give 28 mg of the desired product (yield 85%).

Morphology: pale yellow solid

LC/MS (ESI⁻) m/z; 580, 582 [M−1]⁻

7-b) 3-[(5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carbonyl)amino]propionic acid

Synthesis was carried out in the same manner as in Synthetic Example 8 by using tert-butyl 3-[(5-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carbonyl)amino]propionate to give 14 mg of the desired product (yield 55%).

Morphology: pale yellow solid

¹H-NMR (DMSO-d₆) δ: 2.40-2.60 (5H, m, overlapped_with_DMSO), 3.45 (2H, dd, J=12.3, 6.7 Hz), 7.66 (1H, d, J=8.6 Hz), 7.70 (1H, dd, J=8.6, 2.0 Hz), 7.80 (1H, d, J=4.0 Hz), 8.00 (1H, d, J=4.0 Hz), 8.05 (1H, brs), 8.12 (1H, s), 8.80 (1H, t, J=5.4 Hz), 11.44 (1H, s).

LC/MS (ESI⁺) m/z; 526, 528 [M+1]⁺

LC/MS (ESI⁻) m/z; 524, 526 [M−1]⁻

Synthetic Example 8 [(5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carbonyl)amino]acetic acid 8-a) tert-Butyl[(5-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carbonyl)amino]acetate

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (49 mg, 0.17 mmol) in isopropanol (2.0 mL) was heated with tert-butyl{[5-(hydrazinocarbonyl)thiophene-2-carbonyl]amino}acetate (44 mg, 0.15 mmol) prepared in Reference Synthetic Example 8 and 3 mg of p-toluenesulfonic acid monohydrate at 100° C. for 8 hours and allowed to cool to room temperature. Water was added to the reaction mixture, and the precipitated solid was collected by filtration, washed with water, methanol and chloroform and dried to give 69 mg of the desired product (yield 83%).

Morphology: pale yellow solid

LC/MS (ESI⁻) m/z; 566, 568 [M−1]⁻

8-b) [(5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carbonyl)amino]acetic acid

tert-Butyl[(5-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carbonyl)amino]acetate (69 mg, 0.12 mmol) in CH₂Cl₂ (4.0 mL) was stirred with trifluoroacetic acid (0.14 mL) at room temperature for 4 days. The reaction mixture was concentrated under reduced pressure, and chloroform was added. The precipitated solid was collected by filtration, washed with chloroform and dried to give 35 mg of the desired product (yield 56%).

Morphology: pale yellow solid

¹H-NMR (DMSO-D₆) δ: 2.48 (3H, s, overlapped_with_DMSO), 3.92 (2H, brd, J=5.8 Hz), 7.65 (1H, d, J=8.5 Hz), 7.68 (1H, brd, J=8.5 Hz), 7.86 (1H, d, J=3.8 Hz), 8.03 (1H, d, J=3.8 Hz), 8.05 (1H, brs), 8.13 (1H, s), 9.11 (1H, t, J=5.8 Hz), 11.48 (1H, s).

LC/MS (ESI⁺) m/z; 512, 514 [M+1]⁺

LC/MS (ESI⁻) m/z; 510, 512 [M−1]⁻

Synthetic Example 9 5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carboxylic acid piperidin-1-ylamide

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (29 mg, 0.1 mmol) in dimethyl sulfoxide (4.0 mL) was heated with 5-(hydrazinocarbonyl)thiophene-2-carboxylic acid piperidin-1-ylamide (27 mg, 0.1 mmol) prepared in Reference Synthetic Example 9 at 100° C. for 20 hours and allowed to cool to room temperature. 2 mL of water was added, and the precipitated solid was collected by filtration, washed with 1 mL of chloroform and dried to give 47 mg of the desired product (yield 87%).

Morphology: yellow solid

LC/MS (ESI⁺) m/z; 537, 539 [M+1]⁺

LC/MS (ESI⁻) m/z; 535, 537 [M−1]⁻

Synthetic Example 10 5-{1-[5-(3,4-D-chlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carboxylic acid(4-methylpiperazin-1-yl)amide

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (29 mg, 0.1 mmol) in dimethyl sulfoxide (4.0 mL) was heated with 5-(hydrazinocarbonyl)thiophene-2-carboxylic acid(4-methylpiperazin-1-yl)amide (28 mg, 0.1 mmol) prepared in Reference Synthetic Example 10 at 100° C. for 20 hours and allowed to cool to room temperature 2 mL of water was added and the precipitated solid was collected by filtration, washed with 1 mL of chloroform and dried to give 50 mg of the desired product (yield 93%).

Morphology: pale orange solid

LC/MS (ESI⁺) m/z; 552, 554 [M+1]⁺

LC/MS (ESI⁻) m/z; 550, 552 [M−1]⁻

Synthetic Example 11 5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carboxylic acid morpholin-4-ylamide

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (29 mg, 0.1 mmol) in dimethyl sulfoxide (4.0 mL) was heated with 5-(hydrazinocarbonyl)thiophene-2-carboxylic acid morpholin-4-ylamide (27 mg, 0.1 mmol) prepared in Reference Synthetic Example 11 at 100° C. for 20 hours and allowed to cool to room temperature 2 mL of water was added, and the precipitated solid was collected by filtration, washed with chloroform and dried Synthesis was carried out in the same manner as in Reference Synthetic Example by using to give 40 mg of the desired product (yield 73%).

Morphology: yellow solid

LC/MS (ESI⁺) m/z; 539, 541 [M+1]⁺

LC/MS (ESI⁻) m/z; 537, 539 [M−1]⁻

Synthetic Example 12 5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}-2-[4-pyrrolidin-1-yl]piperidine-1-carbonyl]thiophene

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (29 mg, 0.1 mmol) in isopropanol (4.0 mL) was heated with 5-[4-pyrrolidin-1-yl)piperidine-1-carbonyl]thiophene-2-carbohydrazide (21 mg, 0.1 mmol) prepared in Reference Synthetic Example 12 and 6 mg of p-toluenesulfonic acid monohydrate at 100° C. for 13 hours and allowed to cool to room temperature. The precipitated solid was collected by filtration, washed with 1 mL of chloroform and dried to give 21 mg of the desired product (yield 36%).

Morphology: pale orange solid

LC/MS (ESI⁺) m/z; 591, 593 [M+1]⁺

LC/MS (ESI⁻) m/z; 589, 591 [M−1]⁻

Synthetic Example 13 N-(2-Carbamoylethyl)-3-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidene}hydrazinecarbothioamido]benzamide

3-Amino-N-(2-carbamoylethyl)benzamide (31 mg, 0.15 mmol) in dimethylformamide (0.3 mL) was stirred with thiocarbonyldiimidazole (27 mg, 0.15 mmol) at room temperature for 1 hour and then with 2-(3,4-dichlorophenyl)-4-(1-hydrazonoethyl)-thiophen-3-ol prepared in Reference Synthetic Example 13 at 40° C. for 3 hours. Methanol and water were added to the reaction solution, and the resulting crystals were collected by filtration washed and dried to give 29 mg of the desired product (yield 53%).

Morphology: white solid

LC/MS (ESI⁺) m/z; 550, 552 [M+1]⁺

LC/MS (ESI⁻) m/z; 548, 550 [M−1]⁻

Synthetic Example 14 N-(2-Carbamoylethyl)-3-({1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazinecarbothioamido)benzamide

3-Amino-N-(2-carbamoylethyl)benzamide (56 mg, 0.27 mmol) was stirred with a dimethylformamide solution of thiocarbonyldiimidazole (0.1 M, 2.25 mL, 0.225 mmol) at room temperature for 1.5 hours, and then with a dimethylformamide solution of 3-(1-hydrazonoethyl)-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-ol prepared in Reference Synthetic Example 14 (0.1 M, 1.8 mL, 0.18 mmol) at 40° C. for 1 hour, and then stirred at room temperature for 17 hours. After addition of water and saturated aqueous sodium chlorides the solution was extracted with ethyl acetate, and the extract was dried over anhydrous sodium sulfate and filtered. The solvent was evaporated, and chloroform and hexane were added to the residue. The precipitated solid was collected by filtration, washed with hexane and dried to give 102.7 mg of the desired product (yield 100%).

Morphology: yellow solid

LC/MS (ESI⁺) m/z; 548 [M+1]⁺

LC/MS (ESI⁻) m/z; 546 [M−1]⁻

Synthetic Example 15 3-[2-Chloro-5-(2-{1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazinecarbothioamido)benzoylamino]propionic acid

Ethyl 3-(5-amino-2-chlorobenzoylamino)propionate (122.8 mg, 0.45 mmol) was stirred with a dimethylformamide solution of thiocarbonyldiimidazole (0.1 M, 4.5 mL) at room temperature for 1 hour and with a dimethylformamide solution of 3-(1-hydrazonoethyl)-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-ol prepared in Reference Synthetic Example 14 (0.1 M, 3.0 mL) at room temperature for 6 hours. Water (3.0 mL) was added, and the precipitated solid was removed by filtration. The filtrate was separated by thin layer chromatography to give 57.0 mg of a crude product. An ethanol solution (1.0 mL) of the crude product (26.0 mg, 0.0435 mmol) was stirred with 1 M aqueous sodium hydroxide (131 μL, 0.131 mmol), and the precipitated solid was collected by filtration, washed with water and dried to give 14.6 mg of the desired product (yield 20%).

Morphology: yellow solid

LC/MS (ESI⁺) m/z; 583, 585 [M+1]⁺

LC/MS (ESI⁻) m/z; 581, 583 [M−1]⁻

Synthetic Example 16 6-(2-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidene}hydrazinecarbothioamido)-2,3-dihydrobenzo[1,4]dioxine

2-(3,4-Dichlorophenyl)-4-(1-hydrazonoethyl)-thiophen-3-ol (25 mg, 0.08 mmol) prepared in Reference Synthetic Example 13 in dimethylformamide (0.25 mL) was stirred with 6-isothiocyanato-2,3-dihydrobenzo[1,4]dioxine (24 mg, 0.13 mmol, at 30° C. for 4 hours. Methanol and water were added to the reaction solution, and the resulting crystals were collected by filtration, washed and dried to give 28 mg of the desired product (yield 65%).

Morphology: colorless solid

LC/MS (ESI⁻) m/z; 492, 494 [M−1]⁻

Synthetic Example 17 6-[2-{1-{5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl}ethylidene}hydrazinecarbothiamido]-4H-benzo[1,4]oxazin-3-one

Synthesis was carried out in the same manner as in Synthetic Example 13 by using 6-amino-4H-benzo[1,4]oxazin-3-one (yield 55%).

Morphology: light brown solid

LC/MS (ESI⁺) m/z; 507, 509 [M+1]⁺

LC/MS (ESI⁻) m/z; 505, 507 [M−1]⁻

Synthetic Example 18 7-(2-{1-[5-(3,4-Dichlorophenyl)4-hydroxythiophen-3-yl]ethylidene}hydrazinecarbothioamido)-4H-benzo[1,4]oxazin-3-one

Synthesis was carried out in the same manner as in Synthetic Example 13 by using 7-amino-4H-benzo[1,4]oxazin-3-one (yield 73%).

Morphology: white solid

LC/MS (ESI⁺) m/z; 507, 509 [M+1]⁺

LC/MS (ESI⁻) m/z; 505, 507 [M−1]⁻

Synthetic Example 19 7-(2-{1-[4-Hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazinecarbothioamido)-4H-benzo[1,4]oxazin-3-one

7-Amino-4H-benzo[1,4]oxazin-3-one (33 mg, 0.203 mmol) was stirred with a dimethylformamide solution of thiocarbonyldiimidazole (0.1 M, 2.03 mL, 0.203 mmol) at room temperature for 1 hour and then with a dimethylformamide solution of 3-(1-hydrazonoethyl)-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-ol prepared in Reference Synthetic Example 14 (0.1 M, 1.36 mL, 0.135 mmol) at room temperature for 4 hours Water was added, and the precipitated solid was collected by filtration, washed with water and dried. After addition of chloroform, the solid was collected by filtration washed with chloroform and dried to give 33.6 mg of the desired product (yield 49%).

Morphology: pale yellow solid

LC/MS (ESI⁺) m/z; 505 [M+1]⁺

LC/MS (ESI⁻) m/z; 503 [M−1]⁻

Synthetic Example 20 3-(4-{1-[5-(3,4-Dichlorophenyl)-4-hydroxy-thiophen-3-yl]-ethylidenehydrazinocarbonyl}phenyl)-3-hydroxypropionic acid

Crude potassium 3-[4-(hydrazinocarbonyl)phenyl]-3-hydroxypropionate prepared in Reference Synthetic Example 15 suspended in dimethylformamide (3.0 mL) was stirred with 1.0 M hydrogen chloride-methanol (0.5 mL) and 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (0.15 g, 0.54 mmol) under reduced pressure at room temperature for 4 hours. The resulting solid was collected by filtration and dissolved in dimethyl sulfoxide (2.0 mL) and stirred with 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (99 mg, 0.34 mmol) at 100° C. for 2.5 hours. Water and methanol were added, and the resulting precipitate was collected by filtration and washed with chloroform to give 80 mg of the desired product (yield 33% for the two steps).

Morphology: gray solid

¹H-NMR (DMSO-d₆) δ: 2.21-2.63 (2H), 4.92 (1H, dd, J=9.0&4.5 Hz), 7.49 (1H, d, J=8.0 Hz), 7.63 (1H, d, J=8.5 Hz), 7.69 (1H, dd, J=8.5&2.0 Hz), 7.88 (1H, d, J=8.5 Hz), 8.07 (1H, s), 8.12 (1H, br s).

LC/MS (ESI⁺) m/z; 493, 495 [M+1]⁺

LC/MS (ESI⁻) m/z; 491, 493 [M−1]⁻

Synthetic Example 21 5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carboxyacid (4-methylpiperazin-1-yl)amide potassium salt

5-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carboxylic acid(4-methylpiperazin-1-yl)amide (11 mg, 0.02 mmol) suspended in methanol (0.33 mL) was sonicated with 0.1 M potassium hydroxide-methanol (0.2 mL, 0.02 mmol) in an ultrasonic cleaner for 10 seconds, and the reaction solution was concentrated to give the desired product (11 mg, yield 93%).

Morphology: red solid

Synthetic Examples 22 to 29

Synthesis was carried out in the same manner as in Synthetic Example 1, and the yields and morphology of the resulting compounds the LC/MS conditions used for their analysis and the observed peaks and retention times are shown in Table 5.

In Synthetic Examples 22 to 29, the desired products were prepared by mixing 1 equivalent of 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (prepared by the method disclosed in WO2004/108683) with 1 equivalent of the corresponding hydrazides in dimethyl sulfoxide, in isopropanol-p-toluenesulfonic acid or in dimethylformamide-hydrochloric acid, if necessary with heating and subsequent cooling, and if necessary, concentrating the reaction mixture, adding a poor solvent such as ethanol, methanol, water, chloroform, ether or hexane and collecting the resulting crystals by filtration.

TABLE 5 Syn. LC/MS Observed Observed Retention Ex. Yield condi- peak peak time No. (%) Morphology tions ESI⁺ ESI⁻ (minute) 22 50 pale yellow 3 569 567 2.48 solid 23 49 pale yellow 3 555 553 2.48 solid 24 43 pale yellow 3 485 483 3.63 solid 25 27 brown solid 3 579 577 2.55 26 46 yellow solid 3 527 525 3.63 27 71 yellow solid 3 514 512 3.50 28 52 yellow solid 3 500 498 3.54 29 30 pale yellow 3 528 526 3.35 solid

Synthetic Examples 30 to 38

Synthesis was carried out in the same manner as in Synthetic Example 1, and the yields and morphology of the resulting compounds, the LC/MS conditions used for their analysis and the observed peaks and retention times are shown in Table 6.

In Synthetic Examples 30 to 38, the desired products were prepared by mixing 1 equivalent of 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (prepared by the method disclosed in WO2004/108683) with the corresponding hydrazides, if necessary with heating and subsequent cooling, and if necessary, concentrating the reaction mixture, adding a poor solvent such as ethanol, methanol, water, chloroform, ether or hexane and collecting the resulting crystals by filtration.

TABLE 6 Syn. LC/MS Observed Observed Retention Ex. Yield condi- peak peak time No. (%) Morphology tions ESI⁺ ESI⁻ (minute) 30 48 light brown 3 497 495 3.47 solid 31 32 brown solid 3 591 589 2.43 32 76 light brown 3 581 579 2.42 solid 33 79 light brown 3 567 565 2.42 solid 34 66 colorless 3 539 537 3.42 solid 35 54 yellow solid 36 50 yellow solid 37 56 yellow solid 38 33 pale yellow 8 568 566 4.78 solid

Synthetic Example 39 3-(5-{1-[4-Hydroxy-5-(4-trifluoromethylphenyl)thiophen-3-yl]ethylidenehydrazinocarbonyl}-N-methylthiophene-2-carboxamido)propionic acid 39-a) t-Butyl 3-(5-{1-[4-Hydroxy-5-(4-trifluoromethylphenyl)thiophen-3-yl]ethylidenehydrazinocarbonyl}-N-methylthiophene-2-carboxamido)propionate

2-(4-Trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (35 mg, 0.122 mmol) and the hydrazide (40 mg, 0.122 mmol) prepared in Reference Synthetic Example 22 suspended in dimethylformamide (1 mL) were stirred with concentrated hydrochloric acid (10 mL) for 12 hours. After addition of water, the resulting solid was collected by filtration and dried to give the desired product (yield 62%).

Morphology: white solid

39-b) 3-(5-{1-[4-Hydroxy-5-(4-trifluoromethylphenyl)thiophen-3-yl]ethylidenehydrazinocarbonyl}-N-methylthiophene-2-carboxamido)propionic acid

t-Butyl 3-(5-{1-[4-Hydroxy-5-(4-trifluoromethylphenyl)thiophen-3-yl]ethylidenehydrazinocarbonyl}-N-methylthiophene-2-carboxamido)propionate (30 mg, 0.05 mmol) was stirred with trifluoroacetic acid (300 μL) at room temperature for 15 minutes. The reaction solution was concentrated, and after addition of ether the resulting solid was collected by filtration to give the desired product (yield 56%).

Morphology: white solid

LC/MS (ESI⁺) m/z; 540 [M+1]⁺

LC/MS (ESI⁻) m/z; 538 [M−1]⁻

Retention time: 4.03 minutes (condition 5)

Synthetic Examples 40 to 47

Synthesis was carried out in the same manner as in Synthetic Example 1, and the yields and morphology of the resulting compounds, the LC/MS conditions used for their analysis and the observed peaks and retention times are shown in Table 7.

The desired products were prepared by mixing 2-(4-chlorophenyl)3-hydroxy-4-methylcarbonylthiophene (prepared the method disclosed in WO2004/105683) in Synthetic Examples 40 to 46, or 1 equivalent of 1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone in Synthetic Examples 47 to 54, with the corresponding hydrazides in dimethyl sulfoxide, in isopropanol-p-toluenesulfonic acid or in dimethylformamide-hydrochloric acid, if necessary with heating and subsequent cooling, and if necessary, concentrating the reaction mixture, adding a poor solvent such as ethanol, methanol, water, chloroform, ether or hexane and collecting the resulting crystals by filtration.

TABLE 7 Syn. LC/MS Observed Observed Retention Ex. Yield condi- peak peak time No. (%) Morphology tions ESI⁺ ESI⁻ (minute) 40 40 light brown 3 547/549 545/547 2.37 solid 41 56 colorless 3 533/535 531/533 2.37 solid 42 62 pale yellow 2 505/507 503/505 4.00 solid 43 65 brown solid 3 557/559 555/557 2.40 44 57 yellow solid 3 506/508 504/506 3.09 45 57 yellow solid 8 492/494 490/492 4.55 46 63 ocher solid 8 478/480 476/478 4.47 47 42 yellow solid 2 495 493 3.30, 3.62 48 31 red solid 2 589 587 2.33, 2.54 49 79 orange solid 2 579 577 2.49 50 93 orange solid 2 565 563 2.49 51 74 pale yellow 2 537 535 3.30, 3.59 solid 52 37 pale yellow 2 538 536 3.32 solid 53 56 pale yellow 2 524 522 3.57 solid 54 58 pale yellow 2 510 508 3.55 solid

Synthetic Example 55 N-(2-Carbamoylethyl)-3-(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazinecarbothioamido)benzamide

Synthesis was carried out in the same manner as in Synthetic Example 14 by using 3-(1-hydrazonoethyl)-1-methyl-5-(3,4-dichlorophenyl)-1H-pyrazol-4-ol prepared in Reference Synthetic Example 27 to give 74.3 mg of the desired product (yield 81%).

Morphology: pale yellow solid

LC/MS (ESI⁺) m/z; 548, 550 [M+1]⁺

LC/MS (ESI⁻) m/z; 546, 548 [M−1]⁻

Synthetic Examples 56 to 58

Synthesis was carried out in the same manner as in Synthetic Example 1, and the yields and morphology of the resulting compounds, the LC/MS conditions used for their analysis and the observed peaks and retention times are shown in Table 8.

In Synthetic Examples 56 to 58, the desired products were prepared by mixing 1 equivalent of 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (prepared by the method disclosed in WO2004/108683) with 1 equivalent of the corresponding hydrazides in dimethyl sulfoxide, in isopropanol-p-toluenesulfonic acid or in dimethylformamide-hydrochloric acid, if necessary with heating and subsequent cooling, and if necessary, concentrating the reaction mixture, adding a poor solvent such as ethanol, methanol, water, chloroform, ether or hexane and collecting the resulting crystals by filtration.

TABLE 8 Syn. LC/MS Observed Observed Retention Ex. Yield condi- peak peak time No. (%) Morphology tions ESI⁺ ESI⁻ (minute) 56 48 pale yellow 8 554/556 552/554 4.80 solid 57 37 pale yellow 8 568/570 566/568 5.02 solid 58 66 pale yellow 2 546/548 544/546 3.69 solid

Synthetic Example 59 3-(5-{1-[4-Hydroxy-5-(3,4-dichlorophenyl)thiophen-3-yl]ethylidenehydrazinocarbonyl]-N-methylthiophene-2-carboxamido)propionic acid 59-a) t-Butyl 3-(5-{1-[4-hydroxy-5-(3,4-dichlorophenyl)thiophen-3-yl]ethylidenehydrazinocarbonyl]-N-methylthiophene-2-carboxamido)propionate

Synthesis was carried out in the same manner as in Synthetic Example 39 by using the hydrazide (40 mg, 0.122 mmol) prepared in Reference Synthetic Example 22 to give the desired product (yield 45%).

Morphology: white solid

59-b) 3-(5-{1-[4-Hydroxy-5-(3,4-dichlorophenyl)thiophen-3-yl]ethylidenehydrazinocarbonyl]-N-methylthiophene-2-carboxamido)propionic acid

Synthesis was carried out in the same manner as in Synthetic Example 39 by using t-butyl 3-(5-{1-[4-hydroxy-5-(3,4-dichlorophenyl)thiophen-3-yl]ethylidenehydrazinocarbonyl]-N-methylthiophene-2-carboxamido)propionate (30 mg, 0.05 mmol) to give the desired product (yield 100%).

Morphology: white solid

LC/MS (ESI⁺) m/z; 540, 542 [M+1]⁺

LC/MS (ESI⁻) m/z; 538, 540 [M−1]⁻

Retention time: 4.27 minutes (condition 5)

Synthetic Examples 60 to 74

Synthesis was carried out in the same manner as in Synthetic Example 1, and the yields and morphology of the resulting compounds, the LC/MS conditions used for their analysis and the observed peaks and retention times are shown in Table 9.

The desired products were prepared by mixing 1 equivalent of 2-(3,4-dimethylphenyl)-3-hydroxy-4-methylcarbonylthiophene prepared in Reference Synthetic Example 23 in Synthetic Examples 60 to 66, or 1 equivalent of 2-(4-trifluoromethoxyphenyl)-3-hydroxy-4-methylcarbonylthiophene prepared in Reference Synthetic Example 24 in Synthetic Examples 67 to 74, with 1 equivalent of the corresponding hydrazides in dimethyl sulfoxide, in isopropanol-p-toluenesulfonic acid or in dimethylformamide-hydrochloric acid, if necessary with heating and subsequent cooling, and if necessary, concentrating the reaction mixture, adding a poor solvent such as ethanol, methanol, water, chloroform, ether or hexane and collecting the resulting crystals by filtration.

TABLE 9 Syn. LC/MS Observed Observed Retention Ex. Yield condi- peak peak time No. (%) Morphology tions ESI⁺ ESI⁻ (minute) 60 80 pale yellow 2 541 539 2.85 solid 61 85 pale yellow 2 527 525 2.82 solid 62 41 yellow solid 2 457 455 4.14 63 59 brown solid 2 551 549 2.82 64 40 yellow solid 2 499 497 4.07 65 41 yellow solid 2 486 484 3.97 66 69 yellow solid 2 472 470 4.02 67 54 pale yellow 2 597 595 2.99 solid 68 64 pale yellow 2 583 581 3.00 solid 69 59 pale yellow 2 513 511 4.34 solid 70 67 brown solid 8 607 605 4.12 71 73 pale yellow 2 555 553 4.25 solid 72 37 yellow solid 8 556 554 4.48 73 56 yellow solid 3 528 526 3.37 74 36 yellow solid 3 542 540 3.38

Synthetic Example 75 3-(5-{1-[4-Hydroxy-5-(4-trifluoromethoxyphenyl)thiophen-3-yl]ethylidenehydrazinocarbonyl}-N-methylthiophene-2-carboxamido)propionic acid 75-a) t-Butyl 3-(5-{1-[4-hydroxy-5-(4-trifluoromethoxyphenyl)thiophen-3-yl]ethylidenehydrazinocarbonyl}-N-methylthiophene-2-carboxamido)propionate

Synthesis was carried out in the same manner as in Synthetic Example 39 by using 2-(4-trifluoromethoxyphenyl)-3-hydroxy-4-methylcarbonylthiophene (37 mg, 0.122 mmol) and the hydrazide (40 mg, 0.122 mmol) prepared in Reference Synthetic Example 22 to give the desired product (yield 40%).

Morphology: white solid

75-b) 3-(5-{1-[4-Hydroxy-5-(4-trifluoromethoxyphenyl)thiophen-3-yl]ethylidenehydrazinocarbonyl}-N-methylthiophene-2-carboxamido)propionic acid

Synthesis was carried out in the same manner as in Synthetic Example 39 by using t-butyl 3-(5-{1-[4-hydroxy-5-(4-trifluoromethoxyphenyl)thiophen-3-yl]ethylidenehydrazinocarbonyl}-N-methylthiophene-2-carboxamido)propionate (30 mg, 0.05 mmol) to give the desired product (yield 65%).

Morphology: white solid

LC/MS (ESI⁺) m/z; 556 [M+1]⁺

LC/MS (ESI⁻) m/z; 554 [M−1]⁻

Retention time: 4.10 minutes (condition 5)

Synthetic Examples 76 to 92

Synthesis was carried out in the same manner as in Synthetic Example 1, and the yields and morphology of the resulting compounds, the LC/MS conditions used for their analysis and the observed peaks and retention times are shown in Table 10.

The desired products were prepared by mixing 1 equivalent of 2-(4-bromophenyl)-3-hydroxy-4-methylcarbonylthiophene prepared in Reference Synthetic Example 25 in Synthetic Examples 76 to 84, or 1 equivalent of 2-(3-chlorophenyl)-3-hydroxy-4-methylcarbonylthiophene prepared in Reference Synthetic Example 26 in Synthetic Examples 85 to 92, with 1 equivalent of the corresponding hydrazides in dimethyl sulfoxide, in isopropanol-p-toluenesulfonic acid or in dimethylformamide-hydrochloric acid, if necessary with heating and subsequent cooling, and if necessary, concentrating the reaction mixture, adding a poor solvent such as ethanol, methanol, water chloroform, ether or hexane and collecting the resulting crystals by filtration.

TABLE 10 Syn. LC/MS Observed Observed Retention Ex. Yield condi- peak peak time No. (%) Morphology tions ESI⁺ ESI⁻ (minute) 76 75 pale yellow 8 507/509 505/507 4.72 solid 77 26 brown solid 8 601/603 599/601 4.03 78 66 yellow solid 8 591/593 589/591 3.95 79 66 yellow solid 8 577/579 575/577 4.02 80 53 pale brown 2 549/551 547/549 4.15 solid 81 52 light brown 2 550/552 548/550 3.82 solid 82 98 yellow solid 2 538/536 536/534 3.97 83 98 yellow solid 2 522/524 520/522 4.03 84 45 white solid 8 578/580 576/578 4.78 85 76 yellow solid 3 463/465 461/463 3.34 86 52 yellow solid 3 547/549 545/547 2.30 87 66 yellow solid 3 533/535 531/533 2.27 88 43 brown solid 3 557/559 555/557 2.30 89 68 pale yellow 3 505/507 503/505 3.32 solid 90 72 yellow solid 3 506/508 504/506 3.07 91 51 pale yellow 3 492/494 490/492 3.25 solid 92 64 dark yellow 3 478/480 476/478 3.29 solid

Synthetic Example 93 N-[1-{5-(3,4-Dichlorophenyl)-4-hydroxythiophen-3-yl}ethylidene]-5-{2-(4-oxopyridin-1(4H)yl)acetyl}thiophene-2-carbohydrazide

37 mg (0.12 mmol) of 2-(3,4-dichlorophenyl)-4-(1-hydrazonoethyl)-thiophen-3-ol prepared in Reference Synthetic Example 13, 40 mg (0.15 mmol) of 5-[2-(4-Oxopyridin-1(4H)-yl)acetyl]thiophene-2-carboxylic acid prepared in Reference Synthetic Example 28, 32 mg (0.17 mmol) of 1-[3-(3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride and 22 mg (0.16 mmol) of hydroxybenzotriazole were stirred with 3 ml of dioxane and then with 23 μl (0.17 mmol) of triethylamine at room temperature for 7 days. After addition of water, the precipitated solid was collected by filtration, washed with 2 ml of chloroform, 2 ml of methanol, 5 ml of water and 2 ml of methanol to give 14.5 mg of the desired product (yield 22%).

Morphology: brown solid

LC/MS (ESI⁺) m/z; 546, 548 [M+1]⁺

LC/MS (ESI⁻) m/z; 544, 546 [M−1]⁻

Retention time 3.23 minutes (condition 6)

The structural formulae of the compounds obtained in the Synthetic Examples are given below.

Assay Example 1 Stimulation of Proliferation of a Thrombopoietin-Dependent Cell Line

The response of thrombopoietin receptor to the compound of Synthetic Example 2 of the present invention was assayed using a human leukemic cell line, UT7/EPO-mpl.

(1) Cells and Cell Culture

UT7/EPO-mpl is a stable transformed cell line obtained by introducing into human leukemic cell line UT7/EPO a vector that induces expression of human thrombopoietin receptor (c-mpl) under control of cytomegalovirus immediate-early promoter by the method of Takatoku et al. (J. Biol. Chem., 272:7259-7263 (1997)). Proliferation of this cell line is stimulated by TPO, while its mother cell line UT7/EPO exhibits no response to TPO. These two cell lines were subcultured in IMDM (GIBCO) containing 10% fetal bovine serum (Thermo Electron or BioWest) using a CO₂ incubator (5% CO₂, 37° C.).

(2) Cell Proliferation Assay

The subcultured cells described above were washed twice with PBS and suspended in IMDM containing 10% fetal bovine serum at a cell density of 6×10⁴ cells/ml. The cell suspension was transferred to a 96-well tissue culture plate (CORNING) in 100-μl aliquots. Then either thrombopoietin (Pepro Tech EC, or the compound of Synthetic Example 2 dissolved in dimethyl sulfoxide was diluted 83-fold with IMDM containing 10% fetal bovine serum and added to the aforementioned cell suspension in 20-μl aliquots. The cell suspension was incubated in a CO₂ incubator (5% CO₂, 37° C.) for 4 days. Cell proliferation was assayed using WST-8 reagent (Kishida Chemical Co., Ltd.) according to instructions by the manufacturer. A 10-μl aliquot of 5 mM WST-8 reagent solution was added to each well of the tissue culture plate, and the plate was incubated at 37° C. for 4 hours. The formazan pigment generated was detected by measuring the absorbance at 450 nm with a 96-well microplate reader (Nihon Molecular Devices, Spectramax 190). FIG. 1 shows the results with UT7/EPO-mpl cells, while FIG. 2 shows data obtained with UT7/EPO cells expressing no thrombopoietin receptor.

FIG. 1 demonstrates that proliferation of thrombopoietin-responsive UT7/EPO-mpl cells was stimulated by the compound of Synthetic Example 2 in a concentration-dependent manner, while no effect of this compound on proliferation was observed with UT7/EPO, the mother cell line, as shown in FIG. 2. These results indicate that the compound of Synthetic Example 2 of the present invention acts on the thrombopoietin receptor selectively as an activator.

Assay Example 2

The compounds of the following Synthetic Examples were tested according to the method of Assay Example 1 to determine the concentration of each compound that yields a growth rate corresponding to 50% of the growth of human leukemic cell line UT-7/EPO-mpl observed in the presence of 10 ng/mL TPO (EC₅₀). The results are summarized in Table 11.

TABLE 11 Synthetic EC₅₀ Ex. No. (ng/mL) 1 2.7 2 2.1 4 1.5 5 0.32 7 2.3 8 2.2 9 5.6 10 3.1 11 0.35 12 0.40 13 2.9 14 2.7 15 7.7 16 32 17 16 18 16 19 23 20 3.0 24 1.1 35 0.27 45 3.2 49 1.6 55 3.1 58 0.85 65 2.0 75 3.3 84 2.9 90 0.33 93 0.37

Formulation Example 1

A granule preparation containing the following ingredients is prepared.

Ingredients Compound represented by the formula (1) 10 mg Lactose 700 mg Corn Starch 274 mg HPC-L 16 mg 1000 mg

A compound represented by the formula (1) and lactose are sifted through a 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They are mixed in a V-type blender. The powder mixture is kneaded with a low-viscosity hydroxypropylcellulose (HPC-L) aqueous solution, granulated (extrusion granulation, die size 0.5-1 mm) and dried. The resulting dry granules are sifted through a shaking sieve (12/60 mesh) to obtain a granule preparation.

Formulation Example 2

A powder preparation for capsulation containing the following ingredients is prepared.

Ingredients Compound represented by the formula (1) 10 mg Lactose 79 mg Corn Starch 10 mg Magnesium Stearate  1 mg 100 mg 

A compound represented by the formula (1) and lactose are sifted through a 60-mesh sieve Corn starch is sifted though a 120-mesh sieve. They are mixed with magnesium stearate in a V-type blender. The 10% powder is put in hard gelatin capsules No. 5, 100 mg each.

Formulation Example 3

A granule preparation for capsulation containing the following ingredients is prepared.

Ingredients Compound represented by the formula (1) 15 mg Lactose 90 mg Corn Starch 42 mg HPC-L  3 mg 150 mg 

A compound represented by the formula (1) and lactose are sifted through a 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They are mixed in a V-type blender. The powder mixture is kneaded with a low-viscosity hydroxypropylcellulose (HPC-L) aqueous solution, granulated and dried. The resulting dry granules are sifted through a shaking sieve (12/60 mesh). The granules are put in hard capsules No. 4, 150 mg each.

Formulation Example 4

A tablet preparation containing the following ingredients is prepared.

Ingredients Compound represented by the formula (1) 10 mg Lactose 90 mg Microcrystalline cellulose 30 mg Magnesium Stearate  5 mg CMC-Na 15 mg 150 mg 

A compound represented by the formula (1), lactose, microcrystalline cellulose and CMC-Na (carboxymethylcellulose sodium salt) are sifted through a 60-mesh sieve and mixed. The powder mixture is mixed with magnesium stearate to give a bulk powder mixture. The powder mixture is compressed directly into 150 mg tablets.

Formulation Example 5

An intravenous preparation is prepared as follows.

Compound represented by the formula (1)  100 mg Saturated Fatty Acid Glyceride 1000 ml

Solutions having the above-mentioned composition are usually administered to a patient intravenously at a rate of 1 ml per 1 minute.

INDUSTRIAL APPLICABILITY

The compounds of the present invention which have affinity for thrombopoietin receptor and act as thrombopoietin receptor agonists are useful as preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective, especially as drugs for hematological disorders accompanied by abnormal platelet count and as drugs for diseases treated or prevented by stimulating differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells, and are useful as medicines.

The entire disclosures of Japanese Patent Application No. 2004-361150 filed on Dec. 14, 2004 and Japanese Patent Application No. 2005-134643 filed on May 2, 2005 including specifications, claims, drawings and summaries are incorporated herein by reference in their entireties. 

The invention claimed is:
 1. A compound represented by the formula (1), a tautomer thereof, or a pharmaceutically acceptable salt thereof:

wherein A is a nitrogen atom or CH, when A is a nitrogen atom, B is NR⁹, wherein R⁹ is a C₁₋₁₀ alkyl group, and when A is CH, B is a sulfur atom, R¹ is a phenyl group, wherein said phenyl group is substituted with one or more substituents selected from the group consisting of: a halogen atom, an unsubstituted C₁₋₁₀ alkyl group, a C₁₋₁₀ alkyl group substituted with one or more halogen atom, an unsubstituted C₁₋₁₀ alkoxy group, and a C₁₋₁₀ alkoxy group substituted with one or more halogen atom, L¹ is a bond, X is OH, R² is a C₁₋₆ alkyl group, L² is a bond, L³ is NH, L⁴ is a bond or NH, Y is an oxygen atom or a sulfur atom, and R³ is a dihydrobenzo[1,4]dioxine group, a benzo[1,4]oxazinone group, and a thienyl group, wherein said thienyl group is substituted with a 2-(4-oxopyridin-1(4H)-yl)acetyl group) or a substituent represented by CONR²⁹R³⁰, where R²⁹ is a hydrogen atom or a C₁₋₁₀ alkyl group, and R³⁰ is selected from the group consisting of an unsubstituted amino group, a pyridyl-substituted amino group, a mono-C₁₋₁₀ alkylamino group, a di-C₁₋₁₀ alkylamino group, a N-methylpiperazinyl group, a piperidino group, a morpholino group, and a C₁₋₁₀ alkyl group substituted with one or more substituents selected from the group consisting of: a carboxyl group, a carbamoyl group, a pyrrolidinyl group, a tetrahydrofuryl group and a morpholino group, or R²⁹ and R³⁰ mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)—, wherein G is CR³¹R³², wherein R³¹ is a hydrogen atom, and R³² is a C₁₋₁₀ alkylcarbonylamino group or a pyrrolidinyl group, and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5), or NR²⁹R³⁰, as a whole, is selected from the group consisting of a di-substituted piperidino group or a di-substituted pyrrolidinyl group, wherein the substitutents independently selected from the group consisting of: a hydroxyl group and a C₁₋₁₀ alkoxy group.
 2. The compound, a tautomer thereof, or a pharmaceutically acceptable salt thereof, according to claim 1, wherein R¹ is a phenyl group, wherein said phenyl group is substituted with one or more substituents selected from the group consisting of: a halogen atom, an unsubstituted C₁₋₁₀ alkyl group, a trifluoromethyl group and a trifluoromethoxy group, R² is a methyl group, L⁴ is a bond, Y is an oxygen atom, and R³ is a thienyl group, wherein said thienyl group is substituted with a substituent represented by CONR²⁹R³⁰, where R²⁹ is a hydrogen atom or a methyl group, and R³⁰ is selected from the group consisting of an unsubstituted amino group, a di-methylamino group, a N-methylpiperazinyl group, a piperidino group, a morpholino group, and a methyl group or an ethyl group substituted with one or more substituents selected from the group consisting of: a carboxyl group, a carbamoyl group, a pyrrolidinyl group, a tetrahydrofuryl group and a morpholino group, or R29 and R30 mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)—, wherein G is CR³¹R³², wherein R³¹ is a hydrogen atom, and R³² is a methylcarbonylamino group or a pyrrolidinyl group, and each of m3 and m4 is independently an integer of from 1 to 2, provided that m3+m4 is 3 or 4), or NR²⁹R³⁰, as a whole, is a di-substituted piperidino group or a di-substituted pyrrolidinyl group, wherein the substitutents independently selected from the group consisting of: a hydroxyl group and a methoxy group.
 3. The compound, a tautomer thereof, or a pharmaceutically acceptable salt thereof, according to claim 2, wherein A is CH and B is a sulfur atom.
 4. The compound, a tautomer thereof, or a pharmaceutically acceptable salt thereof, according to claim 2, wherein A is a nitrogen atom, B is NR⁹ where R⁹ is a methyl group.
 5. The compound, a tautomer thereof, or a pharmaceutically acceptable salt thereof, according to claim 3, wherein R³⁰ is selected from the group consisting of an unsubstituted amino group, a di-methylamino group, a N-methylpiperazinyl group, a piperidino group, a morpholino group, and a methyl group or an ethyl group substituted with one or more substituents selected from the group consisting of: a pyrrolidinyl group, a tetrahydrofuryl group and a morpholino group.
 6. The compound, a tautomer thereof, or a pharmaceutically acceptable salt thereof, according to claim 3, wherein R³⁰ is a methyl group or an ethyl group substituted with one or more substituents selected from the group consisting of: a carboxyl group and a carbamoyl group.
 7. The compound, a tautomer thereof, or a pharmaceutically acceptable salt thereof, according to claim 3, wherein R²⁹ and R³⁰ mean, together with each other, —(CH₂)_(m3)-G-(CH₂)_(m4)—, wherein G is CR³¹R³², wherein R³¹ is a hydrogen atom, and R³² is a methylcarbonylamino group or a pyrrolidinyl group, and each of m3 and m4 is independently an integer of from 1 to 2, provided that m3+m4 is 3 or
 4. 8. The compound, a tautomer thereof, or a pharmaceutically acceptable salt thereof, according to claim 3, wherein NR²⁹R³⁰, as a whole, is a di-substituted piperidino group or a di-substituted pyrrolidinyl group, wherein the substitutents independently selected from the group consisting of: a hydroxyl group and a methoxy group.
 9. A composition comprising the compound according to claim 1, a tautomer, or pharmaceutically acceptable salt of the compound, as an active ingredient and at least one additive selected from the group consisting of an oral medicine, an excipient, a lubricant, a binder, a disintegrant, a humectant, a plasticizer, and a coating agent. 